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Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.
Recombinant constructs of Borrelia burgdorferi
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Dattwyler, Raymond J.
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Gomes-Solecki, Maria J. C.
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Luft, Benjamin J.
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Dunn, John J.
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02/20/2007 |
7,179,448 |
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