Title: Sol-gel matrices for direct colorimetric detection of analytes

Abstract

The present invention relates to methods and compositions for the direct detection of analytes using color changes that occur in immobilized biopolymeric material in response to selective binding of analytes to their surface. In particular, the present invention provides methods and compositions related to the encapsulation of biopolymeric material into metal oxide glass using the sol-gel method.

Inventors:

Charych, Deborah H ^[1]; Sasaki, Darryl ^[2]; Yamanaka, Stacey ^[3]

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1. Albany, CA
2. Albuquerque, NM
3. Dallas, TX

Issue Date:

Sat Jan 01 00:00:00 EST 2000

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

OSTI Identifier:

872847

Patent Number(s):

6022748

Assignee:

Sandia Corporation - New Mexico Regents of University of California (CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

C - CHEMISTRY C03 - GLASS C03C - CHEMICAL COMPOSITION OF GLASSES, GLAZES, OR VITREOUS ENAMELS

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B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

B82Y30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

C - CHEMISTRY C03 - GLASS C03C - CHEMICAL COMPOSITION OF GLASSES, GLAZES, OR VITREOUS ENAMELS

C03C14/008 - {the non-glass component being in molecular form}
C03C4/0007 - {for biologically-compatible glass}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/54313 - {the carrier being characterised by its particulate form}
G01N33/552 - Glass or silica

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S436/805 - Optical property
Y10S436/811 - Test for named disease, body condition or organ function
Y10S436/815 - Test for named compound or class of compounds
Y10S436/823 - Immunogenic carrier or carrier per se
Y10S436/829 - Liposomes, e.g. encapsulation

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

sol-gel; matrices; direct; colorimetric; detection; analytes; relates; methods; compositions; color; changes; occur; immobilized; biopolymeric; material; response; selective; binding; surface; particular; provides; related; encapsulation; metal; oxide; glass; method; color change; direct detection; oxide glass; color changes; provides methods; polymeric material; metal oxide; colorimetric detection; sol-gel method; direct colorimetric; /436/