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Behavioral effects of radioprotective agents in mice: Combination of WR-2721 and 16,16 dimethyl prostaglandin E2

Description/Abstract

Although the radioprotective properties of a number of compounds have been investigated in the last 40 years the consideration and testing of the behavioral effects of these agents has only recently begun to be systematically investigated. Behavioral toxicity of an agent ha enhances radiotherapeutic efficacy is not necessarily a limiting factor in clinical use where small numbers of patients can be monitored and treated. However, an effective drug-screening program for radio protective agents must evaluate the behavioral toxicity of those compounds that have potential use for humans in radiation accidents and in civil defense situations.

Authors: Landauer, M.R.; Walden, T.L.; Davis, H.D.
Publication Date:1990 Jan 01
OSTI Identifier: 5681195
Report Number(s):AD-A-231137/1/XAB; AFFRI-SR--90-34
Resource Type:Technical Report
Resource Relation: Pub. in Frontiers in Radiation Biology, p199-207 1990
Research Org:Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
Country of Publication:United States
Language:English
Format: Size: Pages: (10 p)
Subject:63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PROSTAGLANDINS; RADIOSENSITIVITY EFFECTS; RADIOPROTECTIVE SUBSTANCES; TOXICITY; BEHAVIOR; CIVIL DEFENSE; MICE; ANIMALS; DRUGS; MAMMALS; NATIONAL DEFENSE; RODENTS; VERTEBRATES
Availability:NTIS
Update Date:2008 Feb 07

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