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Sample search results for: a53t-alpha-synuclein overexpression impairs

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1 Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's
 

Summary:  ) DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein... , indicating that overexpression of this protein alone can lead to the disease (7). Maintenance of DA neuron... Overexpression of Human -Syn in C. elegans. Using a ...

  

Source: Caldwell, Guy - Department of Biological Sciences, University of Alabama in Tuscaloosa

 

Collection: Biology and Medicine

 
2 Journal of Neuroscience Copy of e-mail Notification zns0212
 

Summary:  . Overexpression or mutation of -synuclein results in the formation of Lewy bodies and neurodegen- eration... dystonia-associated mutant torsinA or combined overexpression of wild-type and mutant torsinA yielded... of -synuclein overexpression and DA-specific toxicity. Here, we report that torsins can protect the DA neurons

  

Source: Caldwell, Guy - Department of Biological Sciences, University of Alabama in Tuscaloosa

 

Collection: Biology and Medicine

 
3 a-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and
 

Summary:  , C.R. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein... . Larsen, K.E. et al. Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine... -linked gene ATP13A2 (also known as PARK9). ...

  

Source: Caldwell, Guy - Department of Biological Sciences, University of Alabama in Tuscaloosa

 

Collection: Biology and Medicine

 
4 a-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and
 

Summary:  , C.R. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein... . Larsen, K.E. et al. Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine... -linked gene ATP13A2 (also known as PARK9). ...

  

Source: Lindquist, Susan - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
5 1191Commentary Introduction
 

Summary:  disease upon inoculation into transgenic mice that overexpress PrP (Colby et al., 2009; Legname et al... P-A oligomer interaction leads to synaptic impairment (Balducci et al., 2010; Lauren et al., 2009). Given... ). Moreover, when neural stem cells are grafted into the brains of transgenic mice overexpressing human

  

Source: Shorter, James - Department of Biochemistry and Biophysics, University of Pennsylvania

 

Collection: Biology and Medicine

 
6 SUPPLEMENTARY MATERIAL Integration of Insulin Receptor/FOXO signaling and dMyc activity during
 

Summary:  overexpression of dmnt, impairs muscle growth and endoreplication. (D-E") Co-overexpression of foxo and dmyc... . (D) Impairment of larval feeding behavior in flies overexpressing Cyclin E or with decreased levels... -F") Overexpression of Cyclin E (CycE) in muscles ...

  

Source: Higgins, Darren - Department of Microbiology and Molecular Genetics, Harvard University

 

Collection: Biology and Medicine

 
7 2006LANDESBIOSCIENCE.DONOTDISTRIBUTE. www.landesbioscience.com Cell Cycle 1397
 

Summary:  , synthetic dosage lethality, gene overexpression, dosage sensitivity, genetic interaction, synthetic genetic... for high-throughput genetic analysis, with a genome-wide "overexpression array", in which each strain... on the array overexpresses a unique yeast gene. The overexpression array enables ...

  

Source: Pál, Csaba - Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences

 

Collection: Biology and Medicine

 
8 Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts
 

Summary:  overexpressing udk Udi Qimron, Arkadiusz W. Kulczyk, Samir M. Hamdan, Stanley Tabor and Charles C. Richardson... . Summary Overexpression of udk, an Escherichia coli gene encoding a uridine/cytidine kinase, interferes... with T7 bacteriophage growth. We show here that inhibition of T7 phage growth by udk overexpression can

  

Source: Richardson, Charles C. - Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine

 
9 Neurobiology of Disease -Synuclein Overexpression in PC12 and Chromaffin Cells
 

Summary:  Neurobiology of Disease -Synuclein Overexpression in PC12 and Chromaffin Cells Impairs... lines overexpressing WT or mutant -syn exhibited impaired DA release without altered calcium threshold... overexpression would be a re- duced size of vesicular pools caused by ...

  

Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University

 

Collection: Biology and Medicine

 
10 Curriculum Vitae Ted M. Dawson, M.D., Ph.D.
 

Summary:  .M. Dawson. "Impaired Ovulation in Mice with Targeted Deletion of the Neuronal Isoform of Nitric Oxide

  

Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University

 

Collection: Biology and Medicine

 
11 Galanin impairs cognitive abilities in rodents: relevance to Alzheimers Disease
 

Summary:  Galanin impairs cognitive abilities in rodents: relevance to Alzheimers Disease J. N. Crawley... of galanin im- pairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing... processes, taken together with the overexpression of galanin in Alzheimers disease, suggests that galanin

  

Source: 

 

Collection: Biology and Medicine

 
12 Differential Sensitivity in the Survival of Oligodendrocyte Cell Lines to
 

Summary:  Differential Sensitivity in the Survival of Oligodendrocyte Cell Lines to Overexpression of Myelin... in oligodendrocyte survival by overexpression studies in vitro and in vivo. The classic and sr proteolipids... functions. Accordingly, we examined the effects of in vitro overexpression of the sr-PLP/DM20 isoforms

  

Source: Bongarzone, Ernesto R. - Department of Anatomy and Cell Biology, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
13 DOI: 10.1126/science.1200215 , 1207 (2011);331Science
 

Summary:  DOI: 10.1126/science.1200215 , 1207 (2011);331Science , et al.Reut Shema in the NeocortexOverexpression... -Term Memory by Overexpression of Protein Kinase Mz in the Neocortex Reut Shema,1 Sharon Haramati,1 Shiri Ron,1... improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium

  

Source: Dudai, Yadin - Department of Neurobiology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
14 dna repair 7 ( 2 0 0 8 ) 686693 available at www.sciencedirect.com
 

Summary:  .elsevier.com/locate/dnarepair Mini review The consequences of Rad51 overexpression for normal and tumor cells Hannah L. Klein... 12 December 2007 Published on line 1 February 2008 Keywords: Rad51 protein Overexpression of Rad51... . Overexpression of Rad51 in different organisms and cell types has a wide assortment of ...

