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Sample search results for: aav5 vector administration

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1 original article The American Society of Gene Therapy Molecular Therapy vol. 17 no. 2, 285293 feb. 2009 285
 

Summary:  label. Both rAAV5 and rAAV1 vectors were capable of transducing a subset of long-lived Clara cells... results demonstrate that the rAAV1 and rAAV5 vectors are indeed able to transduce epi- thelial slow... expression in rAAV1Cre, rAAV2Cre, or ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
2 Current Gene Therapy, 2003, 3, 281-304 281 1566-5232/03 $41.00+.00 2003 Bentham Science Publishers Ltd.
 

Summary:  the development of AAV vector production strategies involving Rep or ITR elements from AAV-5. Within the AAV-2... of AAV- 5-based vectors. Results from vector production indeed indicate that particle titers from helper... of AAV-2 ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
3 original article 594 www.moleculartherapy.org vol. 18 no. 3, 594600 mar. 2010
 

Summary:  -CB-FL and rAAV5-CB-RL vec- tors (the same vectors used for the chimp studies). Figure 2c shows... AAV1 and rAAV5 vectors in the chimpanzee airway in vivo As in vitro polarized airway epithelia cannot... of luciferase activity from each vector was ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
4 Intrastriatal rAAV-Mediated Delivery of Anti-huntingtin shRNAs Induces Partial Reversal of Disease Progression
 

Summary:  strategy was based on the use of recombinant adeno-associated virus serotype-5 (rAAV5) vectors to deliver... demonstrated that rAAV5 vectors can efficiently mediate the widespread and long-term expres- sion of transgenes... hemisphere. Injection of ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
5 Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo
 

Summary:  of rAAV5-HD6 and HD7 We generated rAAV serotype 5 (rAAV5) viral vectors expressing HD6 or HD7... of the hybridization signal of the mRNA expressed from each of the rAAV5 vectors were comparable among all mice (data... ENK, ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
6 JOURNAL OF VIROLOGY, Apr. 2004, p. 33613371 Vol. 78, No. 7 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.7.33613371.2004
 

Summary:  serotype 5 (AAV5) requires sialic acid on host cells to bind and infect. Other parvoviruses, including... . In contrast to AAV5, AAV2 does not bind sialic acid, but rather binds heparan sulfate proteo- glycans at its... to cell receptor attachment, we determined the structure of ...

  

Source: Baker, Timothy S. - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Biology and Medicine

 
7 This is an Accepted Article that has been peer-reviewed and approved for publication in the Journal of Neurochemistry, but has yet to undergo copy-editing and proof correction. Please
 

Summary:  in vivo DOPA production and studies of ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats Tomas... and metabolism. For this purpose, we injected a fixed amount of rAAV5-TH vector and increasing amounts of rAAV5... ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
8 Sites in the AAV5 capsid tolerant to deletions and tandem duplications Kaoru Hida a
 

Summary:  ]. For example, AAV5 may be the vector of choice for gene ther- apy targeted for the lungs; it transduces... containing the AAV2 rep and Topo-AAV5 with wt or library cap, respectively, and a vector plasmid containing... Sites in the ...

  

Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University

 

Collection: Biology and Medicine ; Biotechnology ; Chemistry

 
9 Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia*
 

Summary:  epithelia with rAAV2 or rAAV5 is enhanced 1000-fold by the combined co-administration of proteasome... , treatment with proteasome inhibitors more significantly enhanced transduc- tion with rAAV2 and rAAV5 vectors... and rAAV5 ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
10 HUMAN GENE THERAPY 19:7181 (January 2008) Mary Ann Liebert, Inc.
 

Summary:  of the spinal cord (Kuchler et al., 2002). MATERIALS AND METHODS rAAV vector production rAAV5 virus production... to transport recombinant adeno-associated virus serotype 5 (rAAV5)-derived green flu- orescent protein (GFP... ) or glial cell line-derived neurotrophic factor (GDNF) to the ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
11 Directed evolution of adeno-associated virus to an infectious respiratory virus
 

Summary:  distinct receptors, AAV2 (heparan sulfate) and AAV5 (sialic acid) (13­16). Subsequent selection... combined 2 divergent serotypes that use distinct receptors, AAV2 and AAV5, by subjecting the cap genes... revealed a single AAV variant, AAV2.5T, which is a chimera between AAV2 (aa1­128) and ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
12 JOURNAL OF VIROLOGY, July 2003, p. 73617366 Vol. 77, No. 13 0022-538X/03/$08.00 0 DOI: 10.1128/JVI.77.13.73617366.2003
 

Summary:  of new AAV serotype vectors have demon- strated that both rAAV-5 and rAAV-6 are capable of effi- ciently... 2/5 nomenclature were pseudotyped with AAV-5 capsid as previously described (13). Luciferase vectors... -Strand Genome Conversion of Adeno-Associated Virus Type ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
13 Neurobiology of Disease Positron Emission Tomography Imaging Demonstrates
 

