Oncoprotein kinase
Abstract
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
- Inventors:
-
- San Diego, CA
- La Jolla, CA
- Issue Date:
- Research Org.:
- Univ. of California (United States)
- OSTI Identifier:
- 873579
- Patent Number(s):
- 6193965
- Application Number:
- 09/452,370
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- FG03-86ER60429
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- oncoprotein; kinase; isolated; polypeptide; jnk; characterized; molecular; weight; 46; kd; 55; determined; reducing; sds-page; serine; theonine; activity; phosphorylating; c-jun; n-terminal; activation; domain; polynucleotide; sequences; method; detection; provided; phosphorylates; affects; expression; ap-1; sites; phosphorylates c-jun; ap-1 sites; protein kinase; reducing sds-page; kinase activity; jnk phosphorylates; activation domain; nucleotide sequences; nucleotide sequence; n-terminal activation; c-jun n-terminal; molecular weight; isolated polypeptide; polynucleotide sequences; theonine kinase; /424/514/
Citation Formats
Karin, Michael, Hibi, Masahiko, and Lin, Anning. Oncoprotein kinase. United States: N. p., 2001.
Web.
Karin, Michael, Hibi, Masahiko, & Lin, Anning. Oncoprotein kinase. United States.
Karin, Michael, Hibi, Masahiko, and Lin, Anning. Tue .
"Oncoprotein kinase". United States. https://www.osti.gov/servlets/purl/873579.
@article{osti_873579,
title = {Oncoprotein kinase},
author = {Karin, Michael and Hibi, Masahiko and Lin, Anning},
abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 27 00:00:00 EST 2001},
month = {Tue Feb 27 00:00:00 EST 2001}
}
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