  

Source: Roth, David B. - Langone Medical Center, New York University

 

Collection: Biology and Medicine

 
15 Selective Enrichment of DJ-1 Protein in Primate Striatal Neuronal Processes
 

Summary:  L, Ferreira A, Kosik KS, Greengard P. 1995. Impairment of axonal development and of synaptogenesis

  

Source: Li, Lian - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
16 Changes in the cytosolic concentra-tions of Ca2+
 

Summary:  mouse model. By contrast, overexpression of SPCA2 in a non- malignant mammary epithelial cell line, MCF... , and that overexpression of SPCA2 led to increased basal Ca2+ concentration, strongly suggesting that upregula- tion... of SPCA2? To test this, the authors created a mutant version of SPCA2 with impaired Ca2+ -ATPase ...

  

Source: Kenny, Paraic - Department of Developmental and Molecular Biology , Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
17 This Week in The Journal F Cellular/Molecular
 

Summary:  neurogenesis with irradiation impaired con- textual fear conditioning only in rats. f Behavioral... - trationofregularlyspacedtailshocksnotonly failed to impair subsequent learning, but also eliminatedtheeffectofvariablyspacedshocks... overexpressed tau in hippocampal slicesfromtransgenicmiceexpressingmutant APP. Mutant APP ...

  

Source: Grau, James - Department of Psychology, Texas A&M University

 

Collection: Biology and Medicine

 
18 Neurobiology of Disease Torsin-Mediated Protection from Cellular Stress in the
 

Summary:  and oxidative damage. Overexpression or mutation of -synuclein results in the formation of Lewy bodies... dystonia-associated mutant torsinA or combined overexpression of wild-type and mutant torsinA yielded... of this system, we investigated the capacity of torsins to ameliorate the effects of -synuclein overexpression

  

Source: Caldwell, Guy - Department of Biological Sciences, University of Alabama in Tuscaloosa

 

Collection: Biology and Medicine

 
19 STAM Adaptor Proteins Interact with COPII Complexes and Function in ER-to-Golgi Trafficking
 

Summary:  -PAAuthorManuscriptNIH-PAAuthorManuscriptNIH-PAAuthorManuscript #12;only does STAM2 overexpression disrupt Golgi morphology, but also that it markedly impairs... overexpressing Sec16 (24,30­32). In addition, the impairment in ER-to-Golgi transport associated... to early exocytic compartments and profoundly ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
20 Chaperone-dependent amyloid assembly protects cells from prion toxicity
 

Summary:  impaired, but did not eliminate, interaction with Sis1, the overexpression of Sis1 3-fold was still able... investigated a normally benign amyloid formed by the yeast prion [RNQ ]. Surprisingly, modest overexpression... their conversion into benign or toxic amyloid-like species. Results Overexpression of ...

  

Source: Duennwald, Martin L. - Boston Biomedical Research Institute

 

Collection: Biology and Medicine


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21 Biochem. J. (2000) 352, 921927 (Printed in Great Britain) 921 Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase
 

Summary:  also showed an impairment of glucose-induced insulin secretion as a result of PFK-1 overexpression... Biochem. J. (2000) 352, 921­927 (Printed in Great Britain) 921 Effects of overexpression... Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel Overexpression of the liver subunit of 6

  

Source: Groner, Yoram - Department of Molecular Genetics, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
22 Chaperonin overexpression promotes genetic variation and enzyme evolution
 

Summary:  ARTICLES Chaperonin overexpression promotes genetic variation and enzyme evolution Nobuhiko... indicated that GroEL/GroES overexpression doubled the number of accumulating mutations, and promoted... EL/GroES overexpression, in terms of the number of adapted variants ($2-fold) and their improved specificity and activity

  

Source: Tawfik, Dan S. - Department of Biological Chemistry, Weizmann Institute of Science

 

Collection: Biotechnology ; Biology and Medicine

 
23 Aging Cell (2003) 2, pp123130 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2003 123
 

Summary:  that were transgenically altered to overexpress human superoxide dismutase (SOD) in the motorneurones... . Sun & Tower (1999) simultaneously overexpressed Drosophila superoxide dismutase in two lab strains... overexpression in the shorter-lived strain had a more dramatic increase in longevity than in the long

  

Source: Promislow, Daniel - Department of Genetics, University of Georgia

 

Collection: Biology and Medicine

 
24 The Role of the Golgi Protein Golph3 in Type 2 Diabetes Suzette Farber-Katz
 

Summary:  . For example, glucotoxicity and lipotoxicity both can contribute to impaired beta cell function. Insulin... levels and changes in secretory capacity. When overexpressed and deregulated, Golph3 is also an oncogene... 3fl/fl mice would have impaired glucose tolerance and lower plasma insulin levels, similar

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
25 BioMed Central Page 1 of 15
 

Summary:  min. Root growth of some KNAT1 over-expressing seedlings is impaired (arrows). Scalebars: 100 m. #12... not for citation purposes) 13) of seedlings of the KNAT1 over-expressers showed impaired growth. Sodium... over-expressing plants could be the result of impaired ...

  

Source: Haseloff, Jim - Department of Plant Sciences, University of Cambridge

 

Collection: Biology and Medicine

 
26 Molecular Biology of the Cell Vol. 19, 14851498, April 2008
 

Summary:  of branch formation. Overexpression of spastin dramatically enhances the formation of branches, whereas... overexpression of P60-katanin does not. The excess spastin results in large numbers of short microtubules... had anticipated that overexpressing P60-katanin in cultured neurons would enhance the propensity

  

Source: Baas, Peter W. - Department of Neurobiology and Anatomy, Drexel University

 

Collection: Biology and Medicine

 
27 Caveolin-3 is associated with the calcium release complex and is modified under in vivo triadin
 

Summary:  role of Trisk 95 and Trisk 51 isoforms on muscle physiology, we overexpressed Trisk 95 or Trisk 51... using adenovirus-mediated gene transfer in skeletal muscle of newborn mice. Overexpression of either... of caveolin 3 in both Trisk 95 and Trisk 51 overexpressing skeletal muscles. Using a biochemical approach, we

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
28 Neuron, Vol. 25, 575586, March, 2000, Copyright 2000 by Cell Press Olfaction and Odor Discrimination Are Mediated
 

Summary:  Guanylyl Cyclase ODR-1 581 Figure 5. Overexpression of ODR-1 Impairs Discrimination Between Odors (A... not impair bu/bz discrimination (7 and 8). (D) Overexpression of ODR-1 does not increase sensitivity... between butanone and benzaldehyde or isoamyl alcohol and impairs butanone ad- ...