Summary:  - binant adeno-associated viral (rAAV5) vectors. Local striatal DOPA synthesis provided in this way results... and rAAV5­GCH1 vectors reverses these changes, thus providing un- equivocal evidence that a functional... . The first group of animals received injection of ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
14 JOURNAL OF VIROLOGY, Jan. 2006, p. 426439 Vol. 80, No. 1 0022-538X/06/$08.00 0 doi:10.1128/JVI.80.1.426439.2006
 

Summary:  , which hampered analyses of the contribution of AAV-5 ITRs to vector function in the past and represented... be exploited by flanking vector DNAs with AAV-5 ITRs, as was previously suggested (17, 52). A second example... (10 l; see above). Cloning of AAV genotype ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
15 JOURNAL OF VIROLOGY, Aug. 2002, p. 76517660 Vol. 76, No. 15 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.15.76517660.2002
 

Summary:  and ITR of AAV5 fail to cross-complement those of AAV1 to -4 (6). Vectors constructed from AAV2, AAV3, AAV... variation among the AAV serotypes (7, 30). Unlike AAV2, AAV 2/6 and AAV5 vectors are not inhibited by hep... expression from AAV2- or ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
16 JOURNAL OF VIROLOGY, Mar. 2004, p. 28632874 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.28632874.2004
 

Summary:  . Recently, it has been reported that rAAV-5 vectors more effectively transduce murine lungs. Intranasal... 54-fold and rAAV-5 transduction 30-fold. Combined administration of doxorubicin and LLnL or Z- LLL... also observed with ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
17 2011NatureAmerica,Inc.Allrightsreserved. nature neurOSCIenCe advance online publication
 

Summary:  cortex. All AAV5 vectors had a titer of 1012 particles per ml. We also injected one site in monkey B... a lentiviral vector instead of AAV5 (or a low virus titer instead of a high virus titer), or by enhancing... pseudotyped with serotype 5 (here referred to as ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
18 original article 2096 www.moleculartherapy.org vol. 17 no. 12, 20962102 dec. 2009
 

Summary:  has been achieved by an intravitreally injected AAV vector. Interestingly, AAV5 is apparently the only... cell types from the vitreous, with AAV5 mediating particularly remarkable expression in all retinal... for some AAV serotypes, and AAV2 uses heparan sulfate for cell recognition and ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
19 NATURE NEUROSCIENCE VOLUME 14 | NUMBER 3 | MARCH 2011 387 T E C H N I CA L R E P O R T S
 

Summary:  in somatosensory cortex. All AAV5 vectors had a titer of 1012 particles per ml. We also injected one site in monkey... strong promoter (like hThy-1), by using a lentiviral vector instead of AAV5 (or a low virus titer instead... pseudotyped with serotype 5 (here ...

  

Source: Shenoy, Krishna V. - Neurosciences Program & Department of Electrical Engineering, Stanford University

 

Collection: Engineering ; Biology and Medicine

 
20 HUMAN GENE THERAPY 15:405413 (April 2004) Mary Ann Liebert, Inc.
 

Summary:  vector genome (containing the ITRs/LacZ ex- pression cassette) into AAV5 or AAV8 capsids by cotransfec... -associated virus serotype 5 and 8 (AAV5LacZ, AAV8LacZ) carrying the LacZ reporter, and compared the transduction... , with significant levels of expression detectable at 1 week, ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine


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21 JOURNAL OF VIROLOGY, Jan. 2005, p. 364379 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.364379.2005
 

Summary:  and AAV-5 to generate a novel hybrid ITR vector genome. This hybrid ITR viral vector contained one AAV-2... ITR and one AAV-5 ITR at opposite ends of the viral genome. Hybrid ITR vectors functionally transduced... a single encoded transgene at an ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
22 Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display
 

Summary:  transfer applications. RESULTS Phenotype of Transduced Cells rAAV1 and rAAV5 vectors have been reported... , including AAV1 and AAV5 [42,43]. In this study, we quantitatively evaluated three distinct rAAV vectors, r... cassette under the control of the synthetic CBA ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
23 JOURNAL OF VIROLOGY, Mar. 2002, p. 20432053 Vol. 76, No. 5 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.5.20432053.2002
 

Summary:  for development as a gene delivery vector (2, 5). Although less is known about AAV-5 molecular biology... - fer vector for a longer time than AAV-5, there is a greater understanding of the mechanisms for viral... be used as the helper for generating authentic ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
24 JOURNAL OF VIROLOGY, June 2004, p. 63446359 Vol. 78, No. 12 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.12.63446359.2004
 

Summary:  vector after purification; right lane, rAAV5-GFP vector after purification. VOL. 78, 2004 PREIMMUNIZATION... as previously described (44). rAAV5-eGFP was a pseudotyped vector using the same transgene-containing plasmid... as the rAAV2 ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
25 HUMAN GENE THERAPY 16:781791 (July 2005) Mary Ann Liebert, Inc.
 

Summary:  hippocampal transductions of rAAV1 (A), rAAV2 (B), and rAAV5 (C) (1 1013 to 8 1013 vector genome copies... transduction with rAAV5-pseudo- typed vectors (Peden et al., 2004). Furthermore, intrastriatal rAAV2 injections... and ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
26 HUMAN GENE THERAPY 18:8187 (January 2007) Mary Ann Liebert, Inc.
 

