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Sample search results for: a2a receptor activation

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1 J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0
 

Summary:  in these behavioral actions, since A2A activation reduced the affinity of the agonist binding site of the D2 receptors... for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
2 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... -protein-coupled receptors (GPCRs). At 318 amino acids in length, the A3 subtype is the shortest, while A2A is the longest... - ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
3 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004
 

Summary:  phosphatase 1 regulates the activity of many receptors, enzymes, ion channels, and transcription factors. D1... or Golf to mediate D1-like receptor activation of adenylate cyclase. In human embryonic kidney (HEK) 293... 1 receptor activation of adenylate cyclase is ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine

 
4 P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a
 

Summary:  et al., 1995). Homomeric P2X4 receptors are activated by ATP, but not by ,-methylene ATP (,-me... receptor is not activated by ,-meATP, and is blocked by 8-(3- benzamido-4-methylbenzamido)-naphthalene-1... the level of intracellular calcium ions: whereas activation of P2X ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
5 Copyright C Blackwell Munksgaard 2002 Traffic 2002; 3: 866877
 

Summary:  , Strnad J, Pausch MH, Hadcock JR. Pharmacological char- acterization of the rat A2a adenosine receptor... -9219 Constitutive Activation and Endocytosis of the Complement Factor 5a Receptor: Evidence for Multiple Activated... constitutively ...

  

Source: Bourne, Henry - Department of Cellular and Molecular Pharmacology, University of California at San Francisco

 

Collection: Biology and Medicine

 
6 INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE Olfactory Receptor Interactions
 

Summary:  receptors, and A2A adenosine receptor. These four receptors were further- more found... INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE Olfactory Receptor Interactions with Other Receptors... Olfactory ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
7 Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance
 

Summary:  GPCRs (A1, A2A, A2b, and A3), whereas ATP activates P2X receptors, which are ion channels, as well... . (2003) Adenosine A2A-dopamine D2 receptor- receptor heteromerization: qualitative ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
8 Enhancement of the surface expression of G protein-coupled receptors
 

Summary:  receptors [49], Usp4, which increases plasma membrane expression of adenosine A2A receptors [50], ATBP50... surface level of the A2a receptor. Mol. Pharmacol. 69, 1083­1094 51 Wruck, C.J. et al. (2005) ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
9 The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine
 

Summary:  in mice lacking A2A receptors138 . Caffeine is probably the most widely used psychologically active drug... receptor activation selectively impairs the acquisition of fear conditioning in rats151 . An ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
10 Bruce N. Cronstein, MD You Are Not Arthur Conan Doyle
 

Summary:  A2A receptors in fibrosis in tissues outside of the skin is less clear... laboratory and others indicate that adenosine A2A receptors play an important role... adenosine ...

  

Source: Wang, Da-Neng - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

 

Collection: Biology and Medicine

 
11 The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor
 

Summary:  endogenous P2Y receptors in addition to the P1 adenosine receptors A2A and A2B, which might complicate... receptor family currently encompasses eight members (P2Y1,2,4,6,11,12,13,14 receptors) that are activated... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
12 J Physiol 588.1 (2010) pp 9399 93 SYMPOSIUM REVIEW
 

Summary:  of mossy fibres lead to the activation of NMDA, mGluR5 and adenosine A2A receptors that jointly induce LTP... adenosine A2A receptors are essential for inducing LTP of NMDA-EPSCs (Rebola et al. 2008). ...

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
13 Conserved waters mediate structural and functional activation of family A (rhodopsin-like)
 

Summary:  , engineered A2A-adenosine, 1- and 2-adrenergic receptors, permits comparative analysis of features common... (omitting the T4 lysozyme amino acid sequence present in mutant 2-adrenergic receptor and A2A... identity, mutant ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
14 REVIEW ARTICLE Chemokine receptors and other G protein-coupled receptors
 

Summary:  of invertebrate rhodopsin, b1-adrenergic and b2-adrenergic receptors and the A2A-adenosine receptor have been... -adrenergic and b2-adrenergic receptors, and most recently, the structure of the A2A ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
15 NMDA receptor subunit gating uncovered Alasdair J. Gibb
 

