Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Topic List  Advanced Search  
Sample search results for: ab binding alters

Page:   2  3  4  5 
 
1 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Oct. 2003, p. 58985906 Vol. 69, No. 10 0099-2240/03/$08.00 0 DOI: 10.1128/AEM.69.10.58985906.2003
 

Summary:  I-Cry1Ab nor 125 I-Cry1Ac binding was altered in the BBMV from KCBhyb larvae compared to YDK and CXC... similar to Cry1Ac but also to Cry2Aa. We studied the role of toxin binding alteration in resistance... of resistance by target insect pests due to intense selection pressure (6). ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
2 Allosteric 1 Integrin Antibodies That Stabilize the Low Affinity State by Preventing the Swing-out of the Hybrid Domain*
 

Summary:  and activating or inhibitory mAbs1 that bind to the integrin extracellular domain are thought to alter... .e. ligand binding, (ii) "stimulatory mAbs" that augment ligand binding, and (iii) "neutral mAbs" that do... not have any impact on activity. ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University; Walz, Thomas - Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
3 Use of Single Point Mutations in Domain I of 2-Glycoprotein I to Determine Fine Antigenic Specificity of Antiphospholipid
 

Summary:  containing sequences from domain V of 2GPI en- abled these mAbs to bind to cardiolipin or inhibited binding... of mAb to 2GPI. However, polyclonal autoantibodies from APS pa- tients did not bind these peptides... - 2GPI Abs that were aCL assay negative and inhib- ited ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
4 Bt-R1a Extracellular Cadherin Repeat 12 Mediates Bacillus thuringiensis Cry1Ab Binding and Cytotoxicity*
 

Summary:  Bt-R1a Extracellular Cadherin Repeat 12 Mediates Bacillus thuringiensis Cry1Ab Binding... Cry1A toxins in Manduca sexta. Cry1Ab toxin is reported to bind specific epitopes located... was the minimal 125 I-Cry1Ab binding region de- tected under denaturing conditions. ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
5 CellCell--LibraryBindingLibraryBindingCellCellLibraryBindingLibraryBinding LibraryBinding(technologymapping)
 

Summary:  ()(P)H LibraryBinding12. f(x)=g(Px).Hµµµ pins. Structuralmatch:µ. + * abc + * qrp f=ab+c g=p+qr Boolean... Table: ()µµµµ,µ nµ. #12;BindingFPGAs ()µ. µ f=ab+cdµLUTsn=3. µdecomposition:f=f1+f2,f1=ab,f2=cd3LUTs... ,µ decomposition:f=ab+f2,f2=cd2LUTs ...

  

Source: Kavousianos, Xrysovalantis - Department of Computer Science, University of Ioannina

 

Collection: Computer Technologies and Information Sciences

 
6 Neuron, Vol. 32, 173176, October 25, 2001, Copyright 2001 by Cell Press Of Snakes, Snails, and Surrogates
 

Summary:  .M., Balass, M., Fridkin,close to the negatively charged acetylcholine binding M., Smit, A.B., Brejc, K... , and Surrogates The high-resolution structure of a synthetic 13-residue the loops lining the acetylcholine binding... site and con- tains the binding site motif YXCC.peptide in a tight complex with ...

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
7 The induction of folding cooperativity by ligand binding drives the allosteric response
 

Summary:  with altered effector binding and allostery. FEBS J 272:4487­4496. 22. Reichheld SE, Davidson AR (2006) Two... The induction of folding cooperativity by ligand binding drives the allosteric response... with the antibiotic, Tc, that abrogates its ability to specifically bind its operator DNA. In this work, by ...

  

Source: Stoddard, Barry - Division of Basic Sciences, Fred Hutchinson Cancer Research Center, University of Washington at Seattle

 

Collection: Biology and Medicine

 
8 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 0099-2240/01/$04.00 0 DOI: 10.1128/AEM.67.1.323329.2001
 

Summary:  competed with high affinity (competition constant [Kcom] 1.1 nM) for 125 I-Cry1Ab binding sites. Cry1Aa... , Cry1Fa, and Cry1Ja also competed for 125 I-Cry1Ab binding sites, though the Kcom values ranged from... 179 to 304 nM. Cry1Ab competed for 125 I-Cry1Ac binding ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
9 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Nov. 2002, p. 57115717 Vol. 68, No. 11 0099-2240/02/$04.00 0 DOI: 10.1128/AEM.68.11.57115717.2002
 

Summary:  , Cry1Ab, and Cry1Ac toxins did not bind to BBMV from the resistant YHD2 strain, while specific binding... in binding, neither Cry1A nor Cry1Fa toxin altered the permeability of membrane vesicles from resistant... mechanisms of resistance have been pro- posed, the best-characterized ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
10 Compositional Binding in Network Domains Pamela Zave
 

Summary:  Compositional Binding in Network Domains Pamela Zave AT&T Laboratories--Research, Florham Park, New... Jersey USA pamela@research.att.com Abstract. This paper considers network services that bind identifiers... of such bindings. Five patterns represent the different ways that identifier binding can be ...

  

Source: Fisher, Kathleen - AT&T Labs Research

 

Collection: Computer Technologies and Information Sciences

 
11 The HevCaLP Protein Mediates Binding Specificity of the Cry1A Class of Bacillus thuringiensis Toxins in Heliothis Virescens
 

Summary:  the correlation between BtR-4 gene disruption, lack of HevCaLP, and altered Cry1A toxin binding. Toxin-binding... CaLP production and Cry1Aa toxin binding, while most of Cry1Ab and Cry1Ac binding was independent of the BtR-4... in the resulting YHD2-B strain as well ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
12 Plant Molecular Biology 41: 113, 1999. 1999 Kluwer Academic Publishers. Printed in the Netherlands.
 

Summary:  does not alter DNA-binding specificity of EmBP-1 According to X-ray crystal structures of GCN4 com... are major residues determining DNA- binding specificity (Johnson, 1993; Suckow et al., 1993a,b, 1996). Among... of a single base-contact residue can dramatically alter ...

