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Sample search results for: a3 facilitates lysosomal

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1 Coupled Inositide Phosphorylation and Phospholipase D Activation Initiates Clathrin-coat Assembly on Lysosomes*
 

Summary:  G. Prestwich. A-3 and recombinant protein kinase C (PKC ) were purchased from Calbiochem... system (1 mM ATP, 5 mM creatine phosphate, 10 units/ml creatine kinase), apyrase, A-3, neomycin, various... of 0­1 M ammonium phosphate, pH 3.8, as described elsewhere (27). RESULTS The Kinase Inhibitor ...

  

Source: Traub, Linton M. - Department of Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
2 INSTRUCTIONS Warranty: Pierce Biotechnology (hereafter "Pierce") products are warranted to meet stated product specifications and to conform to label descriptions when stored and used
 

Summary:  wash. 2. Mince tissue into small pieces (< 3 mm3 ) and add 800 µl of Lysosome Enrichment Reagent A. 3... Enrichment Reagent A. 3. Perform Dounce homogenization on ice. Note: To check lysis efficiency, place 5 µl... Enrichment Reagent A. 3. ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
3 Thesmallchemicalvacuolin-1inhibitsCa2 -dependent lysosomal exocytosis but not cell resealing
 

Summary:  scientificreport 887 #12;macrophages. The mouse monoclonal antibodies MEM259, H4A3 and LBPA, against CD63... Thesmallchemicalvacuolin-1inhibitsCa2þ -dependent lysosomal exocytosis but not cell resealing Jan... endosomes and lysosomes by homotypic fusion combined with uncontrolled fusion of the inner and ...

  

Source: Kirchhausen, Tomas - Immune Disease Institute & Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
4 l e t t e r s regulated AtP release from astrocytes through
 

Summary:  exhibiting partial or full destaining shown in (a3) and (b3) were obtained by subtracting (a2) and (b2) from... ) and (b5) are merged images from a3, a4 with b3, b4 respectively, showing that most destained (either... l e t t e r s regulated AtP release from astrocytes through lysosome ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
5 UNIVERSIT JOSEPH FOURIER GRENOBLE I Ecole Doctorale Chimie et Sciences du Vivant
 

Summary:  lysosomes : elles ont le mérite de la clarté et c'était très rassurant de pouvoir compter sur ce savoir... indique clairement que p76 est localisée dans les lysosomes. Enfin, p76 ayant une homologie de séquence... developed in the laboratory. Most importantly, we were able to demonstrate the lysosomal localisation

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
6 Mucolipins: Intracellular TRPML1-3 channels Xiping Cheng, Dongbiao Shen, Mohammad Samie, Haoxing Xu *
 

Summary:  by Wilhelm Just Keywords: Transient receptor potential (TRP) channel Endosome Lysosome Membrane traffic... is predicted to encode ion channels expressed in intracellular endosomes and lysosomes. Loss... certain aspects of endosomal/lysosomal dysfunction. Lysosomes, traditionally believed to be the terminal

  

Source: Xu, Haoxing - Department of Molecular, Cellular and Developmental Biology, University of Michigan

 

Collection: Biology and Medicine

 
7 UNIVERSITE JOSEPH FOURIER GRENOBLE 1 U.F.R. de BIOLOGIE
 

Summary:  ....................................................................... 21 3/ Transport de matériel des endosomes vers le lysosome... ............................................................ 26 B. PROTEOMIQUE ET LYSOSOME... ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
8 Molecular & Biochemical Parasitology 150 (2006) 288299 Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine
 

Summary:  of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than... (Dd2) pfcrt alleles in HEK293 human embryonic kidney cells. PfCRT localized to the lysosomal limiting... membrane and was not detected in the plasma membrane. We observed significant acidification of lysosomes

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
9 Author's personal copy Excess polycation mediates efficient chitosan-based gene transfer by promoting
 

Summary:  prompt the use of functionalising tools to further facilitate endo-lysosomal escape of polyplexes... by promoting lysosomal release of the polyplexes Marc Thibault, Mélina Astolfi, Nicolas Tran-Khanh, Marc... transfection efficiency is not identified. We hypothesised that excess chitosan facilitates ...

  

Source: Buschmann, Michael - Biomaterials and Cartilage Laboratory, École Polytechnique de Montréal

 

Collection: Biology and Medicine ; Materials Science

 
10 TheJournalofCellBiology The Rockefeller University Press, 0021-9525/2004/06/781/8 $8.00
 

Summary:  ). We previously showed that treatment of HeLa cells with "A2" and "A3" siRNA duplexes directed against... ­C). The extent of Hip1R reduction correlated with the level of TGN disruption. Treatment with the A2 or A3 duplex... . 3 A and Table I). However, in cells treated with A2 and ...

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
11 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  through lysosomes with similar kinetics. Fluorescent resonant energy transfer (FRET) analysis revealed... an intermediate stability and a kinetics of dissociation, which occurred in synchrony with lysosomal escape... . In contrast, a rapid dissociation before lysosomal escape was found for the inefficient low DDA chitosan

  

Source: Buschmann, Michael - Biomaterials and Cartilage Laboratory, École Polytechnique de Montréal

 

Collection: Biology and Medicine ; Materials Science

 
12 ENDOCYTIC MECHANISMS FOR TARGETED DRUG DELIVERY Lisa M. Bareford and Peter W. Swaan1
 

Summary:  endosomal fractions or lysosomally associated fractions. Although most drug delivery complexes aim to avoid... lysosomal degradation, more recent studies have shown the clinical utility in directed protein delivery... pathway have serious potential for improving drug delivery for the treatment of lysosomal storage diseases

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
13 Ubiquitin-dependent lysosomal targeting of GABAA receptors regulates neuronal inhibition
 

Summary:  synaptic inhibition. Identification of a Sorting Motif in the GABAAR 2 Subunit That Facilitates Lysosomal... in facilitating sorting of 2 receptors to the late endosome/ lysosome. Live antibody labeling experiments showed... Ubiquitin-dependent lysosomal targeting of GABAA receptors ...

