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Sample search results for: aav-mediated chronic over-expression

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1 Recombinant Adeno-associated Viral Vectors as Therapeutic Agents to Treat Neurological Disorders
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 466 Progress in the therapeutic efficacy of intrastriatal rAAV-mediated l-dopa delivery... genetic forms has been unsuccessful. rAAV-mediated ribozyme knockdown of parkin, an E3 ligase involved... (MPTP), AAV mediated GDNF ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
2 Discovery Medicine, Volume 9, number 46, Pages 204-211, March 2010 Abstract: Given improvements in viral vector design,
 

Summary:  ; Mandel et al., 2006). Furthermore, rAAV mediated over-expression of glutamic acid decarboxylase (GAD... in the Str. Concomitantly, a thinning of the MFB occurs. B. rAAV-mediated nigrostriatal GDNF over-expression... . rAAV-mediated nigral human parkin ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
3 Neurobiology of Aging 27 (2006) 459470 Hypothalamic rAAV-mediated GDNF gene delivery
 

Summary:  Neurobiology of Aging 27 (2006) 459­470 Hypothalamic rAAV-mediated GDNF gene delivery ameliorates... via its effects on dopaminergic neurons in the hypothalamus. Continuous rAAV-mediated GDNF expression... (BAT) were measured. We report here the novel finding that rAAV-mediated ectopic hypothalamic GDNF

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
4 Progress in Direct Striatal Delivery of L-Dopa via Gene Therapy for Treatment of Parkinson's Disease Using Recombinant
 

Summary:  are not practical. More- 49rAAV-MEDIATED L-DOPA GENE THERAPY FOR PD #12;over, peripheral continuous administration... -dopa is available to all dopaminergic regions of the brain. The Advantage of Site-Specific rAAV-Mediated Striatal L... .e., the gene therapy procedure and whether the protein functions appropriately in humans. INTRACEREBRAL ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
5 Neuropathological and Behavioral Consequences of Adeno-Associated Viral Vector-Mediated
 

Summary:  ). Mice, engi- neered to over-express NGF are less susceptible to the damaging effects of MCAO (Guegan et... was to evaluate the effects of rAAV-mediated BDNF and NGF delivery on neuronal survival and behavioral deficits... in the 30-min MCAO model in rats. Because little is known about the effects of over-expression

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
6 This article was published in an Elsevier journal. The attached copy is furnished to the author for non-commercial research and
 

Summary:  ://www.elsevier.com/copyright #12;Author's personal copy rAAV-mediated nigral human parkin over-expression partially ameliorates... Bianco et al., 2004). Likewise, rAAV-mediated nigral parkin over-expression pro- tected the substantia... improvement in the parkin-treated rats. First, ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
7 CREB regulation of nucleus accumbens excitability mediates social isolationinduced behavioral deficits
 

Summary:  )-mediated over- expression of CREB in the NAcSh of isolated animals reversed the increase in anxiety... , but not the reward-related deficits, induced by social isolation. (a,b) AAV-mediated overexpression of CREB... , whereas CREB over- expression decreases reward responses and induces ...

  

Source: Kalueff, Allan V. - Department of Pharmacology, Tulane University

 

Collection: Biology and Medicine

 
8 Nerve Growth Factor Expressed in the Medial Septum Following in Vivo Gene Delivery Using a Recombinant Adeno-Associated Viral Vector
 

Summary:  prior to a FF lesion in rats. This rAAV-mediated NGF delivery was shown to significantly attenuate... delivery method for the treatment of AD. The present study demonstrates the bioactivity of NGF following rAAV-mediated... months (18). rAAV-mediated transgene expression for up to 1 year has also been reported previously (20

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
9 original article The American Society of Gene & Cell Therapy Molecular Therapy vol. 17 no. 11, 18571867 nov. 2009 1857
 

Summary:  & Cell Therapy Single rAAV-mediated Regulated Striatal GDNF expression in vivo for extended periods... nov. 2009 1859 © The American Society of Gene & Cell Therapy Single rAAV-mediated Regulated Striatal... no. 11 nov. 2009 © The American Society of Gene & Cell Therapy Single rAAV-mediated Regulated

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
10 Recombinant Adeno-associated Viral Vector-Mediated Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Protects
 

Summary:  . The onset of rAAV-mediated GDNF transgene expression near the substantia nigra was determined to begin... - course of rAAV-mediated GDNF expression. Previous studies using rAAV encoding different transgenes... different tissues has suggested that rAAV-mediated transgene expression is detectable after some delay

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
11 Capsid modifications overcome low heterogeneous expression of heparan sulfate proteoglycan that limits AAV2-mediated gene transfer and therapeutic
 

Summary:  of receptors in AAV-mediated gene transfer was assessed by competition assays. Finally, we examined the ability... surface receptors other than HSPG will be critical to the advancement of AAV- mediated gene therapy... ]. In an effort to determine whether AAV-mediated HSVtk gene expression in conjunction with ...