Summary:  ). In comparison with homologous AAV2 or AAV5 ITR vectors, hybrid 2:5-ITR vec- tors have been shown to less... AAV5 and AAV2 ITRs, and these two vector genotypes TRANS-SPLICING HYBRID-ITR AAV VECTORS 83 FIG. 2... homologous-ITR ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
27 Species-Specific Differences in Mouse and Human Airway Epithelial Biology of Recombinant
 

Summary:  infection with rAAV5 vectors were significantly different between mouse and human ALI airway epithelia. Our... in polarized human airway epithelia demonstrate that both rAAV2 and rAAV5 vectors have similar levels of apical... in intracellular trafficking between ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
28 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  intrastriatal AAV1-GFP, AAV5-GFP, and AAV-8 GFP administration. *P < 0.05. AAV, adeno-associated virus; GFP... ­27 Specifically, AAV1 and AAV5 sero- types have more favorable properties for reproducible production at high... /5, and AAV2/8 in the basal ganglia of nonhuman primates. We ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
29 SHORT COMMUNICATION Comparative biology of rAAV transduction in ferret,
 

Summary:  AAV serotypes closely mirrors that observed in human epithelia (rAAV14 rAAV2DrAAV5), while transduction of mouse... epithelia was significantly different (rAAV14rAAV5brAAV2). Similarly, ferret, pig and human epithelia also... and rAAV5 transduction of human and mouse ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
30 JOURNAL OF VIROLOGY, Apr. 2005, p. 50475058 Vol. 79, No. 8 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.8.50475058.2005
 

Summary:  resolution structures of AAV2 and AAV5 (40, 63), as well as those of the autonomous parvoviruses Aleutian... experiments with AAV5 have demonstrated improved binding and transduction * Corresponding author. Mailing... affinity is weaker (49). However, AAV3 also lacks R585 and R588. Transduction by AAV4 and ...

  

Source: Baker, Timothy S. - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Biology and Medicine

 
31 A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2
 

Summary:  . Firstly, when the assay was conducted with AAV5(gfp), we only observed a decrease in vector transduction... cathepsin B or L, whereas no significant change was seen with the AAV5 vector (Figure 4b), confirming... 40 30 20 10 0 0 20 M 40 M Ca074-Me AAV2 AAV2AAV8 ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
32 GENE THERAPY Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors
 

Summary:  serotype vectors Initial vector AAV-1 AAV-2 AAV-3 AAV-4 AAV-5 AAV-6 AAV-1pv 1600 ND ND ND ND to 400 1600... the AAV-2 vector. Mingozzi et al20 reported up to 25-fold higher efficiency from AAV-5 in the murine liver... % of the maximum hFIX protein ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
33 HUMAN GENE THERAPY 16:11161123 (September 2005) Mary Ann Liebert, Inc.
 

Summary:  epithelia were infected from the apical mem- brane with rAAV2 or rAAV5 CFTR-PTM vectors in the presence... . Levels of CFTR correction seen with rAAV2 (1.07 0.24 A) and rAAV5 (0.90 0.20 A) CFTR-PTM vectors were... -CF epithelia, and was similar for both rAAV2 and ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
34 JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.16.76627671.2001
 

Summary:  as a gene therapy vector. Detailed sequence comparisons indicate that the AAV-5 capsid proteins are sig... that recombinant AAV-5 vectors might have a unique niche in gene therapy applications. For example, AAV-5 likely... ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
35 Dual Therapeutic Utility of Proteasome Modulating Agents for Pharmaco-Gene Therapy of the
 

Summary:  for the AAV2 vectors groups (Fig. 3B). Enhancement of vector-derived mRNA/ DNA ratios for the AAV5 vector... , rAAV2 vectors performed better than rAAV5 vectors. These findings support the notion that ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
36 Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Gene therapy for hemophilia
 

Summary:  that from an AAV2 vector in dogs with hemophilia B, while expres- sion from AAV5 was lower than that from... AAV2. Sim- ilarly, AAV5 or AAV8 vectors expressing human FIX were not more effective than AAV2 vectors... :875­888. This paper ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
37 Expert Review Designer Gene Delivery Vectors: Molecular Engineering and Evolution
 

Summary:  , respectively (143,144). Likewise, Peden et al. have shown that AAV5 vector can transduce rat brain pre... , and AAV5 vectors to mouse skeletal muscle. Prior immunization with various serotypes did not significantly... ,77,79). ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
38 Adeno-associated viral vectors and stereotaxic
 

Summary:  , AAV5, AAV8, AAV9, AAVDJ Photoreceptor Cells AAV5 Lung AAV9 Heart AAV8 Pancreas AAV8 Kidneys AAV2... Adeno-associated viral vectors and stereotaxic delivery Eric Washburn Vollum Viral Core washbure... types · ~4.7 kb wild type genome #12;AAV Life Cycle #12;Packaging Components of rAAV 1. ...

