Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
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| Title | Iron depletion decreases lung injury after systemic complement activation |
| Creator/Author | Sullivan, J.L. ; Till, G.O. ; Ward, P.A. |
| Publication Date | 1986 Mar 01 |
| OSTI Identifier | OSTI ID: 5447057 |
| Report Number(s) | CONF-8604222- |
| Other Number(s) | Journal ID: CODEN: FEPRA |
| Resource Type | Conference |
| Specific Type | Journal Article |
| Resource Relation | Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States); Journal Volume: 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986 |
| Research Org | VAMC, Charleston, SC |
| Subject | 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IRON; NUTRITIONAL DEFICIENCY; LUNGS; INJURIES; CHELATING AGENTS; COMPLEMENT; DOSE-RESPONSE RELATIONSHIPS; RATS; RESPONSE MODIFYING FACTORS; VENOMS; ANIMALS; BODY; ELEMENTS; MAMMALS; METALS; ORGANS; RESPIRATORY SYSTEM; RODENTS; TRANSITION ELEMENTS; VERTEBRATES |
| Description/Abstract | Iron chelators protect rats from lung injury after complement activation by a cobra venom factor (CVF). Their purpose was to study the effect of prior nutritional iron depletion on CVF lung injury. Weanling Sprague-Dawley rats were given iron-deficient feed supplemented with 0, 10 or 100 mg Fe/kg ad lib. for 3 weeks before CVF infusion. Lung injury after i.v. CVF (25 U/kg) was estimated by the Permeability Index (PI), a measure of lung injury, mean red cell volume (MCV) and weight (WT) were also measured. In each group, 5 rats were given CVF; 4 control rats, saline. Mean MCV of control rats (n=6) given standard rat diet was 61.5. PI's after CVF in Group 1 (p < 0.001) and Group 2 (p < 0.05) were significantly different from that of Group 3. Even moderate iron deficiency (Group 2) decreased lung injury. These results suggest a concentration-dependent effect of endogenous iron on susceptibility to lung injury after systemic complement activation. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: Pages: 452 |
| System Entry Date | 2008 Feb 06 |
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