  

Source: Hemminki, Akseli - Department of Biosciences, University of Helsinki

 

Collection: Biology and Medicine

 
12 Silencing of Hepatic Fatty Acid Transporter Protein 5 in Vivo Reverses Diet-induced Non-alcoholic Fatty Liver Disease and
 

Summary:  , these results demonstrate that a single sdsAAV-mediated delivery of shRNA expression constructs results... in phenotypes that are highly comparable with that of genetically engineered knock-out animals and that AAV-mediated... -consuming. Further, major advantages of AAV-mediated gene knockdown over previously reported methods ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
13 Cellular/Molecular Probing the Functional Equivalence of Otoferlin and
 

Summary:  is properly targeted in IHCs after AAV-mediated gene transfer. A, Layout of the AAV-1/2 Syt1-IRES-eGFP con... in a proof of principle study of AAV-mediated gene transfer into the inner ear via injection... ). Finally, we probed the potential of otoferlin over- expression to restore the synchronous exocytosis

  

Source: Hell, Stefan W. - Department of NanoBiophotonics, Max-Planck-Institut für biophysikalische Chemie

 

Collection: Physics ; Materials Science ; Chemistry

 
14 HUMAN GENE THERAPY 16:781791 (July 2005) Mary Ann Liebert, Inc.
 

Summary:  in parkinsonian rats (Carlsson et al., 2005). rAAV-mediated glial cell line-derived neurotrophic factor (GDNF... for at least 6 months (Kirik et al., 1998) and in marmosets rAAV-mediated GDNF was expressed for at least 17... of rAAV-mediated transduction in the brain (Nguyen et al., 2001). Finally, mannitol, a complex sugar

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
15 Current Gene Therapy, 2001, 1, 137-147 137 1566-5232/00 $20.00+.00 2001 Bentham Science Publishers Ltd.
 

Summary:  ). Despite its many attractive features, further optimization of AAV- mediated gene delivery (ie... . transduction) is needed before AAV-mediated gene transfer becomes therapeutically useful. Although, AAV... of Rac1 (N17Rac1) blocked rAAV- mediated induction of PI3K activity. Therefore, ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
16 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  -OHDA) PTN over- expression. In both experiments the magnitude of nigral DA neu- ron neuroprotection

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
17 Neurobiology of Disease Positron Emission Tomography Imaging Demonstrates
 

Summary:  pool can be efficiently restored after rAAV-mediated gene therapy has not been achieved yet. The [11 C... predictor of the DA levels after rAAV- mediated enzyme replacement in the par- kinsonian brain. These data... ; Stoessl, 2007; Eberling et al., 2008; Marks et al., 2008). We showed previously that ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
18 Proc. Natl. Acad. Sci. USA Vol. 94, pp. 1408314088, December 1997
 

Summary:  were performed to evaluate the time course of expression of rAAV-mediated GDNF protein expression... -mediated transgene expression is transient (27­29), but long-term rAAV-mediated transgene expression has been... neu- rons, first described by Sauer and Oertel (21), to demonstrate that rAAV-mediated nigral GDNF

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
19 Characterization of Intrastriatal Recombinant Adeno-Associated Virus-Mediated Gene Transfer of Human Tyrosine Hydroxylase
 

Summary:  to be pathogenic. The present study reports that (1) rAAV-mediated hTH and hGTPCHI expression was sufficient... tested where appropriate. RESULTS Persistence of rAAV-mediated hTH and hGTPCHI gene expression... , and the animals that survived for 1 year received 2 l of vector. Neuronal specificity of rAAV-mediated gene

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
20 FF Principal Investigator/Program Director (Last, First, Middle): Breese, George R PHS 398 (Rev. 4/98 facsimile)GRBGABAs (Form Page 6) Page FF
 

Summary:  distribution and broad dispersion of AAV-mediated transgene expression in mouse brain. Mol Ther. 8... of NMDA antagonists: Potential relationships to acute and chronic actions of antipsychotic drugs... , Rotella, DL, Kostrewa, RM and Breese, G.R. Acute and chronic treatments with olanzapine and other

  

Source: Elston, Timothy C. - Department of Pharmacology, University of North Carolina at Chapel Hill

 

Collection: Mathematics ; Biology and Medicine


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21 RNA knockdown as a potential therapeutic strategy in Parkinson's disease
 

Summary:  since over-expression of various proteins is known to kill the dopamine neurons of the substantia nigra... ) expression in the SNc of mice using rAAV-mediated expression. TH is the rate limiting enzyme... K, Lewin AS, Mandel RJ. Intrastriatal rAAV-mediated delivery of anti-hun- tingtin shRNAs induces

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
22 Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host
 

Summary:  and the lack of strong inflammatory responses to AAV- mediated gene transfer are all attractive features... . A logical extension of this hypothesis provides an explanation for the difference in outcome of AAV-mediated... , hemophilic dogs and nonhuman primates, have shown long-term expression of the transgene after ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
23 original article The American Society of Gene Therapy Molecular Therapy 1
 

Summary:  that bilateral continuous hypothalamic GDNF over- expression via recombinant adeno-associated virus (r... that bilateral recombinant adeno-associated virus (rAAV)-mediated overexpression of GDNF in the hypothalamus... behavior and energy homeostasis. However, hypothalamic DA levels were unaffected by long-term ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
24 Systemic but Not Intraocular Epo Gene Transfer Protects the Retina from Light-and
 

Summary:  segments [14]. A similar protection from light damage is seen in transgenic mice over- expressing Epo... and Characterization of Epo Expression Following AAV-Mediated Gene Transfer in Albino Rats and rds and rd10 Mice We... in AAV- transduced muscle versus retina. Morphological and Functional Photoreceptor Rescue Following ...

