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Sample search results for: a5 subunit-containing gabaa

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1 Interneuron Diversity series Diversity of inhibitory
 

Summary:  .B. et al. (2004) Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by a5 subunit-containing... to the idea that tonic inhibition in granule cells must be mediated by d-subunit-containing GABAA recep- tors... of synapse because, in expression systems, ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
2 Associate editor: A.L. Morrow Regulation of GABAA receptor trafficking, channel activity,
 

Summary:  and contribute selectively to tonic inhibition. However, this rule would not account for a5 subunit-containing... - unit-specific antiserum suggests that a subset of a5 subunit- containing receptors is localized... ). Deletion of ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
3 Glycine and GABAA Receptor Subunits on Renshaw Cells: Relationship With
 

Summary:  Rcs and -aminobutyric acidA (GABAA) receptors on Renshaw cells. A­D: GlyRc and GABAA subunits 3 (A), 5 (B), 2/3 (C... subunit-containing GABAA receptors postsynaptically. Both characteristics can contribute to strengthen... Glycine and GABAA ...

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University

 

Collection: Biology and Medicine

 
4 TEMPORAL AND REGIONAL REGULATION OF a1, b2 AND b3, BUT NOT a2, a4, a5, a6, b1 OR g2 GABAA RECEPTOR SUBUNIT
 

Summary:  TEMPORAL AND REGIONAL REGULATION OF a1, b2 AND b3, BUT NOT a2, a4, a5, a6, b1 OR g2 GABAA RECEPTOR... previous findings. Expression of a5 mRNA, among other GABAA receptor subunit mRNAs, e.g., a3 and a4... suggested a concomitant up-regulation of b2 messenger RNA. ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
5 Acute Pentylenetetrazol Injection Reduces Rat GABAA Receptor mRNA Levels and GABA Stimulation of
 

Summary:  -benzodiazepine coupling is affected by the phosphorylation state of the receptor. GABAA receptor subunits contain... brain showing binding of 5 nM [3 H]flunitrazepam (A), 5 nM [3 H]muscimol (B), and 2 nM [3 H... Acute Pentylenetetrazol Injection Reduces Rat GABAA ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
6 nature neuroscience volume 1 no 7 november 1998 563 Nervous system signaling depends on the spatially and tempo-
 

Summary:  ). These data indicate that the 2 subunit is required for clustering of 2-subunit-containing GABAA receptors... of gephyrin depends on the pres- ence of the 2 subunit in 2-subunit-containing GABAA recep- tors, and thirdly... specific roles for different sub- articles Fig. 7. Loss of clustered ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
7 Postsynaptic clustering of -aminobutyric acid type A receptors by the 3 subunit in vivo
 

Summary:  site (11, 12). However, the 3 subunit-containing GABAA receptors are characterized by a very low... are missing, and zolpidem-insensitive flumazenil sites are indicative of 3 subunit-containing GABAA receptors... -containing GABAA receptors. These display the zolpidem-insensitive ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
8 Genetic Inactivation of the Serotonin1A Receptor in Mice Results in Downregulation of Major GABAA Receptor Subunits, Reduction
 

Summary:  , and a significant proportion of anxiety patients has a reduced sensitivity to BZs. Here, we show that serotonin1A (5... %) in the amygdala of KO mice. One possibility to explain this difference is that 1 and 2 subunit-containing... Genetic Inactivation of the Serotonin1A Receptor in Mice Results in Downregulation of Major ...

  

Source: Sibille, Etienne - Center for the Neural Basis of Cognition & Department of Psychiatry, University of Pittsburgh

 

Collection: Biology and Medicine

 
9 Distinct Structural Changes in the GABAA Receptor Elicited by Pentobarbital and GABA
 

Summary:  combinations of structurally homolo- gous subunits (9,10). Each subunit contains an extracellular N... and block relief (see Materials and Methods). 2A 1mM GABA 100 M PTX 5 sec 2% I F 2A 5 sec 2% A B 100 M PTX... Distinct Structural Changes in the GABAA Receptor Elicited by Pentobarbital ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
10 Acute neurosteroid modulation and subunit isolation of the -aminobutyric acidA receptor in the bullfrog,
 

Summary:  of the intracellular loop. In addition, the bullfrog 1-like subunit contained multiple conserved regions and residues... to be greatest for 1 (over 2 and 3) subunit containing receptors (Shingai et al. 1991). Modulatory effects... this particular GABA binding site is not known. The partial sequence of the ...

  

Source: Boyd, Sunny K. - Department of Biological Sciences, University of Notre Dame

 

Collection: Biology and Medicine

 
11 2005 Nature Publishing Group GABA (-aminobutyric acid) is the main inhibitory
 

Summary:  synapse formation, but also in more mature neurons with existing synaptic contacts110,111 . subunit-containing... subunit- containing receptors in granule cells of the cerebellum114 and dentate gyrus104 . This could... efficacy (GABA is a partial agonist) at subunit- containing ...

  

Source: Sandini, Giulio - Dipartimento di Informatica Sistemistica e Telematica, Università degli Studi di Genova

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
12 JournalofPhysiology The GABAA receptor constitutes a major inhibitory force
 

Summary:  b2g2 subunit-containing GABAA receptor expressed in HEK cells... probability of the a1b2g2 subunit-containing GABAA receptor is ~0.8 (Steinbach & Akk, 2001). It is apparent... concentrations (>100 mM, 0.6%) of ethanol are known to potentiate a2b1 and a2b1g2 subunit-containing ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
13 Cellular/Molecular Active and Passive Membrane Properties and Intrinsic
 

Summary:  . 4A, 5). Surprisingly, for both GABAA,fast and GABAA,slow the effect of IH on duration was almost... sensi- tivity (Figs. 3, 4A, 5). In contrast to its effects on duration, INaP more strongly af- fected... hippocampal CA1 pyramidal neurons: somatic ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
14 ABBREVIATiONS: GABAR, y-aminobutyric acid type A receptor; GABA, y-aminobutyric acid; HEPES, 4-(2-hydroxyethyl)-1 -piperazineethane-sulfonic acid; PIPES, piperazine-N,N'-bis(2-ethanesulfonic acid); DZP, diazepam; ZOL, zolpidem; I-V. current-voltage, Vh, m
 

