| Sample search results for: abasic clusters implications |
| 1 | Oligonucleotides with Bistranded Abasic Sites Interfere with Substrate Binding and Catalysis by Human Apurinic/Apyrimidinic Endonuclease | ||
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Summary: Oligonucleotides with Bistranded Abasic Sites Interfere with Substrate Binding and Catalysis... DNA repair. The enzyme, which repairs abasic sites, makes a single nick 5 to the phosphodeoxyribose... acting on an oligonucleotide with a single abasic site. We hypothesized that the structural changes |
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Source: Strauss, Phyllis R. - Department of Biology, Northeastern University |
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Collection: Biology and Medicine |
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| 2 | Abasic Site Repair in Higher Eukaryotes Phyllis R. Strauss and Noreen E. O'Regan | ||
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Summary: 3 Abasic Site Repair in Higher Eukaryotes Phyllis R. Strauss and Noreen E. O'Regan 1. INTRODUCTION... of abasic sites generated per mammalian cell per day run as high as 106/cell/d (88). Abasic sites... the large number of abasic sites generated per cell per day, the number of resulting mutations is extremely |
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Source: Strauss, Phyllis R. - Department of Biology, Northeastern University |
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Collection: Biology and Medicine |
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| 3 | DNA Repair 3 (2004) 14471455 Novel role of tyrosine in catalysis by human AP endonuclease 1 | ||
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Summary: in recognizing the abasic site [23,35]. Our data implicate Tyr171 directly in the catalytic event. Electrostatics... ) recognizes abasic sites in ds DNA and makes a single nick in the backbone 5 to the abasic site... . We show that Tyr128 and Tyr269 , which interact upstream and downstream of the ... |
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Source: Strauss, Phyllis R. - Department of Biology, Northeastern University |
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Collection: Biology and Medicine |
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| 4 | Molecular Cell, Vol. 13, 751762, March 12, 2004, Copyright 2004 by Cell Press Snapshots of Replication through | ||
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Summary: of Replication through an Abasic Lesion: Structural Basis for Base Substitutions and Frameshifts and Dbh (Din... B homolog) from two related Sulfolobus strains are able to extend primer strands past abasic sites... an abasic le- right-hand-like structure. The thumb and little finger do-sion. We have determined crystal |
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Source: Ling, Hong - Department of Biochemistry, University of Alberta |
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Collection: Biology and Medicine |
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| 5 | A Core Folding Model for Catalysis by the Hammerhead Ribozyme Accounts for Its Extraordinary Sensitivity to Abasic Mutations | ||
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Summary: Sensitivity to Abasic Mutations Alessio Peracchi,,§ Alexander Karpeisky,| Lara Maloney,| Leonid Beigelman... ReceiVed April 17, 1998; ReVised Manuscript ReceiVed August 4, 1998 ABSTRACT: Introducing abasic... and larger ribozymes are described herein. The deleterious effects of the abasic mutations are not relieved |
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Source: Herschlag, Dan - Department of Biochemistry, Stanford University |
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Collection: Biology and Medicine |
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| 6 | Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation | ||
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Summary: bases or abasic sites: at each cluster site such an enzyme produces two closely spaced single... radiation produces DSBs and clustered lesions containing damaged bases or abasic sites at approximately... that abasic clusters--a damage cluster ... |
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Source: Brookhaven National Laboratory, Environmental Chemistry Division, Department of Applied Science |
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Collection: Environmental Sciences and Ecology |
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| 7 | Cell, Vol. 95, 249258, October 16, 1998, Copyright 1998 by Cell Press Crystal Structure of a Human Alkylbase-DNA | ||
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Summary: ., 1997; David and Williams, 1998). The resultingBoston, Massachusetts 02115 abasic (AP) sites are further... of DNA, causing to DNA containing a transition state mimic of the glyco- the abasic pyrrolidine... nucleotide to flip into the en- sylase reaction, a pyrrolidine abasic nucleotide, which zyme active site |
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Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University |
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Collection: Biology and Medicine |
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| 8 | Effect of lesions on the dynamics of DNA on the picosecond and nanosecond timescales using a | ||
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Summary: is the ¯ipping of the abasic sugar out of the helix and the concomitant intrusion of water into the interior... DNA: an abasic site and a helix terminus. Because these comparisons are looking for small effects... of the oligonucleotides (Fig. 1). When paired with a tetrahydrofuran abasic site analog on the complementary strand |
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Source: Coleman, Robert S. - Department of Chemistry, Ohio State University |
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Collection: Chemistry |
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| 9 | The Coupling of Tight DNA Binding and Base Flipping IDENTIFICATION OF A CONSERVED STRUCTURAL MOTIF IN BASE FLIPPING ENZYMES* | ||
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Summary: recovered (in- crease of 105 -fold) with a DNA substrate lacking the target cytosine base (abasic). Thus... . The molecular basis of enzymatic catalysis is of broad inter- est, with implications for biocatalyst design... -fluorocytosine, and B is an abasic nucleotide. Abox, 5 -GGGAATT- CATGGCGCAGTGGGTGGATCCAG-3 , and 3 |
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Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara |
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Collection: Chemistry ; Biology and Medicine |
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| 10 | DEMETER DNA Glycosylase Establishes MEDEA Polycomb Gene Self-Imprinting | ||
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Summary: in mammals. Imprinted genes reside in chromosomal clusters and are reg- ulated by differentially methylated... -glycosylic bond, creating an abasic site, whereas the lyase activity nicks the DNA. An AP endonuclease generates... the nick to complete the repair process. DNA glycosylase/lyases have not been implicated in mammalian |
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Source: Goldberg, Robert B. - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles |
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Collection: Biology and Medicine |
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| 11 | Z .Mutation Research 460 2000 201210 www.elsevier.comrlocaterdnarepair | ||
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Summary: then expose the target nu- cleotide and cleave the glycosylic bond. The result- ing abasic site is processed... and hypoxanthine, whereas AlkA does not. 1-azaribose and pyrrolidine are potent abasic inhibitors of AlkA and AAG... the structural progress made for the alkylation repair glycosylases AAG and AlkA, and we outline the ... |
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Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University |
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Collection: Biology and Medicine |
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| 12 | New Programs From Old G. RAMALINGAM and THOMAS REPS | ||
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Summary: programmodification operations; D (a,base) yields the program modification performed on base to obtain... apply( D (a,base) + D (b,base), base). The UNIX 2 utility diff yields a simple example of a modification... . A more pre cise interpretation of D (a,base), in the algebra we are interested in, will be given |
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Source: Liblit, Ben - Department of Computer Sciences, University of Wisconsin at Madison |
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Collection: Computer Technologies and Information Sciences |
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| 13 | ANRV260-GE39-03 ARI 21 June 2005 22:14 Immunoglobulin Gene | ||