  

Source: Yan, Zhen - Department of Physiology and Biophysics, State University of New York at Buffalo

 

Collection: Biology and Medicine

 
14 2011 Macmillan Publishers Limited. All rights reserved. Received 5 Jan 2011 | Accepted 15 Jun 2011 | Published 12 Jul 2011 DOI: 10.1038/ncomms1393
 

Summary:  ) is a selective mechanism for the degradation of soluble proteins in lysosomes. CMA contributes to cellular... be measured in vitro using isolated lysosomes. Here we report the development of a photoconvertible... the association of the reporter with lysosomes which can be visualized as a change in the intracellular

  

Source: Verkhusha, Vladislav V. - Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
15 TheJournalofCellBiology The Rockefeller University Press, 0021-9525/2004/02/557/10 $8.00
 

Summary:  a background of 3% in surrounding untransfected cells, NudelN20/C36 had little effect (Fig. 2 A, 3; and Fig. 2... to neither protein are much less effective. Time-lapse microscopy for lysosomes reveals significant N... are driven centripetally to fuse with either lysosomes or trans-Golgi cisternae. Instead ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
16 DOI: 10.1126/science.1205677 , 87 (2011);333Science
 

Summary:  Metabolism A Key Enzyme in the Biogenesis of Lysosomes Is a Protease That This copy is for your personal, non... .1126/science.1204258 A Key Enzyme in the Biogenesis of Lysosomes Is a Protease That Regulates Cholesterol... Mucolipidosis II is a severe lysosomal storage disorder caused by defects in the a and b subunits

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
17 Acid Sphingomyelinase-deficient Macrophages Have Defective Cholesterol Trafficking and Efflux*
 

Summary:  and lysosomes but is rapidly hydrolyzed by lyso- somal sphingomyelinase (L-SMase), a product of the acid... for excretion (6). Thus, the elucidation of cellular molecules and pathways that facilitate and regulate... endosomes and/or lysosomes (3). Here, lysosomal acid lipase hydrolyzes the CE to free ...

  

Source: Tabas, Ira - Department of Physiology and Cellular Biophysics, Columbia University

 

Collection: Biology and Medicine

 
18 Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor*
 

Summary:  Research Laboratories). The anti-LAMP1 (H4A3) and anti-LAMP2 (H4B4) antibodies were obtained from the Developmental... of yeast vac- uolar protein sorting (Vps) protein Vps27p; however, the role of Hrs in lysosomal trafficking... homologue of yeast Vps5p that recognizes the lysosomal targeting code of ...

  

Source: Li, Lian - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
19 Summary. Macroautophagy is a process of regulated turnover of cellular constituents that occurs during
 

Summary:  protein/chaperone complex and facilitates the transport of the targeted protein into the lysosomal matrix... are degraded can be classified as either lysosomal or nonlysosomal. The nonlysosomal pathway is thought... the proteasome. In contrast, lysosomal mechanisms are responsible for the degradation of ...

  

Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University

 

Collection: Biology and Medicine

 
20 Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis
 

Summary:  in dendritic cells (Figure 3A­3C). Our data show that Meth does not block autophagosome formation, but rather... , including lysosomes and associated autophagic organelles. This in turn inhibits receptor... -mediated phagocytosis of antibody-coated particles, MHC class II antigen processing by the ...

  

Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University

 

Collection: Biology and Medicine


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21 DOI: 10.1126/science.1207056 , 678 (2011);334Science
 

Summary:  +Mechanism That Requires the Vacuolar H mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out This copy is for your... Published online 22 September 2011; 10.1126/science.1209307 mTORC1 Senses Lysosomal Amino Acids Through... to the lysosomal surface, the site of mTORC1 activation. We found that the vacuolar H+ ­adenosine ...

  

Source: Sabatini, David M. - Whitehead Institute for Biomedical Research & Department of Biology, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
22 Mycobacteria in the Recycling Pathway JID 2010:201 (1 March) 783 M A J O R A R T I C L E
 

Summary:  (A), 3 (B), or 1 (C) time. ments were performed 3­10 days after infection. Macrophages infected... Lipocalin 2 Trafficking to the Lysosomal Pathway Øyvind Halaas,1 Magnus Steigedal,1,2 Markus Haug,1 Jane A... imaging of infected macrophages revealed that Lcn2 trafficked to lysosomes separate from M. avium, ...

  

Source: Strong, Roland K. - Basic Sciences Division, Fred Hutchinson Cancer Research Center

 

Collection: Biology and Medicine

 
23 The Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
 

Summary:  ,4,5-trisphosphate receptor; LEL, late endosomal and lysosomal; LROs, lysosome-related organelles; MHCII, major... or targeted to the lysosome for degradation. Several channels do participate in intracellular signal... . Keywords: endosomes, intracellular channel, lysosomes, membrane traffic, TRP channel, ...

  

Source: Xu, Haoxing - Department of Molecular, Cellular and Developmental Biology, University of Michigan

 

Collection: Biology and Medicine

 
24 Cytoplasmic Membrane SystemsCytoplasmic Membrane Systems The ................................................ is Comprised of the Endoplasmic Reticulum, Golgi Apparatus, Endosomes,
 

Summary:  The ................................................ is Comprised of the Endoplasmic Reticulum, Golgi Apparatus, Endosomes, Lysosomes, and Vacuoles Other Membrane... are .................................................... to Various Destinations Such as the Plasma Membrane, Lysosomes or Vacuoles in Plant Cells This Route is Also... In the ...

  

Source: Cutler, Chris - Department of Biology, Georgia Southern University

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
25 Molecular Biology of the Cell Vol. 18, 9951008, March 2007
 

Summary:  ABC Transporter PGP-2 in the Biogenesis of a Lysosome-related Fat Storage Organelle Lena K. Schroeder... Monitoring Editor: Sandra Lemmon Caenorhabditis elegans gut granules are intestine specific lysosome... in regulating lysosome biogenesis. Previously, pgp-2( ) activity has been shown to be necessary

  

Source: Hermann, Greg J. - Department of Biology, Lewis and Clark College; Watts, Jennifer - School of Molecular Biosciences, Washington State University

 

Collection: Biology and Medicine

 
26 Copyright 2007 by the Genetics Society of America DOI: 10.1534/genetics.107.080689
 

Summary:  gut granules are lysosome-related organelles with birefringent contents. mrp-4, which encodes an ATP... in the transport of molecules that compose and/or facilitate the formation of birefringent crystals within the gut... is associated with the gut granule, a cell-type-specific lysosome-related organelle that functions in fat