  

Source: Guiltinan, Mark - Department of Horticulture, Pennsylvania State University

 

Collection: Biotechnology

 
13 discrimination mechanism in antigen recognition Structure and kinetics of a transient antibody binding intermediate reveal a kinetic
 

Summary:  and Ab2 , where large conformational changes of CDR loops L3 and H3 completely alter the binding site... -existing conformations (7). One conformation (dubbed Ab2 ), which is 20% populated, has a deep and narrow binding site... (Ab1 ) is 80% populated, has a flat ...

  

Source: Tawfik, Dan S. - Department of Biological Chemistry, Weizmann Institute of Science

 

Collection: Biotechnology ; Biology and Medicine

 
14 Biochem. J. (2002) 362, 265271 (Printed in Great Britain) 265 The transfer of transthyretin and receptor-binding properties from
 

Summary:  ­TTR interaction. The substitution of RBP loops into ERABP did not alter the ligand-binding ability of the protein... in the binding pocket altering the con- formation of the loops, thereby preventing their binding to TTR. It would... [25], have been engineered to ...

  

Source: van Aalten, Daan - Division of Biological Chemistry and Molecular Microbiology, University of Dundee

 

Collection: Biology and Medicine

 
15 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 0099-2240/01/$04.00 0 DOI: 10.1128/AEM.67.2.872879.2001
 

Summary:  the Cry1Ab binding site on the O. nubilalis brush border by three approaches. An optical biosensor... ) injected over a surface of immobilized Cry toxin. Preincubation with Cry1Ab reduced BBMV binding... to immobilized Cry1Ab, whereas preincubation with Cry1F, Cry9C, or Cry9E did not ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
16 Quantifying the Effects of Molecular Orientation and Length on Two-dimensional Receptor-Ligand Binding Kinetics*
 

Summary:  monoclonal antibody (mAb) adsorbed on the plastic surface (12). The ligand binding affinity and kinetics... by a nonblocking mAb, which resulted in a more uniform orientation, or direct binding to the RBC sur- face via... -dimensional affinities and two- dimensional bindings of a ...

  

Source: Zhu, Cheng - Department of Biomedical Engineering, Georgia Institute of Technology and Emory University

 

Collection: Engineering ; Biology and Medicine

 
17 Monoclonal Antibody Epitope Mapping Describes Tailspike -Helix Folding and Aggregation Intermediates*S
 

Summary:  altered the binding of at least one mAb. mAb 51 Epitope Includes the 400­407 Disordered Loop--If each... 405K mutation, which ex- clusively alters the binding of mAb 51 (Table I). This result suggests... intermediates. Identifica- tion of ...

  

Source: Clark, Patricia L. - Department of Chemistry and Biochemistry, University of Notre Dame

 

Collection: Biology and Medicine ; Chemistry

 
18 Subscriber access provided by UPR. Rio Piedras Campus | Library System Biochemistry is published by the American Chemical Society. 1155 Sixteenth Street
 

Summary:  site is being altered. The mAb binding may change the conformation of the ion channel in a way... -clamping and photoaffinity-labeling techniques were used to study the effects of binding of monoclonal antibodies (mAbs... examined here are known to inhibit ligand ...

  

Source: Lasalde Dominicc, Jose A. - Department of Biology, Universidad de Puerto Rico - Rio Piedras

 

Collection: Biology and Medicine

 
19 J. ROBERT MANAK AND MATTHEW P. SCOTT GENE REGULA; AbIle assistants for homeodomain proteins
 

Summary:  studies of bacterial and yeast DNA-binding proteins, the DNA-binding specificities of which are altered... a homeodomain protein, the DNA-binding specificity of MATa is altered so that it now recognizes and represses... the promoters of haploid-specific genes [lo]. The ...

  

Source: Scott, Matthew - Departments of Developmental Biology, Genetics, & Bioengineering, Stanford University

 

Collection: Biotechnology ; Biology and Medicine

 
20 Localization of the Binding Site on Intercellular Adhesion Molecule-3 (ICAM-3) for Lymphocyte Function-associated
 

Summary:  domain 1 had the greatest effect (17). The epitopes of mAb that blocked ICAM-1-dependent binding... residues within domain 1 of ICAM-3 disrupts binding to LFA-1 without affecting mAb epitopes in domain 1... - bilized on plastic. Binding was in the presence of an isotype matched control ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine


Page:   2  3  4  5 
Page:   1  2  3  4  5 
 
21 Proc. Natl. Acad. Sci. USA Vol. 95, pp. 48704875, April 1998
 

Summary:  of calcium. mAb CBRM1 20 does not block ligand binding. Thus, the region on the lower surface of the -pro... - peller domain to which mAb CBRM1 20 binds does not bind ligand and, furthermore, cannot bind other... -binding motif and the 3­4 loop ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
22 Epitope mapping of a monoclonal antibody against human thrombin by H/D-exchange mass spectrometry
 

Summary:  Previous studies had already shown that mAb binding to human thrombin resulted in the inhibition... of clotting could be caused in two distinct ways: The mAb could be binding in the vicinity of the active site... and disallowing the entrance of fibrinogen by steric hindrance, or the mAb ...

  

Source: Komives, Elizabeth A. - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Biology and Medicine

 
23 How the Lac Repressor represses: Lac repressor is really a dimer of dimers:Why? DNA sequencing reveals the presence of additional
 

Summary:  than either binds alone · CAP should increase RNAP's KB for lac promoter DNA · If you alter the lac... · Mutations in CAP or RNAP that alter their interaction should affect promoter binding affinity" T82T84G78A65C... ;@"5$4"'#$/0.1$&'(&'##$,&0*#.&)(A"*B$ ...

  

Source: Lycan, Deborah E. - Department of Biology, Lewis and Clark College

 

Collection: Biology and Medicine

 
24 Synergism of Bacillus thuringiensis toxins by a fragment of a toxin-binding cadherin
 

Summary:  midgut microvilli but did not alter Cry1Ab or Cry1Ac binding localization in the midgut. By BIAcore... August 28, 2007 vol. 104 no. 35 13903 AGRICULTURAL SCIENCES #12;alter the localization of Cry1Ab binding... membrane (CR12-MPED) as the essential ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
25 THE JOURNAL OF BIOLXUXCAL CHEMISTRY Vol. 265, No. 1, Iswe ofJanuary 5, pp. 56Y-581, 1990 0 1990 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in (1.S. A.
 