  

Source: Sandini, Giulio - Dipartimento di Informatica Sistemistica e Telematica, Università degli Studi di Genova

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
25 Behavioral/Systems/Cognitive Cdk5 Modulates Cocaine Reward, Motivation, and Striatal
 

Summary:  by rAAV-mediated Cdk5 NAc-KO. Effect of NAc-specific loss of Cdk5 on cocaine-induced behavioral... . To investigate the role of Cdk5 specifically in the postsynaptic compartment of striatal neurons, we used rAAV-mediated... in situ hybrid- izationanalysisofrAAV-mediatedNAc-specificknock-outofCdk5.Arrowsindicatecorrespond- ing

  

Source: Yan, Zhen - Department of Physiology and Biophysics, State University of New York at Buffalo

 

Collection: Biology and Medicine

 
26 This is an Accepted Article that has been peer-reviewed and approved for publication in the Journal of Neurochemistry, but has yet to undergo copy-editing and proof correction. Please
 

Summary:  studies, by our group and others, have shown a number of therapeutic effects of rAAV mediated over-expression... that rAAV mediated DOPA delivery resulted in functional recovery that was correlated with restoration... to explore if rAAV mediated ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
27 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  when the two genes were coexpressed (Figure 5b,c). rAAV-mediated gene expression has been shown to peak... is over- expressed and to increased DA signaling when it is knocked down. In this respect, we note again

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
28 REVIEW ARTICLE Adeno-Associated Virus Vectors and Hematology
 

Summary:  % of hepatocytes were positive for AAV-mediated gene expression as determined by RNA in situ hybridization... have shown the therapeutic value of AAV-mediated gene transfer in murine and/or canine hemo- philia B... of AAV-mediated gene expres- sion appears to be in favor of the liver. The relative AAV vector dose

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
29 ADVANCES IN VIRUS RESEARCH, VOL. 55 ADENO-ASSOCIATED VIRUS VECTOR-MEDIATED
 

Summary:  will produce different expression patterns. Colocalization studies have demonstrated that AAV-mediated expres... - cycline. E. Dose-Response and Spread in the Brain AAV-mediated expression is dose... tolerated in the brain. Staining for astrocytes (63,79) or microglia (79) followingAAV-mediated transduction

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
30 Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
 

Summary:  that the virus over- expresses HDAC5 in vitro and in vivo and that this overexpression decreases overall levels... chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) to mice... histone methylation at their corresponding promoters. Chronic imipramine ...

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
31 doi:10.1182/blood-2010-08-302729 Prepublished online November 24, 2010;
 

Summary:  tumor formation. This study addresses these questions with high-dose liver-directed AAV-mediated gene... liver-directed AAV-mediated gene transfer of the F9 gene (www. clinicaltrials.gov; identifiers NCT... -directed AAV- mediated gene transfer in canine and murine models. Of 77 dogs receiving AAV vector at ...

  

Source: Bushman, Frederic - Department of Microbiology, University of Pennsylvania

 

Collection: Biology and Medicine

 
32 JOURNAL OF VIROLOGY, June 2004, p. 63446359 Vol. 78, No. 12 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.12.63446359.2004
 

Summary:  infection. Regardless, the data show that the presence of high levels of NAb against wt AAV can reduce rAAV-mediated... for the possibility that rAAV-mediated GDNF expression levels increase over time. Blood was drawn for NAb titer assay... of preexisting immunity to wt AAV2 on rAAV-mediated transgene expression, neuroinflam- ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
33 Evaluation of Pathological Manifestations of Disease in Mucopolysaccharidosis VII Mice after Neonatal
 

Summary:  P, demonstrating that the addition of M6P was not saturated by the over- expression of GUSB... with the effect of AAV-mediated gene therapy in mice [20] and with echocardiographic improvements in RV... . Similar improvements were observed in MPS VII mice after systemic neonatal AAV-mediated gene therapy [20

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
34 Neuron 49, 341348, February 2, 2006 2006 Elsevier Inc. DOI 10.1016/j.neuron.2005.12.027 ReportThe Disease Progression of Mecp2
 

Summary:  in an earlier onset/accelerated disease progression, whereas over- expressing BDNF in the Mecp2 mutant brain led... and Over- expression on Cortical Physiology of the Mecp2 Mutant Mice Whole-cell patch-clamp recordings were... through BDNF. Moreover, over- expression ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
35 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  of -syn could have a therapeutic effect. Hayashito-Kinoh et al.15 used AAV-mediated expression of -syn... and Kirik, D (2009). Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal... with no obvious toxic- ity. Although this transient reduction is not directly comparable to the chronic reduction

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
36 Principal Investigator/Program Director (Last, first, middle): Samulski, Richard Jude BIOGRAPHICAL SKETCH
 

Summary:  and Broad Dispersion of AAV-Mediated Transgene Expression in Mouse Brain. Molecular Therapy, 8... such a treatment of chronic neurological disorders, such as epilepsy. It is hypothesized that AAV- CMV vectors

  

Source: Elston, Timothy C. - Department of Pharmacology, University of North Carolina at Chapel Hill

 

Collection: Mathematics ; Biology and Medicine

 
37 Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA
 

Summary:  of the endogenous genomic DNA. Indeed, over- expression of TET1, but not TET1m, significantly increased Hpa... with TET1 over- expression (Figure S3A). Taken together, these results suggest that the BER pathway... increased the 5hmC level by 43% (Figure 6A). On the other hand, ...