  

Source: Hermann, Greg J. - Department of Biology, Lewis and Clark College

 

Collection: Biology and Medicine

 
27 THEJOURNALOFCELLBIOLOGY JCB: ARTICLE
 

Summary:  vesicle-associated membrane protein (VAMP)/ VAMP7, a late endosome/lysosome v-SNARE (Advani et al., 1998... , 1999), inhibited IgG or complement-mediated particle uptake (Braun et al., 2004). Fusion of lysosomes... is consistent with earlier observations of lysosomal enzyme release by macrophages dur- ing phagocytosis (Werb

  

Source: Chapman, Edwin R. - Molecular and Cellular Pharmacology Training Program & Department of Physiology, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
28 Molecular Cell A Small Molecule Inhibitor
 

Summary:  than 50% loss of cell viability in all of the tumor cell lines we examined (Figures 3A­3C... examined (Figures 3A­3C). In contrast, nontransformed WI38 human fetal lung fibroblasts exhibit no decrease... , and inhibition of lysosomal function. Moreover, this small molecule is able to ...

  

Source: Hardy, Christopher R. - Biology Department, Millersville University

 

Collection: Environmental Sciences and Ecology

 
29 Molecular Regulation of Membrane Resealing in 3T3 Fibroblasts* Received for publication, September 3, 2004, and in revised form, November 8, 2004
 

Summary:  response to brefeldin-A (3). These sensitivities are also unexpected if enlargosomes are exclusively used... signaling pathways, which are termed facilitated and potentiated responses. The facilitated response... requirements of vesicle exocytosis for ini- tial membrane resealing and the ...

  

Source: Chapman, Edwin R. - Molecular and Cellular Pharmacology Training Program & Department of Physiology, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
30 J Inherit Metab Dis (2006) 29:397404 DOI 10.1007/s10545-006-0265-4
 

Summary:  of lysosomal storage disorders Michael H. Gelb · Frantisek Turecek · C. Ron Scott · Nestor A. Chamoles Received... developed assays for lysosomal enzymes in re- hydrated dried blood spots in which a set of substrates... , Canada; Deceased a multiplex assay of the set of enzymes that, when defi- cient, cause the lysosomal

  

Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle

 

Collection: Chemistry ; Biology and Medicine

 
31 UFR Sciences Fondamentales et Appliques Laboratoire des Interactions Ecotoxicologie, Biodiversit et Ecosystmes
 

Summary:  .2 Utilisations du système lysosomal comme biomarqueur de stress environnemental... ....................................................82 2.2.2 Mise en évidence de la structure du système lysosomal ....................................82... lysosomal digestif de L. stagnalis Programme « ERRUP » Evaluation et Réduction des ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
32 M O L E C U L A R B I O L O G Y Remodeling p53
 

Summary:  nucleosomes, perhaps facilitating interaction with other components of the tran- scriptional machinery... , the repair process involved fusion of the cell's degradative organelles, the lysosomes, with the cell surface... . Upon wounding, lysosomes fused with the plasma membrane, rapidly sealing the cell in a Ca2+- triggered

  

Source: Shaw, Bruce E. - Lamont-Doherty Earth Observatory, Columbia University

 

Collection: Geosciences

 
33 Role of autophagy in Caenorhabditis elegans Attila Lajos Kovacs a
 

Summary:  A8.2 atg3 atg-3 atg4 Y87G2A.3, ZK792.8 atg5 Y71G12B.12 atg6 bec-1 atg7 atg-7 atg8 lgg-1, lgg-2 atg9... to introduce the name and concept of autophagy as a general mechanism for bulk lysosomal degradation... the autophagosome; transport and fusion of the autophago- some with the lysosome to form the ...

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine

 
34 ERS1 encodes a functional homologue of the human lysosomal cystine transporter
 

Summary:  ERS1 encodes a functional homologue of the human lysosomal cystine transporter Xiao-Dong Gao1 , Ji... , Institute for Cell and Developmental Biology, State University of New York, USA Cystinosis is a lysosomal... storage disease whose hall- mark is the accumulation of cystine in the lysosome [1,2]. During the normal

  

Source: Dean, Neta - Department of Biochemistry and Cell Biology, SUNY at Stony Brook

 

Collection: Biology and Medicine

 
35 Human Heparanase Is Localized within Lysosomes in a Stable Form Orit Goldshmidt,*,3
 

Summary:  Human Heparanase Is Localized within Lysosomes in a Stable Form Orit Goldshmidt,*,3 Liat Nadav,§,3... intrachain cleavage of glycosidic bonds with a hydrolase mecha- nism. This enzyme facilitates cell invasion... lysosomes and the Golgi ap- paratus. A construct composed of heparanase cDNA fused to green fluorescent

  

Source: Geiger, Benjamin - Department of Molecular Cell Biology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
36 Human Na /H exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria
 

Summary:  of the a3 isoform during osteoclast differenti- ation. J Biol Chem 275: 8760­8765, 2000. 31. Van Dyke RW... . It also does not colocalize with markers of the lysosome, late endosome, trans-Golgi network, or Golgi... exchanger that may regulate intrave- sicular pH and volume and contribute to lysosomal ...

  

Source: Rao, Rajini - Department of Physiology, Johns Hopkins University

 

Collection: Biology and Medicine

 
37 Integrin-Dependent Organization and Bidirectional Vesicular Traffic at Cytotoxic Immune Synapses
 

Summary:  purified from ascites (clone H4A3, Developmental Studies Hybridoma Bank, University of Iowa, Iowa City, IA... ); biotinylated CD107a Ab (clone H4A3, BD Bioscience); CD56 mAb (clone NCAM16.2, BD Bioscience); b-tubulin (clone... by releasing the content of secretory lysosomes at the immune ...