  

Source: Chapman, Michael S. - Department of Biochemistry and Molecular Biology, Oregon Health and Science University

 

Collection: Biology and Medicine

 
39 Brain Tissue Depth (mm) LightPowerDensity(mW/mm2
 

Summary:  and packaging The recombinant AAV vectors were serotyped with AAV5 coat proteins and packaged by the viral... A. Control of BLA glutamatergic projection neurons was achieved using an adeno-associated virus (AAV5) vector... ITC cells BLA CeA ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
40 11/13/11 10:33 AMAbstract Print View Page 1 of 2http://www.abstractsonline.com/Plan/AbstractPrintView.aspx?mID=2...472c-8713-73eddce872b7&cKey=e99c3f48-6778-47ba-9f60-c17304239095
 

Summary:  -neuronal human promoters (hThy1, hSyn) and using AAV5 as the delivery vector, motivated by the translational... ., 2009; Lee et al., 2010). Here we report functionality of AAV5-CaMKII-C1V1 in macaque cortex. Light... advantages of AAV vectors which derive from their ...

  

Source: Shenoy, Krishna V. - Neurosciences Program & Department of Electrical Engineering, Stanford University

 

Collection: Engineering ; Biology and Medicine


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41 Helper Virus-Free, Optically Controllable, and Two-Plasmid-Based Production of Adeno-associated
 

Summary:  -intensive preparation of an additional plasmid [e.g., 16]. In one study, AAV-2 vector pseudotyping with AAV-5 METHODdoi... , the only excep- tion being the AAV-5-based vector. This was, however, not surprising regarding the known... highest titers among all pRC ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
42 Enhanced Preparation of Adeno-Associated Viral Vectors by Using High Hydrostatic Pressure to
 

Summary:  ). Briefly, AAV2-GFP vector backbone, pHelper, and pXR5 (which expresses AAV5 Cap and an AAV5/AAV2 chimeric... and Goudsmit, 2001). In addition, AAV5 vectors are capable of enhanced gene delivery to tissues in which AAV2... , ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
43 original article The American Society of Gene Therapy Molecular Therapy vol. 16 no. 10, 17031709 oct. 2008 1703
 

Summary:  AAV4 AAV6AAV5 AAV9AAV8 cA1 cA2 cA3 cA4 cB1 cB2 cB3 cB4 Figure 1 Amino acid sequences of shuffled... 9 AAV9AAV8AAV6AAV5AAV4AAV2 Figure 2 structural comparison of selected viral chimeras. Molecular... additional opportunities for immune evasion and vector ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
44 HUMAN GENE THERAPY 18:344354 (April 2007) Mary Ann Liebert, Inc.
 

Summary:  of AAV5 and AAV6 showed that whereas both vectors had high transduction rates in well... that is exposed to the virus. Sialic acid is required for AAV5 gene transfer (Wal- ters et al., 2001... ) and is an abundant sugar on the apical sur- face, consistent with the better performance of ...

  

Source: Miller, Dusty - Division of Human Biology, Fred Hutchinson Cancer Research Center

 

Collection: Biology and Medicine

 
45 JOURNAL OF VIROLOGY, Oct. 2006, p. 98319836 Vol. 80, No. 19 0022-538X/06/$08.00 0 doi:10.1128/JVI.00878-06
 

Summary:  therapy vector. MATERIALS AND METHODS Plasmids. The AAV2, AAV5, AAV6, and AAV8 bait plasmids were con... factor receptor (PDGFR) (7, 15, 34). Like AAV5, AAV4 was also shown to interact with sialic acid; however... [AAV5], 442 to 1863 [AAV6], and ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
46 original article 2088 www.moleculartherapy.org vol. 17 no. 12, 20882095 dec. 2009
 

Summary:  variable efficiencies (AAV5).7,18 Additionally, recent work in the retina utilizing AAV vectors... reported for AAV4 and AAV5,7,8,18,22 though AAV4 transduces astrocytes only within the subventricular zone... , and reports of AAV5 transduc- tion ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
47 Intracellular trafficking of adeno-associated viral and JF Engelhardt1,2,3
 

Summary:  -linked sialic acid45 Unknown AAV5 N-linked sialic acid45,46 PDGFR54 Intracellular trafficking of AAV vectors W... for AAV4 and AAV5. AAV5 primarily uses N-linked sialic acid for binding, whereas AAV4 preferentially uses... factor receptor (PDGFR) ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
48 11/13/11 10:34 AMAbstract Print View Page 1 of 2http://www.abstractsonline.com/Plan/AbstractPrintView.aspx?mID=2...472c-8713-73eddce872b7&cKey=3ac40567-8b18-4983-84a3-c744f50c82da
 

Summary:  Abstract Program#/Poster#: 306.13/YY24 Presentation Title: Optogenetic projection targeting with AAV5... to label with unilateral injections of AAV5 in combination with the promoters hSyn and hThy-1 in premotor... traveling of AAV5 between cortex and thalamus. To ...

  

Source: Shenoy, Krishna V. - Neurosciences Program & Department of Electrical Engineering, Stanford University

 

Collection: Engineering ; Biology and Medicine

 
49 original article 2114 www.moleculartherapy.org vol.15no.12,21142123dec.2007
 

Summary:  of bioelectric properties and susceptibil- ity to rAAV infection with rAAV1, rAAV2, and rAAV5 serotype vectors... ) Illustration of the proviral vector used to pseudo- type package into rAAV1, rAAV2, or rAAV5 capsids... with three rAAV sero- types (AAV1, AAV2, ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
50 Current Gene Therapy, 2007, 7, 347-360 347 1566-5232/07 $50.00+.00 2007 Bentham Science Publishers Ltd.
 