Summary:  Analysis of the binding of monoclonal antibodies (mAbs) by Torpedo nicotinic acetylcholine receptor (ACh... -162, and a lo-kDa fragment beginning at Asn-339. Three mAbs, selected for binding to each of the VS... these synthetic peptides revealed three additional mAbs that ...

  

Source: Bridgman, Paul C. - Department of Anatomy and Neurobiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
26 Allosteric Modulation of 2-Adrenergic Receptor by Zn2 GAYATHRI SWAMINATH, JACQUELINE STEENHUIS, BRIAN KOBILKA, and TAE WEON LEE
 

Summary:  of the D4 dopamine receptor, the Zn2 binding site that alters antagonist binding is different from the Na... 2 , both Bmax and KD values for [3 H]DHA binding are altered, consistent with the idea that Zn2... with engineered metal ion binding sites as a method to study ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
27 ORIGINAL PAPER Computational study of the binding of CuII
 

Summary:  ORIGINAL PAPER Computational study of the binding of CuII to Alzheimer's amyloid-b peptide: Do Ab42... and Ab40 bind copper in identical fashion? Yogita Mantri Æ Marco Fioroni Æ Mu-Hyun Baik Received: 29... hypotheses on the pathogen- esis of Alzheimer's disease is that the amyloid-b peptide ...

  

Source: Baik, Mu-Hyun - School of Informatics & Department of Chemistry, Indiana University

 

Collection: Chemistry

 
28 Neutrophil Deactivation by Influenza A Virus Role of Hemagglutinin Binding to Specific Sialic Acid-Bearing
 

Summary:  ,whereas binding of IAV or the other mAbs was not altered ( n = 3). activation per se, and that these functions... for deactivation. IAV competed for binding toneutrophils with Abs directed against CD43, sialyl-Le", CD45... with soluble staph A protein did not alter ...

  

Source: Kazhdan, Michael - Department of Computer Science, Johns Hopkins University

 

Collection: Computer Technologies and Information Sciences

 
29 Proc. Natl. Acad. Sci. USA Vol. 96, pp. 22152220, March 1999
 

Summary:  a conformational change with activation. This mAb, CBRM1 5, binds the I domain very close to the ligand binding... ), and mAbs directed to the I domain can abolish ligand binding to intact integrins (17). Most likely... 5 (27), recognizes the I domain of the integrin Mac-1 and is unique ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
30 CS 611 Advanced Programming Languages Class Notes 15 Fall 1994 Robert L. Constable September 30, 1994
 

Summary:  , 1994 Vijay Menon , Scribe 1 Plan ffl Binding -- Binding Occurrence -- Scope -- Bound Variables -- Free... Variables -- Examples ffl Substitution -- Capture -- ff equality 2 Binding Consider the following –­term... this is a rather simple and straightforward notion, it is neccessary to be precise as to what we mean. 2.1 ...

  

Source: Cornell University, Department of Computer Science, Nuprl Project

 

Collection: Computer Technologies and Information Sciences

 
31 Locking in alternate conformations of the integrin L 2 I domain with disulfide bonds reveals
 

Summary:  binding (4), including mapping of function-blocking mAbs to different epitopes within this domain (8... were coexpressed with the integrin 2 subunit and binding to mAbs was determined by immunofluorescence... flow cytometry. Binding of mAb CBR LFA- 1 1 to the open I ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
32 Molecular flexibility in ab initio drug docking to DNA: binding-site and binding-mode transitions
 

Summary:  Molecular flexibility in ab initio drug docking to DNA: binding-site and binding-mode transitions... on the DNA base sequence. The reliable ab initio prediction of drug­DNA binding achieved by our new MC... namely docking and binding-mode sampling are combined in ...

  

Source: Rohs, Remo - Department of Biological Sciences, University of Southern California

 

Collection: Biology and Medicine

 
33 Conformational changes associated with proteinprotein interactions
 

Summary:  . The predominant unbound isomer (Ab1 ) has a flat, regular binding site, which is reminiscent of antibodies... that bind proteins or peptides. The alternative isomer (Ab2 ) con- tains a deeper, funnel-shaped pocket... ). The recombinant protein antigen TrxShear3 binds to ...

  

Source: Gerstein, Mark - Department of Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine ; Biotechnology

 
34 Subscriber access provided by WEIZMANN INSTITUTE Chemical Research in Toxicology is published by the American Chemical Society.
 

Summary:  ) is an AB5 toxin produced by Shiga toxigenic E. coli (STEC) bacteria. AB5 toxins bind to cognate glycan... susceptibility of AB5 toxins. Therefore, Byres et al. [(2008) Nature 456, 648] investigated the binding... specificity of SubAB. They found the strongest ...

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
35 Methylene Blue Binding to DNA with Alternating AT Base Sequence: Minor Groove Binding
 

Summary:  blue (MB) binding to DNA with AT alter- nating base sequence complement the data obtained in two former... binding to AT alter- nating DNA in the major groove (AT-majg) makes it difficult to locate a global... Although minor grove binding is the preferred binding ...

  

Source: Rohs, Remo - Department of Biological Sciences, University of Southern California

 

Collection: Biology and Medicine

 
36 Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin 2 Subunit Reveals Regions that Become Exposed
 

Summary:  . By contrast, the two activating mAbs CBR LFA-1/2 and MEM48 bind to overlapping epitopes involving residues 534... ­432 and 432­487, respectively. We thus define five different 2 stalk subregions, mAb binding to which... in the headpiece. Several Abs that activate integrins or ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
37 Investigation of the Mechanism of Binding between Internalin B and Heparin Using Surface Plasmon Resonance
 

Summary:  the association phase. The measured response ([AB] + [AC]) was attributed to the simultaneous binding of Inl... - nism Possibilities. The three binding mechanisms, known to result in an alteration in dissociation... not alter binding of InlB or InlB-BGW1 to ...