  

Source: Dustin, Michael - Skirball Institute of Biomolecular Medicine, New York University

 

Collection: Biology and Medicine

 
38 Cellular Microbiology (2005) 7(11), 15791591 doi:10.1111/j.1462-5822.2005.00576.x 2005 Blackwell Publishing Ltd
 

Summary:  's natural puncture repair mechanism is usurped in order to recruit lysosomes to the parasite/ host cell... junction or `parasite synapse.' The fusion of lysosomes necessary for construction of the nascent... cytoskeleton is the development of the necessary infrastructure for transport of lysosomes to the parasite

  

Source: Engman, David M. - Departments of Pathology & Microbiology-Immunology, Northwestern University

 

Collection: Biology and Medicine

 
39 The ubiquitinproteasome system in spongiform degenerative disorders Brandi R. Whatley, Lian Li , Lih-Shen Chin
 

Summary:  ], but also occurs in the brains of patients suffering from neurodegenerative diseases (Fig. 1A) [3... in spongiform neurodegeneration should facilitate the development of novel rational therapies for treating prion... - and K63-linked polyubiquitination, regulate endocytic traffick- ing, lysosomal protein ...

  

Source: Li, Lian - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
40 Cellular Microbiology (2005) 7(7), 10191034 doi:10.1111/j.1462-5822.2005.00531.x 2005 Blackwell Publishing Ltd
 

Summary:  ; clone H4A3); rat monoclonal anti-murine LAMP1 (clone 1D4B; Developmental Study Hybridoma Bank... , fail to acidify, and do not fuse with lysosomes, suggesting that B. henselae resides in a non... -endocytic compart- ment. In contrast to human umbilical vein endothelial cells, bacterial death and lysosomal ...

  

Source: Haas, Albert - Institute for Cell Biology, Universität Bonn

 

Collection: Biology and Medicine


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41 Cytolytic T Lymphocyte-Associated Antigen-4 and the TCR /CD3 Complex, But Not CD28, Interact with
 

Summary:  and its ability to facilitate trafficking to lysosomes for degradation. PMA also increased the expression... in shuttling of excess receptor from the Golgi to the lysosomal compartments for degradation. In support... increase in the appearance of CTLA-4 in the lysosomal compartment. At the same time, the ...

  

Source: Kirchhausen, Tomas - Immune Disease Institute & Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
42 Biol. Cell (2007) 99, 349361 (Printed in Great Britain) doi:10.1042/BC20070029 What is the function of neuronal
 

Summary:  adaptins (large subunits , 1, 2, 3A, 3B, , and ), a medium-sized subunit (µ1A, µ1B, µ2, µ3A, µ3B and µ4... feature of AP-3 is that it contains two subunits which are neuron-specific (3b and µ3b). The AP-3A (, 3A... biogenesis and in the generation of secretory and ...

  

Source: Danglot, Lydia - Institut Jacques Monod, Université Paris 7 - Denis Diderot

 

Collection: Biology and Medicine

 
43 School of Life Sciences School of Engineering IBI Institute of Bioengineering / Institut de bioingnierie
 

Summary:  ://sti.epfl.ch IBI Cross-Disciplinary Sandwich Seminar "Immidazoacridinone-Dependent Lysosomal Photodestruction... we developed a Trojan horse approach to overcome MDR in cancer based on lysosomal sequestration... of cytotoxic imidazoacridinones (IAs) and consequent lysosomal rupture following illumination. IAs

  

Source: Floreano, Dario - Laboratory of Intelligent Systems, Ecole Polytechnique Fédérale de Lausanne

 

Collection: Computer Technologies and Information Sciences ; Engineering

 
44 Expression of GABAB Receptors in Magnocellular Neurosecretory Cells of Male, Virgin Female and Lactating Rats
 

Summary:  ­423 #12;clustered, punctate pattern within SON and PVN neurones (Fig. 1, A3,B3). Diffuse GABABR2... in the SON varied with cell type (Table 1, P < 0.0001; two-way ANOVA; Fig. 3), and A1 OT B1 A2 B2 A3 B3 OT 20... 2) contain intense GABABR1 immunoreactivity. At high magnification ...

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University

 

Collection: Biology and Medicine

 
45 Eukaryotic cells have evolved complex machineries for protein degradation, and the precise regulation of degra-
 

Summary:  (lysosomes) to prevent nonspecific proteolysis2 . The energy expenditure of degradation is related... to understand how degradative pathways are tailored to facilitate key brain functions such as learning... in eukaryotic cells: the proteasome and the lysosome. The ubiquitin­proteasome system (UPS) (FIG. 1

  

Source: Schuman, Erin M. - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
46 Molecular Biology of the Cell Vol. 12, 23642377, August 2001
 

Summary:  of an Endoplasmic Reticulum Membrane Protein in a Tubular Lysosome in Leishmania mexicana Kylie A. Mullin,* Bernardo... - tutively transported to and degraded in a novel multivesicular tubule (MVT) lysosome. This organelle... is a terminal lysosome, which is labeled with the endocytic marker FM 4-64, contains ...

  

Source: McFadden, Geoff - School of Botany, University of Melbourne

 

Collection: Environmental Sciences and Ecology

 
47 Molecular Genetics and Metabolism 90 (2007) 181192 www.elsevier.com/locate/ymgme
 

Summary:  administration of a retroviral vector expressing -L-iduronidase upon lysosomal storage in brain and other organs... of lysosomal storage in thymus, ovary, lung, and testis, correction in these organs was only partial for those... therapy; Lysosomal storage disease; Retroviral vector; Mucopolysaccharidosis; Glycosaminoglycan; ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
48 Atg5-Independent Sequestration of Ubiquitinated Mycobacteria
 

Summary:  escapes from phagosome by 3.5 HPI. (A) 3.5 HPI with DRD1 (1st and 3rd rows) or WT (2nd and 4th rows) Mm... within LAMP-1­positive vacuoles resembling lysosomes. Though double membranes were observed which... : bacterial ubiquitination is followed by sequestration into lysosome-like organelles via an ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
49 Molecular mechanisms of late endosome morphology, identity and sorting
 

Summary:  with lysosomes. Addresses Molecular, Cellular, and Developmental Biology, 347 UCB, University of Colorado... pathway is a highly dynamic system that coordinates multiple trafficking routes (Figure 1). The lysosome... to as multivesi- cular bodies (MVBs). Membrane proteins destined for degradation within the lysosome lumen

  

Source: Odorizzi, Greg - Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder

 

Collection: Biology and Medicine

 
50 General Biology 1 Textbook Reading Assignment: Sadava Ch. 5: Cells: The Working Units of Life
 

Summary:  fractionation Lysosomes Cell wall Microtubules, microfilaments Centrosome, centriole, centromere (see... each other? 8. How is ECM formed; name two cellular processes it facilitates. 9. In a eukaryotic cell