Summary:  unpublished obser- vations). Finally, we have shown that acute re-administration of rAAV5 vectors, which... and thirty days after vector administration. -galactosidase expression was de- tected a early as 3 days post... with escalating doses, a plateaue was reached ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
51 Current Gene Therapy, 2001, 1, 137-147 137 1566-5232/00 $20.00+.00 2001 Bentham Science Publishers Ltd.
 

Summary:  trans-duction efficiency was achieved with rAAV4 and/or rAAV5 vectors in the ependymal cells... of the lateral ventricle compared to rAAV2 vectors. In addition, AAV5 was also able to transduce not only... ) Transduction of murine cerebellar neurons with recombinant ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
52 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  ). All of the vectors contained AAV5 serotype capsids. These had been shown by us and others14... . MAterIAls And MetHods rAAV vectors. All vectors have been packaged in AAV5 capsid and puri- fied... as the PLD2 rAAV vector. ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
53 Systemic Mannitol-Induced Hyperosmolality Amplifies rAAV2-Mediated Striatal Transduction to a
 

Summary:  administration of mannitol prior to vector administration improved gene transfer to striatal neurons, increasing... showing that both systemic administration of mannitol with intrastriatal vector administration and mixing... of Florida Vector ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
54 HUMAN GENE THERAPY 18:871880 (October 2007) Mary Ann Liebert, Inc.
 

Summary:  the vectors with the AAV-5 capsid, which transduces photoreceptors more efficiently than AAV-2 (Yang et al... OPS promoter does not support reporter expression in RPE (Flannery et al., 1997), but because AAV-5 is known... - clei of transduced RPE. Scale bar: 50 m. ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
55 Robust Systemic Transduction with AAV9 Vectors in Mice: Efficient Global Cardiac Gene Transfer Superior
 

Summary:  and globally through systemic vector administration. AAV9 is a serotype newly isolated from human tissues... for cardiac gene delivery by systemic vector administration. Key Words: adeno-associated virus, serotype, gene... ,2,9]. Recently, systemic administration of rAAV ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
56 Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
 

Summary:  AAV2 vectors packaged in AAV5 capsids) was purified by iodixanol step gradients and Sepharose Q column... neurons and glia in the primate midbrain Pseudotyped rAAV2/5 vectors (rAAV2 vectors packaged in an AAV5... proteins for attachment and ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
57 Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
 

Summary:  AAV2 vectors packaged in AAV5 capsids) was purified by iodixanol step gradients and Sepharose Q column... neurons and glia in the primate midbrain Pseudotyped rAAV2/5 vectors (rAAV2 vectors packaged in an AAV5... proteins for attachment and ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
58 11/13/11 10:33 AMAbstract Print View Page 1 of 2http://www.abstractsonline.com/Plan/AbstractPrintView.aspx?mID=2...472c-8713-73eddce872b7&cKey=33a870a7-f4d8-4e91-b1a5-44f8d02f1076
 

Summary:  inhibitory opsin eNpHR3.0, under control of the CaMKII promoter using the AAV5 vector system, in squirrel

  

Source: Shenoy, Krishna V. - Neurosciences Program & Department of Electrical Engineering, Stanford University

 

Collection: Engineering ; Biology and Medicine

 
59 Recombinant Adeno-associated Viral Vectors as Therapeutic Agents to Treat Neurological Disorders
 

Summary:  by lentiviral vectors in the brain has been shown to decrease Ah load in AD mice [90]. rAAV5 encoding neprilysin... I). Another study using rAAV5 to deliver an shRNA in the aggressive R6/1 transgenic HD mouse line... rAAV5 encoding an shRNA ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
60 JOURNAL OF VIROLOGY, June 2008, p. 58875911 Vol. 82, No. 12 0022-538X/08/$08.00 0 doi:10.1128/JVI.00254-08
 

Summary:  distinct serotypes, such as AAV-1 and AAV-2 (30) and pairwise combinations of AAV-1 through AAV-5 (62... different AAV serotypes were present in the lab (for AAV-2, AAV-4, and AAV-5) or kindly provided by James... AAV and AAV-5. The other seven cap genes were ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine


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61 This article was published in an Elsevier journal. The attached copy is furnished to the author for non-commercial research and
 

Summary:  ., 2006; Sondhi et al., 2007). Thus, rAAV1, rAAV5, rAAV8, and rAAV10 have been shown to transduce more... , sharing with colleagues and providing to institution administration. Other uses, including reproduction... ://www.elsevier.com/copyright #12;Author's personal copy Viral vectors for in vivo gene transfer ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
62 Molecular Engineering of Viral Gene Delivery Vehicles
 

Summary:  vectors with new properties, including en- hanced targeting abilities and resistance to immune responses... , is a growing area of research. This review discusses protein engineering approaches to generate viral vectors... with novel gene delivery capabilities. Rational design of viral vectors has yielded successful advances

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
63 JOURNAL OF VIROLOGY, Jan. 2005, p. 214224 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.214224.2005
 

Summary:  portion of hepatocytes even after administration of extremely high vector doses. In order to investigate... administration of the rAAV8 vector at a high dose transduced all the skeletal muscles throughout the body... ). Interestingly, and unlike the rAAV2 vector, rAAV1 ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
64 Dynamics of Retrieval Strategies for Remote Memories
 

Summary:  RI restriction sites. The recombinant AAV vectors were serotyped with AAV5 coat proteins and packaged... as the experimental mice associated with laser light delivery. For BLA optogenetic inhibition, 1.5 ml of AAV5 Ca... attached to the IFL using a connecting plastic sleeve. For ACC ...