  

Source: Bargmann, Cori - Laboratory of Neural Circuits and Behavior, Rockefeller University

 

Collection: Biology and Medicine

 
29 Role of X11 and ubiquilin as In Vivo Regulators of the Amyloid Precursor Protein in Drosophila
 

Summary:  pathogenesis. In contrast to previous reports, we show that overexpression of X11L or human X11 does not alter... -dependent transcription [32]. Fourth, X11a and X11b overexpression increases APP steady-state levels both in vitro... 83 and C99 are not observed in transgenic mice overexpressing X11 [29]. These conflicting

  

Source: Guo, Ming - Brain Research Institute, University of California at Los Angeles

 

Collection: Biology and Medicine

 
30 EUKARYOTIC CELL, Aug. 2006, p. 12431251 Vol. 5, No. 8 1535-9778/06/$08.00 0 doi:10.1128/EC.00048-06
 

Summary:  overexpressed in one parent and several ERG genes that were overexpressed in the other parent were also... overexpressed in the double mutants. Of the 43 genes that were consistently overexpressed in the PDR1r parents... at generation 100, however, 31 were not consistently overexpressed ...

  

Source: Anderson, James B. - Department of Ecology and Evolutionary Biology, University of Toronto

 

Collection: Environmental Sciences and Ecology

 
31 ORIGINAL PAPER Tissue-specific targeting of Hsp26 has no effect on heat
 

Summary:  if overexpression of this protein protects behavior and neural function in Drosophila melanogaster during heat... , and normalized EJP half-width. Overexpression larvae had a similar number of motoneuronal boutons and length... not due to changes at the synapse. We conclude that overexpression had a small thermoprotective effect

  

Source: Robertson, Meldrum - Department of Biology, Queen's University (Kingston); Seroude, Laurent - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
32 ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila
 

Summary:  phenotypes that arise from loss of psn function in vivo. In addition, overexpression of ubqn in the eye... in nature. The degeneration associated with ubqn overexpression can also be suppressed by psn overexpression... , the biological significance of this physical inter- action is unclear. On the one hand, ...

  

Source: Guo, Ming - Brain Research Institute, University of California at Los Angeles

 

Collection: Biology and Medicine

 
33 Cellular/Molecular Overexpressing Temperature-Sensitive Dynamin Decelerates
 

Summary:  flies overexpressing UAS-shits1 displayed a similar pheno- type, the level of impairment... Cellular/Molecular Overexpressing Temperature-Sensitive Dynamin Decelerates Phototransduction... neuronal circuits. We investigated the effects of UAS-shibirets1 overexpression in Drosophila

  

Source: Juusola, Mikko - Department of Biomedical Science, University of Sheffield

 

Collection: Biology and Medicine

 
34 The definitive version of this manuscript is available at www.blackwell-synergy.com Genes to Cells (2006) 11(8): 907-18
 

Summary:  -SD impairment, we tested the possible effect of over-expressing dap on the expression of VG and SD. Since... over-expression leads to sd induction, VG- SD dimer imbalance and impairment of its function in wing... . 1999). This dap over-expression triggers both ectopic expression of sd and ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
35 Hsp110 Chaperones Regulate Prion Formation and Propagation in S. cerevisiae by Two Discrete Activities
 

Summary:  this by overexpressing Ssa1 in the [PSI+ ]s sse1D strain and indeed found that the impaired prion propagation... as propagation, although with opposing effects. [PSI+ ] formation induced upon Sup35 overexpression is stimulated... levels of Ssb1 [17,18], while propagation is inhibited by overexpression of ...

  

Source: Shorter, James - Department of Biochemistry and Biophysics, University of Pennsylvania

 

Collection: Biology and Medicine

 
36 DEVELOPMENTDEVELOPMENT 1035RESEARCH ARTICLE
 

Summary:  knockdown and ubiquitous overexpression induced aberrant ipsilateral projections, suggesting that Sema3d... responded to ubiquitous Sema3d overexpression by pausing for extended periods and increasing... their exploratory behavior at the midline, suggesting that Sema3d overexpression causes the midline environment

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
37 Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
 

Summary:  Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain... , Denmark y These authors contributed equally to this work. Overexpression of human a-synuclein (a... phase, the animals overexpressing the A53T a-syn, in particular, showed a gradual worsening of motor

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
38 Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
 

Summary:  Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain... , Denmark y These authors contributed equally to this work. Overexpression of human a-synuclein (a... phase, the animals overexpressing the A53T a-syn, in particular, showed a gradual worsening of motor

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
39 Age-related neuronal loss in the cochlea is not delayed by synaptic modulation
 

Summary:  of synaptic transmission. Transgenic mice overexpressing NRG1 in spiral ganglion neurons (SGNs) showed... , no significant change in age-related loss of SGNs in either NRG1 / mice or mice overexpressing NRG1 was observed... thresholds by "turning-off" NRG1 overexpression. These data demonstrate for the first time that synaptic

  

Source: Ryugo, David K. - Center for Hearing and Balance, Johns Hopkins University

 

Collection: Biology and Medicine

 
40 The Rockefeller University Press, 0021-9525/2000/03/1021/13 $5.00 The Journal of Cell Biology, Volume 148, Number 5, March 6, 2000 10211033
 

Summary:  , Volume 148, Number 5, March 6, 2000 1021­1033 http://www.jcb.org 1021 P0 Glycoprotein Overexpression... to arrested myelination and impaired sorting of axons by Schwann cells.Myelination was restored by breeding... overexpression.These data reveal new points in nerve development at which Schwann cells are susceptible

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine


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41 10081 How snakes slither 10086 Biodegradable fluorescent polymers
 