Summary:  receptor channel opening. NMDA receptor activation produces long bursts of channel openings [2... -channel activity, the NMDA receptor is an object of beauty and majesty but this fascinating behaviour has yet... . Consider how remarkable receptor ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
16 Purinoceptors on Neuroglia Alexei Verkhrasky & Oleg A. Krishtal &
 

Summary:  , induced [Ca2+ ]i elevation via activation of A2A receptors [77]. In cultured mouse astrocytes adenosine... -dependent regulation of extracellular glutamate. Activation of A2A receptors ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
17 Purine and pyrimidine receptors G. Burnstock
 

Summary:  by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are activated... different P1 receptor subtypes, A1, A2A, A2B and A3, have been ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
18 Purine and pyrimidine receptors G. Burnstock
 

Summary:  , shortly after, the A3 subtype was identified [21]. Four different P1 receptor subtypes, A1, A2A, A2B and A... transmembrane domain. Polymorphisms have been observed in the A1 and the A2A receptors. P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
19 Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach
 

Summary:  antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem... dependent on activation of NR2A-containing receptors, whereas LTD requires activation of NR2B- containing... and NR1a/ NR2B ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
20 Olfactory receptor trafficking to the plasma membrane C. F. Bush and R. A. Hall*
 

Summary:  A2a receptors, were all found to signifi- cantly enhance the plasma membrane localization of M71... performed in heterologous cells and it is not clear whether b2-adrenergic, P2Y1, P2Y2, and A2a receptors... of b2-adrenergic, ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine


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21 Development/Plasticity/Repair Spinal Adenosine A2a Receptor Activation Elicits Long-
 

Summary:  Development/Plasticity/Repair Spinal Adenosine A2a Receptor Activation Elicits Long- Lasting... motoneurons, thus inducing long-lasting (hours) phrenic motor facilitation. A2a receptor ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
22 *National Institute of Child Health and Human
 

Summary:  is the activation of adenylate cyclase. A2A receptors have a wide-ranging distribution that includes immune tissues... trigger adenosine release, and, by the subsequent activation of A2A ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
23 Provided for non-commercial research and educational use only. Not for reproduction, distribution or commercial use.
 

Summary:  pathway for diffusible ligands. The structure of an engi- neered human A2A adenosine receptor in complex... ­13], engineered expressed monoaminergic turkey 1AR [14], engineered expressed human A2A adenosine receptor [15... ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
24 BRADSHAW 978-0-12-374145-5 00388 Multi-Pass Receptors
 

Summary:  - neered human A2A adenosine receptor in complex with the subtype specific antagonist ZM241385 provides... a number of additional surprises. The ligand binds to the A2A ade- nosine receptor in an extended... ] Expressed ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
25 Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G proteins and, in common... (broken red line) to potentiate P2X2/3 receptor activation, which also may be true for 5-hydroxytryptamine... -respon- sive receptor ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
26 Proc. Nail. Acad. Sci. USA Vol. 83, pp. 2345-2349, April 1986
 

Summary:  ,, a2, a3, and a4 are constants that give the 'he values ofthe relative contributions of each receptor... the example mentioned above in which the activity coefficients, a,, a2, a3, and a4, represent affinity... the ...

  

Source: Goldbeter, Albert - Faculté des Sciences, Université Libre de Bruxelles

 

Collection: Biology and Medicine

 
27 The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have
 

Summary:  . Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G... --the human 2 adrenergic receptor (2AR), the avian 1AR and the human A2A adenosine ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
28 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... . Blockade of A2A (P1) receptors antagonises parkinsonian tremor in the rat tacrine model by actions... on specific ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
29 Oligomeric forms of G protein-coupled receptors (GPCRs)
 

Summary:  found in crystals of engineered human b2-adrenergic receptor [29] and an engineered human A2A adenosine... ­1265 30 Jaakola, V.P. et al. (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor... ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
30 The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have
 

Summary:  --the human 2 adrenergic receptor (2AR), the avian 1AR and the human A2A adenosine receptor--as well... ; the human A2A adenosine receptor bound to the antagonist ZM241385 (ref. 25); and bovine ...