  

Source: Contractor, Anis - Department of Physiology, Northwestern University; Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
65 BioMed Central Page 1 of 12
 

Summary:  Pseudotyped AAV vectors were generated by packaging AAV2-based recombinant genomes in AAV1, AAV2 or AAV5... for AAV1 and pLT- RC03 for AAV5) and the relevant pAAV2 vector plasmid. ssAAV vectors were produced... -term expression and repeated ...

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
66 original article 524 www.moleculartherapy.org vol. 17 no. 3, 524537 mar. 2009
 

Summary:  of humoral immunity and repeated administrations of identical vectors.2 The published discrepancies... in the readministration group developed a moderate nAb titer after the second vector administration (3,200) and... in the context of the experiments described here. This would, therefore, predict that a ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
67 [23] Adeno-Associated Virus Vectors for Short Hairpin RNA Expression
 

Summary:  of AAV-5 to -8 between 1984 and 2002 (reviewed by Grimm and Kay, 2003). The most significant expansion... ). This is crucial considering that administration of a particu- lar AAV vector type will result in a humoral immune... , best yields are obtained with AAV serotype 8, followed by ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
68 Global and local fMRI signals driven by neurons defined optogenetically by type and wiring
 

Summary:  with the adeno-associated viral vector AAV5-CaMKIIa::ChR2(H134R)-EYFP todrive expressionofachannelrhodopsin(ChR2... observed with AAV5-CaMKIIa::ChR2- EYFP but not with saline injection (P , 0.001; asterisk, optical... Figure 2 | Nonlocal mapping of the causal role of cells defined by ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
69 BioMed Central Page 1 of 9
 

Summary:  : Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors. Neurore- port 2000, 11... Open AccessResearch Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus... .S. Food and Drug Administration, Center for Biologics Evaluation and Research, ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
70 Characterization of the Relationship of AAV Capsid Domain Swapping to Liver
 

Summary:  where repeated administrations are needed, AAV vectors of different serotypes would also be beneficial... , and trans- gene expression starts with a slow-rising lag phase after vector administration.13 In contrast... by domain swapping, the detectable changes in tissue tropism at this ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
71 This article was published in an Elsevier journal. The attached copy is furnished to the author for non-commercial research and
 

Summary:  AAV encoding parkin was produced using the same expression cassette but the vector was packaged using the AAV5... in rAAV2 (experiment 1) or rAAV5 (experiment 2­3) capsids. TR=terminal repeats (B) The sequence... /5 viruses the pDG plasmid was substituted for the pXYZ5 plasmid which ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
72 RNA knockdown as a potential therapeutic strategy in Parkinson's disease
 

Summary:  of sequential re-administration to the brain is unattrac- tive in a therapeutic setting. Viral vectors provide... to the midbrain, but to date, rAAV1 and rAAV5 appear to provide the widest area of transduction, while gene... ) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
73 RNAi based gene therapy for Spinocerebellar ataxia-7 HHMI Med-Into-Grad Proposal
 

Summary:  , Chiorini, JA and Davidson, BL. Transduction of murine cerebellar neurons with recombinant FIV and AAV5... of viral vector based RNA interference (RNAi) for the mutated allele, is attractive as a potential... treatment for SCA7. The retina is an ideal target for viral vector mediated gene transfer, because

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
74 JOURNAL OF VIROLOGY, Mar. 2004, p. 31103122 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.31103122.2004
 

Summary:  in most hepatocyte nuclei within 24 h after vector administration, but less than 10% of these hepatocytes... at 1 year post-vector administration. VG in genomic DNA ex- tracted from liver tissue were quantified... vector administration. We suggest that while slow ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
75 ARTICLE doi:10.1038/nature09553 Genetic dissection of an amygdala
 

Summary:  CEm CEm CEm h i j m n o PKC-::GluCl-iresCre Merge p q r PosteriorCE AAV 5 CMV hrGFP pA AAV 3STOP CEm... CEl 250 m l CTB injection AnteriorCE v ProjectionsiteInjectionsite AAV 5 EF1 ChR2­YFP pA AAV 3 CEm CEl... Wildtype l CEl h m n o p PKC-+ PKC-­ CEI CEm Merge Cherry/TOPRO CEl CEl CEl CEl ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
76 Vectors of Gene Therapy KATHERINE PARKER PONDER, M.D.
 