  

Source: Linhardt, Robert J. - Center for Biotechnology and Interdisciplinary Studies & Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute

 

Collection: Biotechnology ; Chemistry

 
38 Biochem. J. (1987) 246, 227-232 (Printed in Great Britain) The binding of the cyclic AMP receptor protein to synthetic DNA
 

Summary:  of any specific binding for this altered sequence. Position 5 of the consensus motif is supposed... Biochem. J. (1987) 246, 227-232 (Printed in Great Britain) The binding of the cyclic AMP receptor... Miunchen, Federal Republic of Germany The binding of the cyclic AMP receptor protein (CRP) to symmetrical

  

Source: Clore, G. Marius - Laboratory of Chemical Physics. National Institutes of Health

 

Collection: Biology and Medicine

 
39 Conformational Changes Associated with Protein-Protein Interactions
 

Summary:  unbound isomer (Ab1) has a flat, regular binding site, which is reminiscent of antibodies that bind... , TrxShear3 that binds to Ab1 does not bind to Ab2 , and haptens do not bind to Ab1... -432-6105 Fax: ...

  

Source: Gerstein, Mark - Department of Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine ; Biotechnology

 
40 An isolated, surface-expressed I domain of the integrin L 2 is sufficient for strong adhesive
 

Summary:  it closed prevents activation of cell adhe- sion by Mn2 or an activating mAb that binds to the 2-subunit... and further incubated at 37°C for 30 min in the presence of mAb CBR LFA1 2 (10 g ml) or 1 mM MnCl2. Binding... domains showed equivalently high levels of binding to ICAM-1 when ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
41 Antibody Purification AntibodyPurification
 

Summary:  significantly alter not only the binding capacity but also the volumes of wash buffer required to ensure good... an insoluble precipitate. For this reason, ImmunoPure® Gentle Ag/Ab Binding Buffer, pH 8.0 is offered... immobilized Protein A and Protein G 1 L $ 56 21009 3.75 L $136 21020 ImmunoPure® Gentle ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
42 Structural Determinants for High-Affinity Zolpidem Binding to GABA-A receptors
 

Summary:  annealing (SA) analysis. B, an alter- native, most highly populated (based on the MC) binding mode for fluni... receptors drastically alter the affinity for ligands of the benzo- diazepine binding site. J Biol Chem 272... results in altered benzodiazepine binding ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Teissére, Jeremy Alden - Biology Department, Muhlenberg College; Zhang, Su-Chun - Neuroscience Training Program & Waisman Center, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
43 Genome Analysis Different gene regulation strategies revealed by
 

Summary:  Genome Analysis Different gene regulation strategies revealed by analysis of binding motifs Zeba... ) binding to specific DNA sites. Our large-scale information­theoretical analysis of >950 TF-binding motifs... , eukaryotic TFs exhibit widespread, nonfunc- tional binding and require clustering of sites to ...

  

Source: Ruvinsky, Ilya - Department of Ecology and Evolution, University of Chicago

 

Collection: Biology and Medicine

 
44 Development of photocrosslinked sialic acid containing polymers for use in Ab toxicity attenuation
 

Summary:  that would compete with the cell surface for Ab binding. To explore this hypothesis, we synthesized a series... of photocrosslinked sialic acid containing oligosaccharides and tested their ability to bind Ab and attenuate Ab... are pivotal in the mechanism of Ab ...

  

Source: Cote, Gerard L - Department of Biomedical Engineering, Texas A&M University

 

Collection: Biology and Medicine ; Engineering

 
45 Antibody Multispecificity Mediated by Conformational
 

Summary:  conformation, Ab4 . The six structures therefore indicate that SPE7 can adopt at least four different binding... -bound antibody isomer (Ab4 ) had a relatively flat binding site, with a truncated version of the channel... as observed in Ab1 . The four different antibody conformations ...

  

Source: Tawfik, Dan S. - Department of Biological Chemistry, Weizmann Institute of Science

 

Collection: Biotechnology ; Biology and Medicine

 
46 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 0066-4804/00/$04.00 0
 

Summary:  not shown). Inducers of the EmrAB pump antagonize EmrR binding. The effect of the EmrAB pump inducers (7, 8... Represses the Escherichia coli emrRAB Multidrug Resistance Operon by Directly Binding to Its Promoter Region... regulates the transcription of the multidrug resistance pump-encoding operon, emrRAB, ...

  

Source: Matin, A.C. - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine ; Environmental Management and Restoration Technologies

 
47 Decreased Benzodiazepine Binding with Little Effect on -Aminobutyric Acid Binding in Rat Brain After Treatment
 

Summary:  and no significant interaction. Ab- breviations as in figure 2. b, Specific binding of 50 nM [3 H... Decreased Benzodiazepine Binding with Little Effect on -Aminobutyric Acid Binding in Rat Brain... brain sections were used for quantitative autoradiographic analysis of radioligand ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
48 Quantum Study of Mutational Effect in Binding of Efavirenz to HIV-1 RT
 

Summary:  level of ab initio calculation.15 The computed decrease in binding energy of nevirapine is in strong... Quantum Study of Mutational Effect in Binding of Efavirenz to HIV-1 RT Ye Mei,1 Xiao He,1 Yun Xiang... binding of efavirenz (EFZ), a second generation FDA ap- proved nonnucleoside inhibitor, to HIV-1 ...

  

Source: Zhang, John Z.H. - Department of Chemistry, New York University

 

Collection: Chemistry

 
49 7N -glycansitesperSC 7N -glycan sites per SIgA
 

Summary:  ES/MS/MS Pool Glycans Release Glycans Hydrazinolysis PNGase F N or O links N links 2AB label Mass... Hydrazinolysis PNGase F N or O links N links 2AB label MassGU HPLC AU NP RP Mass Spec Fragmentation N- and O... /MS. Conclusions SIgA1 has several sites capable of binding to pathogens, which can block their attachment

  

Source: Oxford Glycobiology Institute

 

Collection: Chemistry ; Biology and Medicine

 
50 J.S. Murray S.D.S. Jois
 

Summary:  residues of peptides that bind to I-As and I-Ab molecules (27,28). The peptide position 3 isoleucine (I... ) of representative peptides that bind to I-As vs. I-Ab molecules (A). Predicted structure of the I-As /12-mer ligand... , M.D., Brown, J.C. & Siahaan, T.J. Modeling alternative ...

