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Title: Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies

Abstract

The recent outbreak of Zika virus (ZIKV) has been associated with fetal abnormalities and neurological complications, prompting global concern. Here we present the first mathematical analysis of the within-host dynamics of plasma ZiKV burden in a non-human primate model, allowing for characterization of the growth and clearance of ZIKV within an individual macaque.

Authors:
 [1];  [2];  [2];  [3];  [4];  [4];  [5];  [1]
  1. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545,
  2. Infection, Antimicrobials, Modelling, Evolution, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, F-75018 Paris, France,
  3. UMR Emergence des Pathologies Virales, Aix-Marseille University, Institut de Recherche pour le Développement 190, INSERM 1207, École des Hautes Études en Santé Publique, F-13385 Marseille, France,, UMR “Emergence des Pathologies Virales,” Institut Hospitalo-Universitaire Méditerranée Infection, F-13385 Marseille, France,
  4. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215,
  5. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215,, Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139
Publication Date:
Research Org.:
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE; National Institutes of Health (NIH)
OSTI Identifier:
1373602
Alternate Identifier(s):
OSTI ID: 1330177
Report Number(s):
LA-UR-16-28095
Journal ID: ISSN 0027-8424
Grant/Contract Number:  
AC52-06NA25396
Resource Type:
Journal Article: Published Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Volume: 114 Journal Issue: 33; Journal ID: ISSN 0027-8424
Publisher:
Proceedings of the National Academy of Sciences
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Biological Science

Citation Formats

Best, Katharine, Guedj, Jeremie, Madelain, Vincent, de Lamballerie, Xavier, Lim, So-Yon, Osuna, Christa E., Whitney, James B., and Perelson, Alan S. Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies. United States: N. p., 2017. Web. doi:10.1073/pnas.1704011114.
Best, Katharine, Guedj, Jeremie, Madelain, Vincent, de Lamballerie, Xavier, Lim, So-Yon, Osuna, Christa E., Whitney, James B., & Perelson, Alan S. Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies. United States. https://doi.org/10.1073/pnas.1704011114
Best, Katharine, Guedj, Jeremie, Madelain, Vincent, de Lamballerie, Xavier, Lim, So-Yon, Osuna, Christa E., Whitney, James B., and Perelson, Alan S. 2017. "Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies". United States. https://doi.org/10.1073/pnas.1704011114.
@article{osti_1373602,
title = {Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies},
author = {Best, Katharine and Guedj, Jeremie and Madelain, Vincent and de Lamballerie, Xavier and Lim, So-Yon and Osuna, Christa E. and Whitney, James B. and Perelson, Alan S.},
abstractNote = {The recent outbreak of Zika virus (ZIKV) has been associated with fetal abnormalities and neurological complications, prompting global concern. Here we present the first mathematical analysis of the within-host dynamics of plasma ZiKV burden in a non-human primate model, allowing for characterization of the growth and clearance of ZIKV within an individual macaque.},
doi = {10.1073/pnas.1704011114},
url = {https://www.osti.gov/biblio/1373602}, journal = {Proceedings of the National Academy of Sciences of the United States of America},
issn = {0027-8424},
number = 33,
volume = 114,
place = {United States},
year = {Tue Aug 15 00:00:00 EDT 2017},
month = {Tue Aug 15 00:00:00 EDT 2017}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at https://doi.org/10.1073/pnas.1704011114

Citation Metrics:
Cited by: 64 works
Citation information provided by
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