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Sample search results for: a2b adenosine receptor

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1 Bruce N. Cronstein, MD You Are Not Arthur Conan Doyle
 

Summary:  . Prior studies have demonstrated that adenosine A2B receptors regulate production... to the nucleus thereby promoting fatty acid synthesis and accumulation whereas A2B ...

  

Source: Wang, Da-Neng - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

 

Collection: Biology and Medicine

 
2 doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol
 

Summary:  surface adenosine receptors (12). Four subtypes of adenosine receptors have been defined, A1, A2a, A2b... of this process are known. Western blot analysis established that all four aden- osine receptors (A1, A2a, ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
3 In this thesis a combined approach is described to investigate the constitutive activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to
 

Summary:  activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to evaluate... and 4 the yeast system is exploited to study inverse agonism of the human adenosine ...

  

Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden

 

Collection: Physics

 
4 Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins
 

Summary:  July 15, 2004; doi:10.1152/ ajpgi.00164.2004.--Adenosine, acting through the A2b receptor, in- duces... of the A2b receptor may be required for its signaling. vesicle; adenosine; ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
5 The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor
 

Summary:  endogenous P2Y receptors in addition to the P1 adenosine receptors A2A and A2B, which might complicate... are influenced by a physical interaction between GPR80/GPR99 and endogenous P2Y or A2B ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
6 Biochemistry Insect Biochemistry and Molecular Biology 35 (2005) 381389
 

Summary:  insects or Metazoa. The expression of most of the Drosophila adenosine deaminases (ADGF-A2,-B,-C and E... . Extracellular adenosine induces apoptosis of human arterial smooth muscle cells via A(2b)-purinoceptor. Circ... ...

  

Source: Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
7 ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and
 

Summary:  , A2B and A3, and, in 1985, Burnstock and Kennedy proposed a basis for distinguishing between two... (ATP/adenosine diphosphate (ADP)) receptors was proposed by Burnstock in 19786. This helped resolve... and inactivation of ATP, and autoregulation via prejunctional ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
8 For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133
 

Summary:  (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... proliferation is mediated by A2A and A2B receptors, and some of the mitogenic effects are mediated via... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
9 The birth and postnatal development of purinergic signalling G. Burnstock,1
 

Summary:  ),Svenningssonetal.(1995), Sebastiao&Ribeiro(1996),Svenningssonetal.(1997a,b,2000),Huangetal. (2005) A2B,A3Unknown P2... ;Table1(Continued) TissuePurinoceptorsMainfunctionalroleReferences OligodendrogliaA1,A2A,A2B,A3... .(2001),Matuteetal. (2007) ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
10 Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson
 

Summary:  Signaling The Periphery Adenosine A1, A2A, A2B, and A3 receptors (ARs) are all present at peripheral sites... signaling in inflammatory states. Adenosine A2B and A3 receptors have not ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
11 Biochemistry Insect Biochemistry and Molecular Biology 37 (2007) 318329
 

Summary:  50 values for adenosine-induced cAMP response of the human A1, A2A, A2B and A3 receptors expressed... cells, such as human kidney epithelial cell line HEK293 or canine mast cells, the A2B receptors are ...

  

Source: Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
12 Purinergic Signaling and Vascular Cell Proliferation and Death Geoffrey Burnstock
 

Summary:  established.1,2 P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B, and A3) have been identified... muscle cells via A2B receptors.26 Later, it was demonstrated that ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
13 Cellular/Molecular Adenosine-Evoked Hyperpolarization of Retinal Ganglion
 

Summary:  241385), A2B (10 M MRS 1706), and A3 (10 M MRS 1191) receptors had no effect on the NECA-evoked response... (A1, A2A, A2B, and A3) are expressed in the retina and both A1 and A3 receptors are ex- pressed... was abolished by ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
14 Samenvatting In dit proefschrift wordt een gecombineerde aanpak besproken om aan de hand van de
 

Summary:  adenosine A2B receptor de constitutieve activiteit van aan G-eiwitten gekoppelde receptoren (GPCRs) te... wordt dit gistsysteem gebruikt om invers agonisme van de adenosine A2B ...