  

Source: Schountz, Tony - Department of Biological Sciences, University of Northern Colorado

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
51 10.1101/gad.2016011Access the most recent version at doi: 2011 25: 499-515Genes Dev.
 

Summary:  determined the genome-wide binding pro- file of ASH-2 (Fig. 2A­C; Supplemental Fig. S2A,B). Like DPY-30, ASH... 4A,B). Binding at rex sites was nearly eliminated in both null mutants: Limited DPY-27 binding... ; Supplemental Fig. S11A,B). Two types of DCC ...

  

Source: Meyer, Barbara - Department of Molecular and Cell Biology, University of California at Berkeley

 

Collection: Biology and Medicine

 
52 Journal of Invertebrate Pathology 92 (2006) 166171 www.elsevier.com/locate/yjipa
 

Summary:  , alteration of toxin binding to receptors is the most reported resistance mecha- nism (Ferre and Van Rie, 2002... to the A population of binding sites are rec- ognized by Cry1Aa, Cry1Ab, Cry1Ac, Cry1Fa, and Cry1Ja toxins. Both Cry1... Ab and Cry1Ac recognize the B popula- tion of ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
53 ARC Centre of Excellence for AntimatterMatter Studies
 

Summary:  Centre Personnel 99 Centre Finances 104 Centre Contacts 106 Contents #12;ii on binding applied... scattering ionisation excitation binding applied fragme molecules modelling radiopharmaceuticals fundamental... scattering ionisation excitation binding applied fragmentation surfaces defects voids attachment bio

  

Source: Centre for Antimatter-Matter Studies (CAMS)

 

Collection: Physics

 
54 Amphotericin B interactions with soluble oligomers of amyloid Ab1-42 peptide Nicholas W. Smith, Onofrio Annunziata, Sergei V. Dzyuba *
 

Summary:  -42 oligomers as well as to probe the binding of AmB monomer to soluble oligomers of Ab1-42. The conformation... of AmB in the absence of Ab1-42, which suggested that AmB was binding to these soluble unordered... possible sce- narios: (i) the binding constant of AmB to the b-sheet ...

  

Source: Annunziata, Onofrio - Department of Chemistry, Texas Christian University

 

Collection: Chemistry

 
55 Summary & concluding remarks Introduction
 

Summary:  (not shown). Also, increasing concentrations of the detergent decylPEG did not alter the binding... or affected by binding of mannitol are highlighted. Mutations that specifically alter the affinity of EIImtl... of a substrate driven by ATP hydrolysis. The nucleotide binding domain (NBD) ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
56 Genome-wide analysis of transcriptional dependence and probable target sites for Abf1
 

Summary:  to transcription genome-wide, by using ts mutants that dissociate from their binding sites at 37 C. We then combine... and Rap1. We also identify a substantial number of genes likely to bind Rap1 or Abf1, but not affected... by loss of GRF binding. Interestingly, the results strongly suggest that Rap1 can contribute to gene

  

Source: Katz, Laura - Department of Biological Sciences, Smith College

 

Collection: Biology and Medicine

 
57 Proc. Natl. Acad. Sci. USA Vol. 95, pp. 1352513530, November 1998
 

Summary:  mutant with altered ligand-binding specificity GABRIEL O. REZNIK, SANDOR VAJDA, TAKESHI SANO... . Cantor, September 8, 1998 ABSTRACT The biotin-binding site of streptavidin was modified to alter its... . Altering the ligand-binding specificity of a protein by rede- ...

  

Source: Boston University, Center for Advanced Biotechnology; Vajda, Sandor - Department of Biomedical Engineering, Boston University

 

Collection: Biology and Medicine ; Biotechnology

 
58 Novel xylan-binding properties of an engineered family 4 carbohydrate-binding module Lavinia Cicortas Gunnarsson*, Cedric Montanier, Richard B. Tunnicliffe, Mike P.
 

Summary:  ligand. Despite the rather small size of the library, (1.6×106 clones) CBM-variants with altered binding... 1 Novel xylan-binding properties of an engineered family 4 carbohydrate-binding module Lavinia... xylan-binding properties of an engineered family 4 CBM #12;2 Synopsis Molecular ...

  

Source: Williamson, Mike P. - Department of Molecular Biology and Biotechnology, University of Sheffield

 

Collection: Biology and Medicine

 
59 726 Cancer Biology & Therapy 2008; Vol. 7 Issue 5 [Cancer Biology & Therapy 7:5, 726-733; May 2008]; 2008 Landes Bioscience
 

Summary:  ultracentrifugation demonstrated that mAbs C225 and 425 simultaneously bind to distinct antigenic epitopes on domain... III of the soluble wild-type EGFR. Furthermore, neither mAb competed with the other for binding... antibodies (mAbs) binding to the extracellular ...

  

Source: Lelkes, Peter I. - School of Biomedical Engineering, Drexel University

 

Collection: Materials Science ; Biology and Medicine

 
60 VIROLOGY 228, 1118 (1997) ARTICLE NO. VY968371
 

Summary:  Sp1 binding exhibit altered basal and TPA-inducible activities. The mutations introducted... ­Barr virus transactivator that lacks aaffinity of Sp1/Sp3 binding, perhaps due to the altered heptad repeat... VIROLOGY 228, 11­18 (1997) ARTICLE NO. VY968371 Binding of the Ubiquitous Cellular ...

  

Source: Speck, Samuel H. - Division of Microbiology and Immunology, Emory University

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
61 The Binding Sites for Competitive Antagonistic, Allosteric Antagonistic, and Agonistic Antibodies to the I Domain of
 

Summary:  explore the binding sites for mAbs to the I domain of the integrin L 2 that can competitively inhibit... , allosterically inhibit, or activate binding to the ligand ICAM-1. Ten mAbs, some of them clinically important... in three conformational states that differ in affinity for ligand. Six ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
62 Calponin Interaction with -Actinin-Actin: Evidence for a Structural Role for Calponin
 

Summary:  -actinin or filamin. The simulta- neous binding of calponin and -actinin to actin altered the storage... to the binding assays to minimize nonspecific binding did not significantly alter these parameters. The Mc... on the binding of calponin to actin. The results ...