  

Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University

 

Collection: Biology and Medicine

 
38 Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Gene therapy for hemophilia
 

Summary:  -associated virus serotype 2 vector: global distribution and broad dispersion of AAV- mediated transgene expression... , Hutchison S, et al. AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe... cells in non-human primates [48] or in humans with chronic granulomatous disease [49] ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
39 Current Gene Therapy, 2009, 9, 375-388 375 1566-5232/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  -loss in aged leptin-resistant obese rats than hypothalamic GDNF over- expression [101]. We found that nigral rAAV-mediated... such that the peptide contained signalling sequences from immu- noglobulin or NGF, lenti-viral or rAAV mediated over... , ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
40 nature protocols | VOL.5 NO.2 | 2010 | 247 IntroDuctIon
 

Summary:  in generating populations of neurons expressing ChR2 in each injected mouse. Because AAV-mediated ChR2... vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brain. Mol... delivery. Methods Mol. Biol. 515, 199­213 (2009). 31. Tenenbaum, L. et al. Recombinant AAV-mediated gene

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University; Moore, Christopher - McGovern Institute for Brain Research & Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
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41 GENE THERAPY AAV-mediated factor IX gene transfer to skeletal muscle in patients with
 

Summary:  GENE THERAPY AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe... studies, we demonstrated that either skeletal muscle or liver could serve as a target tissue for AAV-mediated... . This requirement rests on 3 distinct features of AAV-mediated gene transfer and F.IX expression in skeletal muscle

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
42 correspondence NATURE|VOL424|17JULY2003|www.nature.com/nature 251
 

Summary:  differences between retroviral and AAV-mediated integration. First, unlike retroviral vectors, AAV-mediated

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
43 64 NATURE MEDICINE VOLUME 5 NUMBER 1 JANUARY 1999 Hemophilia is an X-linked recessive bleeding disorder that
 

Summary:  times. With 16­25% or more activity, the bleeding times were in the normal range, indicating that AAV-mediated... procedures. The studies here demonstrate that rAAV-mediated gene transfer of the hFIX cDNA can correct... threatening and/or lead to chronic problems such as severe arthritis. Therapy for acute bleeding consists

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
44 Adeno-Associated Virus Gene Repair Corrects a Mouse Model of Hereditary Tyrosinemia In Vivo
 

Summary:  to proliferate to efficiently repopulate mutant livers and cure the underlying metabolic disease. Conclusion: AAV-mediated... demonstrate proof-of- principle that an appropriate monogenic liver disease can be corrected by AAV-mediated... to study the clinical significance of AAV-mediated gene repair by homologous recombination. ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
45 Computational Model of Vascular Endothelial Growth Factor Spatial Distribution in Muscle
 

Summary:  through over- expression of VEGF by myocytes [12]. Because of the importance of VEGF, many clinical trials... ,577 and 1,385 10À7 pmol/cm2 , respectively) and over- expression in three distant fibers produces maximum... . In addition, non-uniform over- expression of ...

  

Source: Popel, Aleksander S. - Department of Biomedical Engineering, Johns Hopkins University

 

Collection: Engineering ; Biology and Medicine

 
46 Progress and prospects: techniques for site-directed mutagenesis in animal models
 

Summary:  - quencies of AAV-mediated homologous recombination-- up to 0.1% in human cell lines--even in the absence... by conventional targeting approaches with linear DNA fragments. The mechanism of AAV-mediated homologous recombina... and adenoviral vectors have not worked well for applications of gene targeting. rAAV-mediated gene ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
47 Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology
 

Summary:  451694, 9 pages doi:10.1155/2011/451694 Review Article The PD-1/PD-L1 (B7-H1) Pathway in Chronic... effector function during chronic infection. PD-1 receptor and its ligand PD-L1 of the B7/CD28 family... into exhausted CTLs during chronic infection with human immunodeficiency virus, hepatitis B virus, hepatitis C

  

Source: Zang, Xingxing - Department of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
48 JOURNAL OF VIROLOGY, Jan. 2005, p. 214224 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.214224.2005
 

Summary:  ), hyperlip- idemia (24), tyrosinemia (41), and diabetes mellitus (25), and chronic viral hepatitis (29

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
49 Current Gene Therapy, 2007, 7, 347-360 347 1566-5232/07 $50.00+.00 2007 Bentham Science Publishers Ltd.
 

