Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
|---|---|
| Title | THE INFLUENCE OF 2,4-DINITROPHENOL ON THE RADIATION-INDUCED DOMINANT LETHAL FACTORS IN DROSOPHILA MELANOGASTER |
| Creator/Author | Steger, J.M. |
| Publication Date | 1962 Jan 01 |
| OSTI Identifier | OSTI ID: 4132484 |
| Resource Type | Journal Article |
| Resource Relation | Journal Name: Oncologia; Journal Volume: Vol: 15; Other Information: Orig. Receipt Date: 31-DEC-64 |
| Research Org | Universitat, Zurich |
| Subject | BIOLOGY AND MEDICINE; ADENINE; ANIMAL CELLS; ATP; BIOCHEMISTRY; CHROMOSOMES; DIET; DNP; DROSOPHILA; EMBRYOS; ENZYMES; GENETICS; GONADS; INSECTS; METABOLISM; MUTATIONS; NUCLEIC ACIDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; PHENOLS; RADIATION DOSES; RADIATION EFFECTS; RADIATION PROTECTION; RECOVERY; TOXICITY; X RADIATION |
| Description/Abstract | The influence of the metabolic inhibitor 2,4-dinitrophenol (DNP) on mutability in the fruit fly was investigated under conditions wherein dominant lethal mutations were increased by irradiation. The 72- and 96-hr larvae, whose testes contain mainly spermatocytes, were given 1000 r of 180-kv x radiation. The descendents of irradiated males mated with nonirradiated females were examined for dominant lethal factors. DNP was either injected into the larvae or added to their diet (corn, sugar, agar) at a concentration of 0.005%. This diet was consumed 4-96 hr before irradiation. The rate of dominant lethal factors was lowered by DNP from 82% to 71-6%, depending on the DNP dose given before radiation. The greatest protective effect of DNP (10.6%) was obtained after it was injected, which was estimated to achieve a 10-fold higher testes DNP concentration than the feeding experiments (which gave a 5.4-9.4% decrease in the mutation rate). The possible mechanisms of the protective effect of DNP are considered in relation to its known action in uncoupling oxidative phosphorylation. DNP by lowering intracellular oxygen content may thus directly prevent secondary radiation reactions, or it may depress the metabolic processes necessary for restoration of altered chromosomes. By depressing the adenosine triphosphate content of the cell it may also impair the healing of genetic material responsible for the lethal factors. (BBB) |
| Country of Publication | Country unknown/Code not available |
| Language | German |
| Format | Medium: X; Size: Pages: 247-57 |
| System Entry Date | 2009 Dec 14 |
Top | |