Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
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| Title | Allopurinol therapy and cataractogenesis in humans |
| Creator/Author | Lerman, S. ; Megaw, J.M. ; Gardner, K. |
| Publication Date | 1982 Aug 01 |
| OSTI Identifier | OSTI ID: 6638206 |
| Other Number(s) | Journal ID: CODEN: AJOPA |
| Resource Type | Journal Article |
| Resource Relation | Journal Name: Am. J. Ophthalmol.; (United States); Journal Volume: 94:2 |
| Research Org | Department of Ophthalmology, Emory University, Atlanta, GA |
| Subject | 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; CATARACTS; ETIOLOGY; CHEMOTHERAPY; SIDE EFFECTS; PYRIMIDINES; BIOLOGICAL EFFECTS; RADIOSENSITIVITY EFFECTS; AGE DEPENDENCE; CRYSTALLINE LENS; PATIENTS; ULTRAVIOLET RADIATION; AZINES; BODY; BODY AREAS; DISEASES; ELECTROMAGNETIC RADIATION; EYES; FACE; HEAD; HETEROCYCLIC COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIATIONS; SENSE ORGANS; SENSE ORGANS DISEASES; THERAPY |
| Description/Abstract | Long-term ingestion of allopurinol, an antihyperuricemic agent used to treat gout, may be related to the development of lens opacities in relatively young patients (second to fifth decades of life). Cataracts obtained from three patients taking allopurinol were subjected to high-resolution phosphorescence spectroscopy. The characteristic allopurinol triplet was demonstrated in all three cataracts. Identical spectra were obtained for normal human lenses incubated in media containing 10(-3)M allopurinol and exposed to 1.2 mW/cm2 ultraviolet radiation for 16 hours; control lenses (irradiated without allopurinol) showed no allopurinol triplets. Similar data were obtained for lenses from rats given one dose of allopurinol and exposed to ultraviolet radiation overnight. These data provide evidence that allopurinol can be photobound in rat and human lenses and suggest its cataractogenic potential. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: Pages: 141-146 |
| System Entry Date | 2008 Feb 08 |
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Last Updated: 11/19/2009