Summary:  neutralizing antibodies can affect intrac- erebral rAAV-mediated transduction. Moreover, when rAAV2 pre... careful analysis of rAAV-mediated immune responses in the brain, similar to the studies that have been... preceding disease onset is most likely to occur in the CLN. During chronic inflammation, however, brain

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
50 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  pathology may be superior to infecting sick and dying neurons (Fig. 2A and B). rAAV mediated over-expression... the targeted area as well as providing a direct therapeutic benefit themselves. Using rLV over- expressing... . Nigrostriatal rAAV-mediated GDNF ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
51 Brain Research 886 (2000) 8298 www.elsevier.com/locate/bres
 

Summary:  or substantia nigra thus makes it possible to obtain a regionally restricted over-expression of GDNF within... vivo GDNF over-expression did not modify the extent of the delivery of the GDNF gene to the striatum... the dopamine neurons. Thus, nigrostriatal pathway were partly preserved and sprouting over-expression of GDNF

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
52 Suppression of Insult-Induced Neurogenesis in Adult Rat Brain by Brain-Derived Neurotrophic Factor
 

Summary:  in vitro (31). Moreover, BDNF-over- expression under the nestin promoter produces gaps and heterotopias... cerebral cortex (30). It could be argued that the rAAV-mediated high BDNF levels do not inhibit but delay... , it is inconceivable that they will differentiate into neurons under conditions when ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
53 The phosphorylation state of Ser-129 in human -synuclein determines neurodegeneration
 

Summary:  . We demonstrated that recombinant adeno-associated virus (rAAV)-mediated -syn expression in the SNc... other groups at 4 wk (Fig. 4B; P 0.01­0.001). Typically, AAV- mediated gene expression reaches maximum... the toxicity of human -syn that is phos- phorylated at Ser-129 in a rodent animal model of PD. ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
54 LONG-TERM RESTORATION OF STRIATAL l-AROMATIC AMINO ACID DECARBOXYLASE ACTIVITY USING RECOMBINANT
 

Summary:  for Parkinson's disease, viral vector-mediated over-expression of striatal l-aromatic amino acid decarboxylase... experiments were performed to evaluate whether the rAAV- mediated hAADC expression observed via immuno... groups (repeated measures ANOVA, P q 0.05). To further determine whether rAAV-mediated ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
55 NATURE BIOTECHNOLOGY VOLUME 25 NUMBER 10 OCTOBER 2007 1111 and drugs that act directly on disease genes.
 

Summary:  that stable rAAV- mediated transgene expression was due to proviral integration, as detected by large... Figure 1 Model of AAV-mediated oncogenesis. AVV vector transduction normally results in maintenance... susceptible to rAAV-mediated events that enhance the generation of tumors, and this will need to be ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
56 doi:10.1093/brain/awh374 Brain (2005), 128, 559569 Reversal of dyskinesias in an animal model of
 

Summary:  study we investigated whether rAAV- mediated expression of the DOPA-synthesizing enzymes, TH and GCH1... , Nestler EJ, Jasmin BJ, et al. Chronic alterations in dopaminergic neurotransmission produce a persistent

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
57 Light-Driven Cone Arrestin Translocation in Cones of Postnatal Guanylate Cyclase-1 Knockout Mouse Retina
 

Summary:  remained undetectable in the treated retinas. CONCLUSIONS. AAV-mediated expression of GC1 in a subpopu... to arrestin translocation. Although we have established that rAAV-mediated GC1 ex- pression in cone cells... equivalent of chronic light exposure. The cone arrestin staining pattern observed in untreated GC1 KO cones

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
58 Species-Specific Differences in Mouse and Human Airway Epithelial Biology of Recombinant
 

Summary:  for evaluating suitable vectors for gene therapy of CF and other lung diseases. Studies evaluating rAAV-mediated... . To this end, we first sought to evaluate the Figure 4. Proteasome-modulating agents augment rAAV-mediated... complementation of CFTR using rAAV- mediated CFTR gene delivery. Although mouse ALI ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
59 ORAL PRESENTATION Open Access Immunosuppressive role of fibrinogen-like
 

Summary:  antibodies [3] and can be mimicked by FGL2 protein alone. Moreover, AAV-mediated FGL2 overexpression in rat

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
60 Introduction Cystic fibrosis (CF) is the most common inherited dis-
 

Summary:  evaluating the effect of proteasome inhibitors on AAV-mediated gene transfer in lung, liver, and muscle... . To determine the effect of the proteasome inhibitor on AAV-mediated gene transfer in mouse lung, 6-week... on AAV-mediated gene transfer in liver, 6-week-old C57BL/6 mice were anesthetized with ketamine /xylazine

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine


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61 HUMAN GENE THERAPY 16:299306 (March 2005) Mary Ann Liebert, Inc.
 

Summary:  with selective liver lobes infusion pro- cedure (SE group). In order to obtain AAV-mediated liver trans- duction... two times higher than the TV group. This confirmed that HA or PV delivery route is more efficient at rAAV-mediated... confirmed that HA infusion is equally effective for rAAV-mediated gene transduc- tion, this ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
62 original article The American Society of Gene Therapy Molecular Therapy vol. 17 no. 2, 285293 feb. 2009 285
 

Summary:  in the lung fol- lowing injury and normal cellular turnover.15 Although the effi- ciency of rAAV-mediated gene... AAV is capable of transducing resident lung stem/progenitor cells. Furthermore, it is unclear whether rAAV-mediated... recombination. rAAV-mediated functional expression of cre in the adult mouse lung To investigate ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
63 Journal of Neuroscience Methods 183 (2009) 165175 Contents lists available at ScienceDirect
 

