Bibliographic Citation
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| Title | Radiation-induced mutation at minisatellite loci |
| Creator/Author | Dubrova, Y.E. [Univ. of Leicester (United Kingdom)]|[Vavilov Institute of General Genetics, Moscow (Russian Federation)] ; Nesterov, V.N. ; Krouchinsky, N.G. [Research Institute for Radiation Medicine, Mogilev (Belarus)] [and others] |
| Publication Date | 1997 Oct 01 |
| OSTI Identifier | OSTI ID: 530834 |
| Report Number(s) | CONF-9704100-- |
| Other Number(s) | Journal ID: EMMUEG; ISSN 0893-6692; TRN: TRN: 97:003016-0007 |
| Resource Type | Journal Article |
| Resource Relation | Journal Name: Environmental and Molecular Mutagenesis; Journal Volume: 29; Journal Issue: Suppl.28; Conference: 28. annual meeting of the Environmental Mutagen Society, Minneapolis, MN (United States), 19-23 Apr 1997; Other Information: PBD: 1997 |
| Subject | 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; MAN; BIOLOGICAL RADIATION EFFECTS; MUTATIONS; MICE |
| Description/Abstract | We are studying the radiation-induced increase of mutation rate in minisatellite loci in mice and humans. Minisatellite mutations were scored by multilocus DNA fingerprint analysis in the progeny of {gamma}-irradiated and non-irradiated mice. The frequency of mutation in offspring of irradiated males was 1.7 higher that in the control group. Germline mutation at human minisatellite loci was studied among children born in heavily polluted areas of the Mogilev district of Belarus after the Chernobyl accident and in a control population. The frequency of mutation assayed both by DNA fingerprinting and by eight single locus probes was found to be two times higher in the exposed families than in the control group. Furthermore, mutation rate was correlated with the parental radiation dose for chronic exposure {sup 137}Cs, consistent with radiation-induction of germline mutation. The potential use of minisatellites in monitoring germline mutation in humans will be discussed. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: pp. 14 |
| System Entry Date | 2008 Feb 05 |
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Last Updated: 11/19/2009