Summary:  , identify its cause and target the molecular source. This is possible for tumors that overexpress... that AGTR1, the angio- tensin II receptor type I, is overexpressed in a subset of tumors and could prove... AGTR1. The authors analyzed overexpressed genes in 31 breast cancer-profiling data- sets obtained

  

Source: Yang, Jian - Department of Bioengineering, University of Texas at Arlington

 

Collection: Materials Science ; Engineering

 
42 Neurobiology of Disease Loss-of-Function Analysis Suggests That Omi/HtrA2 Is Not
 

Summary:  . Although overexpression of Omi/ HtrA2 leads to apoptosis after its release into the cytosol (for review... · The Journal of Neuroscience, December 31, 2008 · 28(53):14500­14510 #12;reportedly impairs activation... ., 2006). Results Overexpression-based genetic interactions of pink1 and omi in the eye Omi/HtrA2 encodes

  

Source: Guo, Ming - Brain Research Institute, University of California at Los Angeles

 

Collection: Biology and Medicine

 
43 pubs.acs.org/Biochemistry Published on Web 06/21/2010 r 2010 American Chemical Society 6130 Biochemistry 2010, 49, 61306135
 

Summary:  role of Trisk 95 and Trisk 51 isoforms in muscle physiology, we overexpressed Trisk 95 or Trisk 51... using adenovirus-mediated gene transfer in skeletal muscle of newborn mice. Overexpression of either... of caveolin 3 in both Trisk 95- and Trisk 51-overexpressing skeletal muscles. Using a biochemical approach, we

  

Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa

 

Collection: Biology and Medicine

 
44 Transgenic Overexpression of the Transcription Factor Nkx6.1 in -Cells of Mice Does Not Increase
 

Summary:  Transgenic Overexpression of the Transcription Factor Nkx6.1 in -Cells of Mice Does Not Increase... proliferation in vivo by pharmacological intervention. Based on the finding that overexpression... , we sought to investigate whether overexpression of Nkx6.1 in -cells in vivo could increase -cell mass

  

Source: Sander, Maike - Departments of Pediatrics and Cellular and Molecular Medicine, University of California at San Diego

 

Collection: Biology and Medicine

 
45 ABCA1 Monoclonal Antibodies Advantages
 

Summary:  ) and is a member of the ATPase cassette superfamily of transporters. ABCA1 mutations are associated with impaired... hypoalphalipoproteinemia. Conversely, the overexpression of ABCA1 in animal models has been shown to be protective against

  

Source: Michelson, David G. - Department of Electrical and Computer Engineering, University of British Columbia

 

Collection: Engineering

 
46 Cyclin-Dependent Kinase 2/Cyclin E Complex Is Involved in p120 Catenin (p120ctn)Dependent Cell Growth Control: A New Role for p120ctn in Cancer
 

Summary:  suggest that p120ctn overexpression results in impaired proteasome degradation and maintenance within... progression. Overexpression of the p120ctn isoform 3A in human colon adenocarcinoma cells (HT-29) results... is required for centrosome duplication (15). Cyclin E overexpression in human cancer cells ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
47 Cancer Res. Author manuscript Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin
 

Summary:  , these observations strongly suggest that p120ctn overexpression results in impaired proteasome degradation... . Overexpression of the p120ctn isoform 3A in human colon adenocarcinoma cells (HT-29) results in cytoplasmic... is required for centrosome duplication ( ).15 Cyclin E overexpression in human cancer ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
48 JOURNAL OF BACTERIOLOGY, May 2002, p. 26922698 Vol. 184, No. 10 0021-9193/02/$04.00 0 DOI: 10.1128/JB.184.10.26922698.2002
 

Summary:  . Overexpression of Two Different GTPases Rescues a Null Mutation in a Heat-Induced rRNA Methyltransferase... overexpression of other E. coli genes can restore the severe growth defect observed in rrmJ null mutants, we... constructed an overexpression library from the rrmJ deletion strain and cloned and identified the E. coli

  

Source: Bardwell, James - Department of Molecular, Cellular and Developmental Biology, University of Michigan

 

Collection: Biology and Medicine ; Biotechnology

 
49 Vascular Biology, Atherosclerosis and Endothelium Biology Overexpression of Bcl-2 in Vascular Endothelium
 

Summary:  Vascular Biology, Atherosclerosis and Endothelium Biology Overexpression of Bcl-2 in Vascular... early stages of diabetic retinopathy. Trans- genic mice overexpressing Bcl-2 regulated by the pre... or leukostasis. There- fore, overexpression of Bcl-2 in endothelial cells inhibits the capillary degeneration

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
50 Usa1p Is Required for Optimal Function and Regulation of the Hrd1p Endoplasmic Reticulum-associated Degradation
 

Summary:  present in each strain without drug treatment. F, Hrd1p overexpression suppressed the Hmg2p... -overexpressing plasmid (TDH3-HRD1) were subject to cycloheximide chase for 2 h (gray bars) and compared... - tion of another ERAD-M substrate, Sec61-2p, was also impaired in a usa1 strain (see Fig. 4B, right

  

Source: Sahinalp, S. Cenk - School of Computing Science, Simon Fraser University

 

Collection: Biology and Medicine ; Computer Technologies and Information Sciences

 
51 MOLECULAR AND CELLULAR BIOLOGY, Jan. 2006, p. 371380 Vol. 26, No. 1 0270-7306/06/$08.00 0 doi:10.1128/MCB.26.1.371380.2006
 

Summary:  in FIG. 2. Overexpression of specific protein fragments can impair the degradation of various substrates... the standard deviations. TABLE 2. Overexpressed cDNA clones impair deg1-mediated degradation Gene No... , then mutations that impair Tup1- 2 binding should relieve the inhibitory ...