Summary:  -Containing GABAA Receptors I 23 0) 0 E CO E E >< CO Fig. 4. GABA concentration-response charac- teristics for a5... :745-753 (1989). 11. Pritchett, D. B., and P. H. Seeburg. GABAA receptor a5-subunit creates novel type II... ). Properties of Recombinant ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
15 Principal Investigator/Program Director (Last, first, middle): PHS 398/2590 (Rev. 9/04) Page __ Biographical Sketch Format Page
 

Summary:  .L. Chronic ethanol consumption enhances internalization of 1 subunit-containing GABAA receptors in cerebral... subunit-containing receptors alters responses to ethanol and other anesthetics. J. Pharmacol. Exp. Ther... administration in the rat: Effects on GABAA receptor function and expression in brain. ...

  

Source: Elston, Timothy C. - Department of Pharmacology, University of North Carolina at Chapel Hill

 

Collection: Mathematics ; Biology and Medicine

 
16 Cellular/Molecular Neuroscience Senior Editor: Dr. Laurence O. Trussell
 

Summary:  enhancing tonic inhibition mediated by subunit- containing GABAA receptors. Proc Natl Acad Sci U S A 100... , somewhat analogous to that mediated by subunit-containing receptors in other regions (Farrant and Nusser... be due to subunit-containing synaptic receptors (Kasparov et al., ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
17 164 Current Literature in Basic Science A THALAMIC SLEEP TONIC
 

Summary:  receptor-mediated inhibition is typically gen- erated by subunit-containing extrasynaptic receptors... contain- ing a 2 subunit but do not affect nonsynaptic receptors that contain a subunit. These -subunit­containing... ,5,6,7-tetrahydroisoxazolo[5,4-c]-pyridin-3-ol (THIP), to which such -subunit­containing receptors appear ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
18 Cellular/Molecular The 2 Subunit of GABAA Receptors Is a Substrate for
 

Summary:  posttranslational modificationthatisselectivefor subunit-containingGABAA receptorsubtypes... ). Interaction of GODZ with 2 subunit-containing GABAA receptors expressed in heterologous cells To test whether... . GFP-tagged GODZ partly colocalizes and interacts with 2 subunit-containing ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
19 Cellular/Molecular Distinct 2 Subunit Domains Mediate Clustering and
 

Summary:  gephyrin is perfectly colocalized with 2 subunit-containing GABAA receptors but does not seem to interact... to postsynaptic sites by 2 subunit-containing GABAA receptors, rather than vice versa. Moreover, the findings... into the SpeI site downstream of the 9E10 tag of 9E10 2. Toward construction of ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
20 Dual Potentiating and Inhibitory Actions of a Benz[e]indene Neurosteroid Analog on Recombinant 1 2 2 GABAA
 

Summary:  the mechanisms of action of the benz[e]indene com- pound [3S-(3 ,3a ,5a ,7 ,9a ,9b )]-dodecahydro-7-(2-hy... .022590. ABBREVIATIONS: BI-2, [3S-(3 ,3a ,5a ,7 ,9a ,9b )]-dodecahydro-7-(2-hydroxyethyl)-3a-methyl-1H-benz[e]indene-3... in human embryonic kidney (HEK) 293 cells. Subunits ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine


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21 British Journal of Anaesthesia 93 (6): 81017 (2004) doi:10.1093/bja/aeh272 Advance Access publication September 17, 2004
 

Summary:  , Elliott EM, You T, et al. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by a5... subunit- containing g-aminobutyric acid type A receptors. Proc Natl Acad Sci USA 2004; 101: 3662­7 44... anaesthetic that modu- lates g-aminobutyric acid type A (GABAA) receptors, ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
22 Downregulation of the 5 Subunit of the GABAA Receptor in the Pilocarpine Model of
 

Summary:  - ing of 2-subunit-containing GABAA receptors in synapses of hip- pocampal pyramidal cells of the rat... of interneurons, as has been demonstrated for 1 and 2 subunit-containing recep- tors and different types of basket... et al., 1999) where the 5 subunit-containing receptors could be activated (Mody, 2001). ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
23 Synthesis of GABAA Receptor Agonists and Evaluation of their r-Subunit Selectivity and Orientation in the GABA Binding Site
 

Summary:  activation of specific R-subunit containing receptors. Under close to complete receptor occupancy... included 5a, 5d, 5g, 6a, 6d, and 19. For these compounds, we determined the IC50 values for inhibition... for the different R subunits are shown in Table 3. Intrinsic Agonist Activity ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
24 Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat
 

Summary:  subunit containing receptors (Braestrup and Nielsen, 1981). The present study demonstrates that thalamic n... Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence... benzodiazepines sensitivity of GABAA receptor-mediated responses in neurons from the thalamic ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
25 Cellular/Molecular GODZ-Mediated Palmitoylation of GABAA Receptors Is
 

Summary:  of the 2 subunit is implicated in trafficking and postsynaptic accumulation of 2 subunit- containing GABAA... - . The observed GFP-GODZC157S -induced reduction in clustering of 2 subunit-containing GABAA receptors therefore... to tonic currents mediated by extrasynaptic ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
26 Neuroscience Letters 416 (2007) 275278 Etomidate and propofol-hyposensitive GABAA receptor 3(N265M)
 

Summary:  ethanol concentrations [18]. These effects produced by low ethanol doses on those subunit-containing GABAA... mediated by delta subunit-containing GABAA receptors in hippocampal neurons, J. Neurosci. 24 (2004) 8379... Neuroscience Letters 416 (2007) 275­278 Etomidate and propofol-hyposensitive ...