  

Source: Tang, Jay X. - Department of Physics, Brown University

 

Collection: Physics ; Biology and Medicine

 
63 Obligatory Requirement of Sulfation for P-Selectin Binding to Human Salivary Gland Carcinoma Acc-M Cells and Breast
 

Summary:  ad- hesion-nonblocking mAb against P-selectin), inhibited this binding, indicating the specificity... ). Furthermore, we tested whether the KPL-1 mAb could block the binding of P-selectin to these cells. Fig. 2B... - bation of these cells with the KPL-1 mAb abrogated the ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
64 Molecular Basis of CIB Binding to the Integrin IIb Cytoplasmic Received for publication, March 27, 2002, and in revised form, May 21, 2002
 

Summary:  -hand-containing proteins. Calcium binding to a number of other EF-hand-containing proteins is known to substantially alter... Molecular Basis of CIB Binding to the Integrin IIb Cytoplasmic Domain* Received for publication... to be regulated by molecules that bind to their cytoplasmic domains. We previously ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
65 Subscriber access provided by NATL CANCER INST FREDERICK Biochemistry is published by the American Chemical Society. 1155 Sixteenth
 

Summary:  53 Transactivation Domain Bind to the Taz2 Domain of p300 and Are Differentially Affected... this article #12;Two Distinct Motifs within the p53 Transactivation Domain Bind to the Taz2 Domain of p300... -mediated transactivation are the histone acetyltransferase paralogues CREB- binding protein (CBP) and p300

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
66 Anesthetic Binding in a Pentameric Ligand-Gated Ion Channel: GLIC Qiang Chen,6
 

Summary:  intrinsic TRP-associated sites? How can anesthetic binding alter the function of GLIC? The answers have been... Anesthetic Binding in a Pentameric Ligand-Gated Ion Channel: GLIC Qiang Chen,6 Mary Hongying Cheng... , but the knowledge of anesthetic binding to these proteins remains limited. Here we investigate ...

  

Source: Xu, Yan - Center for the Neural Basis of Cognition & Departments of Anesthesiology & Structural Biology, University of Pittsburgh

 

Collection: Biology and Medicine

 
67 A proteomic approach to study Cry1Ac binding proteins and their alterations in resistant Heliothis virescens larvae
 

Summary:  A proteomic approach to study Cry1Ac binding proteins and their alterations in resistant Heliothis... validate the use of proteomic approaches to identify toxin binding proteins and proteome alterations... correlates with alterations of toxin binding molecules in the ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
68 This article was originally published in a journal published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  to study Cry1Ac binding proteins and their alterations in resistant Heliothis virescens larvae Juan L... validate the use of proteomic approaches to identify toxin binding proteins and proteome alterations... in the laboratory, resistance correlates with alterations of toxin ...

  

Source: Jurat-Fuentes, Juan Luis - Department of Entomology and Plant Pathology, University of Tennessee

 

Collection: Biology and Medicine

 
69 Stochastic evolution of transcription factor binding sites Johannes Berg and Michael Lassig
 

Summary:  , binding sites can appear, disappear, or alter their sequence even be- tween relatively closely related... Stochastic evolution of transcription factor binding sites Johannes Berg and Michael L... step in the process of genetic transcription is the binding of one or several transcription factors

  

Source: Lässig, Michael - Institut für Theoretische Physik, Universität zu Köln

 

Collection: Physics

 
70 Frequent Gain and Loss of Functional Transcription Factor Binding Sites
 

Summary:  Frequent Gain and Loss of Functional Transcription Factor Binding Sites Scott W. Doniger1 , Justin... model to detect the loss of constraint on individual transcription factor binding sites (TFBSs). We find... that a significant fraction of functionally constrained binding sites have been lost in a lineage-specific manner

  

Source: Fay, Justin - Center for Genome Sciences & Department of Genetics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
71 / www.sciencexpress.org / 18 March 2010 / Page 1 / 10.1126/science.1183621 Differences in gene expression may play a major role in
 

Summary:  of significant binding differences (Fig. 1B). SNPs altering the NFB DNA binding motif had a strong effect... in transcription factor (TF) binding in several humans and a single chimpanzee using chromatin immunoprecipitation... followed by sequencing (ChIP-Seq). The binding sites of RNA ...

  

Source: Gerstein, Mark - Department of Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine ; Biotechnology

 
72 Integrin 3 regions controlling binding of murine mAb 7E3: Implications for the mechanism of integrin
 

Summary:  Integrin 3 regions controlling binding of murine mAb 7E3: Implications for the mechanism... (Fig. 5 A and B) (18). Neither the K125A nor the K125R substitution altered 7E3 binding. How- ever... to affect 7E3 binding. Because the loss of 7E3 binding upon ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
73 !#"$&%'()$ 0 2135464798@AABCEDGF@HIPFQQ Bioinformatic Principles Underlying the Information
 

Summary:  which result in alterations of the binding site pattern confers an evolutionary advantage and might... Underlying the Information Content of Transcription Factor Binding Sites Jan T. Kim, Thomas Martinetz... : DNA binding protein, transcription factor, binding site, coevolution, ...

  

Source: 

 

Collection: Computer Technologies and Information Sciences

 
74 Concurrent and Independent Binding of Fc Receptors IIa and IIIb to Surface-Bound IgG
 

Summary:  in the absence of any blocking mAb to allow concurrent binding of both Fc Rs to cell-bound IgG. The single... NA2 and CD32aR/H131 are coex- pressed on K562 cells, the binding of a soluble blocking mAb... anti-mouse IgG poly- clonal Ab. Concurrent and Independent ...

  

Source: Zhu, Cheng - Department of Biomedical Engineering, Georgia Institute of Technology and Emory University

 

Collection: Engineering ; Biology and Medicine

 
75 of January 3, 2010 This information is current as
 

Summary:  -coated target cell binding during phagocytosis and Ab-dependent cellular cytotoxicity, resulting in a phenotype... . Binding assays were performed in the absence or continuous presence of CD32A-Ig molecules or 10 g/ml mAbs... for 1 h at 4°C. After washing twice with binding buffer the ...

