Transcriptional enhancer from milk protein genes
Abstract
The invention relates to novel enhancer nucleotide sequences which stimulate transcription of heterologous DNA in cells in culture. The enhancers are derived from major milk protein genes by the process of deletion mapping and functional analysis. The invention also relates to expression vectors containing the novel enhancers.
- Inventors:
-
- Ballwin, MO
- Berkeley, CA
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- OSTI Identifier:
- 872774
- Patent Number(s):
- 6004805
- Assignee:
- G.D Searle & Co. (Chicago, IL)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- transcriptional; enhancer; milk; protein; genes; relates; novel; nucleotide; sequences; stimulate; transcription; heterologous; dna; cells; culture; enhancers; derived; major; process; deletion; mapping; functional; analysis; expression; vectors; containing; nucleotide sequences; nucleotide sequence; expression vectors; protein genes; milk protein; expression vector; /435/999/
Citation Formats
Casperson, Gerald F, Schmidhauser, Christian T, and Bissell, Mina J. Transcriptional enhancer from milk protein genes. United States: N. p., 1999.
Web.
Casperson, Gerald F, Schmidhauser, Christian T, & Bissell, Mina J. Transcriptional enhancer from milk protein genes. United States.
Casperson, Gerald F, Schmidhauser, Christian T, and Bissell, Mina J. Fri .
"Transcriptional enhancer from milk protein genes". United States. https://www.osti.gov/servlets/purl/872774.
@article{osti_872774,
title = {Transcriptional enhancer from milk protein genes},
author = {Casperson, Gerald F and Schmidhauser, Christian T and Bissell, Mina J},
abstractNote = {The invention relates to novel enhancer nucleotide sequences which stimulate transcription of heterologous DNA in cells in culture. The enhancers are derived from major milk protein genes by the process of deletion mapping and functional analysis. The invention also relates to expression vectors containing the novel enhancers.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Rabbit β-Casein Promoter Directs Secretion of Human Interleukin-2 into the Milk of Transgenic Rabbits
journal, February 1990
- Bühler, Th. A.; Bruyère, Th.; Went, D. F.
- Nature Biotechnology, Vol. 8, Issue 2
A novel transcriptional enhancer is involved in the prolactin- and extracellular matrix-dependent regulation of beta-casein gene expression.
journal, June 1992
- Schmidhauser, C.; Casperson, G. F.; Myers, C. A.
- Molecular Biology of the Cell, Vol. 3, Issue 6
Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells.
journal, December 1990
- Schmidhauser, C.; Bissell, M. J.; Myers, C. A.
- Proceedings of the National Academy of Sciences, Vol. 87, Issue 23
Relative Contribution of Promoter and Intragenic Sequences in the Hormonal Regulation of Rat β-Casein Transgenes
journal, March 1989
- Lee, Kuo-Fen; Atiee, Suzanne H.; Henning, Susan J.
- Molecular Endocrinology, Vol. 3, Issue 3
A Heterologous Hormone Response Element Enhances Expression of Rat β-Casein Promoter-Driven Chloramphenicol Acetyltransferase Fusion Genes in the Mammary Gland of Transgenic Mice
journal, October 1991
- Greenberg, Norman M.; Reding, Theresia V.; Duffy, Tracey
- Molecular Endocrinology, Vol. 5, Issue 10
Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice.
journal, February 1989
- Lee, K. F.; Atiee, S. H.; Rosen, J. M.
- Molecular and Cellular Biology, Vol. 9, Issue 2
Prolactin stimulates milk protein promoter in CHO cells cotransfected with prolactin receptor cDNA
journal, May 1990
- Lesueur, Laurence; Edery, Marc; Paly, Jacqueline
- Molecular and Cellular Endocrinology, Vol. 71, Issue 1
Gene Transfer into Sheep
journal, February 1988
- Simons, J. Paul; Wilmut, Ian; Clark, A. John
- Nature Biotechnology, Vol. 6, Issue 2
Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk
journal, November 1987
- Gordon, Katherine; Lee, Eric; Vitale, James A.
- Nature Biotechnology, Vol. 5, Issue 11
High Level Expression of Active Human Alpha-1-Antitrypsin in the Milk of Transgenic Sheep
journal, September 1991
- Wright, G.; Carver, A.; Cottom, D.
- Nature Biotechnology, Vol. 9, Issue 9
Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.
journal, November 1988
- Andres, A. C.; van der Valk, M. A.; Schonenberger, C. A.