  

Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden

 

Collection: Physics

 
15 Purinergic regulation of vascular tone and remodelling
 

Summary:  ; Burnstock, 2007a). P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B 63 Autonomic & Autacoid... in posthypoxic endo- thelium: role of ectonucleotidases and adenosine A2B ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
16 Purinoceptors on Neuroglia Alexei Verkhrasky & Oleg A. Krishtal &
 

Summary:  to several families of Gi and Go proteins. Four types of adenosine receptors (A1, A2A, A2B and A3... inhibited, whereas A2 receptors potentiated synthesis of cAMP. In primary cultures of rat astrocytes, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
17 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... are positively coupled to adenylate cy- clase through Gs. The human A2B receptor has also been observed to couple... - ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
18 *National Institute of Child Health and Human
 

Summary:  - prises the A1 , A2A , A2B and A3 adenosine receptors, which were identified by convergent data from... roles are not fully known. A1 , A2A , A2B and A3 adenosine receptors have ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
19 RESEARCH PAPER Role of ATP and related purines in inhibitory
 

Summary:  , Table 3). Effects of A1, A2A, A2B and A3 receptor antagonists on relaxations to EFS, adenosine and NECA... , inhibited the relaxations to EFS, adenosine and NECA. The lack of effect of the A1, A2B and A3 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
20 Adenosine-Mediated Presynaptic Modulation of Glutamatergic Transmission in the Laterodorsal Tegmentum
 

Summary:  adenosine A1 receptors (Rainnie et al., 1994). However, adenosine effects on syn- aptic inputs to LDT... IPSCs were reduced by adenosine (50 M). A presynaptic site of action for adenosine A1 receptors... , suggesting the pres- ence of a tonic activation of presynaptic ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine


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21 No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system after chronic A1 receptor
 

Summary:  Chapter 7 No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system... these lines, there are data suggesting cross-talk between the adenosine and serotonin receptor systems... of the adenosine A1 receptor agonist N6 ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
22 Structure based prediction of subtype-selectivity for adenosine receptor antagonists
 

Summary:  into the structural basis of ligand subtype selectivity within the family of adenosine receptors (AR: A1, A2A, A2B... ) of ligand and decoy sets were similar. 2.2. Homology modeling of A1, A2B and A3 ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
23 The Rockefeller University Press $30.00 J. Exp. Med. Vol. 206 No. 11 2417-2427
 

Summary:  ). The immunoregulatory attributes of adenosine are mediated via four transmembrane adenosine receptors: A1, A2A, A2B... | Thammavongsa et al. endothelium: role of ectonucleotidases and adenosine ...

  

Source: Chicago, University of - Department of Microbiology

 

Collection: Biology and Medicine

 
24 0022.3565/87/2423-0882S00.00/0 THE JOURNALor PHARMACOLOGYAND EXP!JUNENTALTHERAPEIITICS
 

Summary:  . A2 adenosine receptors. Blockade of the negative chronotropic effect of bolus Lv. injections of 2... at A1 receptors: blockade of the hypotensive effect of the same series of adenosine ago- nists was used... as an index of activity at A2 receptors. Inaddition, blockade of the ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
25 J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0
 

Summary:  cells were stably transfected with a double hemagglutinin-tagged (HA-tagged) dog adenosine A2A receptor... clear that methylxanthines may act as adenosine receptor antagonists (Fredholm et al., 1976) to produce... Intramembrane receptor­receptor interactions: a novel principle in ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
26 The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine
 

Summary:  depression A2A Brain, heart, lungs, spleen Facilitates neurotransmission; smooth muscle relaxation A2B Large... the peripheral and central nervous systems4 . Separate membrane receptors for adenosine (ADO) and ATP were... -methyl-d-aspartate receptors (NMDARs). ATP is ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
27 Behavioral/Systems/Cognitive A Circadian Clock and Light/Dark Adaptation Differentially
 

Summary:  by the presence of retinal adenosine metabolic pathway enzymes and receptor subtypes A1 and A2A and by the effects... ) Adenosine in vertebrate retina: localization, receptor characterization, and function. Cell Mol Neurobiol 11... Adenosine in the Mammalian Retina Christophe Ribelayga ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
28 Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum
 