  

Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health,

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
27 DEPRESSION AND ANXIETY 24:495517 (2007) Theoretical Review
 

Summary:  polymorphism in human GABA-A receptor subunits genes and unipolar (a3, a5), bipolar (a1, a3, a5, a6) depression... expression of GABA-A (a5, b3, g2, d) and GABA-B (B1) re- ceptor genes in cortex of depressed patients... , g1]; ...

  

Source: Kalueff, Allan V. - Department of Pharmacology, Tulane University

 

Collection: Biology and Medicine

 
28 The Differential Effects of the Nonimmobilizer 1,2-Dichlorohexafluorocyclobutane (F6, 2N) and Isoflurane
 

Summary:  by 5 subunit-containing GABAA receptors (22). Assuming that extrasynaptic receptors underlie tonic... inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by 5 subunit-containing -aminobutyric acid... on synaptic gamma aminobutyric acid (GABA)A receptors located on the somata of hippocam- pal ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
29 Suppression of Neuronal Hyperexcitability and Associated Delayed Neuronal Death by Adenoviral Expression of GABAC Receptors
 

Summary:  GR (1997) The N-terminal domain of human GABA receptor 1 subunits contains signals for homoligomeric... in the retina, is more sensitive to GABA and demonstrates little desensitization compared with the GABAA... in an increased density of GABAA receptors as well as expression of novel GABAC receptors. This ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
30 FOREBRAIN AND MIDBRAIN DISTRIBUTION OF MAJOR BENZODIAZEPINE-SENSITIVE GABAA RECEPTOR SUBUNITS IN THE
 

Summary:  and the 2-subunit are sensitive to BZ modulation; whereas 4- and 6-subunit- containing GABAA receptors have... are believed to contain five subunits containing at least one member of the , , and subunit classes... FOREBRAIN AND MIDBRAIN DISTRIBUTION OF MAJOR BENZODIAZEPINE-SENSITIVE ...

  

Source: Duong, Timothy Q. - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
31 Hindawi Publishing Corporation Neural Plasticity
 

Summary:  see Table 2) GABA-A 5 subunit KO mice 0 hippocampal-dependent trace conditioning, 0 delayed... or contextual conditioning [48] GABA-A 2 subunit HZ mice cued fear conditioning, 0 spatial memory [49... anxiety and memory in rats following muscimol injection [76­78]. Reduced expression of GABA-A receptor

  

Source: Kalueff, Allan V. - Department of Pharmacology, Tulane University

 

Collection: Biology and Medicine

 
32 Receptors with Different Affinities Mediate Phasic and Tonic GABAA Conductances in Hippocampal Neurons
 

Summary:  and the competitive GABAAR antagonist SR95531 (gabazine) on - and -subunit-containing receptors (Wafford et al., 2001... affinities for SR95531 (Wafford et al., 2001), but -subunit containing receptors have a 50-fold higher... affinity for GABA than -subunit-containing receptors (Saxena and Macdonald, 1996). ...

  

Source: Journal Neuroscience -- Rapid Communications

 

Collection: Biology and Medicine

 
33 The -Subunit Governs the Susceptibility of Recombinant -Aminobutyric Acid Type A Receptors to Block by the
 

Summary:  the deactivation of 2-subunit containing recep- tors. These results with recombinant receptors emu- late our recent... ionotropic -amino- butyric acid type A (GABAA) receptors play an important role in the mediation... to modulationbyvariousdrugsdependsonsubunitcompo- sition,wehavecomparedtheeffectofthenonimmobilizer ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
34 BENZODIAZEPINE-MEDIATED REGULATION OF a1, a2, b13 AND g2 GABAA RECEPTOR SUBUNIT PROTEINS IN THE RAT BRAIN HIPPOCAMPUS AND
 

Summary:  BENZODIAZEPINE-MEDIATED REGULATION OF a1, a2, b1­3 AND g2 GABAA RECEPTOR SUBUNIT PROTEINS... --Prolonged flurazepam exposure regulates the expression of selected (a1, b2, b3) GABAA receptor subunit messenger RNAs... both in vivo and in vitro. In this report, the immunostaining density of six specific GABAA receptor

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
35 Cellular/Molecular State-Dependent Cross-Linking of the M2 and M3 Segments
 

Summary:  for the Alignment of GABAA and Acetylcholine Receptor M3 Segments Michaela Jansen and Myles H. Akabas Departments... , Bronx, New York 10461 Construction of a GABAA receptor homology model based on the acetylcholine (ACh... ) receptor structure is complicated by the low sequence similarity between GABAA and ACh M3 transmembrane

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
36 Proc. Natl. Acad. Sci. USA Vol. 92, pp. 7749-7753, August 1995
 

Summary:  subunits ac, ca2, a5, and 132/3 as described (16, 20). Sections from dorsal root ganglia (DRG) were... - nohistochemically in sections ofneonatal brain and DRG using antibodies specific for the a,, a2, a5, and 32... , the a2 and a5 subunit immunoreactivity was ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
37 Decreased Benzodiazepine Binding with Little Effect on -Aminobutyric Acid Binding in Rat Brain After Treatment
 

Summary:  treatment. Results are shown for (A) 5 nM [3 H]flunitrazepam binding, (B) 5 nM [3 H]muscimol binding, (C) 50... ) neu- rotransmission is associated with the presence of a gamma-2 subunit in the GABAA receptor... on the chloride channel of the GABAA receptor complex was examined by 4 - ethynyl-4-n-[2,3-3 H2

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
38 doi:10.1152/ajpregu.00239.2009 297:1028-1036, 2009. First published Aug 12, 2009;Am J Physiol Regulatory Integrative Comp Physiol
 

Summary:  hypothesize that 13-lined ground squirrels selectively ex- press subunit-containing GABAA receptors... , but there is no evidence for its natural expression and physiological function. Seasonal expression of subunit-containing... spontaneous cortical, VRC, and NTS neuronal activity in slices from SA squirrels. Musci- mol (20 M; ...

