Energy Citations Database
Bookmark and Share

Bibliographic Citation

 
Document
For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field.
For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability.
Title Interaction of iododeoxyuridine and its primary metabolite, iodouracil on radiation response
Creator/Author Kinsella, T.J. ; Dobson, P.P. ; Mitchell, J.B.
Publication Date1986 Aug 01
OSTI IdentifierOSTI ID: 6934528
Other Number(s)Journal ID: CODEN: IOBPD
Resource TypeJournal Article
Resource RelationJournal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States); Journal Volume: 8
Research OrgNational Cancer Institute, Bethesda, MD
Subject63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IODODEOXYURIDINE; RADIOSENSITIVITY EFFECTS; IODOURACILS; ANIMAL CELLS; BIOCHEMISTRY; CELL DIVISION; HAMSTERS; IN VITRO; METABOLISM; ANIMALS; ANTIMETABOLITES; AZINES; CHEMISTRY; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; MAMMALS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RIBOSIDES; RODENTS; URACILS; VERTEBRATES
Description/AbstractAn in vitro model using Chinese hamster V79 cells was designed to test the interaction of iododeoxyuridine (IdUrd) and its primary metabolite, iodouracil (IU) on growth and radiation response. A recent clinical pharmacology study documented that while steady-state arterial plasma levels of IdUrd remained linear over the dose range of 250-1200 mg/m2/12 hour intravenous infusion, plasma levels of IU rose to greater than 1 log higher (approaching 10(-4) M) at the completion of the 12-hour infusion. Using these clinically relevant doses of IdUrd and IU, we report no apparent effect on radiosensitization of IU alone, or in combination with IdUrd using exponentially growing V79 cells. Similarly, IU does not result in any growth delay. Thus, unlike the recent reports of 5-fluorouracil being incorporated into DNA following phosphorylation to FdUMP, iodouracil does not appear to follow similar metabolic pathways and is unlikely to contribute to the clinical radiosensitizing potential of iododeoxyuridine.
Country of PublicationUnited States
LanguageEnglish
FormatMedium: X; Size: Pages: 1519-1522
System Entry Date2008 Feb 08

Top