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Sample search results for: a2a receptor antagonism

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1 Draft: 3/12/2009 142:225 Growth Factor Receptor Signaling
 

Summary:  of proliferation and differentiation · Activation; non-receptor tyrosine kinases · Antagonism; SOCS proteins... Draft: 3/12/2009 142:225 Growth Factor Receptor Signaling Outline: 1. Growth factor receptor... protein tyrosine kinase (PTK) signaling (J. Koland) a. Overview of PTK superfamily family · ...

  

Source: Iowa Center for Gene Therapy

 

Collection: Biotechnology ; Biology and Medicine

 
2 J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0
 

Summary:  of schizophrenia outlined above that A2A agonists may be novel antipsychotic drugs by antagonizing the D2 receptor... for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
3 BIOLOGY COLLOQUIUM Monday, October 31, 2011
 

Summary:  -regulation. The pharmacological effect attributed to GnRH receptor antagonism leads to improved symptoms for prostate cancer... . In addition, GnRH receptor antagonism continues for several weeks following removal of the superagonist... )benzimidazole Inhibitors of the Gonadotropin Releasing Hormone (GnRH) ...

  

Source: Heller, Barbara - Department of Applied Mathematics, Illinois Institute of Technology

 

Collection: Mathematics

 
4 research>>research>> Prof. Philip Lazarovici
 

Summary:  of anti-metastatic peptidomimetic lead compounds based on specific integrin-receptor antagonism; (iii... ) Development of a diagnostic kit based on nerve growth factor receptor, TrkA, activity for carcinoma staging... and prognosis; (iv) Characterization of nerve growth factor receptors in the cardiovascular ...

  

Source: Lelkes, Peter I. - School of Biomedical Engineering, Drexel University

 

Collection: Materials Science ; Biology and Medicine

 
5 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... -protein-coupled receptors (GPCRs). At 318 amino acids in length, the A3 subtype is the shortest, while A2A is the longest... - ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
6 P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a
 

Summary:  P2 receptor web: Complexity and fine-tuning Cinzia Volonté a,, Susanna Amadio a , Nadia D... Street, London NW3 2PF, UK Abstract The present review offers a new perspective on a family of receptors... , termed P2 receptors, specific for nucleoside tri- and diphosphates of purines/pyrimidines. We emphasize

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
7 Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach
 

Summary:  antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem... Commentary Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations... receptors (NMDARs), a subtype of ionotropic ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
8 GLP-1 and GIP Reporter Cell Lines Drug Development Bioassays for Diabetes and Obesity Therapeutics
 

Summary:  that activate or antagonize the GLP-1 receptor · Human GIP Receptor CRE-Luciferase: suitable for screening... compounds that activate or antagonize the GIP receptor · CRE-Luciferase: suitable for use as control line... Advantages: · More sensitive than other available GIP or GLP-1 ...

  

Source: Michelson, David G. - Department of Electrical and Computer Engineering, University of British Columbia

 

Collection: Engineering

 
9 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004
 

Summary:  JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165­205, 2004 Dopamine Receptor... The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling... properties that contribute to the definition of the receptor class, although some differences among ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine

 
10 Copyright C Blackwell Munksgaard 2002 Traffic 2002; 3: 866877
 

Summary:  , Strnad J, Pausch MH, Hadcock JR. Pharmacological char- acterization of the rat A2a adenosine receptor... -9219 Constitutive Activation and Endocytosis of the Complement Factor 5a Receptor: Evidence for Multiple Activated... Conformations of a G Protein-Coupled ...

  

Source: Bourne, Henry - Department of Cellular and Molecular Pharmacology, University of California at San Francisco

 

Collection: Biology and Medicine

 
11 Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance
 

Summary:  GPCRs (A1, A2A, A2b, and A3), whereas ATP activates P2X receptors, which are ion channels, as well... . (2003) Adenosine A2A-dopamine D2 receptor- receptor heteromerization: qualitative and quantitative... ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
12 The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine
 

Summary:  disorders, highlighting specific purinergic receptor subtypes, most notably A2A , P2X4 and P2X7 ,that might... in rodents, which is antagonised by caffeine. A2A receptors in the nucleus accumbens mediate this locomotor... . ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
13 ABBREVIATIONS: NMDA, N-methyl-D-aspartic acid; ACPD, 1-aminocyclopentane-1 ,3-dicarboxylic acid; AMPA,a-amino-3-hydroxy-5-methyli-soxazole-4-propionic acid; BAPTA, 1 ,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; DMSO, dimethylsulfoxide; DNQX, 6
 

Summary:  : NMDA receptor (NR)1 A/2A, 29 nM; NR1 A/2B, 300 nM; NR1A/2C, 120 nM; NR1A/2D, 1500 nM. Measurement of EC... the receptors expressed by rat brain poly(AY RNA, NR1A/2A and NR1AJ2B responses showed progressive run-down upon... ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
14 Vol. 275, No. 3 Printed in U.S.A.
 