  

Source: Mladenoff, David - Department of Forest Ecology and Management, University of Wisconsin at Madison

 

Collection: Environmental Sciences and Ecology

 
39 doi:10.1152/ajpregu.00239.2009 297:1028-1036, 2009. First published Aug 12, 2009;Am J Physiol Regulatory Integrative Comp Physiol
 

Summary:  hypothesize that 13-lined ground squirrels selectively ex- press subunit-containing GABAA receptors... , but there is no evidence for its natural expression and physiological function. Seasonal expression of subunit-containing... spontaneous cortical, VRC, and NTS neuronal activity in slices from SA squirrels. Musci- mol (20 M; ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
40 Down-Regulation of Benzodiazepine Binding to 5 Subunit-Containing -Aminobutyric AcidA Receptors in Tolerant Rat
 

Summary:  , it is suggested that down-regu- lation of benzodiazepine recognition sites on 5 subunit- containing GABAA... Down-Regulation of Benzodiazepine Binding to 5 Subunit- Containing -Aminobutyric AcidA Receptors... the results with [3 H]zolpidem, which sug- gested a regionally widespread ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine


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41 Chloride regulation in the pain pathway Theodore J. Pricea,, Fernando Cerverob
 

Summary:  potential (Eanion), which subsequently impacts fast synaptic inhibition mediated by GABAA, and to a lesser... or pharmacological interventions targeting GABAA receptors. © 2008 Elsevier B.V. All rights reserved. Keywords... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160 6. Role of ...

  

Source: Prescott, Steven A. - Pittsburgh Center for Pain Research & Department of Neurobiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
42 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  potential (Eanion), which subsequently impacts fast synaptic inhibition mediated by GABAA, and to a lesser... or pharmacological interventions targeting GABAA receptors. © 2008 Elsevier B.V. All rights reserved. Keywords... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160 6. Role of ...

  

Source: Price, Theodore - Department of Pharmacology, University of Arizona

 

Collection: Biology and Medicine

 
43 Kinetic Differences between Synaptic and Extrasynaptic GABAA Receptors in CA1 Pyramidal Cells
 

Summary:  Kinetic Differences between Synaptic and Extrasynaptic GABAA Receptors in CA1 Pyramidal Cells... , Wisconsin 53706 GABAA-mediated IPSCs typically decay more rapidly than re- ceptors in excised patches... - aptic receptors that generate rapid IPSCs. Key words: GABAA receptors; hippocampus; receptor kinet- ics

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
44 Depression of Early and Late Monosynaptic Inhibitory Postsynaptic
 

Summary:  -0008 KEY WORDS gamma aminobutyric acid; GABAA receptor; GABAB receptor; flur- azepam; tolerance ABSTRACT... was eliminated by prior superfusion of the glutamate receptor antagonists, APV (50 µM) and DNQX (10 µM). GABAA... isolated by perfusion of the GABAA antagonist, picrotoxin (50 µM). There was a significant decrease

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
45 Role of protein kinase A in GABAA receptor dysfunction in CA1 pyramidal cells following chronic benzodiazepine
 

Summary:  with reduced PKA RIIb but not Cb subunit protein. The type of regulatory subunit contained in the PKA... Role of protein kinase A in GABAA receptor dysfunction in CA1 pyramidal cells following chronic... in anticonvulsant tolerance, associated with reduced GABAA receptor (GABAR) subunit protein and miniature ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
46 Networks of interneurons with fast and slow -aminobutyric acid type A (GABAA) kinetics
 

Summary:  Networks of interneurons with fast and slow -aminobutyric acid type A (GABAA) kinetics provide... fast GABAA (GABAA,fast) inhibitory postsynaptic currents (IPSCs), whereas theta rhythms traditionally... local phenomenon. For example, region CA1 of the hippocampus contains a slower class of GABAA ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Kopell, Nancy - Center for BioDynamics, Boston University

 

Collection: Biology and Medicine

 
47 Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on the Mammalian-Specific
 

Summary:  of subunits a1-3 and a5. Subunits c1 and c2 form a strongly supported group, whereas the c3, c4 and e subunits... . Principal Findings. Our analyses support two major monophyletic clades: one clade containing GABAA receptor... a, c, and e subunits, and another one containing GABAA receptor r, b, d, h, and p ...

  

Source: Aris-Brosou, Stéphane - Department of Biology, University of Ottawa

 

Collection: Biology and Medicine

 
48 Neuron, Vol. 25, 449457, February, 2000, Copyright 2000 by Cell Press Interactions between Distinct
 

Summary:  Distinct GABAA Circuits in Hippocampus By virtue of its location and time course, this inhibitory current... of Wisconsin input (Pearce, 1993; Miles et al., 1996). GABAA,slow is a Madison, Wisconsin 53706 slowly rising... with dendritic excitatory in- Boston University puts suggests that GABAA,slow may regulate local dendritic ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
49 Intact Synaptic GABAergic Inhibition and Altered Neurosteroid Modulation of Thalamic Relay Neurons in Mice Lacking Subunit
 

Summary:  in the synaptic inhibition of VB neurons. This suggests subunit containing GABAA receptors may be functionally... depend on the subunit combi- nation of postsynaptic -aminobutyric acid-A (GABAA) receptors. Recombinant... GABAA receptors containing the subunit (heavily expressed in TC ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
50 Interneuron Diversity series Multiple facets of GABAergic neurons
 

Summary:  .O. et al. (1999) Differential expression of a1, a2, a3, and a5 GABAA receptor subunits in seizure... synaptic recep- tors. Downregulation of the a5 subunit, a constituent of extrasynaptic receptors in CA1... and interneuron heterogeneity in control tissue. Multiple actions of GABAergic ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
51 Development of GABAA Receptor-Mediated Inhibitory Postsynaptic Currents in Hippocampus
 

Summary:  Development of GABAA Receptor-Mediated Inhibitory Postsynaptic Currents in Hippocampus MATTHEW I... form 5 August 2002 Banks, Matthew I., Jason B. Hardie, and Robert A. Pearce. Development of GABAA... .1152/jn.00026.2002. Hippocampal CA1 pyramidal cells receive two kinetic classes of GABAA receptor

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
52 SYNAPTIC AND SUBCELLULAR LOCALIZATION OF A-KINASE ANCHORING PROTEIN 150 IN RAT HIPPOCAMPAL CA1 PYRAMIDAL
 

Summary:  of GABAA receptor 1­3 subunits contain consensus PKA substrate sequences (Moss et al., 1992; Mc... on behalf of IBRO. Key words: protein kinase A, calcineurin, post-synaptic den- sity, GABAA receptors... -97, and F-actin, as well as the intracellular loops of GABA receptor type A (GABAA) ...