Summary:  of choice for thera- peutic treatment of animal diseases, including humans. Therefore, rAAV-mediated... the mechanical shutter. 3. Results 3.1. rAAV mediated delivery of ChR2-YFP into neurons To monitor the expression

  

Source: Seung, Sebastian - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT); Tedrake, Russ - Computer Science and Artificial Intelligence Laboratory & Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine ; Engineering

 
64 Behavioural Brain Research 156 (2005) 201213 Research report
 

Summary:  reversal of limb-use asymmetry in the cylinder following either intraperitoneal injection or rAAV-mediated... more chronically symptomatic following the next increased concentration of 6-OHDA. After the final... ;20(4):415­55. [5] Betarbet R, Sherer TB, Mackenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. Chronic pesticide

  

Source: Schallert, Tim - Department of Psychology, University of Texas at Austin

 

Collection: Biology and Medicine

 
65 P E R S P E C T I V E www.ScienceTranslationalMedicine.org 14 October 2009 Vol 1 Issue 2 2ps2 1
 

Summary:  , Reversal of motor impair- ments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated... in the late 1960s (9) and continues to be the mainstay of medical therapy for PD. However, chronic treatment

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
66 Essential Role of the fosB Gene in Molecular, Cellular, and Behavioral Actions of Chronic Electroconvulsive Seizures
 

Summary:  finding that FosB over- expressed in cell lines migrates at 35­37 kDa (J. S. Chen et al., 1997... Essential Role of the fosB Gene in Molecular, Cellular, and Behavioral Actions of Chronic... after chronic perturbation (Winston et al., 1990; Hope et al., 1992, 1994a,b; Pennypacker et al., 1995

  

Source: Vaidya, Vidita - Department of Biological Sciences, Tata Institute of Fundamental Research

 

Collection: Biology and Medicine

 
67 MOLECULAR AND CELLULAR BIOLOGY, May 2003, p. 35583565 Vol. 23, No. 10 0270-7306/03/$08.00 0 DOI: 10.1128/MCB.23.10.35583565.2003
 

Summary:  stimulates the frequency of rAAV-mediated gene targeting by over 100-fold, suggesting that the mechanism of rAAV-mediated... by activating the homology-directed repair of the DSB. To examine whether rAAV-mediated gene targeting can... targeting by a DSB is evidence that one mechanism of rAAV-mediated gene ...

  

Source: Baltimore, David - Division of Biology, California Institute of Technology

 

Collection: Biotechnology ; Biology and Medicine

 
68 Behavioral/Systems/Cognitive Chronic Back Pain Is Associated with Decreased Prefrontal
 

Summary:  of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early over- expression of pro... Behavioral/Systems/Cognitive Chronic Back Pain Is Associated with Decreased Prefrontal and Thalamic... of the brain in chronic pain conditions remains speculative. We compared brain morphology of 26 ...

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collection: Biology and Medicine

 
69 Severity of chronic Chagas disease is associated with cytokine/antioxidant imbalance in chronically infected individuals
 

Summary:  , J.J., Matsushima, K., 1990. Over- expression of mitochondrial manganese superoxide dismutase... Severity of chronic Chagas disease is associated with cytokine/antioxidant imbalance in chronically... the pathogenic mechanisms in chronic Chagas disease, a major cause of morbidity and ...

  

Source: Roche, Benjamin - School of Ecology, University of Georgia

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
70 Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease
 

Summary:  DA neurons of the SN by adeno-associated virus (AAV)-mediated transduction with a myristoylated (Myr... affected in the United States alone (1). It is a chronic, progressive neuro- degenerative disorder... -Akt in the intrastriatal 6OHDA mouse model. (A) (Left Upper) The chronic morphologic studies shown in A and B were

  

Source: Burke, Robert E - Departments of Neurology and Pathology, Columbia University

 

Collection: Biology and Medicine

 
71 Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo
 

Summary:  reported herein. Thus, long-term rAAV-mediated RNAi in the brain does not, in and of itself, negatively... proposed for siRNA-induced untoward effects (Jackson and Linsley, 2004). Over-expression of short... ; Berdusco et al., 1993; Lamontagne et al., 1981) was used as a control for the effects of ribozyme over-expression

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
72 Therapeutic short hairpin RNA expression in the liver: viral targets and vectors
 

Summary:  virus. Such individuals are at a high risk of developing acute or chronic hepatic disease... options for chronically infected patients are limited, and particularly ineffective in case of hepatitis C... for acute and chronic human liver disease is infection with one of the two major types of hepatitis virus

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
73 Adaptation to psychostimulants in striatum Featured Review
 

Summary:  input. AAV-mediated overexpression of FosB increased spine density independent of cocaine treatment... (Hyman et al., 2006). Therefore, it is likely that molecular mechanisms downstream of chronic... revealed that both acute and chronic exposure to psychostimulants differentially regulate expression

  

Source: West, Anne - Department of Neurobiology, Duke University

 

Collection: Biology and Medicine

 
74 Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display
 

Summary:  input. AAV-mediated overexpression of FosB increased spine density independent of cocaine treatment... (Hyman et al., 2006). Therefore, it is likely that molecular mechanisms downstream of chronic... revealed that both acute and chronic exposure to psychostimulants differentially regulate expression

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
75 Long-term Skeletal Muscle Protection After Gene Transfer in a Mouse Model of LGMD-2D
 

Summary:  . The ability of recombinant AAV­mediated gene delivery to restore normal muscle mechanical properties in sgca... that this was believed to be the result of sgca over-expression using a CMV promoter.3 These studies revealed that a fine... be prevented in a mouse model of LGMD-2D using an AAV-mediated gene delivery technique. We ...

