Method of filling a microchannel separation column
Abstract
A method for packing a stationary phase into a small diameter fluid passageway or flow channel. Capillary action is employed to distribute a stationary phase uniformly along both the length and diameter of the flow channel. The method disclosed here: 1) eliminates the need for high pressure pumps and fittings and the safety hazards associated therewith; 2) allows the use of readily available commercial microparticles, either coated or uncoated, as the stationary phase; 3) provides for different types of particles, different particle sizes, and different particle size distributions to be packed in sequence, or simultaneously; 4) eliminates the need for plugging the flow channel prior to adding the stationary phase to retain the packing particles; and 5) many capillaries can be filled simultaneously.
- Inventors:
-
- Livermore, CA
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 874699
- Patent Number(s):
- 6444150
- Assignee:
- Sandia Corporation (Livermore, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; filling; microchannel; separation; column; packing; stationary; phase; diameter; fluid; passageway; flow; channel; capillary; action; employed; distribute; uniformly; length; disclosed; eliminates; pressure; pumps; fittings; safety; hazards; associated; allows; readily; available; commercial; microparticles; coated; uncoated; provides; types; particles; particle; sizes; size; distributions; packed; sequence; simultaneously; plugging; prior; adding; retain; capillaries; filled; particle size; capillary action; pressure pump; fluid passage; fluid passageway; separation column; stationary phase; /264/210/
Citation Formats
Arnold, Don W. Method of filling a microchannel separation column. United States: N. p., 2002.
Web.
Arnold, Don W. Method of filling a microchannel separation column. United States.
Arnold, Don W. Tue .
"Method of filling a microchannel separation column". United States. https://www.osti.gov/servlets/purl/874699.
@article{osti_874699,
title = {Method of filling a microchannel separation column},
author = {Arnold, Don W},
abstractNote = {A method for packing a stationary phase into a small diameter fluid passageway or flow channel. Capillary action is employed to distribute a stationary phase uniformly along both the length and diameter of the flow channel. The method disclosed here: 1) eliminates the need for high pressure pumps and fittings and the safety hazards associated therewith; 2) allows the use of readily available commercial microparticles, either coated or uncoated, as the stationary phase; 3) provides for different types of particles, different particle sizes, and different particle size distributions to be packed in sequence, or simultaneously; 4) eliminates the need for plugging the flow channel prior to adding the stationary phase to retain the packing particles; and 5) many capillaries can be filled simultaneously.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2002},
month = {Tue Jan 01 00:00:00 EST 2002}
}