Modeling radical yields in oriented DNA exposed to high-LET (linear-energy-transfer) radiation
Monte Carlo simulation of energy absorption in oriented fibers of DNA is used to model the dependence of free-radical yields on the orientation of the fibers relative to a flux of ionizing radiation. A large asymmetry was assumed in the thermal conductivity of the fibers that permits rapid transport of vibrational energy along a DNA molecule, but not between different molecules. Based on this assumption, the model predicts that thymine radical anions have a significantly greater probability of undergoing a secondary protonation reaction if they are produced by a flux that is incident perpendicular to the DNA molecules. These results are in qualitative agreement with experimental data on the yield of 5,6-dihydrothymin-5-yl radicals when samples of oriented DNA were exposed at 77 K to neutrons. Keywords: High linear energy transfer, LET (Linear energy transfer), High energy protons, Reprints. (aw)
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 6148658
- Report Number(s):
- AD-A-203247/2/XAB; AFRRI-SR-88-24
- Resource Relation:
- Other Information: Pub. in Radiation Physics and Chemistry, Vol. 32, No. 3, 349-353(1988)
- Country of Publication:
- United States
- Language:
- English
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Radical yields in DNA exposed to ionizing radiation: Role of energy and charge transfer. (Reannouncement with new availability information)
Rapid communication: stochastic model of free-radical yields in oriented DNA exposed to densely ionizing radiation at 77K. Scientific report
Related Subjects
DNA
BIOLOGICAL RADIATION EFFECTS
ENERGY ABSORPTION
MONTE CARLO METHOD
FIBERS
LET
RADICALS
YIELDS
ASYMMETRY
EXPERIMENTAL DATA
MATHEMATICAL MODELS
MOLECULAR STRUCTURE
NEUTRONS
PROTONS
SAMPLING
SIMULATION
THERMAL CONDUCTIVITY
TRANSPORT
ABSORPTION
BARYONS
BIOLOGICAL EFFECTS
DATA
ELEMENTARY PARTICLES
ENERGY TRANSFER
FERMIONS
HADRONS
INFORMATION
NUCLEIC ACIDS
NUCLEONS
NUMERICAL DATA
ORGANIC COMPOUNDS
PHYSICAL PROPERTIES
RADIATION EFFECTS
THERMODYNAMIC PROPERTIES
560162* - Radionuclide Effects
Kinetics
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