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Summary: , abasic endonucleases nick the phosphodi- ester backbone at the abasic site, DNA poly- merase synthesizes... the phosphodiester backbone at the abasic site, and DNA polymerase and ligases repair the gap. AID Deaminates Single... they appeared to cluster within the complementarity-determining re- gions ... |
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Source: Maizels, Nancy - Department of Biochemistry, University of Washington at Seattle |
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Collection: Biology and Medicine |
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| 14 | New Programs From Old G. RAMALINGAM and THOMAS REPS | ||
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Summary: programmodification operations; D (a,base) yields the programmodification performed on base to obtain... = apply( D (a,base) + D (b,base), base). The UNIX 2 utility diff yields a simple example of a modification... algebra is defined as follows: a[[base]]b D = ( D (a,base) + D (b,base)) (base). In [Rama91] two different ... |
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Source: Liblit, Ben - Department of Computer Sciences, University of Wisconsin at Madison |
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Collection: Computer Technologies and Information Sciences |
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| 15 | Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions | ||
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Summary: of individual bases to an abasic backbone (Figure 1b), as an alternative route to the nonenzymatic templated... of bases to an abasic backbone to be unlikely given the unfavorable equilibrium of N-glycosidic bond... to be a promising candidate for replication by base filling since the abasic reaction site is a versatile ... |
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Source: Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University |
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Collection: Chemistry ; Biology and Medicine |
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| 16 | BioMed Central Page 1 of 6 | ||
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Summary: the DNA leaving an abasic site where the strand is nicked at both the 3' and 5' ends [6]. The abasic site... Y [9,10], which excises the mispaired adenine A leaving an abasic site. The abasic site opposite... -class is defined by the presence of an evolutionarily well-conserved [4Fe-4S]2+ ... |
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Source: Lunds Universitet, - Computational Biology and Biological Physics Group |
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Collection: Physics ; Biology and Medicine |
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| 17 | 3-Methyladenine DNA glycosylases: structure, | ||
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Summary: A alkA double mutant,(45) again implicating DNA glycosylase- generated abasic sites as the mutagenic... ,28,47) These and other results implicate the abasic site as the responsible mutagenic lesion, but it remains... to produce an abasic site. The abasic site is then ... |
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Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University |
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Collection: Biology and Medicine |
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| 18 | PRINCIPAL ANGLES BETWEEN SUBSPACES IN AN A-BASED SCALAR PRODUCT: ALGORITHMS AND PERTURBATION | ||
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Summary: PRINCIPAL ANGLES BETWEEN SUBSPACES IN AN A-BASED SCALAR PRODUCT: ALGORITHMS AND PERTURBATION... the method to the computation of principal angles in an A-based scalar product for a symmetric and positive... SUBSPACES IN A-BASED SCALAR PRODUCT 2011 Proof. The proof of the theorem is straightforward if based |
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Source: Knyazev, Andrew - Department of Mathematics, University of Colorado at Denver |
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Collection: Mathematics |
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| 19 | Proliferating Cell Nuclear Antigen Promotes Translesion Synthesis by DNA Polymerase * | ||
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Summary: by Pol on undamaged DNA. PCNA also stimulated translesion synthesis of a model abasic site by Pol... experimental conditions, facile by- pass of the abasic site was also detected by DNA polym- erase or (Rad30... -1-1, has been implicated in damage- induced mutagenesis. However, this checkpoint clamp did not stimulate |
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Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 20 | DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG) | ||
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Summary: structures of Salmonella typhi TAG in the unliganded form and in a ternary product complex with abasic DNA... to other glycosylase-DNA structures, the abasic ri- bose is not flipped into the TAG active site... are the crystal structures of Salmonella typhi TAG alone and in complex with abasic DNA and 3mA, together |
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Source: Eichman, Brandt F. - Department of Biological Sciences, Vanderbilt University |
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Collection: Biology and Medicine |
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| 21 | Majorization for Changes in Ritz Values and Canonical Angles Between Subspaces | ||
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Summary: between Subspaces in an A-Based Scalar Product: Algorithms and Perturbation Estimates, SIAM Journal... . Generalization to an ABased Scalar Product 4. Numerical Examples 5. Conclusions #12;4 1. Angles Between... )/k, if k = 0, k = 1, . . . , q. #12;10 3. Generalization to an ABased Scalar Product Let A Rn |
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Source: Knyazev, Andrew - Department of Mathematics, University of Colorado at Denver |
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Collection: Mathematics |
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| 22 | Noncovalent Spin Labeling DOI: 10.1002/anie.201002637 | ||
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Summary: ,7] The strategy for noncovalent labeling was to disconnect the glycosidic bond of C¸ to give an abasic site (F... ) and the free spin-labeled base ç (Figure 1). The spin label would bind in the abasic site through receptor... containing an abasic site with ç, a slow-moving component appears in the EPR spectrum (shown by arrows |
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Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland. |
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Collection: Chemistry |
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| 23 | Characterization of DNA Damage Induced by a Natural Product Antitumor Antibiotic Leinamycin in Human Cancer Cells | ||
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Summary: to generate SSBs via a -elimination reaction that cleaves the O-P bond on the 3- side of the abasic site (22... of an abasic site (29, 30). To obtain clear evidence that leinamycin-induced DNA strand breaks may... spontaneously occur via -elimination reactions at aldehydic abasic sites, we tested whether methoxyamine |
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Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia |
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Collection: Chemistry |
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| 24 | Retrofitting the AutoBayes Program Synthesis System with Concrete Syntax | ||
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Summary: as for example expectation maximization (EM) [10] and nearest neighbor clustering (k-Means); usually... ) :- ... model_gensym(simplex, Simplex), SDim = [dim( A_BASE, Size1) , dim( A_BASE, Size0) ], SDecl = matrix... , '-dimensional space'])]) , ... var_fresh(I), var_fresh(J), index_make([I, dim( A_BASE, Size0) ... |
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Source: Utrecht, Universiteit - Department of Information and Computing Sciences |
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Collection: Computer Technologies and Information Sciences |
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| 25 | This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research | ||
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Summary: ironsulfur cluster-bearing enzymes, thereby destabilizing and/or releasing Fenton- ready Fe2+ [19... /synthesis of heavily degraded ironsulfur clusters [28], Fur-regulated iron import and utilization [29], as well... R-regulated ironsulfur cluster synthesis machinery). Importantly, to prove that the observed generation of ... |
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Source: Collins, James J. - Wyss Institute for Biologically Inspired Engineering & Department of Biomedical Engineering, Boston University |
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Collection: Engineering ; Biotechnology |
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| 26 | Submitted to J. Biol. Chem. Draft of July 13, 2001 | ||
