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Whole-body fission-neutron irradiation of mice results in changes in plasma and urinary prostaglandin levels. No relationship was found between urinary TxB2 excretion and the neutron dose. Elevated plasma prostaglandin PGE2 at 2-4 days postexposure coincides with increased PGE2 in the urine. A second increase in urinary PGE2 occurred 6-10 days postirradiation, and was dose dependent up to 3.85 Gy. Plasma PGE2 levels at this time were normal. WR-2721 (a radioprotective phosphorothioate) administration markedly increased (24 hr) and then reduced (2-4 days) PGE2 excretion in nonirradiated animals. The urinary PGE2 of WR-2721-pretreated, irradiated mice paralleled those of drug-treated, nonirradiated animals for the first 5 days. However, WR-2721 injection did not modify the elevation of PGE2 occurring 6-10 days postexposure. Urinary TxB2 from nonirradiated groups was not altered by WR-2721, but the combination of drug and radiation resulted in increased levels 1-7 days postexposure. These results further implicate prostaglandins in the biological response to radiation exposure and suggest another mechanism of WR-2721 radioprotection.
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| Authors: |
Steel, L.K.;
Ledney, G.D.
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| Publication Date: | 1987 Jan 01 |
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| OSTI Identifier: | 6895844 |
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| Report Number(s): | AD-A-192645/0/XAB; AFRRI-SR-87-47 |
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| Resource Type: | Technical Report |
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| Resource Relation: | Pub. in Prostaglandin and Lipid Metabolism in Radiation Injury, 207-218(1987) |
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| Research Org: | Armed Forces Radiobiology Research Inst., Bethesda, MD (USA) |
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| Country of Publication: | United States |
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| Language: | English |
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| Format: | Size: Pages: 13 |
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| Subject: | 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD PLASMA; PROSTAGLANDINS; BODY FLUIDS; BIOLOGICAL RADIATION EFFECTS; RADIOSENSITIVITY EFFECTS; RADIOPROTECTIVE SUBSTANCES; PERFORMANCE; URINE; ANIMALS; DRUGS; FISSION NEUTRONS; IRRADIATION; MICE; BARYONS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BLOOD; ELEMENTARY PARTICLES; FERMIONS; HADRONS; MAMMALS; MATERIALS; NEUTRONS; NUCLEONS; RADIATION EFFECTS; RODENTS; VERTEBRATES; WASTES |
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| Availability: | NTIS, PC A03/MF A01. |
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| Update Date: | 2008 Feb 08 |
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