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University; Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
53 Attenuated sensitivity to neuroactive steroids in -aminobutyrate type A receptor delta subunit
 

Summary:  . (38) and illustrated by the GABAA-R 3 knockout (9). It remains to be determined whether subunit-containing... nervous system primarily are carried by Cl ions conducted via -aminobutyric acid type A receptors (GABAA... variants ( 1­6, 1­4, 1­3, , and ) (1). GABAA-Rs are modulated by many drugs, including ...

  

Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego

 

Collection: Biology and Medicine

 
54 Statistical analysis of GABAA receptor modulators' effects in rats with focus on memory improvement and reversing of
 

Summary:  Statistical analysis of GABAA receptor modulators' effects in rats with focus on memory improvement... to determine if (i) the selective 5 GABAA receptor inverse modulator 5IA-II would improve memory in the rat... ; (ii) the selective partial 2 and 3 (and full 5 agonist) GABAA receptor modulator NS.A would

  

Source: Danmarks Tekniske Universitet, Informatics and Mathematical Modelling

 

Collection: Mathematics ; Computer Technologies and Information Sciences

 
55 Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [ 2(R43Q)]
 

Summary:  ``functional uncoupling'' of the 2- subunit. Possible Effects of 2(R43Q) Subunit-Containing GABAA Receptors... .212320199 Bowser et al. #12;Functional Uncoupling of 2(R43Q) Subunit-Containing Receptors May Involve... Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [ 2(R43Q

  

Source: Jackson, Meyer B. - Neuroscience Training Program & Department of Physiology, University of Wisconsin at Madison; Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
56 Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition
 

Summary:  for degradation (12). We noted that residues 318­337 of the 2 subunit contain a number of conserved lysine... residues (Fig. S3), suggesting that the late endosomal/lysosomal targeting of 2 subunit contain- ing... ­16DIV cultured hippocampal cells under control and OGD conditions. Analysis of GFP 2 ...

  

Source: Yan, Zhen - Department of Physiology and Biophysics, State University of New York at Buffalo

 

Collection: Biology and Medicine

 
57 Steroids can have rapid effects on mood and behaviour of animals, and on the function of neurons. A number of
 

Summary:  & Weiss, 1993; Lambert et al. 1995; Ueno et al. 1997). We used pentobarbital and 3a,5a,17b-3... -aminobutyric acid A (GABAA) receptors (Majewska et al. 1988) and it potentiates activation of N... -methyl-D-aspartate (NMDA) receptors (Wu et al. 1991). We are particularly interested in the blocking of GABAA ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
58 Training-induced changes in the expression of GABAA-associated genes in the amygdala after the
 

Summary:  RNAs levels of six GABAA receptor subunits (a1, a2, a3, a5, b2 and c2) and a variety of GABA-related proteins... / A GABAA a3 Open Biosystems 31560694 N / A GABAA a5 Open Biosystems 38328407 6815819 GABAA b2 Open... subunits ...

  

Source: Duong, Timothy Q. - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
59 Genome-wide RNAi analysis of Caenorhabditis elegans
 

Summary:  Supplementary Information) and found that loops 2 and 7 in the GABAA-R a-subunits contain several highly... A5.1 Ion channel Y Y Y55F3C.c Thioredoxin Y Y ZK682.2 Sugar transporter Y Y Y49A3A.1 CE... .9 Brush border esterase/lipase Y Y F11A5.3 RAB2 ...

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge; Mullins, Dyche - Department of Cellular and Molecular Pharmacology, University of California at San Francisco; Watts, Jennifer - School of Molecular Biosciences, Washington State University

 

Collection: Biology and Medicine

 
60 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  . Recent studies have eluci- dated that spinal GABAA receptors are composed of a2, a3 and a5 subunits [20... that also possess a5 and c2 subunits, are benzo- diazepine-insensitive [11]. Tonic receptors generate... to pathologic alterations in GABAA and glycine ...

  

Source: Price, Theodore - Department of Pharmacology, University of Arizona

 

Collection: Biology and Medicine


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61 Patients surviving ischemic stroke often express delayed epileptic seizures (Cocito and others 1982; Kilpatrick and
 

Summary:  and others 2000). Synapses that have mostly 1 subunit­containing GABAA receptors mediate relatively short... express mainly 1 subunit­containing receptors (Klausberger and others 2002). As a result, altered... , amnesic, and, in part, anti- convulsive actions of benzodiazepines appear to be medi- ated by 1 ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
62 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  . The long-lasting kinetics of GDPs are highly suitable E105 P R 50pA 50pA 5 s 200ms Figure 3 Giant... (2009) GABA-A Receptors: Developmental Roles. In: Squire LR (ed.) Encyclopedia of Neuroscience, volume 4... , pp. 453-461. Oxford: Academic Press. #12;GABA-A Receptors: Developmental Roles Y Ben-Ari, ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
63 Communication Vol. 268, So. 29, Issue of October 15. pp. 21505-21508, 1993 THEJOI.HX,AIOF BIUI.W;IC~I.CHE\IISI.IO
 

Summary:  , and yz subunits contain sev- eral cysteine residues andnot all of these aredisulfide-linked, the charged... openfor tens of milliseconds beforeit closes (Bormann et al., 1987). GABA type A (GABAA... ,membrane-spanningsegments.Ifthequaternary structure of the GABAA receptors is similar to that of the ho- ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
64 Cerebral Cortex doi:10.1093/cercor/bhm233
 

Summary:  RNA in the cerebellum is very low during early life (Bovolin et al. 1992; Laurie et al. 1992). Other subunits such as a5... and expression of key postsynaptic GABAA receptor subunits are coregulated by hearing. Keywords: a1 and b2... /3 subunits, auditory cortex, development, GABAA receptor, hearing impairment ...

