Bibliographic Citation
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| Title | Bone metabolic activity measured with positron emission tomography and [[sup 18]F] fluoride ion in renal osteodystrophy: Correlation with bone histomorphometry |
| Creator/Author | Messa, C. ; Goodman, W.G. ; Hoh, C.K. ; Choi, Y. ; Nissenson, A.R. ; Salusky, I.B. ; Phelps, M.E. ; Hawkins, R.A. (UCLA School of Medicine, Los Angeles, CA (United States)) |
| Publication Date | 1993 Oct 01 |
| OSTI Identifier | OSTI ID: 5012435 |
| DOE Contract Number | FC03-87ER60615 |
| Other Number(s) | Journal ID: ISSN 0021-972X; CODEN: JCEMAZ |
| Resource Type | Journal Article |
| Resource Relation | Journal Name: Journal of Clinical Endocrinology and Metabolism; (United States); Journal Volume: 77:4 |
| Subject | 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; BONE TISSUES; METABOLISM; POSITRON COMPUTED TOMOGRAPHY; FLUORINE 18; RADIONUCLIDE KINETICS; KIDNEYS; SKELETAL DISEASES; ANIMAL TISSUES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; CONNECTIVE TISSUE; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; NANOSEC LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; TISSUES; TOMOGRAPHY |
| Description/Abstract | The authors evaluated the bone metabolic activity in patients with renal osteodystrophy using positron emission tomography and [[sup 18]F] fluoride ion. Eight patients had secondary hyperparathyroidism (HPT), and three had low-turnover bone disease. Eleven normal subjects were also studied, and three of the eight HPT patients were reevaluated after therapy. A rate constant (K) describing the net transport of [[sup 18]F] fluoride ion into a bound compartment in bone was calculated using both a three-compartment model and Patlak graphical analysis. Values of K were compared with biochemical data and with histomorphometric indices. The results indicate that K is significantly higher (P < 0.01) in HPT patients than in normal subjects and patients with low-turnover bone disease. Values of K correlated with serum alkaline phosphatase (r = 0.81) and PTH (r = 0.93) levels and with histomorphometric indices of bone formation rate (r = 0.84, P < 0.01) and eroded perimeter (r = 0.77, P < 0.05). Values of K decreased by 40 and 30%, respectively, in two patients who underwent parathyroidectomy and medical therapy. Positron emission tomography studies of bone using [[sup 18]F] fluoride ion can differentiate low turnover from high turnover lesions of renal osteodystropy and provide quantitative estimates of bone cell activity that correlate with histomorphometric data. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: Pages: 949-955 |
| System Entry Date | 2009 Dec 16 |
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