Bibliographic Citation
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| DOI | 10.1016/j.ijrobp.2006.01.020 |
| Title | Proton beam radiotherapy for uveal melanoma: Results of Curie Institut-Orsay Proton Therapy Center (ICPO) |
| Creator/Author | Dendale, Remi [Department of Radiation Oncology, Curie Institut, Paris (France) and Curie Institut-Orsay Protontherapie Center, Orsay (France)]. E-mail: remi.dendale@curie.net ; Lumbroso-Le Rouic, Livia [Department of Ophthalmology, Curie Institut, Paris (France)] ; Noel, Georges [Curie Institut-Orsay Protontherapie Center, Orsay (France)] ; Feuvret, Loic [Curie Institut-Orsay Protontherapie Center, Orsay (France)] ; Levy, Christine [Department of Ophthalmology, Curie Institut, Paris (France)] ; Delacroix, Sabine [Curie Institut-Orsay Protontherapie Center, Orsay (France)] ; Meyer, Anne [Department of Ophthalmology, Hotel Dieu Hospital, Paris (France)] ; Nauraye, Catherine [Curie Institut-Orsay Protontherapie Center, Orsay (France)] ; Mazal, Alejandro [Department of Radiation Oncology, Curie Institut, Paris (France) ; Curie Institut-Orsay Protontherapie Center, Orsay (France)] ; Mammar, Hamid [Department of Radiation Oncology, Curie Institut, Paris (France)] ; Garcia, Paul [Curie Institut-Orsay Protontherapie Center, Orsay (France)] ; D'Hermies, Francois [Department of Ophthalmology, Hotel Dieu Hospital, Paris (France)] ; Frau, Eric [Department of Ophthalmology, Le Kremlin Bicetre Hospital, Le Kremlin Bicetre (France)] ; Plancher, Corine [Department of Biostatistics, Curie Institut, Paris (France)] ; Asselain, Bernard [Department of Biostatistics, Curie Institut, Paris (France)] ; Schlienger, Pierre [Department of Radiation Oncology, Curie Institut, Paris (France) ; Curie Institut-Orsay Protontherapie Center, Orsay (France)] ; Mazeron, Jean Jacques [Curie Institut-Orsay Protontherapie Center, Orsay (France)] ; Desjardins, Laurence [Department of Ophthalmology, Curie Institut, Paris (France) ; Curie Institut-Orsay Protontherapie Center, Orsay (France)] |
| Publication Date | 2006 Jul 01 |
| OSTI Identifier | OSTI ID: 20842910 |
| Other Number(s) | Journal ID: ISSN 0360-3016; IOBPD3; TRN: US07R0653015672 |
| Resource Type | Journal Article |
| Resource Relation | Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 65; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2006.01.020; PII: S0360-3016(06)00162-3; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA) |
| Subject | 62 RADIOLOGY AND NUCLEAR MEDICINE; COBALT 60; MELANOMAS; METASTASES; PATIENTS; PROTON BEAMS; RADIATION DOSES; RADIOTHERAPY; THICKNESS |
| Description/Abstract | Purpose: This study reports the results of proton beam radiotherapy based on a retrospective series of patients treated for uveal melanoma at the Orsay Center. Methods and Materials: Between September 1991 and September 2001, 1,406 patients with uveal melanoma were treated by proton beam radiotherapy. A total dose of 60 cobalt Gray equivalent (CGE) was delivered in 4 fractions on 4 days. Survival rates were determined using Kaplan-Meier estimates. Prognostic factors were determined by multivariate analysis using the Cox model. Results: The median follow-up was 73 months (range, 24-142 months). The 5-year overall survival and metastasis-free survival rates were 79% and 80.6%, respectively. The 5-year local control rate was 96%. The 5-year enucleation for complications rate was 7.7%. Independent prognostic factors for overall survival were age (p < 0.0001), gender (p < 0.0003), tumor site (p < 0.0001), tumor thickness (p = 0.02), tumor diameter (p < 0.0001), and retinal area receiving at least 30 CGE (p = 0.003). Independent prognostic factors for metastasis-free survival were age (p = 0.0042), retinal detachment (p = 0.01), tumor site (p < 0.0001), tumor volume (p < 0.0001), local recurrence (p < 0.0001), and retinal area receiving at least 30 CGE (p = 0.002). Independent prognostic factors for local control were tumor diameter (p = 0.003) and macular area receiving at least 30 CGE (p = 0.01). Independent prognostic factors for enucleation for complications were tumor thickness (p < 0.0001) and lens volume receiving at least 30 CGE (p = 0.0002). Conclusion: This retrospective study confirms that proton beam radiotherapy ensures an excellent local control rate. Further clinical studies are required to decrease the incidence of postirradiation ocular complications. |
| Country of Publication | United States |
| Language | English |
| Format | Medium: X; Size: page(s) 780-787 |
| System Entry Date | 2009 Dec 17 |
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