  

Source: Sanes, Dan H.- Center for Neural Science, New York University

 

Collection: Biology and Medicine

 
65 Cellular/Molecular The Short Splice Variant of the 2 Subunit Acts as an
 

Summary:  in hippocampal neurons showed declustering of GABAARs concomitant with a loss of 2 subunit-containing receptors... Cellular/Molecular The Short Splice Variant of the 2 Subunit Acts as an External Modulator of GABAA... Anesthesiology, University of Wisconsin-Madison, Madison, Wisconsin 53711 GABAA receptors (GABAARs) regulate

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
66 Fragrant Dioxane Derivatives Identify 1-Subunit-containing GABAA Receptors*S
 

Summary:  Fragrant Dioxane Derivatives Identify 1-Subunit-containing GABAA Receptors*S Received... . With the help of FDDs weidentifynative 1-subunit-containingGABAA receptorsinhis... identified native combinations. The physiological role of 1-subunit-containing GABAARs is unknown. Here we

  

Source: Lübbert, Hermann - Fakultät für Biologie, Ruhr-Universität Bochum

 

Collection: Biology and Medicine

 
67 Spiking-Bursting Activity in the Thalamic Reticular Nucleus Initiates Sequences of Spindle Oscillations in Thalamic Networks
 

Summary:  step of 0.04 ms. Source C code was compiled on a Alpha Server 2100A (5/300) using DEC C compiler... , the inhibitory postsynaptic potentials (IPSPs) between RE cells can be reversed and -aminobutyric acid-A (GABAA... properties of RE and TC cells and was in the range of 3­20 s. In a two-dimensional model, ...

  

Source: Bazhenov, Maxim - Computational Neurobiology Lab., Salk Institute for Biological Studies

 

Collection: Biology and Medicine

 
68 Impaired Cl Extrusion in Layer V Pyramidal Neurons of Chronically Injured Epileptogenic Neocortex
 

Summary:  underlies the decrease in time constant. Although low concentrations of furosemide inhibit 6 subunit-containing... of GABAA receptors. Application of furosemide eliminated the differ- ence between the control and undercut... the effect of -aminobutyric acid (GABA) at GABAA receptors (Bormann et al. 1987). Whether activation

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
69 Behavioral/Systems/Cognitive Amygdala-Specific Reduction of 1-GABAA Receptors
 

Summary:  Behavioral/Systems/Cognitive Amygdala-Specific Reduction of 1-GABAA Receptors Disrupts... The heterogeneity and distribution of GABAA receptor subunits mediates differential roles in behavior. It is thought... at a regionally defined receptor subtype. However, the role of specific GABAA receptor subtypes in particular

  

Source: Duong, Timothy Q. - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
70 Epilepsia, 47(4):113, 2006 Blackwell Publishing, Inc.
 

Summary:  cytochromes P450 (CYPs)-sensitive AEDs (5­9). Accordingly, clinical stud- ies have highlighted the usefulness... of GABAA-Receptor Channels Pascale P. Quilichini, Catherine Chiron, Yehezkel Ben-Ari, and Henri Gozlan... of opening of GABAA channels. Conclusions: At clinically relevant concentrations, STP ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
71 Mechanisms of Induction and Expression of Long-Term Depression at GABAergic Synapses in the Neonatal Rat Hippocampus
 

Summary:  -A requires a GABAA receptor-mediated membrane depolarization, which is necessary to remove the Mg2 block from... GABAA receptor-mediated synaptic currents and a de- crease in the frequency, but not amplitude, of Sr2... -induced asynchronous GABAA quantal events. We conclude that LTDGABA-A induction requires the activation

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
72 Interneurons set the tune of developing networks
 

Summary:  A 600 pA 500 pA 250 pA 25 µV 500 pA 250 pA 5 s 2 s5 s5 s Review TRENDS in Neurosciences Vol.27 No.7 July... synapses and cells with both types of synapses that were also more developed. GABAA synapses appeared... ). These oscillations are suppressed by bicuculline. Furthermore, synchronized ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
73 Stimulating electrode AMPA receptor
 

Summary:  receptor: Agonist = N-methyl-D-Aspartate Agonist = AMPA GluGABA Cl- GABAA Interneuron GABAB GABA A receptor... : Agonist = muscimol Cl- GABAA GAD Recording electrode Recording of membrane potential is shown below, along... -4-phosphonobutyric acid. -55 AMPA (Na+, K+) NMDA (Na+ , K+ , Ca2+ ) GABAA (Cl- ) GABAB (K

  

Source: Hasselmo, Michael - Department of Psychology & Computational Neurophysiology Laboratory, Boston University

 

Collection: Biology and Medicine

 
74 arXiv:q-bio/0607031v1[q-bio.NC]20Jul2006 From Systems Biology to Dynamical
 

Summary:  of channels in any form: [C] + [L1C] + [L2C] + [L2Dfast] + [L2Dslow] + [L2O] = [C](0) = 1. (A-5) Rate... of anxiety and anxiolytics. Second a review of GABA ­ GABAA (ligand ­ receptor) interaction is given... and computational work [12, 13] effects of the injection of the positive and negative GABAA ...