Summary:  .4, 5.1) 0.31 (2.8, 3.4) 3 3 5 3 NMDA receptor clones NR1A/2A NR1A/2B NR1N2C NR1A/2D (1 p.M glycmne... glutamate receptors expressed in Xenopus oocytes to ACEA-lOll (fig. 3). NR1A/2A receptors were most ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
15 Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G proteins and, in common... [185]. Data has been presented to suggest that the P2X3 and P2X2/3 receptor antagonism that reduces... . Antagonism of P2X1 and P2X3 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
16 Purine and pyrimidine receptors G. Burnstock
 

Summary:  by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are activated... different P1 receptor subtypes, A1, A2A, A2B and A3, have been cloned and charac- ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
17 Purine and pyrimidine receptors G. Burnstock
 

Summary:  , shortly after, the A3 subtype was identified [21]. Four different P1 receptor subtypes, A1, A2A, A2B and A... transmembrane domain. Polymorphisms have been observed in the A1 and the A2A receptors. P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
18 Neuropharmacology 40 (2001) 749760 www.elsevier.com/locate/neuropharm
 

Summary:  antagonist against NMDA-induced currents in Xenopus oocytes expressing NR1-1a/2A or NR1-1a/2B receptors... M) consistently revealed only a weak antagonism of acampros- ate on native or recombinant NMDA-receptors. In HEK... in the brainstem. The present data indicate ...

  

Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health,

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
19 Chemistry 693: Receptor Pharmacology Instructor: Dr. Kelly Drew
 

Summary:  models of receptor function and receptor antagonism 2. Students will fit data sets provided... Chemistry 693: Receptor Pharmacology Instructor: Dr. Kelly Drew Office/office hrs: Irving I, room... indicated. Late HW is not accepted. CRN# ***** CHEM F693 F01 Topics in Receptor Pharmacology ...

  

Source: Wagner, Diane - Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks

 

Collection: Environmental Sciences and Ecology

 
20 Progress in Neurobiology 70 (2003) 387407 Kainate receptors and synaptic transmission
 

Summary:  Clarke et al. (1997) have reported that antagonism of GABAB receptors did not prevent the reduction... Progress in Neurobiology 70 (2003) 387­407 Kainate receptors and synaptic transmission James E... - and presynaptic roles for kainate receptors, which are a subtype of the ionotropic glutamate ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine


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21 Adenosine triphosphate as a neurotransmitter and neuromodulator Geoffrey Burnstock
 

Summary:  so far, namely A1, A2a, A2b, and A3. The first subclasses for P2-purinoceptors, proposed by Burnstock... , Le Moine C, Fisone G, et al. (1999): Distribution, biochemistry and function of striatal adenosine A2... A receptors. Prog Neurobiol ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
22 TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6
 

Summary:  , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... DPCPX, CPX, XAC Gi (1­3): cAMP nerve terminals A2A Brain, heart, lungs, spleen CGS21680 KF17837, SCH... of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
23 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001)
 

Summary:  were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... TK. 1998. Competitive and selective antagonism of P2Y1 receptors by N6 - methyl 2-deoxyadenosine 3... of skeletal muscle, changes in receptor ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
24 Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and
 

Summary:  this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... cascade (Williams and Jarvis, 2000; Fig. 2). ATP can antagonize ADP actions on P2YT/P2Y12 receptor... Perspectives in Pharmacology P2 Purinergic ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
25 ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and
 

Summary:  were due to indirect action via P1 receptors. Four subtypes of P2 receptors were cloned, namely A1, A2A... , cerebralischaemia, sleep apnoea, pain and inflammation32. A2A receptor antagonists are being ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
26 Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X3 and P2X2/3 receptors and between two
 

Summary:  the sustained response mediated by P2X2/3 receptors. Selective antagonism of P2X3 receptors by Ip5I 1379P... antagonism of P2X3 receptors by Ip5I1380 P.M. Dunn et al British Journal of Pharmacology, vol 130 (6) #12;me... . Selective antagonism of P2X3 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
27 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Encyclopedia of Neuroscience (2009), vol. 1, pp. 105-113 Author's personal copy #12;A2A (P1) receptors... ,b-meATP), whichproduces selec- tive desensitization of the ATP receptor, blocked the responses to NANC nerve stimulation... ,b-meATP, a selective desensitizer of P2X ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
28 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... . Blockade of A2A (P1) receptors antagonises parkinsonian tremor in the rat tacrine model by actions... on specific ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
29 Neuron, Vol. 48, 977985, December 22, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.neuron.2005.11.030 Photoinactivation of Native AMPA Receptors
 

Summary:  covalently cross link to and, as a result, irreversibly antagonize AMPA receptors. Thus, ANQX provides... - ibly antagonizes surface receptors and per- mits the real-time monitoring of AMPA re- ceptor insertion... antagonizes AMPA receptors (n = 8). (C) ANQX-mediated ...

  

Source: Vosshall, Leslie - L:aboratory of Neurogenetics and Behavior, Rockefeller University

 

Collection: Biology and Medicine

 
30 Glycosylation of b1-adrenergic receptors regulates receptor surface expression and dimerizationq
 

Summary:  the b2-adrenergic receptor [15], a2A-adrenergic re- ceptor [30], and dopamine D1 receptor [31]. Con... antagonism of receptor-mediated drug actions in the presence of spare receptors, J. Pharmacol. Toxicol... Glycosylation of ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
31 Abstract The present study uses increased atmospheric pressure as an ethanol antagonist to test the hypothesis
 

Summary:  antagonism is the manner in which its primary effects on receptor function are medi- ated (i.e., whether... which found that pressure antagonizes ethanol potentiation of GABAA receptor function (Davies and Alkana... ATA heliox antagonized the LORR, anticonvulsant effects and in vitro ...

  

Source: Brinton, Roberta Diaz - Laboratory for Neuroscience Research & School of Pharmacy, University of Southern California

 

Collection: Biology and Medicine

 
32 nature neuroscience volume 1 no 3 july 1998 185 Recent studies suggest that tyrosine kinases are important for
 

Summary:  . p 1a/2A (10), P 1aC744,798A/2A (5), l 1b/2A (9), L 1bm207­211/2A (6). (d) Correlation between... -term potentiation (LTP) induction has been attributed to its enhancement of NMDA-receptor currents4­6 because... an ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
33 STUDIES ON THE ROLE OF THE N-TERMINAL DOMAIN OF NR1 IN THE REDOX MODULATION OF NR2A-CONTAINING NMDA RECEPTORS
 

Summary:  ............................................................... 29 Figure 3. Ebselen does not directly antagonize NMDA receptors. .................. 31 Figure 4... . Ebselen does not directly antagonize NMDA receptors. A: NMDA (30 µM)-induced current elicited from a 4... -CONTAINING NMDA ...

  

Source: Sibille, Etienne - Center for the Neural Basis of Cognition & Department of Psychiatry, University of Pittsburgh

 

Collection: Biology and Medicine

 
34 For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133
 

Summary:  (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... ,38 Mice lacking the adeno- sine A2A receptor were found to have an increase in heart rate and high blood... pressure (as well ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
35 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  t Caffeine is an antagonist at A1 and A2A adenosine receptors and epidemiological evidence suggests... receptors have been shown to indirectly reduce the neuroinflammatory response of microglia cells. A1 and A2A... ...

  

Source: Wenk, Gary - Departments of Psychology & Neuroscience, Ohio State University

 

Collection: Biology and Medicine

 
36 The behavioral pharmacology of hallucinogens William E. Fantegrossi a,
 

Summary:  -methyl-D-aspartate (NMDA) antagonism (i.e., phen- cyclidine), muscarinic receptor antagonism (i.e., scopo- lamine), k... -administration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 3. Serotonin receptors and ...

  

Source: Howell, Leonard L. - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
37 The birth and postnatal development of purinergic signalling G. Burnstock,1
 

Summary:  ),Chesselletal.(1997a),Laloetal.(1998), Ralevicetal.(1999),Brown&Dale(2002),Vasiljevetal.(2003) AstrogliaA1,A2A... ;Table1(Continued) TissuePurinoceptorsMainfunctionalroleReferences OligodendrogliaA1,A2A,A2B,A3... .(2001),Matuteetal. (2007) ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
38 Diabetes Metab . Author manuscript Cannabinoid receptors as novel therapeutic targets for the management of
 

Summary:  and the liver are also incriminated in the progression of injury ( ).5 CANNABINOID RECEPTOR ANTAGONISM REDUCES... - 11 39 . Deveaux V , Ichitogani Y , Teixeira-Clerc F . CB2 receptor antagonism reduces diet... Diabetes Metab . Author manuscript Page /1 4 Cannabinoid receptors as novel ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
39 Neuropharmacology of alcohol addiction V Vengeliene, A Bilbao, A Molander and R Spanagel
 

Summary:  components that are mediated by different receptor systems (Grant, 1999). In particular, an antagonism... lines (Cippitelli et al., 2005; Hansson et al., 2007) and CB1 receptor antagonism has been reported... and it was shown that a1, a2, a5 and ...

  

Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health,

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
40 The Glutamate Receptor Ion Channels RAYMOND DINGLEDINE,1
 

Summary:  The Glutamate Receptor Ion Channels RAYMOND DINGLEDINE,1 KARIN BORGES, DEREK BOWIE, AND STEPHEN F... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 III. Receptor structure... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine


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41 Summary and conclusions Summary and Conclusions
 

Summary:  in depressed patients, might be derived from beta receptor antagonism rather than 5-HT1A antagonism. Concerning... . Although antagonism of 5-HT1A receptors during administration of SSRIs might induce augmented levels of 5... . Antagonism of 5-HT2C ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
42 Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm
 

Summary:  subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... Neuropharmacology 43 (2002) 1313­1323 www.elsevier.com/locate/neuropharm P2 receptors in the murine... . The localization of P2Y1, P2Y2, P2Y4, P2X1 and P2X2 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
43 Purinergic signalling *Geoffrey Burnstock
 

Summary:  /ADP, respectively, was proposed (Burnstock, 1978). Four subtypes of P1 receptors have been cloned, namely A1, A2A, A... . Adenosine, via A2A receptors, has a protective effect in a rat model of Parkinson's disease, perhaps... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
44 Genetics of caffeine consumption and responses to caffeine Amy Yang & Abraham A. Palmer & Harriet de Wit
 

Summary:  . The exact mecha- nism of how A2A receptor antagonism can provide dopamine neuron protection remains unclear... and A2A receptors (Daly et al. 1983). Adenosine receptors are ...

  

Source: Das, Soma - Department of Human Genetics, University of Chicago; Ober, Carole - Committee on Genetics & Department of Human Genetics, University of Chicago

 

Collection: Biology and Medicine

 
45 Hyperekplexia, or startle disease, is a rare neurological condition, which is usually inherited in an autosomal
 

Summary:  of the glycine receptor on human chromosome 5 (exons 6 and 7; Shiang, Ryan, Zhu, Hahn, O'Connell & Wasmuth, 1993... . 1996). Heterologous expression studies of recombinant glycine receptors have shown that introducing any... on receptor function, producing, for example, substantial increases in the EC50 for glycine (Langosch, ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
46 ABBREVIATIONS: NMDA, N-methyl-D-aspartate; AMPA, ct-amino-3-hydroxy-4-methylisoxazolepropionic acid; DDB, 2,5-dihydro-2,5-dioxo-1H-ben-zazepine; DDHB, 2,5-dihydro-2,5-dioxo-3-hydroxy-1H-benzazepine; 4-Br-DDHB, 7-Me-DDHB, and 8-Me-DDHB, 4-bromo, 7-methyl,
 

Summary:  in any form reserved. MOLECULAR pHARMAcoLoGY, 41:1130-1141 Competitive Antagonism of Glutamate Receptor... for Glutamate Receptor Antagonism by Benzazepines I 131 atWashingtonUnivSchMedLibronAugust7,2008molpharm... ,2008molpharm.aspetjournals.orgDownloadedfrom #12;Kainate EC50= 120pM Glutamate ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
47 JOURNAL OF CELLULAR PHYSIOLOGY 200:309317 (2004) Significance of N-Methyl-D-Aspartate (NMDA)
 

Summary:  and Taichman, 1994). These suprabasal cells are also found to express atypical integrins (a2, a3, a6, and b1... -mediated pathway. For example, topical Mg2þ application, which can antagonize NMDA receptor currents, greatly... ) Receptor-Mediated Signaling in Human ...

  

Source: Bear, Mark - Picower Institute for Learning and Memory & Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
48 Characterization of the 5-HT7 Receptor Synthesis and Molecular Modeling
 

Summary:  Characterization of the 5-HT7 Receptor Synthesis and Molecular Modeling of Ligands and the Receptor... #12;#12;RIJKSUNIVERSITEIT GRONINGEN Characterization of the 5-HT7 Receptor Synthesis and Molecular... Modeling of Ligands and the Receptor Proefschrift ter verkrijging van het doctoraat in de Wiskunde en

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
49 Binding, gating, anity and ecacy The nature of the problem
 

Summary:  -Katz mechanism Two states and constitutve activity Haemoglobin as a receptor What does `allosteric' mean? What... nicotinic acetylcholine receptor Eect of dierent agonists ont he frog endplate receptor Mutant nicotinic... receptors The glycine receptor ± a gating mutation? The NMDA ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
50 INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM
 

Summary:  for adenosine (A1, A2A, A2B and A3 subtypes, all G-protein-coupled) and P2 receptors for ATP (P2X ionotropic... ., 2001. Activation of protein kinase A and atypical protein kinase C by A2A adenosine receptors... ^18. Ongini, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
51 Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson
 

Summary:  as purines [26,128] (see Table I). Four subtypes of P1 receptors have been cloned--A1, A2A, A2B, and A3 (see... receptors lead to suppression of pain signaling, while A2A receptors lead to pain ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
52 Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression
 

Summary:  .R., Shanley, T.P., 2002. The A2A receptor mediates an endogen- ous regulatory pathway of cytokine expression... Purinergic receptors modulate MAP kinases and transcription factors that control microglial... the proteins important for modulating the inflammatory function of microglia are ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
53 Physiology and Pathophysiology of Purinergic Neurotransmission
 

Summary:  receptors Four subtypes of P1 receptors have been cloned, namely, A1, A2A, A2B, and A3 (see Refs. 370, 423... , WRC-0571 Gi/Go2cAMP A2A Brain, heart, lungs, spleen NECA CGS 21680 CVT-3146 KF17837, SCH58261, ZM... nervous ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
54 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 53:281291 (2001)
 

Summary:  X1 or rat P2X3 receptor subunits. Injected oocytes were incubated #12;ANTAGONISM OF GROUP I P2X... Receptor Antagonism The ability of P2X1 and P2X3 receptors to recover from blockade was assessed 20 min... and irreversible antagonist). Each analogue ex- erted a nonsurmountable ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
55 Vas deferens A model used to establish sympathetic cotransmission
 