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Summary: Submitted to J. Biol. Chem. Draft of July 13, 2001 Characterization of a Spin-Labeled Abasic Double... /apyrimidinic endonuclease; ASR, abasic site repair, bp, base pair; ds, double-stranded; ESR, electron spin resonance; HDP... structure, ss, single- stranded #12;3 Introduction Abasic site repair (ASR) refers to one of several ... |
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Source: Strauss, Phyllis R. - Department of Biology, Northeastern University |
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Collection: Biology and Medicine |
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| 27 | Supplementary information for The structural basis of RNA-catalyzed RNA polymerization | ||
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Summary: -hydrated metal clusters were treated as monomers during refinement, having defined model residues with idealized... geometries of calcium hydrate clusters26,27 , bound waters were not built unless their geometry with respect... to the calcium ion was clearly indicated in difference Fourier maps. For the metal-hydrate clusters ... |
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Source: Bartel, David - Whitehead Institute for Biomedical Research & Department of Biology, Massachusetts Institute of Technology (MIT) |
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Collection: Biotechnology ; Biology and Medicine |
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| 28 | Human Apurinic/Apyrimidinic Endonuclease Is Processive, Daniel C. Carey and Phyllis R. Strauss* | ||
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Summary: abasic sites in the base excision repair pathway. AP endo makes a single nick 5 to an abasic site... in double-stranded DNA. In this study, we investigated whether AP endo locates an abasic site through... a processive or a distributive mechanism. We used a linear multi-abasic site substrate (concatemer |
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Source: Strauss, Phyllis R. - Department of Biology, Northeastern University |
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Collection: Biology and Medicine |
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| 29 | Abstract Deciphering the networks of interactions be-tween molecules in biological systems has gained mo- | ||
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Summary: implicated in the licensing of DNA replication"). A more comprehensive example is shown for cluster B (Fig. 4... associated to different gene expression clusters by mining collections of Medline abstracts. GEISHA is based... on a comparison of the frequency of abstracts linked to different gene clusters and ... |
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Source: Blaschke, Christian - Centro Nacional de Biotecnologia, Universidad Autonoma de Madrid |
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Collection: Biotechnology |
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| 30 | Forma: A Framework for Safe Automatic Array University of Alberta | ||
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Summary: of the original array. From the array point of view, the orig- inal array Aorig is split into one base array Abase... base array Abase and the other two rows are the new satellite arrays. How the satellite fields... is to split a data structure according to access affinity: the fields in a data structure are clustered |
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Source: Amaral, José Nelson - Department of Computing Science, University of Alberta |
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Collection: Computer Technologies and Information Sciences |
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| 31 | DNA polymerases in adaptive immunity Jean-Claude Weill and Claude-Agns Reynaud | ||
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Summary: . Effectively, the action of UNG is restricted to uracil excision, giving rise to abasic sites, and... -passing abasic sites, one should expect that inactivation of a polymerase involved in SHM would result... a deoxycytidyltransferase activity that is directed opposite various damaged bases, as well as abasic sites and normal ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 32 | An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals | ||
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Summary: Backbone 1749 2.4. Properties of Abasic Sites Arising from Depurination 1749 3. Overview: Common Reactions... ). The oxocarbenium ion undergoes subsequent hydrolysis to yield an abasic site 7 (often referred to as an apurinic... site or AP site). It is calculated that spontaneous depurination generates about 10 000 abasic sites |
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Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia |
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Collection: Chemistry |
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| 33 | In vivo Recombination After Chronic Damage Exposure Falls to Below Spontaneous Levels in ``Recombomice'' | ||
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Summary: of recombinogenic strand breaks and abasic sites. As a first step toward revealing the molecular basis... #12;yield abasic sites that are subsequently repaired by downstream BER enzymes (44). It is well... established that conditions that result in increased levels of BER intermediates, such as abasic sites |
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Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT) |
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Collection: Biology and Medicine |
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| 34 | NIST NCSTAR 1-5D (Draft) Federal Building and Fire Safety Investigation of the | ||
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Summary: , or implication that the entities, products, materials, or equipment are necessarily the best available... ............................................................................................................... 77 4.2 Implications of Test Results |
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Source: National Institute of Standards and Technology (NIST), Ceramics Division |
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Collection: Materials Science |
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| 35 | Charge Transport in DNA Oligonucleotides with Various Base-Pairing Patterns Irena Kratochvilova,*, | ||
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Summary: . Structurally and thermally much less stable abasic duplexes have still lower conductivity but not markedly... , four, and five base pairs, respectively, eliminated from their central parts (ABA- SIC3, ABASIC4... , and ABASIC5). All of the duplexes were prepared from single-stranded oligonucleotides synthesized in an ABI |
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Source: Kuel, Petr - Institute of Physics, Academy of Sciences of the Czech Republic |
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Collection: Physics |
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| 36 | Clustering in a Multi-Agent Data Mining Environment | ||
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Summary: Clustering in a Multi-Agent Data Mining Environment Santhana Chaimontree, Katie Atkinson and Frans... }@liverpool.ac.uk Abstract. A Multi-Agent based approach to clustering using a generic Multi-Agent Data Mining (MADM... ) framework is described. The process use a collection of agents, running several different clustering |
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Source: Coenen, Frans - Department of Computer Science, University of Liverpool |
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Collection: Computer Technologies and Information Sciences |
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| 37 | Direct Real Time Observation of Base Flipping by the EcoRI DNA Methyltransferase* | ||
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Summary: for the binding of the methyltransferase to DNA containing abasic sites or base analogs incorpo- rated... - deoxyriboside, and abasic) were purchased from Glenn Research (Ster- ling, VA), and standard phosphoramidites... (purine), or a stable abasic site (spacer)); bot- tom strands, d(CCGCGAATTCCGCC), d(CCGCGAATTCCGCC), and d |
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Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara |
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Collection: Chemistry ; Biology and Medicine |
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| 38 | AID in antibody perfection A.C. Vallura | ||
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Summary: an abasic site for further repair. Neuberger and colleagues reasoned that if AID deaminates DNA directly... ]. Downstream steps in muta- genesis may inhibit progression of AID along the DNA; or, alternatively, clustered... opposite U, at abasic sites, or in the course of repair [58]. However, there is no evidence thus far |
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Source: Maizels, Nancy - Department of Biochemistry, University of Washington at Seattle |
