Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
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| Title | The critical period for peripheral specification of dorsal root ganglion neurons is related to the period of sensory neurogenesis |
| Creator/Author | Smith, C.L. (Univ. of Pittsburgh School of Medicine, PA (USA)) |
| Publication Date | 1990 Dec 01 |
| OSTI Identifier | OSTI ID: 6213889 |
| Other Number(s) | Journal ID: ISSN 0012-1606; CODEN: DEBIA |
| Resource Type | Journal Article |
| Resource Relation | Journal Name: Developmental Biology; (USA); Journal Volume: 142:2 |
| Subject | 59 BASIC BIOLOGICAL SCIENCES; NERVE CELLS; CELL DIFFERENTIATION; AUTORADIOGRAPHY; FROGS; SPINAL CORD; SURVIVAL TIME; THYMIDINE; TRANSPLANTS; TRITIUM COMPOUNDS; AMPHIBIANS; ANIMAL CELLS; ANIMALS; AQUATIC ORGANISMS; AZINES; CENTRAL NERVOUS SYSTEM; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; NERVOUS SYSTEM; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RIBOSIDES; SOMATIC CELLS; VERTEBRATES |
| Description/Abstract | Thoracic sensory neurons in bullfrog tadpoles can be induced to form connections typical of brachial sensory neurons by transplanting thoracic ganglia to the branchial level at stages when some thoracic sensory neurons already have formed connections. In order to find out how many postmitotic sensory neurons survive transplantation, ({sup 3}H)thymidine was administered to tadpoles in which thoracic ganglia were transplanted to the brachial level unilaterally at stages VII to IX. Between 16 and 37% of the neurons in transplanted ganglia were unlabeled, as compared to 46 to 60% in unoperated ganglia. Transplanted ganglia contained fewer unlabeled neurons than corresponding unoperated ganglia, indicating that transplantation caused degeneration of postmitotic neurons. Therefore, a large fraction of the neurons that formed connections typical of brachial sensory neurons probably differentiated while they were at the brachial level. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: Pages: 476-480 |
| System Entry Date | 2008 Feb 07 |
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Last Updated: 11/19/2009