Human jagged polypeptide, encoding nucleic acids and methods of use
Abstract
The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an isolated nucleic acid molecule containing a nucleotide sequence encoding substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the nucleotide sequence does not encode the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. Also provided herein is a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.
- Inventors:
-
- Seattle, WA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 873333
- Patent Number(s):
- 6136952
- Assignee:
- University of Washington (Seattle, WA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- human; jagged; polypeptide; encoding; nucleic; acids; methods; provides; isolated; exhibiting; substantially; amino; acid; sequence; active; fragment; provided; seq; molecule; containing; nucleotide; encode; method; inhibiting; differentiation; hematopoietic; progenitor; cells; contacting; additionally; diagnosing; alagille; syndrome; individual; consists; detecting; disease-associated; mutation; linked; locus; acid molecule; method consists; molecule containing; nucleotide sequence; acid sequence; amino acid; nucleic acid; nucleic acids; sequence encoding; isolated polypeptide; /530/435/999/
Citation Formats
Li, Linheng, and Hood, Leroy. Human jagged polypeptide, encoding nucleic acids and methods of use. United States: N. p., 2000.
Web.
Li, Linheng, & Hood, Leroy. Human jagged polypeptide, encoding nucleic acids and methods of use. United States.
Li, Linheng, and Hood, Leroy. Sat .
"Human jagged polypeptide, encoding nucleic acids and methods of use". United States. https://www.osti.gov/servlets/purl/873333.
@article{osti_873333,
title = {Human jagged polypeptide, encoding nucleic acids and methods of use},
author = {Li, Linheng and Hood, Leroy},
abstractNote = {The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an isolated nucleic acid molecule containing a nucleotide sequence encoding substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the nucleotide sequence does not encode the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. Also provided herein is a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 2000},
month = {Sat Jan 01 00:00:00 EST 2000}
}
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