Summary:  neuromodulator that binds to at least four known G-protein- coupled receptors in the brain (A1, A2A, A2B, and A3... Title Page Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co... ; Accepted: Aug 12, 2011 #12;Abstract The ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
29 PURINERGIC SIGNALING IN ATHEROSCLEROSIS AND RESTENOSIS Geoffrey Burnstock, Autonomic Neuroscience Centre, Royal Free and University
 

Summary:  in angiogenesis [26]. Endothelial cell proliferation is mediated by A2A and A2B receptors and some... of the mitogenic effects are mediated via the modulation of VEGF signaling. There is evidence that A2B receptors... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
30 Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and
 

Summary:  this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... with the excitatory actions of ATP on nerve cells. Adenosine (P1) receptor activation can inhibit ATP release. ATP... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
31 Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm
 

Summary:  subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... adenosine. This is suggestive of P2Y1-mediated relaxation and perhaps a further P2Y receptor subtype... classification of receptors for ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
32 Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells
 

Summary:  , and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Invest... growth of human aortic smooth muscle cells via A2B receptors. Hypertension, 1998, 31, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
33 Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation
 

Summary:  ,23­25 and it is currently recognised that there are four subtypes of P1 receptors (A1, A2A, A2B and A3), seven subtypes of P... inflammatory response (vi) Sensory phenotype: decreased pain threshold107­111 A2B (i) Immunological phenotype... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
34 Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G proteins and, in common... to adenosine, it acts as a prejunctional inhibitor of transmission via P1(A2) purinoceptors. P2X3 receptors... adenosine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
35 Research Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India
 

Summary:  the pig ureter, while intravesical adenosine via A2B receptors on smooth muscle [6]. ATP and adenosine... Y metabotropic receptor subtypes, as well as four subtypes of P1 receptors sensitive to adenosine... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
36 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  neuronal adenosine A2B receptors, J. Neurochem. 86 (2003) 220­227. [35] S. Rosi, V. Ramirez-Amaya, A... t Caffeine is an antagonist at A1 and A2A adenosine receptors and epidemiological evidence suggests... activation directly by blocking ...

  

Source: Wenk, Gary - Departments of Psychology & Neuroscience, Ohio State University

 

Collection: Biology and Medicine

 
37 TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6
 

Summary:  , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... 58261 Gs : cAMP A2B Large intestine, bladder NECA Enprofylline Gs : cAMP A3 Lung, liver, brain, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
38 Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance
 

Summary:  GPCRs (A1, A2A, A2b, and A3), whereas ATP activates P2X receptors, which are ion channels, as well... ; Izquierdo-Claros et al., 1997; Marzullo et al., 1999). F. Purinergic Receptors Purines such as adenosine... between adenosine and dopa- mine ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
39 Current Topics in Medicinal Chemistry 2004, 4, 793-803 793 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
 

Summary:  , two subtypes of the P1 (adenosine) receptor were recognised [5,6], but it was not until 1985... Theuse of theophylline, an adenosine receptor antagonist, as an antiasthmatic agent has focussed... . 1979, 33, 999-1005. [6] Londos, C.; Cooper, D.M.; Wolff, J. Subclasses of external ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
40 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... was the presence of purinoceptors (2). A basis for distinguishing P1 (adenosine) from P2 (ATP/ADP) receptors... in rats and dogs by the P2Y ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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41 Purine and pyrimidine receptors G. Burnstock
 

Summary:  by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are activated... different P1 receptor subtypes, A1, A2A, A2B and A3, have been cloned and charac- ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
42 Purine and pyrimidine receptors G. Burnstock
 

Summary:  , shortly after, the A3 subtype was identified [21]. Four different P1 receptor subtypes, A1, A2A, A2B and A... ]. The human A2B receptor has also been observed to couple through Gq/11 to regulate phospholipase C activity... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
43 Adenosine triphosphate as a neurotransmitter and neuromodulator Geoffrey Burnstock
 

Summary:  so far, namely A1, A2a, A2b, and A3. The first subclasses for P2-purinoceptors, proposed by Burnstock... :85-108 [MEDLINE] Ferre S, Fredholm BB, Morelli M, et al. (1997): Adenosine-dopamine receptor-receptor interactions... Adenosine triphosphate as a neurotransmitter ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
44 REVIEW ARTICLE The journey to establish purinergic signalling in the gut
 

Summary:  of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system. J Comp Neurol 2001; 439: 46... cloned, namely, A1, A2A, A2B, and A3. Seven subtypes of P2X receptors have been identified... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
45 A Role for Adenosine Deaminase in Drosophila Larval Development
 

Summary:  functions by binding to G protein-coupled adenosine receptors (A1, A2a, A2b, and A3 in mammals) that can... the adenosine receptor (AdoR), but fat body disintegration, which is promoted by action of the hemocytes, seems... factor-A; AdoR, ...

