Bibliographic Citation
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| Title | Vulnerability of dorsal root neurons and fibers toward methylmercury toxicity: a morphological evaluation |
| Creator/Author | Yip, R.K. ; Chang, L.W. |
| Publication Date | 1981 Oct 01 |
| OSTI Identifier | OSTI ID: 5705067 |
| Other Number(s) | Journal ID: CODEN: ENVRA |
| Resource Type | Journal Article |
| Resource Relation | Journal Name: Environ. Res.; (United States); Journal Volume: 26:1 |
| Research Org | Univ. of Arkansas, Little Rock |
| Subject | 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; METHYLMERCURY; TOXICITY; NERVE TISSUE; MORPHOLOGICAL CHANGES; BIOLOGICAL EFFECTS; CHLORINE COMPOUNDS; ELECTRON MICROSCOPY; NERVE CELLS; OPTICAL MICROSCOPY; RATS; ANIMAL CELLS; ANIMAL TISSUES; ANIMALS; BODY; HALOGEN COMPOUNDS; MAMMALS; MICROSCOPY; ORGANIC COMPOUNDS; ORGANIC MERCURY COMPOUNDS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES |
| Description/Abstract | The selective and relative sensitivity of various components (dorsal root neurons, dorsal root fibers, and ventral root fibers) of the dorsal root ganglia toward methylmercury toxicity were investigated. Charles River rats were orally administered methymercury chloride at a daily dose of 2.0 mg/kg body wt for 8 weeks. Dorsal root ganglia (L/sub 1/-S/sub 1/) were examined with light and electron microscopy. Extensive Wallerian-like degeneration was observed in the dorsal root fibers while no significant changes were found in the dorsal root neurons and in the ventral root fibers at the light-microscopic level. At the electron-microscopic level, only minor and possibly reversible changes, such as increase in lysosomes, neurofilamentous proliferation, and disintegration of the Nissl substance, were observed in the neuronal cell bodies while severe and irreversible degenerative changes occurred in the dorsal root fibers. No remarkable pathological changes were observed in the ventral root fibers. Schwann cells became hypertrophied and transformed into actively phagocytosing macrophages. It is concluded that while the dorsal root ganglia are highly vulnerable to the toxicity of methylmercury, the relative sensitivity to the toxic impact is: dorsal root fiber > dorsal root neuron (nerve cell body) > ventral root fibers. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: Pages: 152-167 |
| System Entry Date | 2008 Feb 07 |
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Last Updated: 11/19/2009