Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
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| Title | Restriction fragment length polymorphism mapping of quantitative trait loci for malaria parasite susceptibility in the mosquito Aedes aegypti |
| Creator/Author | Severson, D.W. ; Thathy, V. ; Mori, A. [Univ. of Wisconsin, Madison, WI (United States)] [and others] |
| Publication Date | 1995 Apr 01 |
| OSTI Identifier | OSTI ID: 91171 |
| Other Number(s) | Journal ID: GENTAE; ISSN 0016-6731; Other: CNN: Grant AI-33127; TRN: TRN: 95:004999-0013 |
| Resource Type | Journal Article |
| Resource Relation | Journal Name: Genetics; Journal Volume: 139; Journal Issue: 4; Other Information: PBD: Apr 1995 |
| Subject | 55 BIOLOGY AND MEDICINE, BASIC STUDIES; MOSQUITOES; MALARIA; PHENOTYPE; CHROMOSOMES; GENETIC MAPPING; DOMINANT MUTATIONS; GENES; RFLPS; STATISTICS |
| Description/Abstract | Susceptibility of the mosquito Aedes aegypti to the malarial parasite Plasmodium gallinaceum was investigated as a quantitative trait using restriction fragment length polymorphisms (RFLP). Two F{sub 2} populations of mosquitoes were independently prepared from pairwise matings between a highly susceptible and a refractory strain of A. aegypti. RFLP were tested for association with oocyst development on the mosquito midgut. Two putative quantitative trait loci (QTL) were identified that significantly affect susceptibility. One QTL, pgs [2,LF98], is located on chromosome 2 and accounted for 65 and 49% of the observed phenotypic variance in the two populations, respectively. A second QTL, pgs[3,MalI], is located on chromosome 3 and accounted for 14 and 10% of the observed phenotypic variance in the two populations, respectively. Both QTL exhibit a partial dominance effect on susceptibility, wherein the dominance effect is derived from the refractory parent. No indication of epistasis between these QTL was detected. Evidence suggests that either a tightly linked cluster of independent genes or a single locus affecting susceptibility to various mosquito-borne parasites and pathogens has evolved near the LF98 locus; in addition to P. gallinaceum susceptibility, this general genome region has previously been implicated in susceptibility to the filaria nematode Brugia malayi and the yellow fever virus. 35 refs., 2 figs., 3 tabs. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: pp. 1711-1717 |
| System Entry Date | 2008 Feb 04 |
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Last Updated: 11/19/2009