  

Source: Prestwich, Ken - Biology Department, College of the Holy Cross

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
51 Biology 131 Textbook Reading Assignment: Sadava Ch. 5: Cells: The Working Units of Life
 

Summary:  Homeostasis Capsule Intermediate filaments (structure and function) Cell fractionation Lysosomes Cell wall... it facilitates. 6. In a eukaryotic cell, where is an mRNA transcipt translated into protein? If the protein

  

Source: Prestwich, Ken - Biology Department, College of the Holy Cross

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
52 Curr Med Chem. Author manuscript Mannose 6-phosphate receptor targeting and its applications in human
 

Summary:  -enzymes to lysosomes, but it can also modulate the activity of a variety of extracellular M6P-glycoproteins ( ., latent... . These derivatives could be used to favour the delivery of specific therapeutic compounds to lysosomes, notably... in enzyme replacement therapies of lysosomal diseases or in neoplastic drug targeting. In ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
53 Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis.
 

Summary:  @montp.inserm.fr Abstract The lysosomal aspartic protease cathepsin D (cath-D) is over-expressed and hyper... , mature lysosomal cath-D is translocated to the cytosol. Since cath-D is one of the lysosomal enzymes... which requires a more acidic pH to be proteolytically-active relative to the cysteine lysosomal ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
54 MOLECULAR THERAPY Vol. 2, No. 2, August 2000 Copyright The American Society of Gene Therapy
 

Summary:  Lysosomal Storage in Mucopolysaccharidosis VII Mice Cuihua Gao,*, Mark S. Sands,*, Mark E. Haskins... Mucopolysaccharidosis VII (MPS VII) is caused by -glucuronidase ( -gluc) deficiency and results in lysosomal storage due... % of hepatocytes, 1% of normal liver enzyme activity, and a reduction in lysosomal storage in the liver ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
55 ioscience.D distribute.
 

Summary:  , lysosomes (in most higher eukaryotes) or the vacuole (in plants and fungi). Here, we present a set... ; Baylor College of Medicine; Houston, Texas USA Key words: autolysosome, autophagosome, flux, lysosome... happens if there are defects in fusion with endosomes or lysosomes, respectively, or following inefficient

  

Source: Li, Lian - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
56 Molecular Basis for the Sorting of the SNARE VAMP7 into Endocytic Clathrin-
 

Summary:  -stranded antiparallel b sheet, flanked by helix a1 on one face with helix a2 and a truncated helix a3 on the other... a trans-SNARE complex that brings the membranes together to facilitate their fusion (McNew et al., 2000... of differentiated cells. VAMP7 is the required R-SNARE for heterotypic fusion of ...

  

Source: Evans, Phil - Laboratory of Molecular Biology, MRC

 

Collection: Biology and Medicine

 
57 An emergency response team for membrane repair
 

Summary:  in the rapid fusion of lysosomes with the plasma membrane. These observa- tions have led to the proposal... that lysosomes and their associated protein components represent the key machinery of repair. Below, Figure 1... are distinct from the lysosomal compartment are required for membrane repair. Self-sealing? There is a myth

  

Source: Kirchhausen, Tomas - Immune Disease Institute & Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
58 Direct Multiplex Assay of Lysosomal Enzymes in Dried Blood Spots for Newborn Screening
 

Summary:  Direct Multiplex Assay of Lysosomal Enzymes in Dried Blood Spots for Newborn Screening Yijun Li,1 C... . Gelb1,5* Background: Newborn screening for deficiency in the lysosomal enzymes that cause Fabry... five lysosomal enzymes that uses newborn-screening cards containing dried blood spots as the enzyme

  

Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle

 

Collection: Chemistry ; Biology and Medicine

 
59 Activating Mutations of the TRPML1 Channel Revealed by Proline-scanning Mutagenesis*S
 

Summary:  . The surface expression of Lamp-1 was detected using a mouse monoclonal antibody (H4A3) against the luminal... and lysosome (LEL) using the lysosome patch clamp technique, a proline substitution in TRPML1 (TRPML1V432P... ,andmostsignificantly,exhibitedsignificantsurfaceexpres- sion. Because ...

  

Source: Xu, Haoxing - Department of Molecular, Cellular and Developmental Biology, University of Michigan

 

Collection: Biology and Medicine

 
60 Molecular Genetics and Metabolism 87 (2006) 821 www.elsevier.com/locate/ymgme
 

Summary:  2005 Available online 7 November 2005 Abstract Mucopolysaccharidosis VII (MPS VII) is a lysosomal... . Keywords: Gene therapy; Lysosomal storage disease; Mucopolysaccharidosis; Glycosaminoglycan; Retroviral... vector Introduction The mucopolysaccharidoses (MPS) are lysosomal stor- age diseases (LSD) due to de

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine


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61 Lysosome Dispersion in Osteoblasts Accommodates Enhanced Collagen Production during Differentiation*S
 

Summary:  Lysosome Dispersion in Osteoblasts Accommodates Enhanced Collagen Production during Differentiation... , Toronto, Ontario M1C 1A4 Canada Lysosomes are essential organelles for intracellular degrada- tion... ., and Moran, E. (2001) Cell Growth Differ. 12, 61­83), we saw a marked increase in total lysosome organelles

  

Source: Squire, Jeremy - Laboratory Division of Cellular and Molecular Biology, Ontario Cancer Institute, University of Toronto

 

Collection: Biology and Medicine

 
62 Matrix Biology 22 (2003) 163177 0945-053X/03/$30.00 2003 Elsevier Science B.V.yInternational Society of Matrix Biology. All rights reserved.
 

Summary:  (Transduction Labs). Supernatant from hybridoma H4A3 (1:10) specific for the human lysosomal membrane protein... in lysosomes of poorly differentiated breast carcinoma cells Brandon J. Burbach , Andreas Friedl , Christoph... . Colocalization studies using fluorescent markers identify these to be ...

  

Source: Rapraeger, Alan C. - Molecular and Cellular Pharmacology Training Program & Department of Pathology and Laboratory Medicine, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
63 Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal
 

Summary:  -type Pik3c3 and Pik3c3flox allele: A1, 5- GGCCACCTAAGTGAGTTGTG-3; A2, 5-GAAGCCTGGAACGAGAAGAG-3;A3... accumulated excessive numbers of lysosome-like organelles and degenerated more slowly. These differential... insights into the complexity of neuronal endo-lysosomal and autophagic pathways. PIK3C3 (also known ...

