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Title: Hepatopathy following irradiation and adriamycin

Journal Article · · Cancer; (United States)
;

This report describes two cases of hepatopathy following irradiation and adriamycin at doses and volumes of irradiation ordinarily considered within the tolerance of hepatic function. In one case, fatal hepatopathy followed 2400 rad/17 fractions/28 days to the entire liver with preceding and concurrent adriamycin. In the second case moderate clinical changes occurred after treatment in which much of the right lobe of the liver was shielded following 2500 rad/23 fractions/32 days with adriamycin administered before, during, and after irradiation. The locally enhancing effects of adriamycin on hepatic tolerance to irradiation are discussed.

Research Organization:
Midwest Childhood Cancer Center, Milwaukee
OSTI ID:
6751948
Journal Information:
Cancer; (United States), Vol. 42:1
Country of Publication:
United States
Language:
English

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Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
RADIOSENSITIVITY EFFECTS
LIVER
RADIATION INJURIES
RADIOTHERAPY
SIDE EFFECTS
ABDOMEN
CHEMOTHERAPY
CHILDREN
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
HODGKINS DISEASE
IONIZING RADIATIONS
NEOPLASMS
OVARIES
PARTIAL BODY IRRADIATION
PATIENTS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DIGESTIVE SYSTEM
DISEASES
DRUGS
FEMALE GENITALS
GLANDS
GONADS
INJURIES
IRRADIATION
LYMPHOMAS
MAMMALS
MAN
MEDICINE
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
THERAPY
VERTEBRATES
560151* - Radiation Effects on Animals- Man