  

Source: Tóth, János - Institute of Mathematics, Budapest University of Technology and Economics

 

Collection: Mathematics

 
75 RAPID BRAIN-DERIVED NEUROTROPHIC FACTOR-DEPENDENT SEQUESTRATION OF AMYGDALA AND HIPPOCAMPAL GABAA
 

Summary:  RAPID BRAIN-DERIVED NEUROTROPHIC FACTOR-DEPENDENT SEQUESTRATION OF AMYGDALA AND HIPPOCAMPAL GABAA... --During the consolidation of fear memory, it has been shown that GABAA receptors (GABAAR) are rapidly downregulated... reserved. Key words: GABAA receptor, BDNF, internalization, phos- phorylation, PKC, PKA. The majority

  

Source: Duong, Timothy Q. - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
76 Antagonist-Induced Reversal of Functional and Structural Measures of Hippocampal Benzodiazepine Tolerance1
 

Summary:  ), likely corresponding to BZI ( 1-subunit-containing), BZIIA ( 2- or 3-subunit-containing) and BZIIB ( 5... -subunit- containing) receptors (Sieghart, 1995). The first two sites, more prominent in CA1 than in CA3... of the GABAergic system, and especially of the GABAA receptor (GABAR), ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
77 Behavioral/Systems/Cognitive GABAergic Control of Adult Hippocampal Neurogenesis in
 

Summary:  of postmitotic immature neurons to modest functional deficits in 2 subunit-containing GABAA receptors.Incontrast,acomparableforebrain-specificGABAA... - associated trait anxiety and behavioral inhibition. A modest def- icit in 2 subunit-containing GABAARs... at embryonic day 15 (Laurie et al., 1992b), around ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
78 87:1215-1284, 2007. doi:10.1152/physrev.00017.2006Physiol Rev Yehezkel Ben-Ari, Jean-Luc Gaiarsa, Roman Tyzio and Rustem Khazipov
 

Summary:  Perspectives 1216 II. Basic Properties of GABA Signaling 1217 A. GABAA receptors 1217 B. GABAB receptors 1217... 1218 C. Developmental changes in chloride homeostasis 1228 D. Bicarbonate-mediated GABAA excitation... and animal species 1235 IV. Early Operation of GABAA Signaling Prior to Synapse Formation 1235 A. GABA

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
79 Cellular/Molecular Charged Residues in the 1 and 2 Pre-M1 Regions Involved
 

Summary:  to the transmembrane pore domain of the serotonin type-3A (5-HT3A) receptor showed that only when loops 2, 7, and 9... Cellular/Molecular Charged Residues in the 1 and 2 Pre-M1 Regions Involved in GABAA Receptor... is absolutely conserved. We mutated charged pre-M1 residues in the GABAA receptor 1 ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Zhang, Su-Chun - Neuroscience Training Program & Waisman Center, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
80 97:2373-2384, 2007. First published Jan 3, 2007; doi:10.1152/jn.00395.2006J Neurophysiol Kirsty Grant
 

Summary:  receptors (Yang and Uchida 1996) with selectivity for 2 and 3 subunit­containing receptors (Reyn- olds et al... neural networks. Here we describe the effects of the GABAA receptor potentiating anesthetic etomidate... conductances at GABAA receptors and that increased shunting inhi- bition at the level of the proximal dendrites

  

Source: Grant, Kirsty - Unité de Neurosciences Information et Complexité

 

Collection: Biology and Medicine


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81 The population firing rate in the presence of GABAergic tonic inhibition in single neurons and
 

Summary:  during anaesthesia. Keywords: general anesthesia, neural fields, extra-synaptic receptors, GABAA... of the neurotransmitter -aminobutyric acid (GABA) through the synaptic cleft and acti- vates GABAA receptors. These... ). In contrast, the present work focusses 3 #12;on the effect of tonic GABAA receptors on neural population

  

Source: Hutt, Axel - Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Université Henri Poincaré -Nancy-Université

 

Collection: Physics ; Biology and Medicine

 
82 The population firing rate in the presence of GABAergic tonic inhibition in single neurons and
 

Summary:  -synaptic receptors, GABAA, nonlinear gain 2 hal-00640064,version1-10Nov2011 #12;1 Introduction One of the most... acid (GABA) through the synaptic cleft and acti- vates GABAA receptors. These, in turn, open the ion... ). In contrast, the present work focusses 3 hal-00640064,version1-10Nov2011 #12;on the effect of tonic GABAA

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
83 The activity-dependent plasticity of glutamatergic synapses has been described extensively (Nicoll & Malenka, 1995) and
 

Summary:  plasticity in the neonatal rat hippocampus (McLean et al. 1996). Thus, concomitant activation of GABAA... . Ionotropic glutamate receptor antagonists were present throughout the experiments to isolate GABAA receptor... -mediated postsynaptic potentials (GABAA PSPs) or currents (GABAA PSCs). 2. Repetitive ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
84 Transient Plasticity of Hippocampal CA1 Neuron Glutamate Receptors Contributes to Benzodiazepine
 

Summary:  actions are likely mediated by a1 subunit-containing GABARs and their anxiolytic actions by a2 subunit-containing... that the distinct clinical effects of benzodiazepines (BZs) are mediated by the contributions of different GABAA

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
85 nature neuroscience volume 4 no 5 may 2001 477 Ligand-gated ion channels are allosteric proteins that couple
 

Summary:  -FLAGN20´C and 1-mycE20´C subunits. *Subunit containing an engineered Cys residue. Each combination... -tagged wild type, 1-FLAGS17´C and 1-mycH17´C subunits. *Subunit containing an engineered Cys residue. Each... -FLAG subunit contained the FLAG epitope sequence ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University; Jackson, Meyer B. - Neuroscience Training Program & Department of Physiology, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
86 Cellular and Network Models for Intrathalamic Augmenting Responses During 10-Hz Stimulation
 

Summary:  or not the site of stimulation influ- compiled on a Alpha Server 2100A (5/300) using GCC compiler ences... from decorticated 1987) and in vivo (Pare´ et al. 1991) leads to GABAA- and cats. The simplest network... . Lateral GABAA inhibition between identical that high-threshold currents are activated ...

  

Source: Bazhenov, Maxim - Computational Neurobiology Lab., Salk Institute for Biological Studies

 

Collection: Biology and Medicine

 
87 UNIVERSIT PARIS XI FACULT DE MDECINE PARISSUD
 

Summary:  ..................................................................................................................... 124 1. Implication des récepteurs GABAA dans le contrôle homéostatique de la balance Excitation... ..................................................... 124 2. Marquages immunocytochimiques des récepteurs GABAA contenant la ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
88 Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks
 

Summary:  cells (see Figs. 4a, 5a, 7b), whereas six stimuli per cycle caused a transition to 3­4 Hz oscillations... the 3­4 Hz paroxysmal oscillations back to 6­10 Hz spindle waves. Conversely, the GABAA recep- tor... single or burst stimuli. We suggest that differential activation of thalamic GABAA and GABAB ...