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Collection: Biology and Medicine |
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| 39 | Substrate Binding by Human Apurinic/Apyrimidinic Endonuclease Indicates a Briggs-Haldane Mechanism* | ||
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Summary: Apurinic/apyrimidinic endonuclease (AP endo) makes a single nick 5 to a DNA abasic site. We have character... been expressed in Escherichia coli. The substrate was a 49- base pair oligonucleotide with an abasic... the abasic site during treatment with uracil-DNA glycosylase with a reducing agent. Otherwise, a 20-mer |
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Source: Strauss, Phyllis R. - Department of Biology, Northeastern University |
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Collection: Biology and Medicine |
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| 40 | An Alternative Prior Process for Nonparametric Bayesian Clustering | ||
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Summary: -get-richer implications: Small # of large clusters Large # of small clusters Rich-get-richer isn't always appropriate... An Alternative Prior Process for Nonparametric Bayesian Clustering Hanna Wallach (UMass Amherst... for Bayesian Clustering :: 2 Nonparametric Bayesian ... |
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Source: Berger, Emery - Department of Computer Science, University of Massachusetts at Amherst |
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Collection: Computer Technologies and Information Sciences |
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| 41 | Supplementary Material Comparative chemometric and QSAR/SAR study of structurally | ||
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Summary: with AmpC-Lactamase: Possible Implications for Substrate-Assisted Catalysis. J. Am. Chem. Soc. 122 (2000... structures without hydrogen bonding: DNA with pyrene paired at abasic sites. Nucl. Acids Res. 30 (2002) 5561... without hydrogen bonding: DNA with pyrene paired at abasic sites. Nucl. Acids Res. 30 (2002) 5561-5569. 1 |
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Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas |
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Collection: Chemistry |
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| 42 | Rob Stewart, Ph.D.Rob Stewart, Ph.D. Associate Professor of Health Sciences | ||
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Summary: :00-8:00 a.m., Ballroom B Induction, Repair and Biological Consequences of Clustered DNA Lesions #12;HPS 2006... , Thursday, June 29, 2006CELCEL--8 Induction, Repair and Biological Consequences of Clustered DNA8 Induction... , Repair and Biological Consequences of Clustered DNA LesionsLesions Rob Stewart, Purdue University School |
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Source: Stewart, Robert D. - School of Health Sciences, Purdue University |
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Collection: Biology and Medicine |
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| 43 | Notes & Tips A nonisotopic assay for unambiguous assignment of DNA | ||
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Summary: but leave be- hind an abasic or apurinic/apyrimidinic (AP)1 site in DNA [4]. Thus, for the analysis... strand scission adjacent to the abasic site. The lack of current DNA glycosylase assays to concur- rently... detect abasic DNA products and AP-lyase products has likely been a contributing factor in controversies |
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Source: Boston University, Center for Advanced Biotechnology |
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Collection: Biotechnology |
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| 44 | ARBEITSGRUPPEN DEPARTEMENT FR CHEMIE UND BIOCHEMIE | ||
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Summary: -ray tomography and gas adsorption: comparison and implications for surface smoothness, Atmos. Chem. Phys. Discuss... of nickel and cobalt spin clusters Polyhedron 26, 369-377 (2007) 55. J. Grimm, J. Fleniken, K. W. Krämer, D... Boskovic Synthesis, structure and magnetic properties of a novel Tb4 spin cluster and synthesis of a ... |
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Source: Mühlemann, Oliver - Institut für Zellbiologie, Universität Bern |
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Collection: Biology and Medicine |
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| 45 | The Cost of Privacy: Destruction of Data-Mining Utility in Anonymized Data Publishing | ||
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Summary: knowledge Abase is the minimum information about sensitive attributes that he can learn after any... separately. Abase is the distribution of sensitive attributes in the original table, which is revealed by any... to the adversary. We for- mally define Abase as the vector of probabilities representing the distribution |
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Source: Shmatikov, Vitaly - Department of Computer Sciences, University of Texas at Austin |
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Collection: Computer Technologies and Information Sciences |
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| 46 | PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Columbia University HHMI] | ||
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Summary: ://www.informaworld.com/smpp/title~content=t713697337 Evaluation of lesion clustering in irradiated plasmid DNA C. Leloup a ; G. Garty a ; G. Assaf... of lesion clustering in irradiated plasmid DNA',International Journal of Radiation Biology,81:1,41 -- 54... ;Evaluation of lesion clustering in irradiated plasmid DNA C. LELOUP1 , ... |
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Source: Nevis Laboratories, Radiological Research Accelerator Facility |
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Collection: Fission and Nuclear Technologies ; Biology and Medicine |
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| 47 | Site-Directed Spin-Labeling of Nucleic Acids by Click Chemistry: Detection of Abasic Sites in Duplex DNA by EPR | ||
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Summary: Site-Directed Spin-Labeling of Nucleic Acids by Click Chemistry: Detection of Abasic Sites... that can detect and identify local structural deformations in duplex DNA, in particular abasic sites... , for the first time, abasic sites in duplex DNA by X-band CW-EPR spectroscopy and give information about other |
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Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland. |
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Collection: Chemistry |
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| 48 | Fluorescence Probing of Aminofluorene-Induced Conformational Heterogeneity in DNA Duplexes | ||
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Summary: structurefunction relationships (1315). AF-induced S/B heterogeneity has been implicated in the modulation... Society Published on Web 01/15/2008 #12;sequencing (17), abasic sites (18), base flipping (19, 20), metal... the spacing between the isotopic ions in the (M - 3H)3- cluster. (B) LC-TOF/MS chromatograms of individual ... |
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Source: Cho, Bongsup P. - Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island; Rhode Island, University of - Department of Physics, Division of Biological and Medical Physics |
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Collection: Biology and Medicine |
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| 49 | DOI: 10.1126/science.1211917 , 1229 (2011);333Science | ||
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Summary: in the epigenetics field, particularly given studies implicating TET in global and locus- specific DNA demethylation... - base by thymine-DNA glycosylase (TDG). Subsequent repair of the resulting abasic site would restore... unmodified cytosine. TDG has been previously implicated in demethyl- ation, as its absence is embryonic |
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Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences |
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Collection: Biology and Medicine |
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| 50 | Effect of Protein Binding on Ultrafast DNA Dynamics: Characterization of a DNA:APE1 Complex | ||
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Summary: oligonucleotide at the abasic site opposite the coumarin with only a fourfold reduction in rate. In addition... in binding constant relative to a native oligonucleotide containing a guanine opposite the abasic site. Thus... a fluorescent coumarin group replaces a native base (Fig. 1) (7). An abasic-site analog (THF) (8) is ... |
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Source: Coleman, Robert S. - Department of Chemistry, Ohio State University |
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Collection: Chemistry |
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| 51 | Mutation Research 485 (2001) 2336 Nucleotide excision repair "a legacy of creativity" | ||