Summary:  release via A2A receptors in the epididymal portion and via A2B receptors in the prostatic portion... to exogenous NA involved both a1A and a2A/D adrenoceptors. The main postjunctional receptor to ATP is ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
56 P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock
 

Summary:  phase hyperaemia mediated via A2A receptors on smooth muscle cells. Red blood cells as regulators... phase of the reactive hyperaemia as has been shown by infusion of adenosine deaminase or a selective A2A... REVIEW P2 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
57 Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum
 

Summary:  Title Page Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co... ; Accepted: Aug 12, 2011 #12;Abstract The adenosine A2A receptor (A2AR) is a potential drug target... neuromodulator that ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
58 Diverse Roles for the Eph Family of Receptor Tyrosine Kinases in Carcinogenesis
 

Summary:  , under certain conditions activa- tion of Eph receptors antagonizes the activation of mi- togen... in cancer Type of cancer or cancer cell line. (with references) Eph family members Ephrins A1 A2 A3 A4 A5 B1... Diverse Roles for the Eph Family of Receptor Tyrosine ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
59 Purines and Sensory Nerves Geoffrey Burnstock
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 380 Abstract P2X and P2Y nucleotide receptors are described on sensory neurons and their peripheral... and joints mediating reflex responses and nociception. Purinergic receptors on fibres in the dorsal spinal... been published ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
60 Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
 

Summary:  in development of this disease.2;4 It was hypothesized that antagonism of D2 and 5-HT2A receptors and enhancement... -HT2A antagonism and weak D2 Keywords: Arylpiperazine; Dopamine receptors; Serotonin receptors... APDs (partial agonism or antagonism at the D2 ...

  

Source: Champagne, Frances A. - Department of Psychology, Columbia University

 

Collection: Biology and Medicine


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61 n engl j med 353;16 www.nejm.org october 20, 2005 The new england journal of medicine
 

Summary:  ) is an antiinflammatory protein that physically interacts with and inhibits cytosolic phospholipase A2a (cPLA2a).41... that breach epithelial barriers, for instance, directly activate complement and toll-like receptors, two... in alleviating inflam- matory disorders results from the pleiotropic effects of ...

  

Source: Rhen, Turk - Department of Biology, University of North Dakota

 

Collection: Biology and Medicine

 
62 Stereoselectivity of 8-OH-DPAT toward the serotonin 5-HT1A receptor: Biochemical and molecular modeling study
 

Summary:  that at postsynaptic 5- HT1A receptors in hippocampus both isomers act as partial agonists, because they antagonize... Stereoselectivity of 8-OH-DPAT toward the serotonin 5-HT1A receptor: Biochemical and molecular... February 2006 Accepted 10 May 2006 Keywords: 5-HT1A receptor 5-HT synthesis R-8-OH-DPAT ...

  

Source: Skolnick, Jeff - Center for the Study of Systems Biology, Georgia Institute of Technology

 

Collection: Chemistry ; Biology and Medicine

 
63 Transient Plasticity of Hippocampal CA1 Neuron Glutamate Receptors Contributes to Benzodiazepine
 

Summary:  Transient Plasticity of Hippocampal CA1 Neuron Glutamate Receptors Contributes to Benzodiazepine... receptor (AMPAR)-mediated and reduced NMDA receptor (NMDAR)-mediated excitation in CA1 pyramidal neurons 2... receptor-mediated whole-cell currents in CA1 neurons from hippocampal slices prepared from 0-, 1-, 2

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
64 CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate
 

Summary:  CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic... of DHPG effects that result in per- sistent epileptiform activity, and antagonism of CB1 receptors has... region and CB1 receptor antagonism prevents the depres- sion. We ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
65 Critical ReviewsTM in Neurobiology, 16(3)187224 [2004] 0892-0915/04 $20.00 2004 by Begell House, Inc. 187
 

Summary:  , Inc. 187 Glutamate Receptor Gating Kevin Erreger,¹ Philip E. Chen,² David J.A. Wyllie,² & Stephen F... 30322-3090; kerrege@emory.edu ABSTRACT: Ionotropic glutamate receptors (iGluRs) mediate the vast... of glutamate receptor ion channels,with an emphasis on the functional and structural aspects of how agonist

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
66 ASSOCIATE EDITOR: DIANNE M. PEREZ The Significance of G Protein-Coupled Receptor
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 925 4. A2a-adenosine receptor structure... (Warne et al., 2008, 2011), A2a-adenosine (Jaakola et al., 2008; Xu et al., 2011), chemokine C... ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
67 Brain Research 872 (2000) 262265 www.elsevier.com/locate/bres
 

Summary:  of striatal D1 to muscarinic receptors changes in aging rats housed in an enriched environment a,b , d a b... cells that express D1 and D2 receptors. We used radioligand binding assays to examine whether EC... produces plasticity in striatal receptor density and receptor density ratios. After 30 days of EC, ...