  

Source: Gibson, Matt - Stowers Institute for Medical Research; Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
46 Physiology and Pathophysiology of Purinergic Neurotransmission
 

Summary:  receptors Four subtypes of P1 receptors have been cloned, namely, A1, A2A, A2B, and A3 (see Refs. 370, 423... 241385, KW 6002 GS1cAMP A2B Large intestine, bladder NECA (nonselective) Enprofylline, MRE2029- F20, MRS... /ADP, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
47 Evolutionary origins of the purinergic signalling system G. Burnstock1
 

Summary:  Physiological Society, doi: 10.1111/j.1748-1716.2009.01957.x 415 #12;receptors A1, A2A, A2B and A3... an inhibitory effect, whereas A2A and A2B stimulate production of cyclic AMP (cAMP) (Fredholm et al. 2001... , A2A Enteric neurones P2X3, P2X4, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
48 Purinergic signalling *Geoffrey Burnstock
 

Summary:  2B and A3 (see Ralevic & Burnstock, 1998). All P1 adenosine receptors are typical G protein... /ADP, respectively, was proposed (Burnstock, 1978). Four subtypes of P1 receptors have been cloned, namely A1, A2A, A... receptors mediating ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
49 Purinergic signalling in the nervous system: an overview
 

Summary:  adenosine receptors A1, A2A, A2B and A3 are G- protein coupled (Figure 1). Typically, A1 and A3 couple... to the Gi/o family of G proteins inhibiting cyclic AMP (cAMP) production, whereas A2A and A2B stimulate c... /or ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
50 pubs.acs.org/jmcPublished on Web 01/22/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 17991809 1799
 

Summary:  (A1, A2A, A2B, and A3) have been considered as poten- tial therapies for neurodegenerative,4... ligands was also assessed for A1 and A3 AR subtypes expressed in mammalian cells (A2B subtype selec... . One of the major spotlights is on the ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
51 Genetics of caffeine consumption and responses to caffeine Amy Yang & Abraham A. Palmer & Harriet de Wit
 

Summary:  ubiquitously throughout the body. Of the four receptors that have been identified (A1, A2A, A2B, and A3), the A... of other substances. Genome association studies link variations in adenosine and dopamine receptors... conditions, the main effects of caffeine are due ...

  

Source: Das, Soma - Department of Human Genetics, University of Chicago; Ober, Carole - Committee on Genetics & Department of Human Genetics, University of Chicago

 

Collection: Biology and Medicine

 
52 0022.3565/86/2362.0350S02.oo/0 THE JOURN"L or PH..R COLO<:Y..,..D EXPF.H'''ENT''L THER"PEl'TIC~
 

Summary:  with specific receptors on pre- or post- synaptictissues (Dalyet 01.,1981).Presynaptically,adenosine inhibits... , particularly in tissues containing multi- ple subpopulations of adenosine receptors mediating different... analogs were also adminis- tered in an attempt to characterize the ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
53 INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM
 

Summary:  for adenosine (A1, A2A, A2B and A3 subtypes, all G-protein-coupled) and P2 receptors for ATP (P2X ionotropic... the neuroprotective properties of A1 adenosine receptor analogues have been known for several years, the role of other... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
54 Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate
 

Summary:  protein-coupled P1 receptor subtypes have been cloned: A1, A2A, A2B and A3.19 P2 receptors are subdivided... Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate in urological... purinergic ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
55 J Physiol 589.2 (2011) pp 283295 283 The dynamics of single spike-evoked adenosine release
 

Summary:  , the modulation of adenosine release by specific G-protein coupled receptor agonists strongly suggests... mediated by glutamate receptor activation In control conditions (absence of 4-AP), adenosine release... of the adenosine release stems from AMPA receptor ...