  

Source: Hochstrasser, Mark - Department of Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine

 
52 Functional analysis of Bacillus subtilis YkoJ, a cell envelope affector induced by secretion
 

Summary:  overexpression in Lactococcus lactis. Overproduction in L. lactis did not impair growth, and even induction... Overexpression of a poorly folding secreted protein in B. subtilis was shown to cause upregulation of yko... of deletion and overexpression of ykoJ using DNA microarrays. Deletion of ykoJ has little ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
53 Overexpression of copper zinc superoxide dismutase impairs human trophoblast cell fusion and differentiation
 

Summary:  Overexpression of copper zinc superoxide dismutase impairs human trophoblast cell fusion... the demonstration that SOD-1 gene overexpression can impair neurotransmitter transport and alter neuromuscular... :526-533. 66. Elroy-Stein O, Groner Y 1988 Impaired neurotransmitter uptake in PC12 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
54 Embryonic stem cell markers expression in cancers Matthieu Schoenhals
 

Summary:  ) cells. In conjunction with Klf4 and c-Myc, their over-expression can induce pluripotency in both mouse... expression data, including the Oncomine Cancer Microarray database. We found significant overexpression... -renew. The overexpression of Oct3/4, Sox2, Klf4 and/or c-Myc could contribute to the pathologic self-renewal ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
55 Am J Physiol Heart Circ Physiol . Author manuscript Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the
 

Summary:  Am J Physiol Heart Circ Physiol . Author manuscript Page /1 8 Effects of cardiac overexpression... isoforms in the heart. Cardiac overexpression of AC6 (AC6 Tg) has been shown to be protective in response... .05) in AC6 Tg (3.8 0.07 mm) than WT (3.6 0.05 mm) after TAC. Thus, cardiac AC6± ± overexpression improves

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
56 Effects of Cardiac Overexpression of Type 6 Adenylyl Cyclase Affects on the Response to Chronic Pressure Overload
 

Summary:  1 Effects of Cardiac Overexpression of Type 6 Adenylyl Cyclase Affects on the Response to Chronic... isoforms in the heart. Cardiac overexpression of AC6 (AC6 Tg) has been shown to be protective in response... (3.8±0.07 mm) than WT (3.6±0.05 mm) after TAC. Thus, cardiac AC6 overexpression improves cardiac

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
57 Overexpression of miR165 Affects Apical Meristem Formation, Organ Polarity Establishment and Vascular Development in Arabidopsis
 

Summary:  development. Results Overexpression of miR165 impairs shoot apical meristem formation To investigate the roles... Overexpression of miR165 Affects Apical Meristem Formation, Organ Polarity Establishment... by an alteration in the expression of miR165 and miR166. Previous work showed that overexpression of ...

  

Source: Ye, Zheng-Hua - Department of Plant Biology, University of Georgia

 

Collection: Biology and Medicine

 
58 ISSN: 1524-4539 Copyright 2008 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online
 

Summary:  synthase overexpression impairs myocardial contractility. Circ Res. 2007; 100:e32­e44. 29. Luo W, Grupp IL... to Pressure Overload by Cardiomyocyte Overexpression of Neuronal Nitric Oxide Synthase Delays http... .ahajournals.orgDownloaded from #12;Cardiomyocyte Overexpression of Neuronal Nitric Oxide ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
59 Sudden infant death syndrome and serotonin: animal models
 

Summary:  into dysfunction and cause SIDS is uncertain. Recently, lethal effects in transgenic mice with overexpression... serotonin 1A auto- receptor binding, which is opposite to its overexpression in the mice, and the peak... , their abnormalities are more severe and their death is more likely.(19) Overexpression of the serotonin 1A

  

Source: Wagner, Diane - Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks

 

Collection: Environmental Sciences and Ecology

 
60 JOURNAL OF BACTERIOLOGY, Dec. 2006, p. 81898195 Vol. 188, No. 23 0021-9193/06/$08.00 0 doi:10.1128/JB.01119-06
 

Summary:  Residues and Novel Effects of Overexpression of the Streptomyces coelicolor Developmental Protein Bld... , while two others are not. We find that overexpression of bldB in S. coelicolor blocks sporulation prior... normal in both the bldB null mutant and the bldB overexpression strain. To our surprise, ...

  

Source: Nodwell, Justin - Department of Biochemistry and Biomedical Sciences, McMaster University

 

Collection: Biology and Medicine


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61 The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors
 

Summary:  overexpressing DFz2, indicating that Wg movement is impaired as a result of the excess trapping of Wg by cells... overexpressing DFz2 (Figs. 6B,C), suggesting that Wg movement from the D/V margin into the wing blade is impaired... of the ligand. For example, in the context of Hh signaling, ...

  

Source: Higgins, Darren - Department of Microbiology and Molecular Genetics, Harvard University

 

Collection: Biology and Medicine

 
62 Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of -Synuclein in the Nigrostriatal System
 

Summary:  Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of -Synuclein... by 8 weeks. Significant motor impairment developed in those animals in which dopa- mine neuron cell... for -synuclein in the pathogenesis of Parkinson's disease. Targeted overexpression of -synuclein

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
63 in vivo analysis of Drosophila deoxyribonucleoside kinase function in cell cycle, cell survival and anti-cancer drugs resistance
 

Summary:  NK function in vivo, we constructed transgenic Drosophila strains and impaired the nucleotide de novo... strains that allow ectopic or over-expression of dNK. We observed that dNK over-expression, when the de... pathway we decided to impair the de novo pathway using antifolates such as AM or MTX that inhibit

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
64 HMA1, a new Cu-ATPase of the chloroplast envelope, is essential for growth under adverse light conditions
 

Summary:  of vectors for stable expression in Arabidopsis - To construct the vector for HMA1 overexpression... overexpressing plants. Sequence analyses - Subcellular localizations were predicted using the following programs... of HMA1 by expression in yeast Heterologous expression of H160 impairs yeast cell growth and leads

  

Source: Wollman, Francis-André - nstitut de Biologie Physico-Chimique & Université Pierre-et-Marie-Curie, Paris 6

 

Collection: Biology and Medicine ; Renewable Energy

 
65 Target mimicry provides a new mechanism for regulation of microRNA activity
 

Summary:  of their overexpression. Overexpression of ips1 mutants with impaired or lacking the region of complementarity with miR399... on PHO2 mRNA accumulation of overexpression of IPS1 or of ips1CR with impaired region of complementarity... but instead sequesters miR-399. Thus, IPS1 ...

