Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma
- Univ. of Michigan Medical Center, Ann Arbor, MI (United States)
The purpose was to determine the potential advantage of combining halogenated pyrimidine radiosensitization and continuous low dose rate irradiation in human malignant glioma. An established glioma line (U-251) was incubated with 5-bromo-2-doxyuridine (BrdUrd) at clinically achievable concentrations at three dose rates of interest - 100 cGy/min (typical of external beam therapy), 43 cGy/hr (typical of temporary afterloaded implants), and 12 cGy/hr (typical of permanent implants). After exposure to 1 [mu]M BrdUrd, the greatest enhancement ratio was seen at the 12 cGy/hr dose rate, implying a BrdUrd induced inverse dose rate effect independent of a G[sub 2]M block. Under these conditions, the mean inactivation dose after 1 [mu]M BrdUrd exposure was equivalent for 100 cGy/min and 12 cGy/hr. These results support the use of halopyrimidines as sensitizers of temporary afterloaded and permanent implants. 26 refs., 3 figs., 1 tab.
- OSTI ID:
- 6646577
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics; (United States), Vol. 26:4; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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BROMOURACILS
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HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MEDICINE
NEOPLASMS
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