Structure-function relationships in radiation-induced cell and tissue lesions: special references to the contributions of scanning electron microscopy and hematopoietic tissue responses
Contributions of scanning electron microscopy to the field of radiation biology are briefly reviewed and presented in terms of an overall goal to identify and characterize the structural features of radiation-induced lesions in vital cell and tissue targets. In the context of lesion production, the major radiation-elicited response sequences, the types and nature of measured end points, and governing temporal and radiobiological parameters are discussed and illustrated by using results derived from both in vitro cell systems and in vivo studies that measured tissue responses from various organ systems (respiratory, digestive, circulatory, and central nervous systems). Work in our laboratory on the nature of early and late hematopathologic tissue responses (aplastic anemia and myeloid leukemia) induced by protracted radiation exposure and the bridging effect of repair processes relative to the expression of these pathologies is highlighted.
- Research Organization:
- Argonne National Lab., IL
- OSTI ID:
- 6274023
- Journal Information:
- Scan. Microsc.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
Similar Records
CRC handbook of radiobiology
Preleukemic state in atomic bomb survivors, with special reference to retro- and prospective analysis
Related Subjects
ANEMIAS
RADIOINDUCTION
HEMATOPOIETIC SYSTEM
BIOLOGICAL RADIATION EFFECTS
LEUKEMIA
RADIOBIOLOGY
SCANNING ELECTRON MICROSCOPY
LYMPHOCYTES
RADIATION INJURIES
STRUCTURE-ACTIVITY RELATIONSHIPS
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTRON MICROSCOPY
HEMIC DISEASES
INJURIES
LEUKOCYTES
MATERIALS
MICROSCOPY
NEOPLASMS
RADIATION EFFECTS
SOMATIC CELLS
SYMPTOMS
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture