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Title: Gamma-irradiated bacterial preparation having anti-tumor activity

Abstract

A bacterial preparation from Pseudomonas species isolated #15 ATCC 55638 that has been exposed to gamma radiation exhibits cytotoxicity that is specific for neoplastic carcinoma cells. A method for obtaining a bacterial preparation having antitumor activity consists of suspending a bacterial isolate in media and exposing the suspension to gamma radiation. A bacterial preparation of an aged culture of an amoeba-associated bacteria exhibits anti-reverse transcriptase activity. A method for obtaining a bacterial preparation having anti-reverse transcriptase activity from an amoeba-associated bacterial isolate grown to stationary phase is disclosed.

Inventors:
 [1];  [2];  [3]
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  1. Oak Ridge, TN
  2. Clinton, TN
  3. Montrose, CO
Issue Date:
Research Org.:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
OSTI Identifier:
872666
Patent Number(s):
5985268
Assignee:
Lockheed Martin Energy Research Corp. (Oak Ridge, TN)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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DOE Contract Number:  
AC05-96OR22464
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
gamma-irradiated; bacterial; preparation; anti-tumor; activity; pseudomonas; species; isolated; 15; atcc; 55638; exposed; gamma; radiation; exhibits; cytotoxicity; specific; neoplastic; carcinoma; cells; method; obtaining; antitumor; consists; suspending; isolate; media; exposing; suspension; aged; culture; amoeba-associated; bacteria; anti-reverse; transcriptase; grown; stationary; phase; disclosed; bacterial preparation; gamma radiation; stationary phase; pseudomonas species; pseudomonas sp; /424/435/

Citation Formats

Vass, Arpad A, Tyndall, Richard L, and Terzaghi-Howe, Peggy. Gamma-irradiated bacterial preparation having anti-tumor activity. United States: N. p., 1999. Web.
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Vass, Arpad A, Tyndall, Richard L, & Terzaghi-Howe, Peggy. Gamma-irradiated bacterial preparation having anti-tumor activity. United States.
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Vass, Arpad A, Tyndall, Richard L, and Terzaghi-Howe, Peggy. Fri . "Gamma-irradiated bacterial preparation having anti-tumor activity". United States. https://www.osti.gov/servlets/purl/872666.
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@article{osti_872666,
title = {Gamma-irradiated bacterial preparation having anti-tumor activity},
author = {Vass, Arpad A and Tyndall, Richard L and Terzaghi-Howe, Peggy},
abstractNote = {A bacterial preparation from Pseudomonas species isolated #15 ATCC 55638 that has been exposed to gamma radiation exhibits cytotoxicity that is specific for neoplastic carcinoma cells. A method for obtaining a bacterial preparation having antitumor activity consists of suspending a bacterial isolate in media and exposing the suspension to gamma radiation. A bacterial preparation of an aged culture of an amoeba-associated bacteria exhibits anti-reverse transcriptase activity. A method for obtaining a bacterial preparation having anti-reverse transcriptase activity from an amoeba-associated bacterial isolate grown to stationary phase is disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
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Works referenced in this record:

Inhibition of mouse retroviral disease by bioactive glutaminase-asparaginase
journal, February 1991

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