  

Source: McCormick, David - Department of Neurobiology, Yale University

 

Collection: Biology and Medicine

 
89 Cellular/Molecular The GDPGTP Exchange Factor Collybistin: An Essential
 

Summary:  that mutants A4 and A5, which together span the short peptide sequence PFPLTSMDKA (Fig. 4C,D), disrupted... whether the A4 and A5 alanine mutants disrupted collybistin-gephyrin colocalization in mamma- liancells... ,wenextintroducedthesemutationsintopEGFP-gephyrin. These mutations were sufficient to either ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
90 Pharmacology Biochemistry and Behavior, Vol. 64, No. 4, pp. 673680, 1999 1999 Elsevier Science Inc.
 

Summary:  on the responsiveness of GABAA receptors to certain ligands as well as to environ- mental stimuli, however, raises... the question of whether the early exposure may have altered composition of GABAA re- ceptors, because... the functional responsiveness of GABAA re- #12;#12;678 KELLOGG lates the GABAA ...

  

Source: Kellogg, Carol K. - Department of Brain and Cognitive Sciences, University of Rochester

 

Collection: Biology and Medicine

 
91 nature neuroscience volume 4 no 5 may 2001 477 Ligand-gated ion channels are allosteric proteins that couple
 

Summary:  -mycE20´C subunits. *Subunit containing an engineered Cys residue. Each combination was either left... -tagged wild type, 1-FLAGS17´C and 1-mycH17´C subunits. *Subunit containing an engineered Cys residue. Each... -FLAG subunit contained the FLAG epitope sequence ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
92 KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a
 

Summary:  (K+ /Cl­ ) exchanger KCC2 (also called Solute Carrier Family 12, Member 5; SLC12A5), which controls... of interneurons through both GABAA and AMPA/NMDA receptor activation. Once in the cortex, upregulation... - neuronmotilitythroughitsabilitytoreducemembrane potential upon GABAA receptor activation, which ...

  

Source: Polleux, Franck - Department of Pharmacology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
93 Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking*
 

Summary:  Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking... inhibitory signaling in the brain via stimula- tion of both GABAA receptors (GABAAR), which are chlo- ride... of the GABAB receptor 1 (GABABR1) with the GABAA receptor 2S subunit robustly promotes cell surface expression

  

Source: Teissére, Jeremy Alden - Biology Department, Muhlenberg College

 

Collection: Biology and Medicine

 
94 Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking*
 

Summary:  Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking... inhibitory signaling in the brain via stimula- tion of both GABAA receptors (GABAAR), which are chlo- ride... of the GABAB receptor 1 (GABABR1) with the GABAA receptor 2S subunit robustly promotes cell surface expression

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
95 Neuregulin1 Downregulates Postsynaptic GABAA Receptors at the Hippocampal Inhibitory Synapse
 

Summary:  Neuregulin1 Downregulates Postsynaptic GABAA Receptors at the Hippocampal Inhibitory Synapse... - nobutyric acid (GABA)A receptors subunits in hippocampal slices, and the mean amplitude of GABAergic... . KEY WORDS: neuregulin; GABAA receptor; hippocampal CA1; down- regulation; mRNA; mIPSC INTRODUCTION

  

Source: Corfas, Gabriel - F.M. Kirby Neurobiology Center, Children's Hospital Harvard Medical School

 

Collection: Biology and Medicine

 
96 Changes on the properties of glycine receptors during neuronal development
 

Summary:  . As shown in Table 1, all the different GlyR subunits contain consensus sequences for PKC-, PKA-, PKG... , the synaptic receptors are made up of h subunit-containing receptors. 4.4. Glycine transmission regulates... by GABAA and AMPA receptors. Finally, the high level of plasticity found in immature GlyRs is ...

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University

 

Collection: Biology and Medicine

 
97 Activity-and age-dependent GABAergic synaptic plasticity in the developing rat hippocampus
 

Summary:  ) 0±15 using the whole-cell patch-clamp recording technique. Spontaneous GABAA receptor... -mediated postsynaptic currents (sGABAA-PSCs) were isolated in the presence of ionotropic glutamate receptor antagonists... (DPs) at 0.1 Hz, was able to induce long-lasting changes in both frequency and amplitude of sGABAA

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
98 Compartmental Localization of -Aminobutyric Acid Type B Receptors
 

Summary:  observations). Zucker and Ehinger (1998) have shown that the two 1/ 2/3 subunit-containing GABAA receptor bands... attributed to GABAA and GABAC receptors, specific retinal functions have also been shown to be mediated... Kernan and Whiting 1996). There are at least three pharmacologically distinct classes of GABA receptors, ...

  

Source: Grzywacz, Norberto - Center for Vision Science and Technology, University of Southern California

 

Collection: Biology and Medicine

 
99 Pre & Postsynaptic Tuning of Action Potential Timing by Spontaneous GABAergic Activity
 

Summary:  has a major detrimental effect on spike timing. In fact, GABAA receptors tune the relationship between... the excitability and fidelity of pyramidal neurons via a postsynaptic (the reversal potential for GABAA activity... the excitability of pyramidal neurones, depending on the difference between the reversal potential for GABAA

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
100 Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto
 

Summary:  released GABA onto low-conductance extrasynaptic subunit-containing GABAA receptors (33). Ac- cordingly... to these effects. compartmental model GABA GABAA receptor knockout network synchrony How is information coded... ) in the pyramidal cell layer (6, 7, 9, 24, 29). Via synaptic GABAA receptors, PV BCs ...

  

Source: Kopell, Nancy - Center for BioDynamics, Boston University

 

Collection: Biology and Medicine


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