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
31 TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6
 

Summary:  , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... DPCPX, CPX, XAC Gi (1­3): cAMP nerve terminals A2A Brain, heart, lungs, spleen CGS21680 KF17837, SCH... after nerve ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
32 1999 Macmillan Magazines Ltd 7. Carter, C. S. et al. Anterior cingulate cortex, error detection, and the on-line monitoring of
 

Summary:  ±5 ; however, the individual roles of the three highly homologous a2-adrenergic-receptor subtypes (a2A, a2B, a2... the genes encoding the three a2- adrenergic-receptor subtypes were disrupted. Here we show that both the a2A... ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
33 UCB Pharma research day--25 October 2007 `Glia-neuron interactions and purinergic receptors
 

Summary:  . In the early 1990s, P1 and P2 receptors were cloned and characterised: four P1 receptor subtypes (A1, A2A, A2B... in dentate granule cells (CG). P2Y1R signalling in astrocytes activates presynaptic NMDA receptors via... by ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
34 Progress in Neurobiology 70 (2003) 387407 Kainate receptors and synaptic transmission
 

Summary:  for metabotropic effects on transmitter release that can be initiated by activation of kainate receptors. Recent... for only one receptor class. Thus, kainate activates AMPA receptors to produce large sustained cur- 1... kainate receptors in- clude ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
35 Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and
 

Summary:  this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... ) that are rapidly activated and desensitized; group 2 includes P2X2, P2X4, P2X5, and P2X6 receptors that have lower... with the excitatory actions of ATP on ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
36 Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression
 

Summary:  .R., Shanley, T.P., 2002. The A2A receptor mediates an endogen- ous regulatory pathway of cytokine expression... demonstrated that P2 purinergic receptor activation by ATP decreases cytokine, nitric oxide (NO), inducible... microglia with TNF-a and the P2X7 ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
37 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001)
 

Summary:  were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... fibers are activated via P2X3 receptors by ATP released from mucosal epithelial cells, leading... activity of extracellular H+ and Zn2+ on ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
38 ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and
 

Summary:  were due to indirect action via P1 receptors. Four subtypes of P2 receptors were cloned, namely A1, A2A... , cerebralischaemia, sleep apnoea, pain and inflammation32. A2A receptor antagonists are being ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
39 EDITED B'r' Bertha K. Madras Harvard Medical School
 

Summary:  , and serotonin (5-HT3) receptors. Currently, 12 neu- ronal nAChR subunits have been identified (a2--a1 0 and 132... effects by binding to and activating neuronal nicotinic acetylcholine receptors (nAChRs) in the brain... . Nicotinic receptors are ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
40 Associate editor: A.L. Morrow Regulation of GABAA receptor trafficking, channel activity,
 

Summary:  to primarily postsynaptic localization of a1/a2/ a3hg2 receptors, the same receptor subtypes are also abundant... Associate editor: A.L. Morrow Regulation of GABAA receptor trafficking, channel activity... density; PP, protein phosphatase; RACK, ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
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41 G protein-coupled receptors (GPCRs) are the largest family of transmembrane proteins in vertebrates and they
 

Summary:  of the receptor, thereby allow- ing interactions with heterotrimeric G proteins. Activated... proteins to activatedGPCRs2 .Furthermore,arrestinscandirectlylink active receptors to clathrin-coated pits... to the protein clathrin, on the cytosolic side of the membrane. Fine-tuning of GPCR ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
42 doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol
 

Summary:  activation (15), a downstream effect of A2a activation. In contrast, A1 receptor activation may have a role... AMP), activation of A1, A2a, or A3 ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
43 Special issue: Allosterism and Collateral Efficacy Conformational complexity of
 

Summary:  protein in the absence of an agonist. The activity of receptors can be either increased or decreased... ' are defined as ligands that fully activate the receptor. `Partial agonists' induce submaximal activation... of the more active con- formation relative to the ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
44 PC PE PS PI SPM GangChol
 

Summary:  of the EGF receptor is increased. #12;Cholesterol depletion also leads to the activation of MAP kinase... suppresses the activity of this receptor and is probably important in maintaining the EGF receptor... signaling, including the EGF receptor, has led to the ...