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Summary: elaborated extensively on its implications. A cursory survey illustrates his many 0921-8777/01/$ see front... structurally [2]. The implications of the double stranded structure, however, in providing an inherent... areas of interest arise concerning future studies NER, in particular, and by implication other repair |
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Source: Karplus, Kevin - Department of Biomolecular Engineering, University of California at Santa Cruz |
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Collection: Biotechnology ; Chemistry |
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| 52 | ARBEITSGRUPPEN DEPARTEMENT FR CHEMIE UND BIOCHEMIE | ||
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Summary: Clusters and Implications to the Light Up- #12;9 Conversion in "Computational Chemistry: Reviews of Current... Properties of Ag2S and PbS Clusters in Zeolite A Chem. Eur. J., 11, 7191-7198 (2005). 11. Gion Calzaferri... -760. DFT study of mixed valent Mn(II/III) hexacyanide clusters. 20. S.G. Baca, I.G. ... |
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Source: Mühlemann, Oliver - Institut für Zellbiologie, Universität Bern |
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Collection: Biology and Medicine |
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| 53 | Chemistry & Biology, Vol. 12, 357369, March, 2005, 2005 Elsevier Ltd All rights reserved. DOI 10.1016/j.chembiol.2004.12.011 Delineation of the Chemical Pathways Underlying | ||
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Summary: of guanine leads to 8-oxoguanine and its secondary ox- idation products, 8-nitroguanine, as well as abasic... double-strand breaks by direct reaction with DNA [32, 34, 35]. How- ever, base lesions, abasic sites... breaks, abasic sites, and base lesions induced and effective measure of recombination at a single lo |
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Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT) |
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Collection: Biology and Medicine |
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| 54 | Pure Appl. Chem., Vol. 83, No. 3, pp. 677686, 2011. doi:10.1351/PAC-CON-10-09-28 | ||
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Summary: on noncovalent interactions between a spin-labeled nucleobase and an abasic site in duplex DNA. Keywords: EPR... Postsynthetic spin labeling of nucleobases by click chemistry: Detection of abasic sites The success... been used to detect abasic sites in DNA [21], which are biologically relevant nucleic acid lesions [22 |
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Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland. |
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Collection: Chemistry |
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| 55 | Towards an Infrastructure for Temporal Databases: Report of an Invitational ARPA/NSF Workshop | ||
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Summary: .rea of research for the last fifteen years, with a corpus nearing 700 papers [Kline93]. Most d&abase conferences |
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Source: Snodgrass, Richard T. - Department of Computer Science, University of Arizona |
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Collection: Computer Technologies and Information Sciences |
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| 56 | Noncysteinyl Coordination to the [4Fe-4S]2+ Cluster of the DNA Repair Adenine | ||
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Summary: of a unique subfamily of DNA repair enzymes that also contain a [4Fe-4S]2+ cluster, which has been implicated... Noncysteinyl Coordination to the [4Fe-4S]2+ Cluster of the DNA Repair Adenine Glycosylase Mut... -Coordinated Cluster, Troy E. Messick,§ Nikolas H. Chmiel,| Marie-Pierre Golinelli,|, Michael R. ... |
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Source: Joshua-Tor, Leemor - W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory |
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Collection: Biology and Medicine |
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| 57 | Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase | ||
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Summary: completely when the target cytosine is replaced with an abasic sugar.23 Thus, Val121 is important... is replaced with an abasic site (Table 2). F84A is decreased dramatically in catalysis as well (Table 3, 1000... affinity using abasic DNA with F84A demonstrates a direct coupling of the loop positioning and target |
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Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara |
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Collection: Chemistry ; Biology and Medicine |
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| 58 | Single-Turnover Analysis of Mutant Human Apurinic/Apyrimidinic Endonuclease, Julie A. Lucas, Yuji Masuda,|, Richard A. O. Bennett,| Nathaniel S. Strauss,,@ and Phyllis R. Strauss*, | ||
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Summary: and cleavage of abasic site-containing DNA. Apurinic/apyrimidinic endonuclease (AP endo) is a human enzyme... that is critical to the repair of abasic sites in DNA arising through either base excision repair or oxidative... damage. AP endo recognizes abasic sites in DNA and cleaves the phosphodiester backbone 5 to the ... |
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Source: Strauss, Phyllis R. - Department of Biology, Northeastern University |
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Collection: Biology and Medicine |
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| 59 | Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 | ||
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Summary: of 10-3 to 10-4 when synthesizing undamaged DNA and can traverse various lesions, such as abasic sites... - plex with an abasic site (Ling et al. 2004a). While recent pre-steady-state kinetic data (Fiala and Suo... and Schaa¨ r 2004) based on the crystal structure of Dpo4 with an abasic lesion (Ling et al. 2004a |
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Source: Schlick, Tamar - Department of Chemistry, New York University |
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Collection: Chemistry |
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| 60 | Domain Mapping of Human Apurinic/Apyrimidinic Endonuclease STRUCTURAL AND FUNCTIONAL EVIDENCE FOR A DISORDERED AMINO TERMINUS AND A TIGHT | ||
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Summary: , became strikingly less accessible to protease digestion in the presence of abasic site-containing DNA... of the nuclease fold, there must be multiple means by which DNA containing an abasic site associates... in the repair of abasic sites in DNA. These sites can arise through spontaneous loss of a nucleobase, through |
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Source: Strauss, Phyllis R. - Department of Biology, Northeastern University |
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Collection: Biology and Medicine |
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| 61 | Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases and REV1 | ||
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Summary: is a deoxycytidyl transferase that shows the highest catalytic activity opposite template guanines and abasic sites... (14, 15). Rev1 is primarily responsible for inserting dC residues opposite abasic sites during... oligonucleotide-based system was used in which the template strand contained a model abasic site at a well ... |
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Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 62 | Cosmological Implications from an XRay FluxLimited Sample of Galaxy Clusters | ||
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Summary: Cosmological Implications from an XRay FluxLimited Sample of Galaxy Clusters Thomas H. Reiprich... . A new Xray selected/Xray fluxlimited galaxy cluster sample of the 63 Xray brightest clusters... in the sky has been compiled from recent Xray cluster catalogs based on the ... |
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Source: Reiprich, Thomas - Department of Astronomy, University of Virginia |
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Collection: Physics |
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| 63 | ARTICLE IN PRESS An investigation of the variation in the transition bias among various | ||
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Summary: . Oxygen free radicals have at least two mutagenic effects: (i) they generate abasic sites (Schaaper et al... -generation of abasic sites-is expected to affect the ts/tv ratio because DNA polymerases tend to incoporate A opposite... abasic sites; if the site which has become abasic was G, then we get a C to A ... |
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Source: Eyre-Walker, Adam - Department of Biology and Environmental Science, University of Sussex |