  

Source: Richardson, Magnus - Systems Biology Centre, University of Warwick

 

Collection: Biology and Medicine

 
56 Ecto-5V-nucleotidase activity in brain membranes of zebrafish (Danio rerio)
 

Summary:  modifies cell functioning by operating G-protein-coupled receptors (A1, A2A, A2B, A3), which can inhibit (A... , studies in teleost brain have shown that adenosine A1 receptors appeared similar to that found in mammals... ) 203­207206 #12;A2A ...

  

Source: Eizirik, Eduardo - Centro de Biologia Genômica e Molecular da Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul

 

Collection: Environmental Sciences and Ecology

 
57 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  . In addition, we predicted structures for the human A1, A2B, and A3 adenosine receptors (ARs) and used... (À3.3 kcal/mol), E174 in A2B Fig. 1. Predicted structure of ZM241385/human A2A adenosine ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
58 Cellular/Molecular Calcium Increases in Retinal Glial Cells Evoked by Light-
 

Summary:  that adenosine potentiation of Mu¨ller cell Ca2 responses is mediated primarily by A2B receptors, in agreement... . In the presence of 2 M NECA, the A2B receptor antagonist MRS 1706 (1 M) reduced the ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
59 The Uroepithelial-associated sensory web , E Balestreire1
 

Summary:  family ErbB1­3 receptors,17 A1, A2a, A2b, and A3 adenosine receptors,18 a- and b-adrenergic receptors,19... : a,b-AR, a,b -adrenergic receptor; Ach, acetylcholine; Ad, adenosine; AdR, ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
60 Historical review: ATP as a neurotransmitter
 

Summary:  , SCH58261 GS, [cAMP A2B Large intestine, bladder NECA (nonselective) Enprofylline, MRE2029F20 GS, [c... to adenosine by ectoenzymes, so that some of the actions of ATP were directly on P2 receptors, whereas others... were due to the indirect action of adenosine on P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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61 Cardioprotective Effects of Mineralocorticoid Receptor Antagonists at Reperfusion
 

Summary:  '-nucleotidase (CD73), as well as adenosine A2b receptor knock-out mice could no longer be protected, suggesting... a role for adenosine and the A2b receptor in the mechanism. A 1 mg/kg ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
62 P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock
 

Summary:  hyperaemia via endothelial P2Y1 receptors, followed by degradation of ADP to adenosine resulting in late... REVIEW P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock... protein- coupled) receptors. In this article we consider the dual role of ATP in regulation of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
63 Pathophysiology and Therapeutic Potential of Purinergic Signaling
 

Summary:  subtypes of P1 receptors were cloned, namely, A1, A2A, A2B, and A3. In 1985, Burnstock and Kennedy proposed... Y receptors in endothelial cells to release nitric oxide (NO), resulting in relaxation. Adenosine... ). The therapeutic poten- tial of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London; Saunders, Mark - Benfield Hazard Research Centre, Department of Space and Climate Physics, University College London

 

Collection: Biology and Medicine ; Geosciences

 
64 Editorial Manager(tm) for Nuclear Medicine Communications Manuscript Draft
 

Summary:  there are still controversies on how adenosine receptors (A1, A2A, A2B, and A3) mediate the cardioprotection... and relates with the activation of adenosine receptors in rat hearts. FastSPECT GLA imaging is not only useful... of ...

  

Source: Arizona, University of - Center for Gamma-Ray Imaging

 

Collection: Engineering ; Biology and Medicine

 
65 Adenosine A3 receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury
 

Summary:  Adenosine A3 receptor stimulation induces protection of skeletal muscle from eccentric exercise... , Zambraski EJ, Rader EP, Campbell KP, Liang BT. Adenosine A3 receptor stimulation induces protection... of this study was to determine whether adenosine receptor ...