  

Source: Anderson, Brenda - Department of Psychology, SUNY at Stony Brook

 

Collection: Biology and Medicine

 
68 Introduction Chapter 1 1 Introduction
 

Summary:  functional receptors that met the operational criteria of this class (i.e. susceptibility to antagonism... proteins called receptors, regulate the signaling pathways that enable cells to communicate... family of receptors that are coupled to heterotrimeric guanine nucleotide binding proteins, and which

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
69 -Tetrahydrocannabinol Antagonizes the Peripheral
 

Summary:  ( )- 9 -Tetrahydrocannabinol Antagonizes the Peripheral Cannabinoid Receptor-mediated Inhibition... inhibi- tion of adenylyl cyclase at the CB2 receptor. Morever, ( )- 9 -THC antagonizes the agonist... either of the two receptors (Fig. 3). ( )- 9 -THC Antagonism in ...

  

Source: Vogel, Zvi - Department of Neurobiology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
70 0022.3565/87/2423-0882S00.00/0 THE JOURNALor PHARMACOLOGYAND EXP!JUNENTALTHERAPEIITICS
 

Summary:  antagonizing adenosine receptor-mediated hypotension. XAC also selectivelyblockedpotentiationby adenosine ofthe... /and Accepted for publication May 15, 1987 ABSTRACT Caffeine. a nonselectiveadenosine receptor antagonist, 7... . A2 adenosine receptors. Blockade of the negative chronotropic effect of bolus Lv. ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
71 Adenosine-Mediated Presynaptic Modulation of Glutamatergic Transmission in the Laterodorsal Tegmentum
 

Summary:  1 and A2a purine receptors regulate striatal acetylcholine release. J Neurochem 55:31­38. Brundege... antagonized adenosine inhibition of the evEPSCs with the A1 receptor antagonist CPT (Ki 10.9 nM at A1... by ITU could be completely antagonized ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
72 Cellular and Pharmacological Selectivity of the Peroxisome Proliferator-Activated Receptor-/ Antagonist GSK3787S
 

Summary:  Cellular and Pharmacological Selectivity of the Peroxisome Proliferator-Activated Receptor... of high-affinity agonists for peroxisome prolifera- tor-activated receptor- / (PPAR / ) has led... ), was characterized using in vivo and in vitro models. Orally adminis- tered GSK3787 caused antagonism of 4

  

Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University

 

Collection: Biology and Medicine

 
73 Pathophysiology and Therapeutic Potential of Purinergic Signaling
 

Summary:  subtypes of P1 receptors were cloned, namely, A1, A2A, A2B, and A3. In 1985, Burnstock and Kennedy proposed... ). The therapeutic poten- tial of adenosine A2A receptor antagonists in Parkinson's 64 BURNSTOCK #12;disease is ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London; Saunders, Mark - Benfield Hazard Research Centre, Department of Space and Climate Physics, University College London

 

Collection: Biology and Medicine ; Geosciences

 
74 Development/Plasticity/Repair Glutamate Acting on AMPA But Not NMDA Receptors
 

Summary:  - mental material). Thus, antagonizing the effects of gluta- mate acting through AMPA receptors im- paired... in A2). A2, Reconstructions of hippocampal primordia from E15 GAD67­EGFP KI mice cultured for 3 DIV... Development/Plasticity/Repair Glutamate Acting on AMPA But Not NMDA ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm; Ecole Polytechnique, Centre de mathématiques

 

Collection: Biology and Medicine ; Mathematics

 
75 PHS 398/2590 (Rev. 09/04) Page 1 Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Dykstra, Linda A.
 

Summary:  receptor antagonism (SR141716A), and CB1 receptor agonism (CP-55940). Behav Pharmacol. 16: 381-388. Allen... muscarinic acetylcholine receptor-deficient mice. Psychopharmacology Fischer, B.D. and Dykstra, L... .A. Interactions between an NMDA antagonist and low-efficacy opioid receptor ...

  

Source: Elston, Timothy C. - Department of Pharmacology, University of North Carolina at Chapel Hill

 

Collection: Mathematics ; Biology and Medicine

 
76 Structural aspects of AMPA receptor activation, desensitization and deactivation
 

Summary:  and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core... antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2... Structural aspects of AMPA receptor activation, desensitization and ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
77 0026-895X/951030582.06$3.00/0 Copyright t by The American Society for Pharmacology and Experimental Therapeutics
 

Summary:  -preferring receptors. Because the antagonism by this drug is noncompet- itive, its effectiveness should... . Differential Antagonism of a-Amino-3-hydroxy-5-methyl-4- isoxazolepropionic Acid-Preferring and Kainate... -Preferring Receptors by 2,3-Benzodiazepines TIMOTHY J. WILDING and JAMES E. HUETINER ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
78 Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: interactions with ETA receptors
 

Summary:  was antagonized by an ETB receptor blocker. A similar 25% decrease in RBF was observed when ETB recep- tors were... is not affected by ETA antagonism, so tonic stimulation of ETA receptors seems an unlikely explanation... Dual constrictor and dilator actions of ETB receptors in the rat ...

