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Monte Carlo simulation of energy absorption in oriented fibers of DNA is used to model the dependence of free-radical yields on the orientation of the fibers relative to a flux of ionizing radiation. A large asymmetry was assumed in the thermal conductivity of the fibers that permits rapid transport of vibrational energy along a DNA molecule, but not between different molecules. Based on this assumption, the model predicts that thymine radical anions have a significantly greater probability of undergoing a secondary protonation reaction if they are produced by a flux that is incident perpendicular to the DNA molecules. These results are in qualitative agreement with experimental data on the yield of 5,6-dihydrothymin-5-yl radicals when samples of oriented DNA were exposed at 77 K to neutrons. Keywords: High linear energy transfer, LET (Linear energy transfer), High energy protons, Reprints. (aw)
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| Authors: |
Miller, J.H.;
Wilson, W.E.;
Swenberg, C.E.;
Myers, L.S.;
Charlton, D.C.
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| Publication Date: | 1988 Nov 01 |
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| OSTI Identifier: | 6148658 |
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| Report Number(s): | AD-A-203247/2/XAB; AFRRI-SR-88-24 |
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| Resource Type: | Technical Report |
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| Resource Relation: | Pub. in Radiation Physics and Chemistry, Vol. 32, No. 3, 349-353(1988) |
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| Research Org: | Armed Forces Radiobiology Research Inst., Bethesda, MD (USA) |
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| Country of Publication: | United States |
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| Language: | English |
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| Format: | Size: Pages: 6 |
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| Subject: | 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; BIOLOGICAL RADIATION EFFECTS; ENERGY ABSORPTION; MONTE CARLO METHOD; FIBERS; LET; RADICALS; YIELDS; ASYMMETRY; EXPERIMENTAL DATA; MATHEMATICAL MODELS; MOLECULAR STRUCTURE; NEUTRONS; PROTONS; SAMPLING; SIMULATION; THERMAL CONDUCTIVITY; TRANSPORT; ABSORPTION; BARYONS; BIOLOGICAL EFFECTS; DATA; ELEMENTARY PARTICLES; ENERGY TRANSFER; FERMIONS; HADRONS; INFORMATION; NUCLEIC ACIDS; NUCLEONS; NUMERICAL DATA; ORGANIC COMPOUNDS; PHYSICAL PROPERTIES; RADIATION EFFECTS; THERMODYNAMIC PROPERTIES |
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| Availability: | NTIS, PC A02/MF A01. |
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| Update Date: | 2008 Feb 07 |
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