Anatomic and functional imaging of tagged molecules in animals
Abstract
A novel functional imaging system for use in the imaging of unrestrained and non-anesthetized small animals or other subjects and a method for acquiring such images and further registering them with anatomical X-ray images previously or subsequently acquired. The apparatus comprises a combination of an IR laser profilometry system and gamma, PET and/or SPECT, imaging system, all mounted on a rotating gantry, that permits simultaneous acquisition of positional and orientational information and functional images of an unrestrained subject that are registered, i.e. integrated, using image processing software to produce a functional image of the subject without the use of restraints or anesthesia. The functional image thus obtained can be registered with a previously or subsequently obtained X-ray CT image of the subject. The use of the system described herein permits functional imaging of a subject in an unrestrained/non-anesthetized condition thereby reducing the stress on the subject and eliminating any potential interference with the functional testing that such stress might induce.
- Inventors:
-
- Yorktown, VA
- Grafton, VA
- Knoxville, TN
- Knoxville, VA
- Issue Date:
- Research Org.:
- Jefferson Solence Ass. LLC (Newport News, VA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 908986
- Patent Number(s):
- 7209579
- Application Number:
- 10/341,715
- Assignee:
- Jefferson Solence Ass. LLC (Newport News, VA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
- DOE Contract Number:
- AC05-84ER40150
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Weisenberger, Andrew G, Majewski, Stanislaw, Paulus, Michael J, and Gleason, Shaun S. Anatomic and functional imaging of tagged molecules in animals. United States: N. p., 2007.
Web.
Weisenberger, Andrew G, Majewski, Stanislaw, Paulus, Michael J, & Gleason, Shaun S. Anatomic and functional imaging of tagged molecules in animals. United States.
Weisenberger, Andrew G, Majewski, Stanislaw, Paulus, Michael J, and Gleason, Shaun S. Tue .
"Anatomic and functional imaging of tagged molecules in animals". United States. https://www.osti.gov/servlets/purl/908986.
@article{osti_908986,
title = {Anatomic and functional imaging of tagged molecules in animals},
author = {Weisenberger, Andrew G and Majewski, Stanislaw and Paulus, Michael J and Gleason, Shaun S},
abstractNote = {A novel functional imaging system for use in the imaging of unrestrained and non-anesthetized small animals or other subjects and a method for acquiring such images and further registering them with anatomical X-ray images previously or subsequently acquired. The apparatus comprises a combination of an IR laser profilometry system and gamma, PET and/or SPECT, imaging system, all mounted on a rotating gantry, that permits simultaneous acquisition of positional and orientational information and functional images of an unrestrained subject that are registered, i.e. integrated, using image processing software to produce a functional image of the subject without the use of restraints or anesthesia. The functional image thus obtained can be registered with a previously or subsequently obtained X-ray CT image of the subject. The use of the system described herein permits functional imaging of a subject in an unrestrained/non-anesthetized condition thereby reducing the stress on the subject and eliminating any potential interference with the functional testing that such stress might induce.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 24 00:00:00 EDT 2007},
month = {Tue Apr 24 00:00:00 EDT 2007}
}