Summary:  vectors for in vivo administration to humans. To this point, the produc- TABLE 4.3 Summary of Retroviral... #12;the extensive testing performed prior to administration of vectors to humans is an added safety... CHAPTER 4 Vectors of Gene Therapy KATHERINE PARKER PONDER, M.D. INTRODUCTION ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
77 Current Gene Therapy, 2009, 9, 375-388 375 1566-5232/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  , we and others have shown that there is apparently little to no brain immune response to the AAV5... administration of the DA precursor levodopa. Other strategies have also been em- ployed with mixed results... delivered either by direct infusion of recombinant protein (GDNF) or by viral vector-mediated over

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
78 SUPPLEMENTARY INFORMATION 1www.nature.com/nature
 

Summary:  are available online at www.optogenetics.org. The recombinant AAV vectors were serotyped with AAV5 coat proteins... , efficacy and transduction region. a, AAV5-CaMKII::ChR2-EYFP: Costaining for the excitatory marker Ca... .1038/nature09108 SUPPLEMENTARY INFORMATION Supplementary Figure 5 ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
79 Adv Biochem Engin/Biotechnol (2005) 99: 1x DOI 10.1007/10_006
 

Summary:  receptors [93­95]. It has also been shown that AAV3 also binds heparan sulfate, AAV4 and AAV5 bind... to specific sialic acid linkages [96], and AAV5 binds to the PDGF receptor [97], whereas the receptors... distinct gene delivery properties. For example, in the brain AAV2 se- lectively transduces neurons, ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
80 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  si-312 si-312 AAV5 em pty R atsyn 100 80 60 40 20 0 b Figure 5 Quantitative estimation... terminal repeats and were packaged in AAV5 capsids that were purified as described previously.4,23 The GFP... in addition to the shRNA cassette driven by an H1 promoter. Empty ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine


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81 1526 VOLUME 13 | NUMBER 12 | DECEMBER 2010 nature neurOSCIenCe a r t I C l e S
 

Summary:  substantial sedative effects. By contrast, central administration of norepinephrine directly... min after administration of the adrenergic 2 receptor agonist clonidine or the 1 receptor antagonist... , photostimulation always caused sleep-to-wake transitions (probability = 1.00). Administration of either clonidine

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
82 original article The American Society of Gene & Cell Therapy Molecular Therapy vol. 17 no. 11, 18571867 nov. 2009 1857
 

Summary:  immediately after the vector administration initially lost a small amount of body weight and then began... and approximatemg/ kg body weight was given). Following vector administration, animals were placed on DOX diets... , enabling longitudinal in vivo tracking of GDNF expression after nigral ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
83 COLE DOCTORALE : DES GNOMES AUX ORGANISMES UNIVERSIT D'VRY VAL D'ESSONNE
 

Summary:  ........................................................................................................................... 2 2.2. Caractéristiques et production du vecteur AAV... ............................................................................. 5 2.3. Les différents sérotypes AAV... ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
84 The phosphorylation state of Ser-129 in human -synuclein determines neurodegeneration
 

Summary:  expressing the AAV5 capsid gene. The final titers were 1.0 1013, 1.7 1013, and 0.9 1013 vector genome (vg... and in the ventral tegmental area (Fig. 1A). These data are in agreement with our findings that showed that rAAV5... with GFP (Fig. 3 A­C). We also note that the use of ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
85 www.sciencemag.org/cgi/content/full/1167093/DC1 Supporting Online Material for
 

Summary:  element (WPRE) to enhance expression. The recombinant AAV vectors were serotyped with AAV5 coat proteins... on a Leica MZ16FA stereomicroscope. Lentivirus production and transduction Lentiviral vectors carrying... phosphate co-transfection of 293FT cells with the lentiviral vector, ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
86 Sponsored Research Administration SPONSORED RESEARCH ADMINISTRATION
 

Summary:  Sponsored Research Administration SPONSORED RESEARCH ADMINISTRATION Renee Lechner Director Bonnie... Brown Coordinator Last Modified 09/14/2011 Senior Administrators SKY PARK ALVARADO Julie Alsbrooks... Carolyn Martinson Cheryl Whittemore Terri Owens Administrator Technician Administrator ...

  

Source: Ponce, V. Miguel - Department of Civil and Environmental Engineering, San Diego State University

 

Collection: Engineering

 
87 Sustained Striatal Ciliary Neurotrophic Factor Expression Negatively Affects
 

Summary:  administration of CNTF on cells in the striatum, a recombinant adeno-associated viral vector was engi- neered... by recombinant adeno-associated viral vectors (rAAV2). Wild-type and R6/1 HD transgenic (R6/1) mice that received... into the striatum of R6/1 HD trans- genic mice. We hypothesized that continuous intrastria- tal ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
88 Neurobiology of Disease Continuous Low-Level Glial Cell Line-Derived Neurotrophic
 

Summary:  Using Recombinant Adeno-Associated Viral Vectors Provides Neuroprotection and Induces Behavioral... -associated viral vectors (rAAVs) expressing GDNF may be a suitabledeliverysystemforthispurpose... recombinant lentiviral or adeno- associated viral vectors (rAAVs) and has been evaluated in intact

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
89 Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
 

