Bibliographic Citation
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| Title | Effects of sulfate aerosols upon cardiopulmonary function in squirrel monkeys (final report). (Second year final report: effects of nitrate and /or sulfate aerosols upon cardiopulmonary function) |
| Creator/Author | Greenberg, H.L. ; Avol, E.L. ; Bailey, R.M. ; Bell, K.A. |
| Publication Date | 1977 Jun 24 |
| OSTI Identifier | OSTI ID: 6503156 |
| Report Number(s) | PB-279393 |
| Resource Type | Technical Report |
| Research Org | Rancho Los Amigos Hospital, Inc., Downey, CA (USA). Professional Staff Association |
| Subject | 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; AMMONIUM SULFATES; BIOLOGICAL EFFECTS; TOXICITY; CARDIOVASCULAR SYSTEM; PATHOLOGICAL CHANGES; PHOSPHATES; RESPIRATORY SYSTEM; SULFUR DIOXIDE; ZINC SULFATES; AEROSOL GENERATORS; AEROSOLS; HISTAMINE; HUMIDITY; INHALATION; MONKEYS; PARTICLE SIZE; AMINES; AMMONIUM COMPOUNDS; ANIMALS; AZOLES; CHALCOGENIDES; COLLOIDS; DISEASES; DISPERSIONS; HETEROCYCLIC COMPOUNDS; IMIDAZOLES; INTAKE; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; PRIMATES; SIZE; SOLS; SULFATES; SULFUR COMPOUNDS; SULFUR OXIDES; VERTEBRATES; ZINC COMPOUNDS |
| Description/Abstract | Squirrel monkeys were exposed to nominal concentrations of 2.5 mg/cu m of the following generated aerosols: zinc ammonium sulfate at both low (40%) and high (85%) nominal relative humidities, histamine diphosphate at low relative humidity, and ammonium bisulfate at low relative humidity. There were few statistically significant changes in oscillatory resistance, however, several trends toward increased resistance were present. Additional studies were performed using two different aerosol nebulizers to produce histamine diphosphate particles in two distinct size distributions, an order of magnitude different in size. These results, supported by data collected during sulfur dioxide exposures of squirrel monkeys, are used to discuss the suitability of Saimiri sciureus as a sensitive indicator species and oscillatory resistance as a valuable measurement of proximal airway changes. Development of the esophageal balloon technique as a means of measuring compliance and resistance in the unanesthetized squirrel monkey is discussed. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: Pages: 103 |
| Availability | NTIS PC A06/MF A01. |
| System Entry Date | 2008 Feb 08 |
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Last Updated: 11/19/2009