  

Source: Weigel, Detlef - Abteilung 6 Molekularbiologie, Max-Planck-Institut für Entwicklungsbiologie

 

Collection: Biology and Medicine

 
66 Please cite this article in press as: Liu, W., et al., RACK1 is involved in -amyloid impairment of muscarinic regulation of GABAergic transmission. Neurobiol. Aging (2009), doi:10.1016/j.neurobiolaging.2009.10.017
 

Summary:  of these signaling molecules. We further examined whether overexpression of RACK1 could restore the impaired... Please cite this article in press as: Liu, W., et al., RACK1 is involved in -amyloid impairment... in -amyloid impairment of muscarinic regulation of GABAergic transmission Wenhua Liua, Fei Doub, ...

  

Source: Yan, Zhen - Department of Physiology and Biophysics, State University of New York at Buffalo

 

Collection: Biology and Medicine

 
67 Leukemia Research 30 (2006) 10191025 Aven overexpression: Association with poor prognosis
 

Summary:  Leukemia Research 30 (2006) 1019­1025 Aven overexpression: Association with poor prognosis... patients in the standard-risk group. Aven overexpression was an independent poor prognostic factor... -associate, suggesting that Aven independently impairs Apaf-1-mediated caspase activation. Although it is known that Aven

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
68 Traffic 2010; 11: 10341043 2010 John Wiley & Sons A/S doi:10.1111/j.1600-0854.2010.01080.x
 

Summary:  genes that suppress this phenotype when overexpressed. We identified SMY2 as a gen- eral suppressor... , to identify proteins that, when overexpressed, overcome the lethality associated with defective cargo capture... that are impaired in their association with this site will promote their capture into vesicles, either by ...

  

Source: Miller, Liz - Department of Biological Sciences, Columbia University

 

Collection: Biology and Medicine

 
69 Wien Med Wochenschr (2010) DOI 10.1007/s10354-010-0838-6
 

Summary:  efficacy in HER2-overexpressing breast cancers and is approved for patients whose tumors carry... use remain unresolved. Many breast cancer patients with HER2 overexpression do not respond to initial... overexpressed in about 15­20% of invasive breast cancers. HER2-positive breast cancer patients have different

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
70 EARLY RESPONSIVE TO DEHYDRATION 15, a Negative Regulator of Abscisic Acid Responses in Arabidopsis1
 

Summary:  of ERD15 is detrimental to the basal freezing tolerance of Arabidopsis. Overexpression of ERD15 Impairs... levels by overexpression or RNAi silencing altered the responsiveness of the transgenic plants... to the phytohormone abscisic acid (ABA). Overexpression of ERD15 reduced the ABA sensitivity of ...

  

Source: Palva, Tapio - Department of Biosciences, University of Helsinki

 

Collection: Biology and Medicine

 
71 2005 FASEB The FASEB Journal express article 10.1096/fj.05-4869fje. Published online December 21, 2005.
 

Summary:  that overexpression of MT-desmin but not normal desmin protein impairs UPS proteolytic function in the heart... , 2005. Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts Jinbao Liu,*,,1... by a mutant (MT) or misfolded protein impairs the UPS. However, this has not been demonstrated ...

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
72 Hsp110 Chaperones Regulate Prion Formation and Propagation in S. cerevisiae by Two Discrete Activities
 

Summary:  this by overexpressing Ssa1 in the [PSI+ ]s sse1D strain and indeed found that the impaired prion propagation... as propagation, although with opposing effects. [PSI+ ] formation induced upon Sup35 overexpression is stimulated... levels of Ssb1 [17,18], while propagation is inhibited by overexpression of ...

  

Source: Lindquist, Susan - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
73 Proc. Natl. Acad. Sci. USA Vol. 95, pp. 26862690, March 1998
 

Summary:  photomorphogenesis of seedlings was studied by using trans- genic plants overexpressing CRY2 protein, and cry2 mutant... - and light-grown Arabidopsis seedlings (12). hy4 (or cry1) mutants impaired in CRY1 exhibit decreased... sensitivity to blue light (7, 10), whereas transgenic plants overexpressing CRY1 show increased

  

Source: Lin, Chentao - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
74 INTRODUCTION Alzheimer's disease (AD) is a neurodegenerative disorder of
 

Summary:  in overlapping patterns in Drosophila and that dominant adult phenotypes produced by overexpression of presenilin... can be suppressed by overexpression of filamin in the same tissue. Taken together, these results... development and that overexpression of filamin can suppress dominant adult phenotypes generated

  

Source: Cooley, Lynn - Department of Genetics, Yale University

 

Collection: Biology and Medicine

 
75 Niemann-Pick Type C1 (NPC1) Overexpression Alters Cellular Cholesterol Homeostasis*
 

Summary:  Niemann-Pick Type C1 (NPC1) Overexpression Alters Cellular Cholesterol Homeostasis* Received... - nese hamster ovary (CHO) cell lines overexpressing the human NPC1 protein (CHO/NPC1). NPC1 overexpres... of NPC1, we generated stable Chinese hamster ovary (CHO) cell lines that overexpress NPC1 and examined

  

Source: Traub, Linton M. - Department of Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
76 Human SCO2 is required for the synthesis of CO II and as a thiol-disulphide oxidoreductase for SCO1
 

Summary:  to reduced cysteines in SCO1 is perturbed in cells from both SCO backgrounds. Overexpression of wild-type SCO... the copper-binding cysteines of SCO1. RESULTS SCO2 mutations impair CO II synthesis and delay its turnover... mitochondrial translation experiments in control and SCO2 myoblasts overexpressing wild-type or mutant SCO2

  

Source: Leary, Scot - Department of Biochemistry, University of Saskatchewan; Shoubridge, Eric - Montreal Neurological Institute, McGill University

 