  

Source: Zhu, Cheng - Department of Biomedical Engineering, Georgia Institute of Technology and Emory University

 

Collection: Engineering ; Biology and Medicine

 
76 Aminoglycoside Binding in the Major Groove of Duplex RNA: The Thermodynamic and Electrostatic
 

Summary:  reactions, and binding-induced alterations in the structure of the host RNA. These modulatory effects... : aminoglycoside-RNA recognition; binding-induced drug protonation; drug-induced alteration in RNA structure; RNA... protonation reactions, and binding-induced ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
77 Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules
 

Summary:  isotypic control Ab, X ligand binding-blocking mAb 3.9 (Biosource International, Camarillo, CA), M... by plasmin digestion in a mode where X 2 dominates the integrin- dependent binding. The bacterial protease... subtilisin also enhances binding by X 2. The X ligand ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
78 Vaccine 21 (2003) 44214429 Analysis of the immunogenic properties of a single-chain polypeptide
 

Summary:  for FLSC. Binding of representative mAbs to these epitopes was not blocked by antibodies to a number... antibodies (mAbs), 17b and 48d [3]. Characterization of the 17b-binding site was provided from an X... and the Fab fragment of 17b [4]. Binding of these mAbs ...

  

Source: Kramer, Fred - Public Health Research Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey

 

Collection: Biology and Medicine

 
79 Similar Structural Basis for Membrane Localization and Protein Priming by an RNA-dependent RNA Polymerase*
 

Summary:  . In D, those residues that were not found to be involved in binding of 3AB but that, when altered... . Poliovirus polymerase binds with high affinity to the membrane-bound viral protein 3AB but uridylylates only... tether and the protein primer overlap. Mutation of flanking residues ...

  

Source: Kirkegaard, Karla - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
80 Ca2 /Calmodulin Regulation of the Arabidopsis Kinesin-Like
 

Summary:  Ca2 /Calmodulin Regulation of the Arabidopsis Kinesin-Like Calmodulin-Binding Protein B. E... State University, Fort Collins The kinesin family motor protein KCBP (kinesin-like calmodulin binding... protein) was identified during a screen for Arabidopsis calmodulin-binding proteins [Reddy, et al., 1996b

  

Source: Reddy, A.S.N - Department of Biology, Colorado State University

 

Collection: Biology and Medicine ; Biotechnology


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
81 Structural Requirements for Imidazobenzodiazepine Binding to GABAA Receptors
 

Summary:  GABAA receptors drastically alter the affinity for ligands of the benzodi- azepine binding site. J Biol... subunit of the -aminobutyric acid type A receptors results in altered benzodiazepine binding specificity... Structural Requirements for Imidazobenzodiazepine Binding to GABAA ...

  

Source: Jackson, Meyer B. - Neuroscience Training Program & Department of Physiology, University of Wisconsin at Madison; Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Teissére, Jeremy Alden - Biology Department, Muhlenberg College

 

Collection: Biology and Medicine

 
82 Identification of the Hfq-binding site on DsrA RNA: Hfq binds without altering DsrA secondary structure
 

Summary:  Identification of the Hfq-binding site on DsrA RNA: Hfq binds without altering DsrA secondary... A:Hfq complex. Hfq could bind to and alter the structure of DsrA or Hfq could be protecting DsrA via steric... - age by Hfq, we predicted that altering the sequence of this ...

  

Source: Feig, Andrew - Department of Chemistry, Wayne State University

 

Collection: Chemistry ; Biology and Medicine

 
83 Ribosomal antibiotics: structural basis for resistance, synergism and
 

Summary:  concentrations, the SA component dalfopristin binds to the PTC and induces marked conformational alterations... of this base and the alterations caused by sparsomycin binding in the whole PTC (indicated in blue as opposed... confor- mational alterations in the PTC [41,42], thereby ...

  

Source: Martin, Jan M.L. - Department of Organic Chemistry, Weizmann Institute of Science

 

Collection: Chemistry

 
84 Low-Neurovirulence Theiler's Viruses Use Sialic Acid Moieties on N-linked Oligosaccharide Structures for Attachment
 

Summary:  and viral persistence. Analysis of BeAn virus binding and infection in cells with altered (mutated) cell... residues alters binding of Theiler's murine encephalomy- elitis virus to BHK-21 cells. J. Virol. 74, 1994... -surface expression of sialic acid containing glyconjugates indicated that both ...

  

Source: Lipton, Howard L. - Department of Microbiology and Immunology, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
85 ORIGINAL ARTICLE Xudong Huang Craig S. Atwood Robert D. Moir
 

Summary:  , the rat/mouse homologue of Ab, containing three amino acid substitutions within the metal-binding domain... .40±0.05 before use. 955 #12;Turbidometric, Congo Red, and thioflavine-T binding assays for Ab1­42-mediated... ) turbidity (absorbance at 400 nm) changes against the incubation buffer blank alone 957 ...

  

Source: Wisconsin at Madison, University of - Laboratory of Endocrinology, Aging and Disease

 

Collection: Biology and Medicine

 
86 Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis
 

Summary:  , in some cases, be altered by the binding context: For in- stance, the binding specificity of the complex... of glutamine with lysine at position 50 has been shown to dramatically alter the binding specificity through... that alterations in the overall structure of ...

  

Source: Bulyk, Martha L. - Division of Genetics, Brigham and Women's Hospital, Harvard University; Morris, Quaid - Department of Electrical and Computer Engineering, University of Toronto

 

Collection: Biology and Medicine ; Computer Technologies and Information Sciences

 
87 Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring
 

Summary:  of the specific mean fluorescence intensity (MFI) of TS2 4 mAb binding to wild-type and mutant L 2. MFI of TS2 4 mAb... with a disulfide bond (HA L 2) (11). By contrast, mAbs that indirectly, i.e., allosterically block binding to ICAM... ) (8). By contrast, TS2 14 ...