  

Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa

 

Collection: Biology and Medicine

 
66 Purinergic signalling in autonomic Alexander V. Gourine1
 

Summary:  ) inhibitory neurons in the myenteric plexus expressing P2X2, P2X3, P2Y1, P2Y6 and A2B receptors, in addition... -protein-coupled P1 (adenosine) receptors, seven subtypes of ionotropic P2X receptor subunits (which form homomeric... ligands for ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
67 Adenosine is crucial for deep brain stimulationmediated attenuation of tremor
 

Summary:  , resulting in accumulation of its catabolic product, adenosine. Adenosine A1 receptor activation depresses... infusion of A1 receptor agonists directly reduces tremor, whereas adenosine A1 receptor­null mice show... notion that caffeine, a nonselective ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
68 proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS Predicted structures of agonist and
 

Summary:  Alignments of the four adenosine receptor (AR) subtypes, A1, A2A, A2B, and A3 from the PredicTM method... and A2B adenosine subtypes are linked to Gs proteins, increasing the intracellular levels of cAMP ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
69 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001)
 

Summary:  were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... , 1976a], and a basis for distinguishing P1 (adenosine) from P2 (ATP/ADP) receptors was pro- #12... :246­254. Vainio M, Törnquist K. 2000. The role of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
70 Postnatal development of P2 receptors in the murine gastrointestinal tract
 

Summary:  further subdivided into A1, A2A, A2B and A3. P2 receptors have been divided into two families (Ab... ¼ adenosine, suggesting P2Y1 receptors. This was supported by the sensitivity of responses to 2-Me... equipotent suggesting a P2Y2 and/or P2Y4 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
71 UCB Pharma research day--25 October 2007 `Glia-neuron interactions and purinergic receptors
 

Summary:  . In the early 1990s, P1 and P2 receptors were cloned and characterised: four P1 receptor subtypes (A1, A2A, A2B... receptors for adenosine and AMP (named P1 receptors) and for ATP and ADP (named P2 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
72 Nature Macmillan Publishers Ltd 1997 arterial blood sampling (0.5 ml samples) and
 

Summary:  , observed after blockade of peripheral adenosine receptors, and was not specific for caffeine. This find... reduction after antagonist with- drawal, suggests receptor-mediated regula- tion of the plasma adenosine... in the world1 , with actions mediated primarily by adenosine ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
73 ADENOSINE, PROLONGED WAKEFULNESS, AND A1-ACTIVATED NF-UB DNA BINDING IN THE BASAL FOREBRAIN OF THE RAT
 

Summary:  of adenosine increased NF-UB DNA binding while pretreatment of the slices with the A1 adenosine receptor... during prolonged wakefulness, act through an A1 adenosine receptor and a second messenger system... of the highly selective A1 adenosine ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
74 Purinergic receptors as future targets for treatment of
 

Summary:  expressing P2X2, P2X3, P2Y1, P2Y6 and A2B receptors, as well as with cholinergic motor neurons; these neurons... Purinergic receptors as future targets for treatment of functional GI disorders Geoffrey Burnstock... in different gut regions. Following cloning experiments in the early ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
75 Adenosine does not save the heart of anoxia-tolerant vertebrates during prolonged oxygen deprivation
 

Summary:  interaction with at least four (i.e., A1, A2A, A2B and A3) cell membrane receptors (Newby, 1984; Newby et al... of the non-specific adenosine receptor antagonist aminophylline while measuring cardiac output (Q), heart... and Stecyk, in press). Given the ...

  

Source: Farrell, Anthony P. - Faculty of Land and Food Systems, University of British Columbia

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
76 International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors
 

Summary:  and Weetman, 1976), receptors for purines were subdivided into P1 (adenosine) and P2 (ATP and ADP) receptors... adenosine; CysLT, cyst- einyl leukotriene receptor; I B, inhibitor of nuclear factor (NF)- B; PMA, phorbol... ) or the activation of adenosine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
77 The American Journal of Physiology, Renal Physiology --Manuscript F-00256-2007 --
 

Summary:  mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in mice... to A1-adenosine receptor (A1AR) -agonist cyclohexyl-adenosine (CHA). Time course of the response

  

Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg

 

Collection: Biology and Medicine

 
78 The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle
 

Summary:  receptor antagonist, abolished inhibitory effects of adenosine at all three temperature conditions but did... AM), a nonselective P2 receptor antagonist, inhibited the action of ATP but not adenosine, while... for ATP taken at three temperature conditions tested. 3.1.2. P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
79 J Physiol 586.14 (2008) pp 33073312 3307 TOPICAL REVIEW
 