Collection: Biology and Medicine

 
77 BIOINFORMATICS ORIGINAL PAPER Vol. 25 no. 7 2009, pages 875881
 

Summary:  of aging, including 56 genes consistently overexpressed with age, the most significant of which was APOD... with these signatures and found that age-related gene expression changes most notably involve an overexpression... overexpressed in each experiment and 4.62% underexpressed. Admittedly, this is a relatively relaxed cutoff

  

Source: Church, George M. - Wyss Institute for Biologically Inspired Engineering & Department of Genetics, Harvard University; de Magalhães, João Pedro - School of Biological Sciences, University of Liverpool

 

Collection: Biology and Medicine ; Biotechnology

 
78 Introduction Epithelial tissue functions depend largely on a polarized
 

Summary:  is extracellular (Fig. 2B). Overexpression of PVF1, using MS1096-Gal4, a strong wing-specific driver, retained... . Incubation of live discs overexpressing PVF1 with the antibody demonstrated that the majority of apical PVF1... is extracellular (not shown). The restricted apical localization of overexpressed PVF1 was maintained ...

  

Source: Shilo, Benny - Department of Molecular Genetics, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
79 INTRODUCTION The 14-3-3 proteins are a family of small acidic molecules that
 

Summary:  1 blocks Ras overexpression-induced activation of Raf-1 in yeast cells (Irie et al., 1994... forms of Raf-1 (Fu et al., 1994; Li et al., 1995). Therefore the mechanism by which overexpression of 14... whether activation of Raf-1 by overexpressed 14- 3-3 proteins requires the participation of additional

  

Source: Higgins, Darren - Department of Microbiology and Molecular Genetics, Harvard University

 

Collection: Biology and Medicine

 
80 Identification of loci determining susceptibility to the lethal effects of amyloid precursor
 

Summary:  protein transgene overexpression Joseph Krezowski1,{ , Danielle Knudson1,{ , Christine Ebeling1 , Rose... vary depending on the genetic background of the mouse. FVB/N mice overexpressing human APP695 develop... . 129S6 mice are resistant to the lethal effects of APP overexpression, allowing sufficient levels of Ab

  

Source: Giri, Ranjit K. - National Brain Research Centre (India)

 

Collection: Biology and Medicine


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81 MOLECULAR AND CELLULAR BIOLOGY, Sept. 2009, p. 51685180 Vol. 29, No. 18 0270-7306/09/$08.00 0 doi:10.1128/MCB.00482-09
 

Summary:  , including GATA-1s-expressing fetal megakaryocyte progenitors. Moreover, our data reveal that overexpression... July 2009. 5168 #12;The effect of overexpression of GATA-2 is less clear. Ec- topic expression of GATA... . Furthermore, by using a mouse model of human GATA1 DS-AMKL mutations, we reveal that GATA-2 overexpression

  

Source: Li, Zhe - Division of Genetics, Brigham and Women's Hospital, Harvard University

 

Collection: Biology and Medicine

 
82 [Fly 3:1, 1-10; Jan/Feb/Mar 2009]; 2009 Landes Bioscience 1 Fly 2009; Vol. 3 Issue 1
 

Summary:  for lifespan extension by increasing activity of genes that promote antioxidant defenses. Overexpression... by catalyzing the repair of oxidized methionine, and overexpression of msrA in the nervous system can extend... lifespan.12 Enhancement of the redox process by overexpression of glucose-6-phosphate dehydrogenase (G6PD

  

Source: Schmidt, Paul - Department of Biology, University of Pennsylvania

 

Collection: Biology and Medicine

 
83 Cell, Vol. 109, 371381, May 3, 2002, Copyright 2002 by Cell Press Prickle Mediates Feedback Amplification
 

Summary:  of overexpression that amplifies differences between Frizzled levels on phenotypes suggests that information... of the clones. (H) Polarity disruption in the region where Fz is overexpressed in ptc-GAL4/UAS-fz flies... . The approximate location of the Fz overexpression domain is shaded green. (I) Pk localization in a ...

  

Source: Scott, Matthew - Departments of Developmental Biology, Genetics, & Bioengineering, Stanford University

 

Collection: Biotechnology ; Biology and Medicine

 
84 The EMBO Journal Vol.17 No.19 pp.57085717, 1998 Cloning of mammalian Ire1 reveals diversity in the
 

Summary:  of the ER stress-response in yeast. The mammalian Ire1 is located in the ER membrane and its over-expression... in mammalian cells activates both the endogenous ER chaperone GRP78/BiP and CHOP-encoding genes. Over-expression... induced by tunicamycin treatment. Over-expression of murine Ire1 also leads to the development

  

Source: Ron, David - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

 

Collection: Biology and Medicine

 
85 Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation
 

Summary:  through Stat3 activation, protected cells from H/R-induced apoptosis. Adenoviral overexpression... at the protein and mRNA levels. Overexpression of Mn-SOD significantly reduced H/R-induced ROS and apoptosis... after H/R may be functionally impaired mitochondria [4,5]. Excessive ROS not only exert direct effects

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
86 CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis
 

Summary:  -asso- ciated protein CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) in vitro. The overexpression of one of its regulatory... (toc1) mutants and TOC1-overexpressing plants also indicate a role for the TOC1 gene product... extracts requires phosphorylation by CK2 (11). Plants overexpressing CKB3 (CKB3-ox plants) are affected

  

Source: Tobin, Elaine - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
87 Procedure No 400.10 Subject: Fire Protection Impairment Program
 

Summary:  Procedure No 400.10 Subject: Fire Protection Impairment Program Reference: NFPA (see bottom... taken during the impairment to ensure that increased risks are minimized and the duration... of the impairment is limited. Procedures set forth in this policy do not apply to routine scheduled maintenance

  

Source: Karsai, Istvan - Department of Biological Sciences, East Tennessee State University

 

Collection: Biology and Medicine

 
88 Cellular/Molecular Activity-Independent Regulation of Dendrite Patterning by
 

Summary:  synaptic functions. In immature neurons, overexpression of PSD-95 decreases the proportion of primary... . Finally, overexpression of PSD-95 in COS-7 cells disrupts microtubule organization, indicating that PSD-95... as a stop signal for branching and that overexpression of PSD-95 results in decreased secondary den- drite

  

Source: Rongo, Christopher - Department of Genetics, Rutgers University

 

Collection: Biology and Medicine

 
89 Understanding the Role of the HSP70 Molecular Chaperone Family in Maintaining Protein Homeostasis
 

Summary:  Compensatory Chaperone Networks through Gene Expression. B. HSP70 Overexpression and its Effects on Protein... . Generation of Transgenic HSP-1 Overexpression Strains ii. HSP-1 Overexpression and PolyQ Aggregation iii... . The Effect of Chaperone Overexpression on Cellular Function iv. HSP-1 ...