  

Source: Pike, Linda J. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
45 For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133
 

Summary:  (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... ,38 Mice lacking the adeno- sine A2A receptor were found to have an increase in heart rate and high ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
46 Purinergic signalling in the nervous system: an overview
 

Summary:  adenosine receptors A1, A2A, A2B and A3 are G- protein coupled (Figure 1). Typically, A1 and A3 couple... to the Gi/o family of G proteins inhibiting cyclic AMP (cAMP) production, whereas A2A and A2B stimulate c... , and all adeno- sine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
47 REVIEW ARTICLE The journey to establish purinergic signalling in the gut
 

Summary:  cloned, namely, A1, A2A, A2B, and A3. Seven subtypes of P2X receptors have been identified... and P2Y12 receptors were demonstrated on enteric neurons. Differential gene expression of A1, A2A, A2B... of adenosine A1, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
48 Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation
 

Summary:  ,23­25 and it is currently recognised that there are four subtypes of P1 receptors (A1, A2A, A2B and A3), seven subtypes of P... 40,41 ), several classes of receptors (sometimes having opposite actions) are activated at effector... feedback (iv) Metabolic phenotype: ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
49 Role of delivery and trafficking of d-opioid peptide receptors in opioid
 

Summary:  activate MOP receptors and produce potent spinal analgesia. Among the agents used in pain treatment, opioid... receptors are internalized and processed in the degradation pathway after being activated in this way [14... attenuation of signaling. In general terms, it is accepted that ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
50 Bovine Papillomavirus E5 Protein Induces the Formation of Signal Transduction Complexes Containing Dimeric Activated
 

Summary:  Dimeric Activated Platelet-derived Growth Factor Receptor and Associated Signaling Proteins* (Received... (PDGF) recep- tor, resulting in constitutive activation of the receptor and cell growth transformation... , activated PDGF receptor complexes were separated from ...

  

Source: DiMaio, Daniel - Departments of Genetics & Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine

 
51 nature neuroscience volume 1 no 3 july 1998 185 Recent studies suggest that tyrosine kinases are important for
 

Summary:  terminals in specific brain regions and released during neuronal activity14. Zinc inhibits NMDA receptors... . p 1a/2A (10), P 1aC744,798A/2A (5), l 1b/2A (9), L 1bm207­211/2A (6). (d) Correlation between... is the reduction ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
52 Proc. Natl. Acad. Sci. USA Vol. 95, pp. 1524115246, December 1998
 

Summary:  -derived growth factor (PDGF) receptor and induces constitutive tyrosine phosphorylation and activation... of the receptor, resulting in cell transformation. The E5 protein does not resemble PDGF, but rather activates... the receptor in a ligand-independent fashion, thus providing a ...

  

Source: DiMaio, Daniel - Departments of Genetics & Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine

 
53 Complex expression of natural killer receptor genes in single natural killer cells ZAHEED HUSAIN,*{{ CHESTER A. ALPER,{1 EDMOND J. YUNIS*{ &
 

Summary:  cells. Activation or non-inhibitory (DS) receptors (e.g. 2DS1, 2DS2, 3DS1) contain a positively charged... but associate with DAP12 to form an activating receptor which contains an immunoreceptor tyrosine... -based activation motif (ITAM) in the cytoplasmic domain.5 CD94/NKG2 hetero- ...

  

Source: Alper, Chester A. - Immune Disease Institute, Harvard University

 

Collection: Biology and Medicine

 
54 Department of Chemistry Sponsor: National Institute of Neurological Disorders and Stroke
 

Summary:  to dampen the excessive receptor activity has been a long pursued therapeutic strategy. 2,3-Benzodiazepine... receptor subunits, and characterize the structure-activity relationship, including the number of inhibitory... results on the receptor properties and the ...

  

Source: Knuth, Kevin H. - Department of Physics, State University of New York at Albany

 

Collection: Physics

 
55 Desensitized nicotinic receptors in brain Hai Wanga,*, Xiulan Sunb
 

Summary:  of nicotine, such as that which occurs when smoking, results in little receptor activation; however... subtypes because they contain no g, y or e subunits, and consist of various complements of a2­a10 and h2­h4... subunits [153]. Additionally, ...

  

Source: Cooper, Robin L. - Department of Biology, University of Kentucky

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
56 Draft: 3/12/2009 142:225 Growth Factor Receptor Signaling
 

Summary:  -dependent receptor PTK activation · Epidermal growth factor family receptor signaling o Overview of Erb... of proliferation and differentiation · Activation; non-receptor tyrosine kinases · Antagonism; SOCS proteins... Draft: 3/12/2009 142:225 Growth Factor ...