  

Source: Hogan, Brigid L.M. - Department of Cell Biology, Duke University; Stephens, Matthew - Departments of Statistics & Human Genetics, University of Chicago; Wang, Fan - Department of Cell Biology, Duke University

 

Collection: Biology and Medicine ; Mathematics

 
64 1069RESEARCH ARTICLE INTRODUCTION
 

Summary:  nucleotide polymorphism (SNP) mapping to locate sm237 between SNPmarkers snp-Y47G6A3.21) and snp-R12E2 (­1... of lysosome. Our results suggest that UNC-108 promotes cell corpse degradation, possibly by C. elegans Rab... endocytosis, acting in the endosomal trafficking from early to late endosome and late endosome to ...

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine

 
65 Abstract Most teleost fish are ammoniotelic, and rela-tively few are ureotelic, in which the majority of nitroge-
 

Summary:  was the presence of numerous large, black- stained lysosomes, which contained cored vesicles, sug- gesting a second... of these vesicles with the pavement cell apical membrane, or it could al- low facilitated diffusion of urea across... , the ammoniotelic P. notatus ex- hibited neither the vesicular trafficking nor the popula- tion of ...

  

Source: Gilmour, Katie - Department of Biology, University of Ottawa

 

Collection: Biology and Medicine

 
66 MaterialsScienceandEngineeringDepartmentSpecialSeminar 12:00 p.m. Thursday, February 17, 2011
 

Summary:  to lysosome degradation before the nucleic acid is released. This is of particular concern in the case... by a lipid bilayer of low M. This 3D complex fluid contains membrane properties that facilitate endosomal

  

Source: Shim, Moonsub - Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign

 

Collection: Materials Science

 
67 EMBO reports VOL 4 | NO 7 | 2003 2003 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION scientific report
 

Summary:  to the active site (Fig. 3B) and may facilitate interaction of GlcCerase with the lysosomal membrane... TYLWRRQ 1 1 1a 3 A B Fig. 4 | Mutations in acid--glucosidase. (A) The sequence of the 497 residues of acid... 704 Gaucher disease, the most common lysosomal storage disease, is caused ...

  

Source: Sussman, Joel L. - Department of Structural Biology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
68 # 2007 The Author Journal compilation # 2007 Blackwell Publishing Ltd
 

Summary:  of digesting most biological macro- molecules, are released from lysosomes into the phago- some, contributing... based on parallels in the lysosomal world (11). Even there, the identities of most transporters... endosomes and finally into a phagolysosome by fusion with lysosomes (normally the terminal organelles

  

Source: Haas, Albert - Institute for Cell Biology, Universität Bonn

 

Collection: Biology and Medicine

 
69 BioMed Central Page 1 of 19
 

Summary:  file 1), while collagens (col4a1, col4a2, col8a1, col9a3, and col11a1; Figure 3) and muscle... ) information has facilitated the development of an Ambystoma salamander Affymetrix microarray platform [35... and DL14 (N = 109) extracellular region (N = 23; 6.64E-10) muscle contraction (N = 15; 6.62E-13) ...

  

Source: Keller, Christopher - Department of Biology, Minot State University

 

Collection: Fossil Fuels ; Biology and Medicine

 
70 Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/
 

Summary:  mutants whereas it mainly localized to basolateral membranes in wild type (Figure 3A­3C, 3J). Similarly... to be recycled back to the plasma membrane, degraded in lysosomes or delivered to the trans-Golgi network. Early... it is also observed on the cytosolic surface of endosomes and lysosomes [19]. ...

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine

 
71 Biol. Chem., Vol. 391, pp. 923935, August 2010 Copyright by Walter de Gruyter Berlin New York. DOI 10.1515/BC.2010.109 Article in press -uncorrected proof
 

Summary:  proc- essing initiated in the follicular lumen and completed in endo-lysosomal compartments. However... - and two-chain forms, is localized to endo-lysosomes in the papillary thyroid carcinoma cell line KTC-1... to endo-lysosomes (Linke et al., 2002a; Brix, 2005). In the acidic milieu of endo-lysosomes, ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
72 Mouse Model for Mucopolysaccharidosis type I (MPSI)
 

Summary:  Mouse Model for Mucopolysaccharidosis type I (MPSI) IDUA knockout mouse for the study of lysosomal... .lynett@uilo.ubc.ca Technology Details: Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder... that is required for glycosaminoglycan (GAG) degradation. The IDUA deficiency in MPS disorders leads to ...

  

Source: Michelson, David G. - Department of Electrical and Computer Engineering, University of British Columbia

 

Collection: Engineering

 
73 The Vacuolar-ATPase Complex Regulates Retinoblast Proliferation and Survival, Photoreceptor
 

Summary:  -specific iso- forms of ATP6V1B1 and ATP6V0a3, respectively.27 No v-AT- Pase gene mutations have yet been linked... in their eye at 2 (A), 3 (B), or 5 (C) dpf. Con- versely, v-ATPase mutants showed in- creased levels... of endosomes, lysosomes, and the luminal compartments of several cell ...

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
74 N-Glycans Mediate Apical Recycling of the Sialomucin Endolyn in Polarized MDCK Cells
 

Summary:  is subsequently internalized, and via a cytoplasmic tyro- sine-based sorting motif is targeted to lysosomes from... complexes in these compartments to direct proteins to endosomes, lysosomes or the basolateral cell surface... (7). The association with glycolipid-enriched microdomains in the Golgi complex may facilitate

  

Source: Weisz, Ora A. - Laboratory of Epithelian Cell Biology, University of Pittsburgh

 

Collection: Biology and Medicine

 
75 Endosome-to-cytosol transport of viral nucleocapsids Isabelle Le Blanc (1,2)*, Pierre-Philippe Luyet (1)*, Vronique Pons (1), Charles
 