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Collection: Biology and Medicine |
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| 64 | The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe | ||
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Summary: -only clusters seem to be next to clusters implicated in photosyn- thesis or electron transport. These GOS... used sequence similarity clustering to explore proteins with a comprehensive dataset consisting... families. A total of 3,995 medium- and large-sized clusters consisting of only ... |
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Source: Herr, Amy E. - Department of Bioengineering, University of California at Berkeley |
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Collection: Biology and Medicine ; Chemistry |
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| 65 | Stereoselectivity in DNA-Templated Organic Synthesis and Its Origins Xiaoyu Li and David R. Liu* | ||
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Summary: of the 12 template nucleotides closest to the 5 bromide in the end-of-helix reaction with chiral abasic... aromatic bases from the 3 end of the abasic region instead of from the 5 end also induced stereoselec... helix is consistent with our model implicating the conformation of the template and reagent |
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Source: Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University |
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Collection: Chemistry ; Biology and Medicine |
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| 66 | Small interfering RNAs (siRNAs) can target the RNA interference (RNAi) | ||
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Summary: et al. reveal the molecular details by which this occurs, and implicate Rac1b as the main culprit... or uracil from G·T and G·U mismatches and remains stably bound to the resulting abasic site until... the abasic site, and the 2.1-Å-resolution crystal structure of the central region of human TDG conjugated |
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Source: Nelson, Celeste M. - Departments of Molecular Biology & Chemical Engineering, Princeton University |
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Collection: Biology and Medicine ; Biotechnology |
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| 67 | int. j. radiat. biol 2001, vol. 77, no. 2, 155 164 DNA strand break yields after post-high LET irradiation | ||
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Summary: irradiation incubation with endonuclease-III and evidence for hydroxyl radical clustering J. R. MILLIGAN*, J... . Conclusion: The results provide evidence for clustered DNA These products include breaks in one or both... -called clustered or multipleRadiation Oncology, University of California at San Francisco, San Francisco, CA ... |
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Source: Nevis Laboratories, Radiological Research Accelerator Facility |
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Collection: Fission and Nuclear Technologies ; Biology and Medicine |
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| 68 | Homologous recombination prevents methylation-induced toxicity in Escherichia coli | ||
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Summary: A and constitutive Tag glycosylases constitute a second mechanism to remove principally N3-meA, creating an abasic... glycosylases remove methylated bases (filled circle) and the resulting abasic site is recognized and cleaved... formation. (C) Depurination of methylated bases results in the formation of abasic sites which |
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Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT) |
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Collection: Biology and Medicine |
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| 69 | research papers 812 doi:10.1107/S090744490702464X Acta Cryst. (2007). D63, 812825 | ||
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Summary: , Biological Chemistry Cluster, River Campus Box 270216, University of Rochester, Rochester, New York 14627... allowed structures to be determined for numerous nucleotide variants. However, abasic and other... transition-state mimics or abasic residues, since these modifications have the potential to further reduce |
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Source: Wedekind, Joseph E. - Department of Biochemistry and Biophysics, University of Rochester |
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Collection: Biology and Medicine |
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| 70 | Identification of the Hammerhead Ribozyme Metal Ion Binding Site Responsible for Rescue of the Deleterious Effect of a Cleavage Site Phosphorothioate | ||
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Summary: and substrate variants at positions P9, G10.1, and P1.1 (the cleavage site). Abasic and phenyl... of saturating Cd2+ ; mutant ribozymes are denoted by the residue that is modified: pyr, 4-pyridinone; X, abasic... nucleotide; e.g., A9X refers to a ribozyme with an abasic residue at position 9; S refers to phosphorothioate |
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Source: Herschlag, Dan - Department of Biochemistry, Stanford University |
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Collection: Biology and Medicine |
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| 71 | Benefit/cost analysis for Transportation Infrastructure: A Practitioner's Workshop:Infrastructure: A Practitioner s Workshop | ||
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Summary: Abased in region A. the region's factors of production (e.g. labor) are mobile and migrate out... are profit driven and so consider the implications of transportation on BOTH there costs and and revenues |
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Source: Texas A&M University, Texas Transportation Institute |
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Collection: Engineering |
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| 72 | Molecular Cell, Vol. 15, 607620, August 27, 2004, Copyright 2004 by Cell Press The Fanconi Anaemia Gene FANCC Promotes | ||
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Summary: approach to identifyenously generated abasic sites. Moreover in these ver- the type of repair defect in FA... damage. DT40 cells also transit teins well implicated in recombination repair (BRCA1, very rapidly... for the repair of endogenously generated abasic sites in theseen in human FA cells. FANCC knockout (KO) cells |
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Source: Patel, KJ - Laboratory of Molecular Biology, MRC |
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Collection: Biology and Medicine |
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| 73 | Stereoelectronic Effects in Nucleosides and Nucleotides and | ||
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Summary: Stereoelectronic Effects in Nucleosides and Nucleotides and their Structural Implications... , "Stereoelectronic Effects in Nucleosides & Nucleotides and their Structural Implications", Dept of Bioorganic... et al, "Stereoelectronic Effects in Nucleosides & Nucleotides and their Structural Implications |
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|
Source: Uppsala Universitet - Department of Population Biology |
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Collection: Environmental Sciences and Ecology |
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| 74 | Dissociative electron attachment to abasic DNA Sylwia Ptasin ska* and Le on Sanche | ||
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Summary: Dissociative electron attachment to abasic DNA Sylwia Ptasin´ ska* and Le´ on Sanche Received 15th... on that group. Zheng et al.15 repeated these experiments with abasic forms of the tetramer GCAT, i.e., XCAT... by the presence of an abasic site; in both XCAT and GCXT, the yield of detached bases was found to be up |
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|
Source: Simons, Jack - Department of Chemistry, University of Utah |
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Collection: Chemistry |
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| 75 | Cell, Vol. 110, 3342, July 12, 2002, Copyright 2002 by Cell Press DEMETER, a DNA Glycosylase Domain Protein, | ||
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Summary: , intron. (B) Conservation of DNA glycosylase domain, cysteine cluster, and lysine-rich region in Ara... glycosylases with a (4Fe-4S)2 cluster. Conserved cysteines are in red boxes. (E) Comparison of DME to Xenopus... )2 cluster in place. Thisconserved domain search of NCBI databases revealed #12;Cell 36 ... |
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Source: Goldberg, Robert B. - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles |
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Collection: Biology and Medicine |
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| 76 | Mikstko, J. & McLaren, B.M. (2008). What's in a Cluster? Automatically Detecting Interest-ing Interactions in Student E-Discussions. In B. Woolf, E. Aimeur, R. Nkambou, S. Lajoie | ||