- Genes & Development, Vol. 2, Issue 11
Transgenic Production of a Variant of Human Tissue-Type Plasminogen Activator in Goat Milk: Generation of Transgenic Goats and Analysis of Expression
journal, September 1991
- Ebert, Karl M.; Selgrath, James P.; DiTullio, Paul
- Nature Biotechnology, Vol. 9, Issue 9
A pregnancy-specific mammary nuclear factor involved in the repression of the mouse beta-casein gene transcription by progesterone.
journal, March 1992
- Lee, C. S.; Oka, T.
- Journal of Biological Chemistry, Vol. 267, Issue 9
Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor.
journal, July 1991
- Schmitt-Ney, M.; Doppler, W.; Ball, R. K.
- Molecular and Cellular Biology, Vol. 11, Issue 7
The bovine α-lactalbumin promoter directs expression of ovine trophoblast interferon in the mammary gland of transgenic mice
journal, June 1991
- Stinnakre, M. G.; Vilotte, J. L.; Soulier, S.
- FEBS Letters, Vol. 284, Issue 1
Expression analysis of ruminant α-lactalbumin in transgenic mice: Developmental regulation and general location of important cis -regulatory elements
journal, February 1992
- Soulier, S.; Vilotte, J. L.; Stinnakre, M. G.
- FEBS Letters, Vol. 297, Issue 1-2
Prolactin and Glucocorticoid Hormones Control Transcription of the β-Casein Gene by Kinetically Distinct Mechanisms
journal, June 1990
- Doppler, Wolfgang; Höck, Wolfgang; Hofer, Paul
- Molecular Endocrinology, Vol. 4, Issue 6
Hormonal response region in the mouse mammary tumor virus long terminal repeat can be dissociated from the proviral promoter and has enhancer properties.
journal, February 1985
- Ponta, H.; Kennedy, N.; Skroch, P.
- Proceedings of the National Academy of Sciences, Vol. 82, Issue 4
Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.
journal, January 1989
- Doppler, W.; Groner, B.; Ball, R. K.
- Proceedings of the National Academy of Sciences, Vol. 86, Issue 1
Lactogenic Hormone and Cell Type-Specific Control of the Whey Acidic Protein Gene Promoter in Transfected Mouse Cells
journal, November 1991
- Doppler, Wolfgang; Villunger, Andreas; Jennewein, Patricia
- Molecular Endocrinology, Vol. 5, Issue 11
Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.
journal, March 1987
- Andres, A. C.; Schonenberger, C. A.; Groner, B.
- Proceedings of the National Academy of Sciences, Vol. 84, Issue 5
Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.
journal, April 1992
- Schmitt-Ney, M.; Happ, B.; Ball, R. K.
- Proceedings of the National Academy of Sciences, Vol. 89, Issue 7
Transfection of beta-casein chimeric gene and hormonal induction of its expression in primary murine mammary epithelial cells.
journal, May 1990
- Yoshimura, M.; Oka, T.
- Proceedings of the National Academy of Sciences, Vol. 87, Issue 10
High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.
journal, March 1992
- Dale, T. C.; Krnacik, M. J.; Schmidhauser, C.
- Molecular and Cellular Biology, Vol. 12, Issue 3
Expression of Human Anti-Hemophilic Factor IX in the Milk of Transgenic Sheep
journal, May 1989
- Clark, A. J.; Bessos, H.; Bishop, J. O.
- Nature Biotechnology, Vol. 7, Issue 5
Bovine AlphaS1-Casein Gene Sequences Direct High Level Expression of Active Human Urokinase in Mouse Milk
journal, May 1990
- Meade, Harry; Gates, Liora; Lacy, Elizabeth
- Nature Biotechnology, Vol. 8, Issue 5
High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice.
journal, July 1990
- Archibald, A. L.; McClenaghan, M.; Hornsey, V.
- Proceedings of the National Academy of Sciences, Vol. 87, Issue 13
Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice.
journal, October 1991
- Greenberg, N. M.; Anderson, J. W.; Hsueh, A. J.
- Proceedings of the National Academy of Sciences, Vol. 88, Issue 19
A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice.
journal, August 1988
- Pittius, C. W.; Hennighausen, L.; Lee, E.
- Proceedings of the National Academy of Sciences, Vol. 85, Issue 16
Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.
journal, January 1988
- Schoenenberger, C. A.; Andres, A. C.; Groner, B.
- The EMBO Journal, Vol. 7, Issue 1