  

Source: Northwestern University, Dynamics of Complex Systems in Science and Engineering Center

 

Collection: Engineering

 
90 Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration
 

Summary:  Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration... not observe an improvement of the R6/2 phenotype. Hsp27 overexpression had no effect in reducing oxidative... is generally in mid-life, and patients develop psychiatric disturbances, impairment of motor coordination

  

Source: Morimoto, Richard - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University

 

Collection: Biology and Medicine

 
91 HMA1, a New Cu-ATPase of the Chloroplast Envelope, Is Essential for Growth under Adverse Light Conditions*S
 

Summary:  . Construction of Vectors for Stable Expression in Arabidopsis--To construct the vector for HMA1 overexpression... envelope proteins derived from chloroplasts of WT, hma1 mutants, and HMA1-overexpressing plants. Sequence... in Yeast Heterologous Expression of H1 60 Impairs Yeast Cell Growth and Leads to Cellular Zinc and Copper

  

Source: Wollman, Francis-André - nstitut de Biologie Physico-Chimique & Université Pierre-et-Marie-Curie, Paris 6

 

Collection: Biology and Medicine ; Renewable Energy

 
92 98:3568-3580, 2007. First published Oct 3, 2007; doi:10.1152/jn.00604.2007J Neurophysiol Diasinou Fioravante, Rong-Yu Liu, Anne K. Netek, Leonard J. Cleary and John
 

Summary:  impairment of vesicle mobilization and/or fusion in synapsin- overexpressing cells (Fig. 3). To further study... and heterosynaptic plastic- ity. Overexpression of synapsin reduced basal transmission and en- hanced homosynaptic... ; Molecular Probes) was used to label vesicle pools in control and ...

  

Source: Byrne, John H. - Department of Neurobiology and Anatomy, University of Texas Medical School at Houston

 

Collection: Biology and Medicine

 
93 MOLECULAR AND CELLULAR BIOLOGY, Feb. 2011, p. 793802 Vol. 31, No. 4 0270-7306/11/$12.00 doi:10.1128/MCB.01117-10
 

Summary:  by downregulating SR proteins and upregulating a RBFOX protein and that SR protein overexpression impairs regulated... protein may impair the selection of an * Corresponding author. Mailing address for Xiang-Dong Fu: De... splicing regu- lators. We found that overexpression of a Fox protein (now renamed ...

  

Source: Hertel, Klemens J. - Department of Microbiology and Molecular Genetics, University of California, Irvine

 

Collection: Biology and Medicine

 
94 BioMed Central Page 1 of 1
 

Summary:  for PI(4,5)P2 only if enhanced by phophatidylserine. Virus production was strongly impaired by PI(4,5)P2... depletion under 5ptaseIV overexpression. Our results suggest that the N-terminal polybasic region of MA

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
95 Cdk1, Plks, Auroras and Nrks ... the mitotic bodyguards. Patrick Salaun, Yoann Rannou and Claude Prigent*
 

Summary:  in cytokinesis has been found in different organisms. Septum formation is impaired in the fission yeast kinase... defective mutants while ectopic septum are formed when the kinase is overexpressed (35, 36). In Drosophila... be involved later in mitosis because its overexpression induced a bypass of the Taxol induced mitotic

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
96 miR-125b-2 is a potential oncomiR on human chromosome 21
 

Summary:  human DS-AMKL, miR-125b-2 is highly overexpressed. In line with the observed impairment of proliferation... ) and megakar- yocytic/erythroid progenitors (MEPs). miR-125b-2 overexpression did not affect megakaryocytic... R-125b-2 on MEPs accentuated the Gata1s mutation, whereas growth of DS-AMKL/TL cells was ...

  

Source: Li, Zhe - Division of Genetics, Brigham and Women's Hospital, Harvard University

 

Collection: Biology and Medicine

 
97 983RESEARCH ARTICLE INTRODUCTION
 

Summary:  overexpression also impaired dMyc activity (see Fig. S4 in the supplementary material; Fig. 5H-K). Quantification... was observed (Fig. 1K). To test whether endoreplication is necessary for growth, we overexpressed in muscles... , respectively. Conversely, overexpression of wild-type InR resulted in a ...

  

Source: Higgins, Darren - Department of Microbiology and Molecular Genetics, Harvard University

 

Collection: Biology and Medicine

 
98 L E T T E R S Essential role for eIF4GI overexpression in the
 

Summary:  L E T T E R S Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast... , is indicative of low metastatic potential6,7 . In IBC, E-cadherin is overexpressed8 and supports formation... that the unique pathogenic properties of IBC result in part from overexpression of the translation initiation

  

Source: Bedwell, David M. - Department of Microbiology, University of Alabama at Birmingham

 

Collection: Biology and Medicine

 
99 DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma
 

Summary:  overexpression of DEPTOR impaired the regulation of its expression (Figures S3E and S3F), we focused on other... DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required... TORC2 kinase activities. DEPTOR overexpression suppresses S6K1 but, by relieving feedback inhibition

  

Source: Sabatini, David M. - Whitehead Institute for Biomedical Research & Department of Biology, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
100 OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted
 

Summary:  of the domains 4, 4b and 5b in mammalian cells, we compared the overexpression effects of the isoforms containing... transfected by vectors expressing each variant and the detection of the over-expressed OPA1 was performed... referred here as a, b, c, d, and e (Fig.2A). 24 hours after transfection, all the OPA1 isoforms were ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics


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