  

Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa

 

Collection: Biology and Medicine

 
76 List of Awardees for the 21st Annual Neuroscience Center Retreat March 21, 2009
 

Summary:  Neurons 16. Huijing Xia et al. ­ Over-expression of ACE2 in the Brain Reduces Blood Pressure by Restoring... Baroreflex and Autonomic Functions in Chronically Hypertensive Mice 20. Na Li et al. ­ Pigment Epithelium

  

Source: Louisiana State University Health Sciences Center in New Orleans, Department of Biochemistry and Molecular Biology

 

Collection: Biology and Medicine

 
77 NATURE MEDICINE VOLUME 6 NUMBER 5 MAY 2000 595 NEW TECHNOLOGY
 

Summary:  with this vector system. One well-known example is rAAV-mediated gene therapy for cystic fibrosis. For this... AAV vectors. Based on this, we have developed a new approach to en- hance the efficiency of rAAV-mediated gene... circularized molecule. Fig. 3 Intermolecular cis activation in- creases rAAV-mediated gene transfer in fi

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
78 Treatments for neuropsychiatric disorders include drug therapies, surgical interven-
 

Summary:  . AAV-mediated expression may be less stable because a much smaller percentage (less than 1... remission. Chronic pain. Electrical stimulation methods include local peripheral nerve stimulation, local... ., Stippich, C., Unterberg, A. & Tronnier, V. M. Motor cortex stimulation for long-term relief of chronic

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
79 JOURNAL OF VIROLOGY, Jan. 2005, p. 364379 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.364379.2005
 

Summary:  . AAV-mediated expression may be less stable because a much smaller percentage (less than 1... remission. Chronic pain. Electrical stimulation methods include local peripheral nerve stimulation, local... ., Stippich, C., Unterberg, A. & Tronnier, V. M. Motor cortex stimulation for long-term relief of chronic

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
80 Expert Review Designer Gene Delivery Vectors: Molecular Engineering and Evolution
 

Summary:  al. AAV-mediated gene transfer for retinal diseases. Expert Opin. Biol. Ther. 6:1279­1294 (2006). 26... and harvesting on two cell lines, a human megakaryocytic and a B-cell chronic lymphocytic leukemia cell line

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry


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81 The idea of gene-based therapeutics has been around for some time, but it only received serious attention
 

Summary:  expansion has been observed in gene therapy trials for chronic granalomatous disease17 . The safety

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
82 COMBINED ECOLOGICAL RISK ASSESSMENT OF SEDIMENT AND WATER COLUMN CONTAMINATED BY DIFFUSE POLLUTION
 

Summary:  of contaminants on living organisms are generally evaluated using the basic concepts of acute and chronic toxicity... . Acute toxicity is related to water column concentration, while chronic toxicity is related to the water... the chronic effect of contaminated sediments on biota. The methodology has been adapted and modified

  

Source: Melching, Charles S. - Department of Civil and Environmental Engineering, Marquette University

 

Collection: Environmental Sciences and Ecology ; Engineering

 
83 Immunology 101 Acute and chronic infection Thymectomy Comparing data Appendix Mathematical models of CD8 T cell responses
 

Summary:  Immunology 101 Acute and chronic infection Thymectomy Comparing data Appendix Mathematical models... of CD8 T cell responses: responses during acute and chronic viral infections Vitaly V. Ganusov... 101 Acute and chronic infection Thymectomy Comparing data Appendix Outline 1 Immunology 101 Immune

  

Source: Haase, Markus - Elektrotechniek, Wiskunde en Informatica, Technische Universiteit Delft

 

Collection: Mathematics

 
84 NATURE BIOTECHNOLOGY VOLUME 24 NUMBER 8 AUGUST 2006 949 AAV hits the genomic bull's-eye
 

Summary:  at the target locus10. (b) Two potential mechanisms of AAV-mediated gene correction are recombination and repair... homologous recombination as the most likely mechanism for AAV-mediated gene correction. b Adenovirus Adeno

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
85 Chronicpainremainsoneofthemostindomitablemedical, biological and social challenges today. During the last
 

Summary:  and clinical treatments for acute and chronic pain. Despite these obvious accomplishments, the role of cortical... in the pathophysiology of pain,especially in patients sufferingfromchronicpain.Thereisgrowingevidencethat chronic pain... that chronic pain is associated with a unique brain ...