Summary:  in purinergic signalling 3309 purines and pyrimidines have been identified: P1 adenosine receptors (A1, A2A, A2B... be an extracellular messenger. However, after receptor subtypes for ATP and its breakdown product, adenosine, were... phagocytotic ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
80 Kidney International, Vol. 64 (2003), pp. 13891397 Unusual absence of endothelium-dependent or -independent
 

Summary:  [38, 39]. Simi- larly, an inhibitory adenosine A2b receptor located on rat renal endothelial cells... - sions followed: P1 receptors into A1, A2A, A2B, and A3 and P2 receptors into P2X ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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81 Adenosine Released by Astrocytes Contributes to Hypoxia-Induced Modulation of Synaptic Transmission
 

Summary:  of excitatory synaptic transmission me- diated by activation of presynaptic A1 adenosine receptors. The glia... -specific metabolic inhibitor fluorocitrate (FC) was as effective as the A1 adenosine receptor antagonist CPT... the excitatory synaptic transmission through the release of ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
82 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  .deaminase Inosine Smooth muscle receptors P2 Purinoceptor 5 -nucleo- ATP resynthesis Adenosine Adenosine uptake... vasoconstriction (+) via P2X receptors on the muscle cells. Adenosine (ADO), resulting from rapid breakdown of ATP... also: Adenosine; ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
83 of May 17, 2010 This information is current as
 

Summary:  that modulates immune responses by interacting with four subtypes (A1, A2A, A2B, and A3) of membrane receptors... and increased density of its receptors (49). In addition, adenosine accumulates in solid tumors where it plays... ...

  

Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle

 

Collection: Chemistry ; Biology and Medicine

 
84 http://tpx.sagepub.com Toxicologic Pathology
 

Summary:  A2B Mast cells Increased IL-8 and histamine release Vascular smooth muscle Relaxation A3 Neutrophils... active at times of very early injury. Keywords. Adenosine receptor; arteriopathy; coronary; canine; gene... biomarkers for the clinical diagnosis of acute vascular damage. ...

  

Source: Zhao, Hongyu - School of Public Health, Yale University

 

Collection: Biology and Medicine

 
85 Faculty Competition for Post-Doctoral Fellows Shane Perrine, Psychiatry
 

Summary:  , Physiology Adenosine Receptor Modulation of Post Myocardial Infarction Fibroblast Function Patrick Mueller

  

Source: Cinabro, David - Department of Physics and Astronomy, Wayne State University

 

Collection: Physics

 
86 doi:10.1152/physiolgenomics.00068.2005 23:89-102, 2005. First published Jul 26, 2005;Physiol. Genomics
 

Summary:  , adenosine receptors (subtypes A1, A2A, A2B, and A3), to exert a variety of physiological effects (27... inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network... Weng, and Jiang-Fan Chen. Genetic and ...

  

Source: Weng, Zhiping - Center for Advanced Genomic Technology, Boston University

 

Collection: Biotechnology

 
87 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 53:281291 (2001)
 

Summary:  -4), histamine (H1), serotonin (5-HT3) or adenosine (A1 and A2B) receptors [Lambrecht et al., 1992, 2000; Boyer... to characterize the receptors mediating depolarization of the rat iso- lated vagus nerve by ,-methylene adenosine... of a Series of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
88 Rapid Stimulation of Presynaptic Serotonin Transport by A3 Adenosine Receptors
 

Summary:  :431­447. Feoktistov I and Biaggioni I (1997) Adenosine A2B receptors. Pharmacol Rev 49: 381­402. Fredholm BB (2003... and Hill SJ (1994) Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary ...

  

Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University

 

Collection: Biology and Medicine

 
89 doi:10.1152/ajpgi.00147.2006 291:605-610, 2006. First published May 4, 2006;Am J Physiol Gastrointest Liver Physiol
 

Summary:  50: 870­877, 1996. 23. Murthy KS, McHenry L, Grider JR, and Makhlouf GM. Adenosine A1 and A2b... , and adenosine A1 receptors) are capable of mediating sustained contraction via sequential activation of PI 3... in smooth muscle by receptor ...