  

Source: Iowa Center for Gene Therapy

 

Collection: Biotechnology ; Biology and Medicine

 
57 Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson
 

Summary:  as purines [26,128] (see Table I). Four subtypes of P1 receptors have been cloned--A1, A2A, A2B, and A3 (see... receptors lead to suppression of pain signaling, while A2A receptors lead to pain ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
58 J Physiol 586.14 (2008) pp 33073312 3307 TOPICAL REVIEW
 

Summary:  in purinergic signalling 3309 purines and pyrimidines have been identified: P1 adenosine receptors (A1, A2A, A2B... -terminus tail. B, the 3 different forms of the P2X7 receptor upon activation by ATP: closed channel, open... at the sites of injury. P2Y6 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
59 Glycosylation of b1-adrenergic receptors regulates receptor surface expression and dimerizationq
 

Summary:  the b2-adrenergic receptor [15], a2A-adrenergic re- ceptor [30], and dopamine D1 receptor [31]. Con... at activating the b1AR-N15A mutant than the wild-type receptor in the cyclic AMP generation studies, but yet... -stimulated adenylyl cyclase ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
60 Original Paper Cells Tissues Organs 2002;172:255264
 

Summary:  RNA was primarily localised in the cytoplasm (fig. 1a, 2a, b). The cytoplasmic expression of transcripts also... ; Patel et al., 1996]. P2Y receptors mediate vasodilatation by Ca2+-dependent activation of nitric oxide... receptor subtypes during the dif- ferentiation ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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61 Adenosine A3 receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury
 

Summary:  . Neither the A1 receptor agonist 2-chloro-N6 -cyclo- pentyladenosine (0.05 mg/kg) nor the A2A receptor... demonstrated a potent cytoprotective role of adenosine A1, A2A, and A3 receptors in ischemia and ...

  

Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa

 

Collection: Biology and Medicine

 
62 ASSOCIATE EDITOR: DIANNE M. PEREZ The Significance of G Protein-Coupled Receptor
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 925 4. A2a-adenosine receptor structure... in the activation or inactivation of the receptor system at large. Pharmacological dogma generally dictates... (Warne ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
63 P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock
 

Summary:  phase hyperaemia mediated via A2A receptors on smooth muscle cells. Red blood cells as regulators... phase of the reactive hyperaemia as has been shown by infusion of adenosine deaminase or a selective A2A... or macrophage cells. Proinflammatory ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
64 Purinergic signalling *Geoffrey Burnstock
 

Summary:  /ADP, respectively, was proposed (Burnstock, 1978). Four subtypes of P1 receptors have been cloned, namely A1, A2A, A... . Adenosine, via A2A receptors, has a protective effect in a rat model of Parkinson's disease, perhaps... , ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
65 Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins
 

Summary:  of cellular functions by interacting with specific cell surface G protein-coupled receptors (A1, A2a, A2b... receptor on which it acts (4, 8, 26). For example, A2a receptors in the synovial tissue have ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
66 STUDIES ON THE ROLE OF THE N-TERMINAL DOMAIN OF NR1 IN THE REDOX MODULATION OF NR2A-CONTAINING NMDA RECEPTORS
 

Summary:  NMDA receptor activity. Despite intense investigation, many questions remain unanswered regarding NMDA... of the NMDA receptor redox site that occurred as a result of seizure activity (Sanchez et al., 2000... with the activity of the channel (Jin et al., 2003). Hypothetically, when NMDA ...