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Summary: Miksátko, J. & McLaren, B.M. (2008). What's in a Cluster? Automatically Detecting Interest- ing... Science, 5091 (pp. 333-342). Berlin: Springer. What's in a Cluster? Automatically Detecting Interesting... of clusters of contributions representing interaction patterns that are of pedagogical interest (e |
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Source: McLaren, Bruce Martin - School of Computer Science, Carnegie Mellon University |
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Collection: Computer Technologies and Information Sciences |
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| 77 | dna repair 5 ( 2 0 0 6 ) 294302 available at www.sciencedirect.com | ||
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Summary: , oxidative base damage, covalent base modifications by enzymes, and spontaneously generated abasic sites... mutations. Lastly, we consider the implication of multiple ran- dom mutations in tumors. Fig. 1... remove different lesions in DNA, e.g. alkylated, abasic and modified bases are removed by base excision |
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Source: Bielas, Jason H. - Bielas, Jason H. - Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington at Seattle |
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Collection: Biology and Medicine |
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| 78 | Nov 612:31 PM Mth171 Agenda Thu. 11/6 | ||
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Summary: :48 PM Volume Formulae: It is a (perhaps suprising) fact that the volume of any prism is V = (Abase... suprising) fact that the volume of any pyramid is V = (1/3)(Abase)(h) That is, the volume of a pyramid |
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Source: Hasenbank, Jon - Mathematics Department, University of Wisconsin-La Crosse |
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Collection: Mathematics ; Multidisciplinary Databases and Resources |
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| 79 | The Power of Word Clusters for Text Classification Noam Slonim and Naftali Tishby | ||
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Summary: The Power of Word Clusters for Text Classification Noam Slonim and Naftali Tishby School... already suggested applying this method for document clustering, gene expression data analysis, spectral... classification. Specifically, we apply the information bottleneck method to find word-clusters that preserve |
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Source: Hebrew University, School of Computer Science and Engineering, Machine Learning Lab. |
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Collection: Computer Technologies and Information Sciences |
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| 80 | Comparison of methods for melt detection over Greenland using active and passive microwave measurements | ||
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Summary: . These winter mean images are the estimates of s0 dry and Tdry b used in the implementation of a-based melt... : the definition for q(t) and a constant threshold q0. 4.1 a-based methods The simplified melt event model... QSCAT, ERS and SSM/I measurements. This is termed a-based melt detection because the threshold is based |
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Source: Long, David G. - Department of Electrical and Computer Engineering, Brigham Young University |
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Collection: Engineering |
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| 81 | Chemical Properties of the Leinamycin-Guanine Adduct Tony Nooner, Sanjay Dutta, and Kent S. Gates* | ||
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Summary: biological implications of this rapid depurination process are considered. Finally, during the course... cytotoxicity. Our results indicate that leinamycin is an efficient reagent for the rapid generation of abasic... sites in DNA under physi- ological conditions. Abasic sites, and the strand breaks |
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Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia |
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Collection: Chemistry |
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| 82 | Subspace Clustering, Ensemble Clustering, Alternative Clustering, Multiview Clustering | ||
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Summary: . The anti- monotonic reverse implication, if a subspace T does not contain a cluster, then any superspace... Subspace Clustering, Ensemble Clustering, Alternative Clustering, Multiview Clustering: What Can We... Though subspace clustering, ... |
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Source: Kriegel, Hans-Peter - Institut für Informatik, Ludwig-Maximilians-Universität München |
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Collection: Computer Technologies and Information Sciences |
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| 83 | Table of Contents 1. RADIO OBSERVATIONS OF CLUSTER HALOS | ||
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Summary: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 7. SIMULATIONS OF PLASMAPHYSICAL PROCESSES IN CLUSTERS Numerical Simulation Implications... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... |
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Source: Boehringer, Hans - Max-Planck-Institut für extraterrestrische Physik |
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Collection: Physics |
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| 84 | Abstract The topological organization of interfacing neuronal populations in the basal forebrain of rats was | ||
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Summary: by these methods may help to define neuronal clusters in this brain area where simple two-dimensional histology... failed to reveal such an arrangement. Neuronal clusters have been sug- gested in many brain regions... implicated in attention, motivation, memory, cortical plasticity as well as in a number of neuropsychiatric |
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Source: Nadasdy, Zoltan - Division of Biology, California Institute of Technology; Zaborszky, Laszlo - Center for Molecular and Behavioral Neuroscience, Rutgers University at Newark |
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Collection: Biology and Medicine |
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| 85 | Tight Clustering: a Resampling-based Approach for Identifying Stable and Tight | ||
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Summary: to obtain the underlying biological implication of the clusters in a more reliable manner. We present here... Tight Clustering: a Resampling-based Approach for Identifying Stable and Tight Patterns in Data... for clustering that produces tight and stable clusters without forcing all ... |
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Source: Wong, Wing Hung - Department of Statistics, Stanford University |
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Collection: Mathematics ; Biology and Medicine |
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| 86 | THEJOURNAL OF BIOLOGICAL CHEMISTRY 01993by The American Society for Biochemistry and Molecular Biology, Inc | ||
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Summary: tobase-on cobam- ides. The Co/Fe-S componentalso contains a 14Fe-4SI2+/'+cluster withan E'oat pH 7... acetate (Fig. 1). In additiontotheCo/Fe-Scomponent,othercorrinoid- containing enzymes are implicated... for the analogous corrinoid/iron-sulfur protein from C. thermoaceticum, which also has abase-off cobamide (32 |
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Source: Ferry, James G. - Department of Biochemistry and Molecular Biology, Pennsylvania State University |
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Collection: Biology and Medicine |
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| 87 | The University of Western Ontario DEPARTMENT OF PHYSICS AND ASTRONOMY | ||
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Summary: formation in the Perseus cluster of galaxies" ABSTRACT The Perseus cluster rivals the Coma cluster... by the special location in the central a galaxy cluster. In this talk I will discuss the emerging astrophysical... description of the ISM in NGC1275, and its implications for ... |
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Source: Lennard, William N. - Department of Physics and Astronomy, University of Western Ontario |
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Collection: Materials Science ; Physics |
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| 88 | Meta Clustering Rich Caruana, Mohamed Elhawary, Nam Nguyen, Casey Smith | ||
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Summary: Meta Clustering Rich Caruana, Mohamed Elhawary, Nam Nguyen, Casey Smith Cornell University Ithaca... , New York 14853 {caruana, hawary, nhnguyen, casey}@cs.cornell.edu Abstract Clustering is ill... error, clustering quality depends on how the clusters will be used. Devising clustering ... |