Summary:  : forward primer: 5'-AGG CAC AGC CAT ACA AGT CAA A-3', reverse primer: 5'-TTT GGA AGC ATG ACA CAT CCA-3... to the trans-Golgi network (TGN), while others are routed to late endosomes and lysosomes for degradation 2... and lysosomes, where intraluminal vesicles will eventually be degraded 6 . The intra-luminal ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
76 THSE PRESENTE A L'UNIVERSIT D'ORLANS POUR OBTENIR LE GRADE DE
 

Summary:  OF SCIENCES AND TECHNICS CONCEPTION AND SYNTHESIS OF IMINOGLYCOLIPIDS AS INHIBITORS OF LYSOSOMAL ENZYMES... ....................................................................................................................................... 14 I. Lysosomal storage disorders... ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
77 Suppression of Macrophage Eicosanoid Synthesis by Atherogenic Lipoproteins Is Profoundly Affected by Cholesterol-Fatty Acyl
 

Summary:  and control cells was 0.05%. U18666A (3- -[2-diethylaminoethoxy]androst-5-en-17-one hy- drochloride) was from... that inhibit trafficking of cholesterol from late endosomes/lysosomes to the endo- plasmic reticulum (ER... ACAT was inhibited and pre- vented when late endosomal/lysosomal lipid trafficking was ...

  

Source: Tabas, Ira - Department of Physiology and Cellular Biophysics, Columbia University

 

Collection: Biology and Medicine

 
78 Proc. Natl. Acad. Sci. USA Vol. 96, pp. 1101511022, September 1999
 

Summary:  by defects in the parasite's lysosome endosome compartment resembling those seen in lysosomal storage... of protease trafficking from flagellar pocket to the lysosome endosome compartment. The inhibitors were... . USA 96 (1999) #12;appeared within the abnormally dilated parasite lysosomes and the flagellar ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
79 Human Genes and Disease 320 Spring 2009
 

Summary:  (Hermann) I. lysosome assembly is probably more complex in multicellular animals than in yeast. A. Genetic... of lysosomes (Bryant and Stevens, 1998). a. Many of the genes encode SNAREs, Rabs, and components of protein... , 2001). B. Lysosomes in multicellular animals are functionally more diverse than yeast ...

  

Source: Lycan, Deborah E. - Department of Biology, Lewis and Clark College

 

Collection: Biology and Medicine

 
80 Electron Microscopy of Degenerative Changes in the Chick Basilar Papilla
 

Summary:  of inclusion bodies and lysosomes. By 15­18 hours, lysosomes increased and became denser, afferent terminals... are seen occasionally, but typical lysosomes and phago- somes are infrequent. Some vesicles and vacuolar... and lysosomes are present but not numerous in the control material. In addition to the ...

  

Source: Rubel, Edwin - Department of Physiology and Biophysics, University of Washington at Seattle

 

Collection: Biology and Medicine


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81 Volume 115, number 2 FEBS LETTERS June 1980 FORMYL-MET-LEU-PHEINDUCESCHEMOT~I[SANDACROSOMALENZYME
 

Summary:  chemotaxis in rabbit neutrophils [3]. It also causes the release of lysosomal enzymes, a process which must... necessarily involve a fusion of the lysosomal and plasma mem- branes [4]. Functional analogies between... lysosomes and the acrosome in sperm have been drawn [5,6]. Here we describe the selective release of bull

  

Source: Balaram , P. - Molecular Biophysics Unit, Indian Institute of Science, Bangalore

 

Collection: Biology and Medicine

 
82 Integrin 1 Regulates Phagosome Maturation in Macrophages through Rac Expression1
 

Summary:  with early endosomes, late endosomes, and lysosomes. This process is facilitated by movement of phagosomes... , defective acquisition of lysosome membrane markers, and re- duced F-actin accumulation in the periphagosomal... endosomes, late endosomes, and lysosomes, a process described as phagosome maturation. ...

  

Source: Rockey, Don - Department of Cell Biology, Duke University

 

Collection: Biology and Medicine

 
83 DOI: 10.1002/cbic.200900142 6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin
 

Summary:  .35 (t, J3,4 =3.5 Hz, 1H; H-4), 4.21 (d, 1H; H-3), 4.07 (dd, J6a,6b =11.3 Hz, 1H; H-6a), 3.99 (t, 1H; H-6... -4), 4.18 (d, 1H; H-3), 3.82 (dd, J6a,6b =10.0 Hz, J5,6a =6.9 Hz, 1H; H-6a), 3.77 (t, J5,6b =10.0 Hz... = 9.7 Hz, 1H; H-6a), 3.64 (t, J2,3 =J3,4 =9.7 Hz, 1H; ...

  

Source: Sussman, Joel L. - Department of Structural Biology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
84 The endosomal system is a major membrane-sorting apparatus. New evidence reveals that novel coat proteins assist specific
 

Summary:  (Figure 1). From endosomes, proteins may move to the lysosome/vacuole or recycle back to the TGN or cell... for diverting lysosomal enzymes from the flow of proteins to the cell surface involves sorting at the TGN via... with sorting signals in the MPR cytosolic tail. Although this is a major route for TGN exit of many lysosome

  

Source: Traub, Linton M. - Department of Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
85 original article The American Society of Gene & Cell Therapy Molecular Therapy vol. 18 no. 5, 873880 may 2010 873
 

Summary:  ­880 may 2010 873 Sanfilippo syndrome type B (MPS IIIB) is a lysosomal storage disease resulting from... , hearing, time to activity onset, and day- time activity level, but no reduction of lysosomal stor- age... on lifespan, motor function, or central nervous system (CNS) lysosomal storage. AAV/BMT treatment resulted

  

Source: Orrock, John - Department of Zoology, University of Wisconsin at Madison

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
86 Molecular Genetics and Metabolism 82 (2004) 419 www.elsevier.com/locate/ymgme
 

Summary:  , or was markedly reduced, respectively, in the RV-treated MPS VII mice with low (panels A3 and D3) and high (panels... dogs with low serum GUSB activity (panel A3). M1339 had some erosions of the articular sur- face... Mucopolysaccharidosis VII (MPS VII) is a lysosomal storage disease ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
87 DOI: 10.1126/science.1204592 , 1429 (2011);332Science
 

Summary:  -TFEB, or TFEBS142A-3xFlag vectors. Bafilomycin was added where indicated (400 nM for 4 hours). Quantification... /GFP negative) in HeLa cells stably expressing GFP-mRFP-LC3 and transfected with pcDNA, WT-TFEB or TFEBS142A-3x... Autophagy to Lysosomal Biogenesis This copy is for your ...