  

Source: Sibille, Etienne - Center for the Neural Basis of Cognition & Department of Psychiatry, University of Pittsburgh

 

Collection: Biology and Medicine

 
67 Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm
 

Summary:  subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... ., 1978; McConalogue et al., 1996) and the subsequent activation of specific receptors #12;1314 C. Giaroni... roles in the modulation of motility in the GI tract. ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
68 q 2001 International Society for Neurochemistry, Journal of Neurochemistry, 76, 18871894 1887 Journal of Neurochemistry, 2001, 76, 18871894
 

Summary:  construct for the third intracellular loop of human a2A- adrenergic receptor (a2-AR-I3L) was generously... and their interaction apparently was enhanced by activation of the receptor by DOR agonist DPDPE. The C... -arrestin- and dynamin-dependent mechanism. k ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
69 Eph receptor tyrosine kinases and ephrins have been identified in organisms ranging from sponges to flies and worms to chick,
 

Summary:  they are mutually activated. The ligand-binding domain of Eph receptors is located in the amino-terminal so... , but also to several other targets in the forebrain [42·,54]. The conserved module of graded ephrin-A2/A5... -interacting Ste20 kinase couples Eph receptors ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
70 Binding, gating, anity and ecacy The nature of the problem
 

Summary:  -Katz mechanism Two states and constitutve activity Haemoglobin as a receptor What does `allosteric' mean? What... of structure-activity relationships for agonists and of the eects of mutating receptors David Colquhoun... of the receptor, once the agonist has bound, to change conformation ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
71 Purines and Sensory Nerves Geoffrey Burnstock
 

Summary:  transmitter from their central processes, P2Y1 receptor activation may decrease the release of sensory... and under voltage clamp, a fast- activating inward current (mediated by P2X3 receptors), a sustained... ) and ryanodine receptors and their activation by ATP have ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
72 CO-IMMUNOPRECIPITATION AS A STRATEGY TO EVALUATE
 

Summary:  , and codesensitization of adenosine A2A receptors and dopamine D2 receptors. J Biol Chem 277:18091­18097. Hu LA, Tang Y... , if the retention of receptor activity is important, it should be appreciated that many receptors will ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
73 The Glutamate Receptor Ion Channels RAYMOND DINGLEDINE,1
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 VI. Receptor activation and desensitization... in the dose-response curve for activation of mixtures of wild-type and mutant NMDA receptor subunits [NR1(Q387... ) observed that upon agonist binding, activation of ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
74 BI-DIRECTIONAL MODULATION OF BED NUCLEUS OF STRIA TERMINALIS NEURONS BY 5-HT: MOLECULAR EXPRESSION AND
 

Summary:  is mediated by activation of postsynaptic 5-HT1A receptors. Here, we used a combination of in vitro whole... /Dep and the 5-HTDep response was medi- ated by activation of 5-HT2A, 5-HT2C and/or 5-HT7 receptors. Single cell... an interplay between 5-HT1A and 5-HT7 recep- tors. Hence, modulation of 5-HT7 ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
75 JOURNAL OF CELLULAR PHYSIOLOGY 200:309317 (2004) Significance of N-Methyl-D-Aspartate (NMDA)
 

Summary:  -epithelialization, and the process of re-epithelialization is inhibited by NMDA receptor activation. We also demonstrate... . Moreover, NMDA receptor activation might play a role in contact-mediated inhibition of growth, a process... - senger cascades is in a large part determined by the amount and duration of ...

  

Source: Bear, Mark - Picower Institute for Learning and Memory & Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
76 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Encyclopedia of Neuroscience (2009), vol. 1, pp. 105-113 Author's personal copy #12;A2A (P1) receptors... - cytes. ATP can activate P2X7 receptors in astrocytes to release glutamate, GABA, and ATP, which regulate... ' activity dilates vessels via ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
77 Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate
 

Summary:  protein-coupled P1 receptor subtypes have been cloned: A1, A2A, A2B and A3.19 P2 receptors are subdivided... properties.20,21 P2X receptors are ligand-gated ion channels. Activation of P2X receptors results in rapid... widely ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
78 Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum
 

Summary:  Title Page Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co... ; Accepted: Aug 12, 2011 #12;Abstract The adenosine A2A receptor (A2AR) is a potential drug target... neuromodulator that ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
79 In this thesis a combined approach is described to investigate the constitutive activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to
 

Summary:  activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to evaluate... . At first, constitutively active mutant (CAM) human adenosine A2B receptors have been used to discriminate... the greatest intrinsic activity on ...