  

Source: Hu, Wen-Hui - Department of Physiology, Virginia Commonwealth University

 

Collection: Biology and Medicine

 
90 Vas deferens A model used to establish sympathetic cotransmission
 

Summary:  receptors in the epididymal portion and adenosine A2B receptors in the prostatic portion of the rat vas... release via A2A receptors in the epididymal portion and via A2B ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
91 ne of the first and most enduring facts most students learn in biology class is
 

Summary:  ] Adenosine triphosphate (ATP) PhosphateAdenosine Energy trapped in bonds ATP ATP ADP P2X receptor P2Y... designated P2 receptors) and for its final breakdown product, adenosine (which he called P1 receptors). Fur... . P2Y receptors also recognize ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
92 cGMP signalling in pre-and post-conditioning: the role of mitochondria
 

Summary:  adenosine receptor, presumably A2b, was involved. Both Philipp et al.38 and Kuno et al.39 noted PKC had... the adenosine agonist NECA given at reperfusion,40 a NOS step must reside downstream of the A2b ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
93 Neurons respond to a variety of attractive and repulsive guid-ance cues to navigate to their targets1. Genetic, biochemical and
 

Summary:  92. A second proposed netrin receptor, the A2B adeno- sine receptor, seems to bind netrin... . & Tessier-Lavigne, M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B... ...

  

Source: Bargmann, Cori - Laboratory of Neural Circuits and Behavior, Rockefeller University

 

Collection: Biology and Medicine

 
94 MOLECULAR AND CELLULAR BIOLOGY, Mar. 1995, p. 13891397 Vol. 15, No. 3 0270-7306/95/$04.00 0
 

Summary:  receptor subunits in the brain (19, 24, 37). To visualize the distribution of the dsRNA adenosine deaminase... -Specific Adenosine Deaminase MARY A. O'CONNELL,1 SABINE KRAUSE,1 MIYOKO HIGUCHI,2 J. JUSTIN HSUAN,3 NICHOLAS F. TOTTY... for modification 1 December 1994/Accepted 15 December 1994 Double-stranded RNA (dsRNA)-specific ...

  

Source: Jenny, Andreas - Department of Developmental and Molecular Biology , Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
95 proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS GPCR 3D homology models for ligand
 

Summary:  3, (no sufficient data for A2b subtype), as well as to select AA2AR antagonists ver- sus AA2AR... learned from blind predictions of adenosine A2a receptor complex Vsevolod Katritch,1 Manuel Rueda,2 Polo... - mined high resolution structures of b-adrenergic (b2AR,6,7 b1AR8) and ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
96 Endothelium-Derived Vasoconstriction by Purines and Pyrimidines
 

Summary:  by To¨lle et al1 claims to show for the first time that adenosine 5 -tetraphosphate (AP4) is released... , that AP4 is the most potent mediator of vascular smooth muscle constric- tion via P2X1 receptors or... in response to sheer stress produced by changes in blood flow act largely on P2Y receptor subtypes (but also

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
97 Progress in Neurobiology 66 (2002) 355474 Descending control of pain
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 424 11.2.1. Generation of adenosine: actions at multiple adenosine receptors... transmitters and specific receptor types in the modulation and expression of ...

  

Source: Meagher, Mary - Department of Psychology, Texas A&M University

 

Collection: Biology and Medicine

 
98 ATP signalling in epilepsy Ashwin Kumaria & Christos M. Tolias &
 

Summary:  and is believed to inhibit distant synapses by acting on adenosine receptors. Such a mechanism is consistent... hippocampal region have the opposite effect to A1 receptors in a piriform cortex kindling model. Adenosine... - leptogenesis [14], although the expression and function of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
99 Calcium Signaling in Specialized Glial Cells MONICA R. METEA AND ERIC A. NEWMAN*
 

Summary:  increases (Fries et al., 2005; Reifel Saltzberg et al., 2003). Activation of A2B aden- osine receptors... -nucleoti- dases. Adenosine, in turn, activates A1 adenosine receptors on the ganglion cells, leading... receptors. ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
100 Adenosine Receptor, Protein Kinase G, and p38 Mitogen-Activated Protein Kinase-Dependent Up-Regulation of
 

Summary:  to inhibitory Gi/o proteins (A1 and A3 receptors), stimulatory Gs proteins (A2A and A2B receptors), as well... as Gq protein-linked PLC (A1, A2B, and A3 receptors) (Feoktistov and Biaggioni, 1997; Fred- ...

  

Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University

 

Collection: Biology and Medicine


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