  

Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg

 

Collection: Biology and Medicine

 
79 Purinergic Signaling and Vascular Cell Proliferation and Death Geoffrey Burnstock
 

Summary:  established.1,2 P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B, and A3) have been identified... , but it may be that the levels of expression of the A2A receptors are low relative to A2B Received September... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
80 Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1401-1405, February 1996
 

Summary:  in T-cell activation (T-cell receptor/antigen/major histocompatibility complex/reaction mechanism/antagonism... two impor- tant literature observations about T-cell receptor antagonism. The first observation... , but here antagonism results from incomplete receptor ...

  

Source: Rabinowitz, Joshua D. - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University

 

Collection: Biology and Medicine ; Biotechnology


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81 Cellular/Molecular Adenosine-Evoked Hyperpolarization of Retinal Ganglion
 

Summary:  receptors to decrease neurotransmitter release or A2A receptors to potentiate neuro- transmitter release... release are primarily mediated by the A2A receptor- induced activation of P-type Ca2 channels and ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
82 Telephone: (419) 383-4182, 383-4187 FAX: (419) 383-2871
 

Summary:  .Sanchez@utoledo.edu For more information on Steroid Receptor Research, see: Steroid Receptor Associated Proteins Resource... or Glucocorticoid Receptor Resource Training B.A., Biology, 1974, Wesleyan University Ph.D., Human Genetics, 1983... Interests: Control of steroid receptor physiology by molecular ...

  

Source: Toledo, University of - Center for Diabetes and Endocrine Research (CeDER)

 

Collection: Biology and Medicine

 
83 pubs.acs.org/Biochemistry Published on Web 10/02/2009 r 2009 American Chemical Society 10286 Biochemistry 2009, 48, 1028610297
 

Summary:  expression when coexpressed with the adenosine A2A receptor, as well as a much larger increase when... and adenosine A2A receptor. Interestingly, D2R and A2AR are known to be capable of functional interactions... ., and ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
84 Minireview: Neuronal Steroid Hormone Receptors: They're Not Just for Hormones Anymore
 

Summary:  Minireview: Neuronal Steroid Hormone Receptors: They're Not Just for Hormones Anymore JEFFREY D... , by interac- tion with intracellular steroid hormone receptors acting as reg- ulators of transcription... . These intracellular steroid hormone receptors have often been considered to be activated solely by cognate hormone

  

Source: Blaustein, Jeffrey D. - Center for Neuroendocrine Studies, University of Massachusetts at Amherst

 

Collection: Biology and Medicine

 
85 Glutamate activates a trio of ionotropic receptors that are named for the agonists kainate, AMPA and NMDA.
 

Summary:  . In particular, the selective, non-competitive antagonism of AMPA receptors by GYKI 53655 (1-(4-aminophenyl)-3... produced much weaker antagonism at neuronal kainate receptors. At 100 µM, SYM 2206 caused less than 15... , 196­205. PATERNAIN, A. V., MORALES, M. & LERMA, J. (1995). Selective ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
86 THE EXPRESSION OF DOMINANT-NEGATIVE SUBUNITS SELECTIVELY SUPPRESSES NEURONAL AMPA AND KAINATE RECEPTORS
 

Summary:  , was largely absent from the long thin processes that appeared to be axons (compare arrow- heads in Fig. 6A2^A3... RECEPTORS ANTOINE ROBERT,a RHONDA HYDE,a1 THOMAS E. HUGHESb and JAMES R. HOWEaà a Department of Pharmacology... glutamate receptor subtypes is to direct the expression of ...

  

Source: Howe, James R.- Department of Pharmacology, Yale University

 

Collection: Biology and Medicine

 
87 Olfaction: Attracting Both Sperm and Leslie B. Vosshall
 

Summary:  . Oka, Y., Omura, M., Kataoka, H., and Touhara, K. (2004). Olfactory receptor antagonism between... Olfaction: Attracting Both Sperm and the Nose Dispatch Leslie B. Vosshall Odorant receptor genes... chemotaxis. New data demonstrate that human odorant receptor hOR 17-4 may play similar roles in both tissues

  

Source: Vosshall, Leslie - L:aboratory of Neurogenetics and Behavior, Rockefeller University

 

Collection: Biology and Medicine

 
88 121Prolactin Antagonists/Kuo, Coss, and WalkerVol. 9, No. 2Endocrine, vol. 9, no. 2, 121131, October 1998 0969711X/98/9:121131/$10.75 1998 by Humana Press Inc. All rights of any nature whatsoever reserved. Prolactin Receptor Antagonists
 

Summary:  to demonstrate. This is in large part because ligand:receptor ratios of 1:2 must be exceeded before self-antagonism... representation of agonism and self-antagonism in a system requiring receptor dimerization for biological activity... reserved. 121 Review Prolactin Receptor Antagonists ...