  

Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden

 

Collection: Physics

 
80 GPCR agonist binding revealed by modeling and crystallography
 

Summary:  with recently determined agonist-bound structures of b-ad- renergic and adenosine A2A receptors reveals high... agonist binding predictions Adenosine A2A receptor (AA2AR) modeling studies [18,29] provide another... . Agonist ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine


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Page:   1  2  3  4  5 
 
81 Physiology and Pathophysiology of Purinergic Neurotransmission
 

Summary:  receptors Four subtypes of P1 receptors have been cloned, namely, A1, A2A, A2B, and A3 (see Refs. 370, 423... . The intracellular segment of the receptor interacts with the appropriate G protein, with subsequent activation... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
82 Genetics of caffeine consumption and responses to caffeine Amy Yang & Abraham A. Palmer & Harriet de Wit
 

Summary:  and A2A receptors (Daly et al. 1983). Adenosine receptors are G-protein-coupled receptors locat- ed... ubiquitously throughout the body. Of the four receptors that have been identified (A1, ...

  

Source: Das, Soma - Department of Human Genetics, University of Chicago; Ober, Carole - Committee on Genetics & Department of Human Genetics, University of Chicago

 

Collection: Biology and Medicine

 
83 The role of ephrins and Eph receptors in cancer Hanna Surawska, Patrick C. Ma, Ravi Salgia*
 

Summary:  that further activate signal transduction cascades. 2.1. Eph receptors Eph receptors are divided either... signaling While most receptor tyrosine kinases become activated by dimerization, the Eph­ephrin axis... observed in Eph­ephrin bi-directional signaling. ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
84 Cellular/Molecular Neurosteroid Access to the GABAA Receptor
 

Summary:  neuroactive steroid modulated receptor activity only when applied to the inner membrane leaflet... of GABAA receptor activity. Neuroactive steroid modulation of GABAA receptors has enjoyed increasing recent... to the receptor is not necessary for potentiation. ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
85 INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM
 

Summary:  ., 2001. Activation of protein kinase A and atypical protein kinase C by A2A adenosine receptors... for adenosine (A1, A2A, A2B and A3 subtypes, all G-protein-coupled) and P2 receptors for ATP (P2X ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
86 Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
 

Summary:  -coupled receptors ( 2A, M4, D2S, and A1) with the G Fig. 2. Oligomerization of a2A and M4 receptors on the plasma... proteins interact with G protein-coupled receptors (GPCRs). In the absence of receptor activation, the 2A... ...

  

Source: Xiang, Kevin Y. - Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign

 

Collection: Biology and Medicine

 
87 Bradfield; Mechanisms of Liver Carcinogenesis 18 UNIT VI: Nuclear Receptors: Zn Finger proteins and their roles in
 

Summary:  homology. Many of these orphans probably not receptors at all, many appear to be constituitively active... activated receptor (PPAR) and vitamin D receptor (VDR) are all bound to chromatin as a heterodimer... GR/PR/MR Receptor Signaling KEY 7) ...

  

Source: Bradfield, Christopher A. - McArdle Laboratory for Cancer , University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
88 Recombinant Production and Properties of Binding of the Full Set of Mouse Secreted Phospholipases A2 to the Mouse M-Type Receptor
 

Summary:  cases to inhibition of enzymatic activity, and the extent of deglycosylation of the receptor decreases... ) 685-8665. E-mail: gelb@chem.washington.edu. 1 Abbreviations: sPLA2, secreted phospholipase A2 [a... leads to inhibition of enzymatic activity (29, 32). The ...

  

Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle

 

Collection: Chemistry ; Biology and Medicine

 
89 Topology of Class A G Protein-Coupled Receptors: Insights Gained from Crystal Structures of Rhodopsins,
 

Summary:  ., 2004), and strokes and cere- bral hypoperfusion (altered adenosine A2A receptor function... 2A adenosine receptors have been solved at high resolution. This review focuses on the elucidation... Receptor versus Rhodopsin. ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
90 Adenosine triphosphate as a neurotransmitter and neuromodulator Geoffrey Burnstock
 

Summary:  so far, namely A1, A2a, A2b, and A3. The first subclasses for P2-purinoceptors, proposed by Burnstock... BS, Smith WB, Chiu CS, et al. (2001): Activation-dependent changes in receptor distribution... , Le Moine C, Fisone G, et al. (1999): Distribution, biochemistry and function of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
91 List of Abbreviations Acknowledgments
 