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
88 JOURNAL DE PHYSIQUE Colloque C2, supplment au n02, Tome 45, fvrier 1984 page C2-519
 

Summary:  Créteil, France Résumé - Les lysosomes thyroïdiens ont é t é étudiés à l ' a i d e d'une microsonde d e... s t détecté dans des lysosomes homogènes de t a i l l e e t de den- s i t é variables. Après traitement au... gluconate d'aluminium c e r t a i n s lysosomes à contenu hétérogène renfermant de p e t i t s ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
89 Autophagy 6:6, 798-799; August 16, 2010; 2010 Landes Bioscience AutophAgic punctum
 

Summary:  of lysosomes seems to be more tolerable by neurons, but the mechanism under- lying this phenotype is unclear... to their endomembrane sys- tem. Alternatively, since sorting of many lysosomal proteins requires PtdIns3P, this Punctum... and hence the conventional phenotype may also result from a build- up of nonfunctional ...

  

Source: Stephens, Matthew - Departments of Statistics & Human Genetics, University of Chicago

 

Collection: Biology and Medicine ; Mathematics

 
90 AGGREGATION PROPERTIES OF AMPHIPHILIC DNA-CARRIERS FOR GENE DELIVERY
 

Summary:  hexagonal phase is beneficial for transfection because it facilitates the endosomal escape of the gene... , preventing its degradation in the lysosome. A comparative study performed on two SAINT amphiphiles (Figure 3A... by endocytosis; (5) when the lipoplex remains entrapped into the endosome, it is degraded in the lysosome; (6

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
91 289:217-224, 2005. First published Mar 1, 2005; doi:10.1152/ajprenal.00022.2005AJP -Renal Apodaca, Craig P. Smith and Mark L. Zeidel
 

Summary:  -flow experiments. Oocytes expressing mouse urea transporter A3 (UT-A3) exhibited 7.5-fold faster phloretin... between these membrane vesicles, suggesting that UT-A3 is not a water carrier. In conclusion, we describe... aquaporin-1 (AQP1) and mouse urea transporter ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
92 Molecular Biology of the Cell Vol. 18, 11291142, April 2007
 

Summary:  interfering RNAs in mammalian cells disrupts endosome-to-lysosome trafficking of epidermal growth factor... to the plasma membrane or transport to the lysosome for degradation. Cargo proteins destined for the lysosome... endosomes) then fuse with lysosomes, thus allowing the deg- radation of cargo proteins ...

  

Source: Li, Lian - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
93 Since the discovery that Tcell immunity relies on `denatured, unfolded, sequential determinants'1
 

Summary:  with lysosomes. This acidic environment allows degradation of antigens. The known unknowns of antigen... Highly dynamic subcellular structures that eminate from late endocytic­lysosomal and... /or phagolysosomal compartments. They are known to contain MHC class II molecules, CD63, CD82 and lysosome

  

Source: Utrecht, Universiteit - Departement Biologie, Theoretical Biology/Bioinformatics Group

 

Collection: Biology and Medicine

 
94 LETTER doi:10.1038/nature10348 Ebola virus entry requires the cholesterol transporter
 

Summary:  for lysosomes with a mouse monoclonal antibody raised against LAMP1 (H4A3; Santa Cruz Biotechnology). The LAMP1... complex, which is involved in the fusion of endosomes to lysosomes6 , and 39 independent mutations... that disrupt the endo/lysosomal cholesterol transporter protein ...

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
95 Chemistry & Biology Direct Measurement of Cathepsin B Activity
 

Summary:  , recent reports have shown that the cathepsin proteases can be released from the lysosome during apoptosis... the release of cathepsin B from the lysosomes. Bio- chemical characterization of apoptosis in cells from... of lysosomal proteases known as cathepsins that may act through caspase-dependent or independent mech- anisms

  

Source: Chait, Brian T. - Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University

 

Collection: Biology and Medicine

 
96 Biochem. J. (2003) 371, 525532 (Printed in Great Britain) 525 Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II,
 

Summary:  (2001) Biochem. J. 353, 283­290]. To facilitate the identification of selective sub- INTRODUCTION... are reported to be localized primarily in vesicles; however, DPP-II is described as a lysosomal enzyme, whereas... DPP-VII is located in vesicles that are distinct from lysosomes. Although lysosomes and DPP

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
97 Regulation of Notch by Itch AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand
 

Summary:  it to the lysosomes where it is degraded. Furthermore Itch/AIP4 catalyzes Notch polyubiquitination through unusual K29... but without facilitating their degradation [14]. Itch activity on junB is enhanced by Ser/Thr phosphorylation... chains and targeting Notch to lysosomal degradation. We also show that Itch does not interact ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
98 THE JOURNAL OF GENE MEDICINE RESEARCH ARTICLE J Gene Med 2006; 8: 962971.
 

Summary:  are known to facilitate wide distribution of lysosomal enzymes by the axonal transport [25,53]. Passini et... % and conferred high levels of enzyme activity. GALC accumulated in lysosomes of transduced cells and was also... neural cells. GALC was able to accumulate in lysosomes as well as to enter the ...

  

Source: Bongarzone, Ernesto R. - Department of Anatomy and Cell Biology, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
99 Introduction Lysosomes are one of the major degradative compartments of
 

Summary:  recognition tag on lysosomal enzymes, a process that facilitates recognition of those enzymes by mannose 6... Introduction Lysosomes are one of the major degradative compartments of mammalian cells... of action through a series of intermediate compartments. Lysosomal enzymes are recognized by one of the two

  

Source: Murphy, Robert F. - Department of Biological Sciences & School of Computer Science, Carnegie Mellon University

 

Collection: Biology and Medicine ; Computer Technologies and Information Sciences

 
100 REVIEW Open Access Limitations of drug registries to evaluate orphan
 

Summary:  for the treatment of lysosomal storage disorders Carla EM Hollak1* , Johannes MFG Aerts2 , Ségolène Aymé3 and Jeremy... . The existing registries for orphan drug treatments for lysosomal storage disorders (LSD's) illustrate... these limitations. LSD's are inherited disorders of lysosomal metabolism with a wide variety in ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics


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