Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders
Abstract
The localization of nuclear apparatus proteins (NUMA) is used to identify tumor cells and different stages in the tumor progression and differentiation processes. There is a characteristic organization of NuMA in tumor cells and in phenotypically normal cells. NuMA distribution patterns are significantly less diffuse in proliferating non-malignant cells compared to malignant cells. The technique encompasses cell immunostaining using a NuMA specific antibody, and microscopic analysis of NuMA distribution within each nucleus.
- Inventors:
-
- Berkeley, CA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 873984
- Patent Number(s):
- 6287790
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- utilization; nuclear; structural; proteins; targeted; therapy; detection; proliferative; differentiation; disorders; localization; apparatus; numa; identify; tumor; cells; stages; progression; processes; characteristic; organization; phenotypically; normal; distribution; patterns; significantly; diffuse; proliferating; non-malignant; compared; malignant; technique; encompasses; cell; immunostaining; specific; antibody; microscopic; analysis; nucleus; normal cells; tumor cells; malignant cells; structural protein; /435/436/
Citation Formats
Lelievre, Sophie, and Bissell, Mina. Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders. United States: N. p., 2001.
Web.
Lelievre, Sophie, & Bissell, Mina. Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders. United States.
Lelievre, Sophie, and Bissell, Mina. Mon .
"Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders". United States. https://www.osti.gov/servlets/purl/873984.
@article{osti_873984,
title = {Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders},
author = {Lelievre, Sophie and Bissell, Mina},
abstractNote = {The localization of nuclear apparatus proteins (NUMA) is used to identify tumor cells and different stages in the tumor progression and differentiation processes. There is a characteristic organization of NuMA in tumor cells and in phenotypically normal cells. NuMA distribution patterns are significantly less diffuse in proliferating non-malignant cells compared to malignant cells. The technique encompasses cell immunostaining using a NuMA specific antibody, and microscopic analysis of NuMA distribution within each nucleus.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Core filaments of the nuclear matrix.
journal, March 1990
- He, D. C.; Nickerson, J. A.; Penman, S.
- Journal of Cell Biology, Vol. 110, Issue 3
Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: Distribution in a human/hamster hybrid cell
journal, November 1980
- Lydersen, Bjorn K.; Pettijohn, David E.
- Cell, Vol. 22, Issue 2
Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis.
journal, March 1992
- Compton, D. A.; Szilak, I.; Cleveland, D. W.
- Journal of Cell Biology, Vol. 116, Issue 6