Summary:  export pump BUD budesonide C colon CA cholic acid CAR constitutive active/androstane receptor CDCA... transporter PAR pregnane activated receptor PCS precision-cut slices PCIS precision-cut intestinal slices PCLS... growth factor receptor FXR farnesoid X receptor ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
92 Modified Receptor Internalization upon Co-expression of 5-HT1B Receptor and 5-HT2B Agnes Janoshazi*, Maud Deraet*, Jacques Callebert, Vincent Setola, Silke Guenther, Bruno
 

Summary:  receptor subtype upon activation of that receptor subtype. In contrast heterologous desensitization... the activity of a GPCR kinase (GRK)/-arrestin (Marion et al., 2004). Receptor oligomerization is a pivotal... receptor internalization kinetics involved ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
93 Spinal neurons are sensitized following stimuli that activate nociceptors. This central sensitization is
 

Summary:  -methyl-D-aspartate (NMDA) receptor activation is required for their induction (Randic et al. 1993; Liu & Sandkühler, 1995... systems (Basbaum & Fields, 1984). Rapid Report Serotonin 5-HT2 receptor activation induces a long... indicated an essential requirement for activation of ...

  

Source: Hochman, Shawn - Department of Physiology, Emory University

 

Collection: Biology and Medicine

 
94 Stereoselectivity of 8-OH-DPAT toward the serotonin 5-HT1A receptor: Biochemical and molecular modeling study
 

Summary:  of 5-HT1A receptors' activation: decrease of synthesis, turnover [2] and release of 5-HT in different... different intrinsic activity of both enantiomers at 5-HT1A receptors. It is also noteworthy... at the level at presynaptic 5-HT1A receptors between racemic 8-OH-DPAT and its ...

  

Source: Skolnick, Jeff - Center for the Study of Systems Biology, Georgia Institute of Technology

 

Collection: Chemistry ; Biology and Medicine

 
95 Growth differentiation factor 11 signals through the transforming growth factor-b receptor ALK5 to
 

Summary:  : ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­­ ­ ­ ­ ­ ­ ­ ­ ­+ + + + + + + + + + + + ­ ­ + + + + Type II: A2a A2b BRIITII A2a A2b BRIITII TGF-1 No receptor ALK4 ALK5 ALK7 No ligand Xnr1/Cripto GDF11... ,C) R4-2 cells. The results ...

  

Source: Ibáñez, Carlos - Department of Neuroscience, Karolinska Institutet

 

Collection: Biology and Medicine

 
96 Critical ReviewsTM in Neurobiology, 16(3)187224 [2004] 0892-0915/04 $20.00 2004 by Begell House, Inc. 187
 

Summary:  to activation and gating of AMPA, kainate, and NMDA receptors.We refer the reader to several excellent reviews... and receptor activation [Banke et al. 2001]. Elucidation of the structure of the GluR2 bind- ing domain has... ]. IV. CHANNEL ACTIVATION AND GATING: AMPA/KA ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
97 Associate editor: Neve Sensitization of adenylate cyclase by Gai/o-coupled receptorsB
 

Summary:  , and Research Service, Veterans Affairs Medical Center, Portland, OR 97239, USA Abstract Activation of receptors... , persistent activation of Gai/o-coupled receptors produces a paradoxical enhancement of adenylate cyclase... activity, thus increasing cyclic AMP accumulation when the ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine

 
98 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  -inflammatory influence of A2A receptor activation to proinflammatory [8]. Caffeine is an antagonist at both adenosine... , Effects of adenosine A(1) and A(2A) receptor activation on the ...

  

Source: Wenk, Gary - Departments of Psychology & Neuroscience, Ohio State University

 

Collection: Biology and Medicine

 
99 Probing the role of the cation interaction in the binding sites of GPCRs using unnatural amino acids
 

Summary:  . Jaakola VP, et al. (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound... receptor and the D2 dopamine receptor. Receptors were expressed in Xenopus oocytes, and activation of a G... that ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
100 Purinergic signalling in autonomic Alexander V. Gourine1
 

Summary:  -receptor-mediated) and facilitatory (A2A-receptors-mediated) presynaptic actions of adenosine... , adenosine evokes slow EPSP-like excitatory responses mediated via A2A receptors [49]. Adenosine is also... ­1409 49 Gao, N. et ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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