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collection: Biology and Medicine

 
86 PEG Conjugation Moderately Protects Adeno-Associated Viral Vectors Against
 

Summary:  .C.: American Chemical Society. Herzog RW. 2004. AAV-mediated gene transfer to skeletal muscle. Methods Mol Biol... tumor necrosis factor receptor type I (PEG sTNF-RI) for chronic in- flammatory diseases. Adv Drug Deliv... (1):209­211. Luxon BA, Grace M, Brassard D, Bordens R. 2002. Pegylated interferons for the treatment of ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
87 Sustained Striatal Ciliary Neurotrophic Factor Expression Negatively Affects
 

Summary:  -term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral... are particularly susceptible to the toxic effects of mutant huntingtin. To observe the effects of chronic... of rAAV2 vector does not lead to chronic changes in gene expression profile, striatal pathology, weight

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
88 Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions
 

Summary:  EA. Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic... kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions

  

Source: de Lange, Titia - Laboratory for Cell Biology and Genetics, Rockefeller University

 

Collection: Biology and Medicine

 
89 JOURNAL OF VIROLOGY, Apr. 2004, p. 41654175 Vol. 78, No. 8 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.8.41654175.2004
 

Summary:  and the cell cycle can affect the efficiency of rAAV-mediated gene repair. MATERIALS AND METHODS Mutant e... with various agents known to induce rAAV trans- duction before rAAV-mediated gene repair was evaluated... or cytoplasmic injection of both forms of viral DNA. Evaluation of rAAV-mediated gene correction in transgenic

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
90 OCTOBER 28-29 Cancer and Genetics
 

Summary:  - steroidal anti-inflammatory drug (NSAID) treatment; however, chronic NSAID treatment is associated

  

Source: Wu, Dapeng Oliver - Department of Electrical and Computer Engineering, University of Florida

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
91 McMaster Health Forum puts focus on need for better chronic pain management July 18, 2011
 

Summary:  McMaster Health Forum puts focus on need for better chronic pain management July 18, 2011 A strong... endorsement for the creation of a national, multi-stakeholder network to raise awareness about chronic pain... and increase support for and coordination in comprehensive chronic pain management was vocalized at a day

  

Source: Thompson, Michael - Department of Civil Engineering, McMaster University

 

Collection: Materials Science

 
92 JOURNAL OF VIROLOGY, Mar. 2005, p. 36063614 Vol. 79, No. 6 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.6.36063614.2005
 

Summary:  process. Thus, the present study provides new insights into the risk of rAAV-mediated insertional... to carefully consider rAAV-mediated insertional mutagenesis because of the following reasons. First, vector... regeneration, such as chronic liver inflammation. In this regard, the following observations in the present

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
93 JOURNAL OF VIROLOGY, Mar. 2004, p. 28632874 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.28632874.2004
 

Summary:  for the clinical testing of rAAV-mediated gene therapy (1, 34­36). The lung is the primary target for gene therapy

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
94 JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
 

Summary:  - creased 100-fold. Thus, delivering AAV as a CaPi coprecipitate markedly enhanced AAV-mediated gene... gene transfer by binding virus to the cell surface, we hypothesized that AAV-mediated gene transfer... proteoglycan in order to enhance gene transfer. To determine whether CaPi coprecipitation would improve AAV-mediated

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
95 EPFL School of Life Sciences -2009 Annual Report Table Of Contents
 

Summary:  ., Björklund T., Aebischer P. and Kirik D.(2009). Dose optimization for long-term rAAV-mediat- ed RNA

  

Source: 

 

Collection: Computer Technologies and Information Sciences

 
96 JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.15.69696976.2001
 

Summary:  that extrachromosomal, not integrated, genomes are the major form of rAAV in the liver and are the primary source of rAAV-mediated... uncertainties as to whether rAAV-mediated hepatic gene expression can persist lifelong after a single vector... . 4. rAAV-mediated gene expression in partially hepatecto- mized mice. The figure ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
97 Central insulin and leptin-mediated autonomic control of glucose
 

Summary:  ]. To study the impact of chronic leptin treatment on hypothalamic insulin signaling, metabolical- ly normal... , chronic leptin treatment abolished the acute increase in hypothalamic insulin sensitivity [24... ]. Furthermore, chronic leptin treat- ment caused an increase in IR-b assembly with SOCS-3, which

  

Source: Toledo, University of - Center for Diabetes and Endocrine Research (CeDER)

 

Collection: Biology and Medicine

 
98 Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase
 

Summary:  . Weissmann N, Manz D, Buchspies D, Keller S, Mehling T, Voswinckel R et al. Con- genital erythropoietin over-expression... the effects with chronic (4 months) sEH inhibition. Methods and results In isolated lungs from WT mice, acute... , but potentiation of vasoconstriction following sEH inhibition was not evident. Chronic ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
99 OctOber 27-28 cancer and Genetics
 

Summary:  -B pathway in AAV-mediated transduction of DCs. Western blot analyses with cytosolic and nuclear fractions

  

Source: Wu, Dapeng Oliver - Department of Electrical and Computer Engineering, University of Florida

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
100 Summer Research Program 2010 Table of Contents
 

Summary:  the major points of regulation for KRAB-ZFPs through four different assays. Each KRAB-ZFP studied was over-expressed... mouse E14 embryonic stem cells (ESCs) using TRE inducible Lentiviral vectors for the over-expression... for FL-SMN and a-SMN Injected Mice Pups AAV-MEDIATED RESCUE OF SMA TYPE-I MICE P.J. HURLEY; V. SETOLA; P

  

Source: Lausanne, Ecole Polytechnique Fédérale de - Processor Architecture Laboratory

 

Collection: Engineering ; Computer Technologies and Information Sciences


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