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
88 Biochemistry 1994,33, 14565-14578 14565 Kinetic Mechanism of Adenine Nucleotide Binding to and Hydrolysis by the
 

Summary:  the removal of Mg2+does not appear to alter the mechanism of mantATP binding, it does increase k - 1... Biochemistry 1994,33, 14565-14578 14565 Kinetic Mechanism of Adenine Nucleotide Binding... the unwinding of duplex DNA during DNA replication in a reaction that is coupled to the binding and hydrolysis

  

Source: Cistola, David P. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis; Lohman, Timothy M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
89 Moreaux et al. APRIL AND TACI INTERACT WITH SYNDECAN-1 ON THE SURFACE
 

Summary:  with the control MoAb. Figure 2. Strong binding of APRIL at the cell membrane of HMCLs through HS chains: (a... with the anti-BLyS MoAb and black histogram shows that obtained with a control MoAb. Figure 3. Binding of TACI... on primary myeloma cells: (a­b) ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
90 Biochemistry 1993,32, 11385-1 1389 11385 Binding Affinities of Synthetic Peptides, Pyridine-2-carboxamidonetropsinand
 

Summary:  indicate that 2-PyN binds the 5-bp sequences with altered specificityin the orderof decreasingaffinity 5... M 2-PyN, respectively. Table I: Apparent First-OrderAffinity Constants (M-*)ab binding site peptide 5... Biochemistry 1993,32, 11385-1 1389 11385 Binding Affinities of Synthetic ...

  

Source: Mrksich, Milan - Department of Chemistry, University of Chicago

 

Collection: Chemistry

 
91 Arrangement of Domains, and Amino Acid Residues Required for Binding of Vascular Cell Adhesion
 

Summary:  and analyzed the mutant constructs for maintenance of functional mAb epitopes and cell binding activity... binding assays after 48-72 h as previously de- scribed (Osbornet al., 1992). Bindingof Ramos cells and mAbs... to domain 1, and EDll, GH12 and GE4, which map to domain 4. mAb 4B9 ...

  

Source: Kirchhausen, Tomas - Immune Disease Institute & Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
92 The Membrane Anchor Influences Ligand Binding Two-dimensional Kinetic Rates and Three-dimensional Affinity of Fc RIII (CD16)*
 

Summary:  extend the membrane-proximal ligand-binding Ig domain further above the membrane. It may also alter... by insufficient mAb binding at sub-saturation concentrations. The radioimmunoassay for determining the CD16... , but not the reverse, rate constant and thereby also altered the ...

  

Source: Zhu, Cheng - Department of Biomedical Engineering, Georgia Institute of Technology and Emory University

 

Collection: Engineering ; Biology and Medicine

 
93 Vault: A Secure Binding Service Guor-Huar Lu, Changho Choi, and Zhi-Li Zhang
 

Summary:  and the service cannot alter binding insertion requests from owners to the service or binding query replies from... , namely, an attacker interposed between users and the service cannot alter binding insertion requests from... ; !!"#$%&' () " #$%0' 123 1(224 546147 84)496)" ...

  

Source: Zhang, Zhi-Li - Department of Computer Science and Engineering, University of Minnesota

 

Collection: Computer Technologies and Information Sciences

 
94 Cellular/Molecular An Arginine Involved in GABA Binding and Unbinding But
 

Summary:  -GABA). One might ex- pect a binding site mutation that effects the unbinding rate to simultaneously alter... be explained solely by altering binding and unbinding rates If, as the data suggest, mutation of 2-R207 affects... these measures depend on both binding and gating, it is often ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Zhang, Su-Chun - Neuroscience Training Program & Waisman Center, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
95 The structure of ribosome-lankacidin complex reveals ribosomal sites for
 

Summary:  that the 17-member polyketide antibiotic lankacidin produced by Streptomyces rochei binds at the peptidyl... that the macrolide lankamycin, a second antibiotic produced by the same species, binds at a neighboring site... , at the ribosome exit tunnel. These two antibiotics can bind to the ri- bosome simultaneously and display ...

  

Source: Martin, Jan M.L. - Department of Organic Chemistry, Weizmann Institute of Science

 

Collection: Chemistry

 
96 Defining Affinity with the GABAA Receptor Mathew V. Jones,1 Yoshinori Sahara,1,2 Jeffrey A. Dzubay,1 and Gary L. Westbrook1,3
 

Summary:  by a factor of 150 altered the binding rate estimate only by a factor of two, a negligible difference... binding rate estimates but would not qualitatively alter our conclusions. Physical properties governing... the binding rate is assumed to be diffusion-limited. In this view, the ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
97 Kinetics of MHC-CD8 Interaction at the T Cell Membrane1 Jun Huang,* Lindsay J. Edwards,
 

Summary:  with MHC. Using anti-TCR mAb we isolated and characterized the specific two-dimensional MHC-CD8 binding... interactions, an anti-TCR V 2 mAb (B20.1) was used to block TCR-MHC bind- ing. Also, an anti-CD8 blocking mAb... which yielded a binding curve (,) ...

  

Source: Zhu, Cheng - Department of Biomedical Engineering, Georgia Institute of Technology and Emory University

 

Collection: Engineering ; Biology and Medicine

 
98 Saccharomyces cereVisiae Replication Protein A Binds to Single-Stranded DNA in Multiple Salt-Dependent Modes
 

Summary:  Saccharomyces cereVisiae Replication Protein A Binds to Single-Stranded DNA in Multiple Salt... the single-stranded DNA (ssDNA) binding properties of the Saccharomyces cereVisiae replication protein A (sc... to determine whether scRPA can bind to ssDNA in multiple binding modes. We measured the occluded site ...

  

Source: Cistola, David P. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis; Lohman, Timothy M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
99 A Knowledge-Based Energy Function for Protein-Ligand, Protein-Protein, and Protein-DNA Complexes
 

Summary:  the summation is over all atomic pairs. The binding free energy of a dimer AB is obtained as follows: Since... . The correlation coefficients between experimentally measured protein- ligand binding affinities and those... function also makes highly accurate predictions of binding affinities of protein-protein ...

  

Source: Zhou, Yaoqi - School of Informatics, Indiana University

 

Collection: Biology and Medicine

 
100 Glycosaminoglycan-protein interactions: definition
 

Summary:  with heparin (Fig. 4A,B).35,59 Tyrosine residues, also enriched in known heparin binding sites, may hydrogen... Glycosaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding... , are of great biological importance, structural requirements for protein-GAG binding have not ...

  

Source: Linhardt, Robert J. - Center for Biotechnology and Interdisciplinary Studies & Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute

 

Collection: Biotechnology ; Chemistry


Page:   1  2  3  4  5