  

Source: Coss, Djurdjica - Department of Reproductive Medicine, University of California at San Diego

 

Collection: Biology and Medicine

 
89 Expression of P2X and P2Y receptors in the intramural parasympathetic ganglia of the cat urinary bladder
 

Summary:  is known to antagonize P2X1 and P2X3 receptors (28). All the neurons that were responsive to ,-meATP (10 M... , Padilla F, Ford APDW, and Burnstock G. Antagonism of ATP responses at P2X receptor subtypes by the p... 1 Expression of P2X and P2Y receptors in the intramural parasympathetic ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
90 oo26-895x196/o3o54o-o7$3.oo/o Copyright by The American Society for Pharmacology and Experimental Therapeutics
 

Summary:  OpM NBQX +3OpM ACEA-lOll EE 542 Antagonist Pharmacology of AMPA and Kainate Receptors Fig. I . Antagonism... sites in rat cortical membranes (39) and was found to antagonize kainate-preferring receptors... ., and Lerma, J. Selective antagonism of AMPA receptors unmasks ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
91 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  ). 4. Discussion In the present study, we have demonstrated that hydrocortisone antagonized P2 receptor... antagonized by PPADS, a non-selective antagonist of P2 receptors, which supports the involvement of P2... receptors, produced some antagonism against the effect ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
92 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  's personal copy New regulatory mechanisms of TGF-b receptor function Jong Seok Kang, Cheng Liu and Rik... in development, tissue homeostasis and disease. Upon binding to their cell surface receptors, TGF-b family... that the signaling responses are also exten- sively defined by regulatory mechanisms at the level of the receptors

  

Source: Derynck, Rik - Cardiovascular Research Institute, University of California at San Francisco

 

Collection: Biology and Medicine

 
93 Pharmacology of ionotropic glutamate receptors: A structural perspective Philipp Stawski, Harald Janovjak, Dirk Trauner
 

Summary:  antagonism, allosteric modulation, or receptor desensitization can be beautifully illustrated using i... (s) Citation GluN1 1Y20 ACPC (29) a 59 GluN1 1PBQ 5,7-Dichlorokynureniuc acid (54) ant 58 GluN1/GluN2A 2A5T... Glycine (2), glutamic acid (1) a, a 60 GluN2A ...

  

Source: Trauner, Dirk - Department Chemie, Ludwig Maximilians Universität München

 

Collection: Chemistry

 
94 CB2 cannabinoid receptor mediation of antinociception Mohab M. Ibrahim a
 

Summary:  . The CB2 receptor-selective agonist AM1241 produces antinociceptive effects that are antagonized by CB2... selective for CB1 receptors and, thus, may have antagonized the actions of WIN55,212-2 at CB2 receptors... CB2 cannabinoid receptor mediation of antinociception ...

  

Source: Buckley, Nancy E. - Biological Sciences Department, California State Polytechnic University at Pomona

 

Collection: Biology and Medicine

 
95 Cannabinoid receptors as novel therapeutic targets for the management of non alcoholic steatohepatitis
 

Summary:  in the progression of injury (5). CANNABINOID RECEPTOR ANTAGONISM REDUCES DEVELOPMENT OF NAFLD CB1 receptors promote... al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med... . Deveaux V, Ichitogani Y, Teixeira-Clerc F, et al. CB2 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
96 Progress in Neurobiology 66 (2002) 355474 Descending control of pain
 

Summary:  . . . . . . . . . . . . . . . . . . . . . 424 11.2.2.2. A potential role of A2A receptors... transmitters and specific receptor types in the modulation and expression of mechanisms of descending... ; OFQ, orphaninFQ; ORL, opioid-receptor-like; OT, oxytocin; PAG, ...

  

Source: Meagher, Mary - Department of Psychology, Texas A&M University

 

Collection: Biology and Medicine

 
97 3 -Hydroxypregnane Steroids Are Pregnenolone Sulfate-Like GABAA Receptor Antagonists
 

Summary:  effect on GABAA receptors can account for the apparent antagonism of potentiating steroid effects... . As another test of whether direct block of GABAA receptor function can account for the apparent antagonism... to wild-type receptors, we observed no significant ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
98 Leading Edge Insider Influence on ErbB Activity
 

Summary:  .shilo@weizmann.ac.il DOI 10.1016/j.cell.2010.09.042 The receptor tyrosine kinase ErbB is activated by ligand... . Receptor tyrosine kinases (RTKs) are a large family of single-pass transmem- brane receptors that convert... binding induces receptor dimerization and leads to trans- phosphorylation of tyrosines ...

  

Source: Shilo, Benny - Department of Molecular Genetics, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
99 Phencyclidine-Induced Deficits in Prepulse Inhibition of Startle are Blocked by Prazosin, an Alpha-1 Noradrenergic
 

Summary:  adrenergic receptors and that antagonism of alpha-1 receptors may play a major role in mediating the blockade... antagonism of these receptors. This notion is corroborated by the finding that Seroquel, a novel putative... -induced deficits in PPI not through alpha-1 ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
100 The Novel Antipsychotic Drug Lurasidone Enhances NMDA Receptor-Mediated Synaptic Responses
 

Summary:  antagonizing 5-HT7 receptors, which is consistent with evidence that 5-HT7 receptor antagonism contributes... receptor antagonism. Materials and Methods Animals. All animal experiments were performed with the approval... -mediated synaptic responses in frontal cortex. ...

  

Source: Yan, Zhen - Department of Physiology and Biophysics, State University of New York at Buffalo

 

Collection: Biology and Medicine


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