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Source: Caruana, Rich - Department of Computer Science, Cornell University |
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Collection: Computer Technologies and Information Sciences |
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| 89 | 10.1101/gad.1963010Access the most recent version at doi: 2010 24: 2107-2114Genes Dev. | ||
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Summary: genes, have both been implicated in oncogenesis (Ehrlich 2009). Additionally, it is clear... in mammals (Millar et al. 2002; Hardeland et al. 2003). The resulting abasic site would then be replaced... 45 family of proteins, previously implicated in active demeth- ylation in X. laevis (Barreto et al |
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Source: Papavasiliou, F. Nina - Laboratory of Lymphocyte Biology, Rockefeller University |
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Collection: Biology and Medicine |
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| 90 | Coherent Dependence Clusters Jens Krinke | ||
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Summary: of the dependence relation used in forming dependence clusters and discusses some implications. Harman et al. [15... Coherent Dependence Clusters Syed Islam Jens Krinke David Binkley Mark Harman Centre for Research... Large clusters of mutual dependence can cause problems for com- prehension, testing and ... |
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Source: Harman, Mark - Department of Computer Science, King's College London |
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Collection: Computer Technologies and Information Sciences |
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| 91 | Actuarial Science Related Career Opportunities | ||
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Summary: cessing, al analysis abase manipulation, VA, How to De About Act Proficiency in word pro spreadsheets |
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Source: Wisconsin at Madison, University of - Department of Engineering Physics, Computational Materials Group |
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Collection: Fission and Nuclear Technologies ; Materials Science |
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| 92 | The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI | ||
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Summary: .HhaI/DNA structure in which the target cytosine and sugar were replaced with an abasic South-constrained carbocyclic... sugar analog.25 We recently identified a motif observed in many DNA modifying enzymes, implicated... . Binding and kinetic constants for the WT, R165A and V12lA M.HhaI KD AdoMet (M) KD DNA-Abox (pM)a KD ... |
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Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara |
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Collection: Chemistry ; Biology and Medicine |
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| 93 | SURVEY AND SUMMARY Comparative analysis of editosome proteins in | ||
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Summary: -resolution X-ray crystal structures of HAP1 in complex with abasic DNA have been resolved, allowing a detailed... substitution of these amino acids results in a decrease in abasic incision potency and an increase in 3¢®5¢ DNA... to one of the kinesin light chain repeats (IPB002151C), which has been implicated in protein |
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Source: Schnaufer, Achim - Institute of Immunology and Infection Research, University of Edinburgh |
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Collection: Biology and Medicine |
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| 94 | McGill Global Health Programs Annual Report 2009/2010 | ||
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Summary: the creat ith key instit ation13 . Mo cGill Univers Global Heal abase has se ository for b ut the multit... cators involv tinues to ma abase in ord areness of gl Gill and foste ong the man dents, institu olved... in glob n interactive nity service, all aim of fo d to raise aw sion in this re of research abase curre |
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Source: Barthelat, Francois - Department of Mechanical Engineering, McGill University |
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Collection: Engineering |
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| 95 | Identification of critical chemical features for Aurora kinase-B inhibitors using Hip-Hop, virtual screening and molecular docking | ||
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Summary: cluster analysis and test set containing structurally diverse as well as the selective inhibitors... -terminal lobe is rich in b-strands, which implicated in nucleotide binding, interact with kinase regulators... discovery [15]. These recent findings implicate Aurora B/A kinases as an important regulator of both genomic |
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Source: Lee, Keun Woo - Department of Biochemistry, Gyeongsang National University |
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Collection: Biotechnology ; Biology and Medicine |
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| 96 | Application of Surface Spectroscopies and Microscopies to Elucidate Sorption Mechanisms on Oxide Surfaces | ||
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Summary: -CrOOH surface clusters formed rather than a precipitate that was distributed over the surface. ' Consequently... ; desorption would be dominated by the dissolution of the chromium hydroxide surface clusters. Introduction... .OlD 3040 1.0 0.008 $=O.20b 1.98 6.2 0.005 3.01 2.9 0.011 3.39 0.71 0.009 aBased on standards and internal |
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Source: Sparks, Donald L. - Department of Plant and Soil Sciences, University of Delaware |
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Collection: Environmental Management and Restoration Technologies |
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| 97 | Accelerating FPGA Routing Using Architecture-Adaptive A* Techniques Akshay Sharma | ||
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Summary: that is used to speed up FPGA routing. Previously published A*-based techniques are either targeted to a class... entry. Clearly, we would like to identify clusters of wires that have similar cost-to-target estimates... -to-target lookup table. Our first technique for clustering wires together is inspired by two observations: ... |
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Source: Hauck, Scott - Department of Electrical Engineering, University of Washington at Seattle |
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Collection: Computer Technologies and Information Sciences ; Engineering |
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| 98 | SEMANTIC REPRESENTATIONS OF NEARSYNONYMS FOR AUTOMATIC LEXICAL CHOICE | ||
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Summary: meaning and a set of explicit differences to its nearsynonyms. That is, nearsynonyms cluster together... . After considering a statistical model and its weaknesses, we develop a clustered model of lexical... synonyms into subconceptual clusters that are linked to the ontology. A cluster acts as a formal ... |
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Source: Edmonds, Phil - Sharp Laboratories of Europe |
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Collection: Computer Technologies and Information Sciences |
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| 99 | SEMANTIC REPRESENTATIONS OF NEAR-SYNONYMS FOR AUTOMATIC LEXICAL CHOICE | ||
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Summary: meaning and a set of explicit differences to its near-synonyms. That is, near-synonyms cluster together... . After considering a statistical model and its weaknesses, we develop a clustered model of lexical... -synonyms into subconceptual clusters that are linked to the ontology. A cluster acts as a formal ... |
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Source: Toronto, University of - Department of Computer Science, Computational Linguistics Group |
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Collection: Computer Technologies and Information Sciences |
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| 100 | Multiview Clustering: A Late Fusion Approach Using Latent Models | ||
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Summary: Multiview Clustering: A Late Fusion Approach Using Latent Models Eric Bruno Viper group, Computer... .Marchand-Maillet@unige.ch ABSTRACT Multi-view clustering is an important problem in informa- tion retrieval due to the abundance... note a late fusion approach for multi- view clustering based on the latent modeling of ... |
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Source: Genève, Université de - Computer Vision and Multimedia Laboratory |
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Collection: Computer Technologies and Information Sciences |
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