Bibliographic Citation
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| Title | CHEMICAL ELEMENTS IN THE SERUM OF MAN IN HEALTH AND DIABETES MELLITUS. X- RAY EMISSION SPECTROGRAPHIC DETERMINATIONS (thesis) |
| Creator/Author | Anspaugh, L.R. |
| Publication Date | 1963 Sep 01 |
| OSTI Identifier | OSTI ID: 4079022 |
| Report Number(s) | UCRL-10873 |
| DOE Contract Number | W-7405-ENG-48 |
| Resource Type | Technical Report |
| Resource Relation | Other Information: Orig. Receipt Date: 31-DEC-64 |
| Research Org | California. Univ., Berkeley. Lawrence Radiation Lab. |
| Subject | GENERAL AND MISCELLANEOUS; AGE; BIBLIOGRAPHY; BLOOD SERUM; COPPER; DIABETES; DISEASES; ELEMENTS; INFECTIONS; IRON; MAN; MEDICINE; PHOSPHORUS; POTASSIUM; QUANTITATIVE ANALYSIS; QUANTITY RATIO; SPECTROSCOPY; VARIATIONS; X RADIATION |
| Description/Abstract | The use of the x-ray spectrograph in determining the levels of chemical elements in serum is discussed. Particular attention is devoted to the development of proper background correction formulas and tests of experimental reliability. These spectrographic and analytical techniques were used to determine the levels of 29 elements in a pooled serum powder sample of 125 healthy males and individual serum powder samples from 33 diabetic subjects. Limits of sensitivity varied from 0.01 to 24 mu g/cc whole serum depending on the particular element studied. Diabetics were found to have significantly higher levels of P and K. A highly significant correlation between serum Cu levels and the age at onset of diabetes was found. There was not an inverse correlation between serum Cu and serum Fe levels as would be expected if this effect were due to fortuitous infections in the individuals with high serum Cu. The possible significance of these findings in the pathogenesis of diabetes is discussed. Four of the diabetics were found to have extremely low values of serum Fe although the Cu level was within normal limits. The possibility is raised that this may reflect poor control of their diabetes. (100 references.) (C.H.) |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: Pages: 78 |
| System Entry Date | 2008 Feb 05 |
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