Summary:  R2­eYFP AAV5 vectors were stereotactically injected into the cortex of PV::Cre transgenic mice... generation in vivo. We injected Camk2a (CaMKIIa)::ChR2­eYFP and Cre-dependent eNpHR­eYFP AAV5... YFP AAV5 in prefrontal cortex. Blue light drove ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
90 PEG Conjugation Moderately Protects Adeno-Associated Viral Vectors Against
 

Summary:  PEG Conjugation Moderately Protects Adeno-Associated Viral Vectors Against Antibody Neutralization... : AAV gene therapy vectors have significant clinical promise, but serum neutralization poses a chal... with activated polyethylene glycol chains to protect the vector from neutralizing antibodies. Two key parameters

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
91 JOURNAL OF VIROLOGY, Apr. 2004, p. 41654175 Vol. 78, No. 8 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.8.41654175.2004
 

Summary:  strand genome conversion of AAV-2 and AAV-5 is not rate limiting following apical infection of polarized... . Targeted Correction of Single-Base-Pair Mutations with Adeno-Associated Virus Vectors under Nonselective... 28 July 2003/Accepted 2 January 2004 Recombinant adeno-associated virus (rAAV) vectors ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
92 SUPPLEMENTARY METHODS Strategies for microbial opsin expression in PV
 

Summary:  Supplementary Fig. 4. The recombinant AAV vectors were serotyped with AAV5 coat proteins and packaged... of Cre-activated recombinant AAV vectors. Because of the issues described above, double-floxed inverted... double-floxed reverse ChR2-EYFP cassette was cloned into a modified version of the pAAV2-MCS ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
93 original article The American Society of Gene & Cell Therapy Molecular Therapy vol. 18 no. 5, 873880 may 2010 873
 

Summary:  was pseudotyped with the AAV5 capsid proteins and produced at the University of Florida Vector Core. The virus... (AAV) vectors has resulted in sus- tained increased NAGLU activity, reduced glycosaminoglycan... in the neonatal period20,21 or the replacement was with sustained weekly ...

  

Source: Orrock, John - Department of Zoology, University of Wisconsin at Madison

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
94 original article The American Society of Gene Therapy Molecular Therapy 1
 

Summary:  and AAV5 cap genes in addi- tion to adenovirus helper genes. The virus was subsequently purified... administration of glial cell line­derived neurotrophic factor (GDNF) in primate and humans to study Parkinson... AAV-mediated transgene expression in the nigrostriatal tract, we performed a preliminary experiment using a single ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
95 Frontiers in Macromolecular Imaging
 

Summary:  antibodies directed against AAV1, AAV2, AAV5, AAV6, and AAV8, which represent the range of sequence homology... for producing second generation of AAV vectors which can be used for vector re-administration. Molecular piracy... Neutralization escape viral gene delivery ...

  

Source: McQuade, D. Tyler - Department of Chemistry and Biochemistry, Florida State University

 

Collection: Chemistry

 
96 Correction: 21 May 2009 www.sciencemag.org/cgi/content/full/1168878/DC1
 

Summary:  regulatory element (WPRE) to enhance expression. The recombinant AAV vectors were serotyped with AAV5 coat... -inducible recombinant AAV vectors (2-4), the DNA cassette carrying two pairs of incompatible lox sites (loxP and lox2722... of the pAAV2-MCS vector carrying the EF-1 promoter and ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University; Vosshall, Leslie - L:aboratory of Neurogenetics and Behavior, Rockefeller University

 

Collection: Biology and Medicine

 
97 MOLECULAR THERAPY Vol. 4, No. 4, October 2001 Copyright The American Society of Gene Therapy
 

Summary:  , R. W., Zabner, J., and Chiorini, J. A. (2001). Adeno- associated virus serotype 4 (aav4) and aav5... Expanding AAV Packaging Capacity with Trans-splicing or Overlapping Vectors: A Quantitative Comparison... adeno-associated (rAAV) viral vectors hold great therapeutic potential for human diseases. However

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
98 LETTER doi:10.1038/nature09820 Amygdala circuitry mediating reversible and
 

Summary:  transduced with an adeno-associated virus serotype 5 (AAV5) carrying codon-optimized channelrhodopsin (ChR2... YFP plasmids were designed and constructed by standard methods and packaged as AAV5. Virus (0.5 ml... .AllviruseswerepackagedatUniversityofNorthCarolina (UNC)Vector Core. ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
99 Fax +41 61 306 12 34 E-Mail karger@karger.ch
 

Summary:  and AAV5 vec- tors. Neuroreport 2000;11:2669­2673. 5 Haskell RE, Hughes SM, Chiorini JA, Alisky JM... ;28:216­221 DOI: 10.1159/000091919 Cerebellar Neurons and Glial Cells Are Transducible by Lentiviral Vectors... . In vitro, primary cell cultures of rat cerebellar granule cells were infected with lentiviral ...

  

Source: Bongarzone, Ernesto R. - Department of Anatomy and Cell Biology, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
100 JOURNAL OF VIROLOGY, 0022-538X/98/$04.00 0
 

Summary:  Secondary Vector Administration CHRISTOPHER B. WILSON,1,2 * LISA J. EMBREE,3 DAVID SCHOWALTER,3 RICHARD... and the ability to achieve expression after repeated vector administration have been limited by the development... the time of vector administration. Systemic ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine


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