Resorcinol: Final goitrogenic product in water from a goitrogenic well
- Univ. of Mississippi, Jackson (United States) Veterans Administration Medical Center, Jackson, MS (United States)
- Oak Ridge National Lab., TN (United States)
- University of Alabama, Birmingham (United States) Veterans Administration Medical Center, Birmingham (United States)
- Vanderbilt Univ., Nashville, TN (United States)
In Candelaria, Colombia, SA, goiter prevalence among children was 23% in Zone A and 11% in Zone B (p <0.05). Socioeconomic conditions, dietary composition or iodine intake could not explain this difference. However, the water for the town was supplied by two wells through independent pipeline systems, one located in Zone A and the other in Zone B. Within a year, the goiter prevalence rose to 31% in Zone B, while that in Zone A remained the same, 26% (p,NS). This indicated that water from well A might contain goitrogens. Rats drinking water or activated carbon extracts from well A developed larger thyroid glands and more pronounced thiourea-like antithyroid effects than rats drinking water or extracts from well B. Similar results were obtained by the acute in vivo suppression of thyroid 131I-uptake in mice and by in vitro assays, Elemental analysis and infrared spectrometry of well A goitrogenic water extracts (GWE) gave composition and common absorption bands similar to those of aquatic humic substances (HS). The HS, fulvic and humic acids, inhibited thyroid peroxidase (TPO) in vitro with 15% of the potency of propylthiouracil (PTU). GC/MS analysis of GWE identified over 30 organic compounds, including resorcinol. In contrast only four compounds, not including resorcinol, were identified in well B non-GWE. Resorcinol was goitrogenic and antithyroid in two different rat strains.
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6969353
- Journal Information:
- [Formerly used by DOE/TIC for titles for which valid CODEN was not available. Now invalid] 92-DEC-15; (Country unknown/Code not available), Vol. 5:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DRINKING WATER
CONTAMINATION
GOITER
EPIDEMIOLOGY
RESORCINOL
TOXICITY
SOUTH AMERICA
WATER POLLUTION
CHILDREN
FULVIC ACIDS
GAS CHROMATOGRAPHY
HUMIC ACIDS
IODINE 131
MASS SPECTROSCOPY
PEROXIDASES
RATS
SOCIO-ECONOMIC FACTORS
THYROID
TRACER TECHNIQUES
AGE GROUPS
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
DEVELOPERS
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
ENZYMES
GLANDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INSTITUTIONAL FACTORS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LATIN AMERICA
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PHENOLS
POLLUTION
POLYPHENOLS
PROTEINS
RADIOISOTOPES
RODENTS
SEPARATION PROCESSES
SPECTROSCOPY
VERTEBRATES
WATER
540320* - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology