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Title: Thin film composition with biological substance and method of making

Abstract

The invention provides a thin-film composition comprising an underlying substrate of a first material including a plurality of attachment sites; a plurality of functional groups chemically attached to the attachment sites of the underlying substrate; and a thin film of a second material deposited onto the attachment sites of the underlying substrate, and a biologically active substance deposited with the thin-film. Preferably the functional groups are attached to a self assembling monolayer attached to the underlying substrate. Preferred functional groups attached to the underlying substrate are chosen from the group consisting of carboxylates, sulfonates, phosphates, optionally substituted, linear or cyclo, alkyl, alkene, alkyne, aryl, alkylaryl, amine, hydroxyl, thiol, silyl, phosphoryl, cyano, metallocenyl, carbonyl, and polyphosphate. Preferred materials for the underlying substrate are selected from the group consisting of a metal, a metal alloy, a plastic, a polymer, a proteic film, a membrane, a glass or a ceramic. The second material is selected from the group consisting of inorganic crystalline structures, inorganic amorphus structures, organic crystalline structures, and organic amorphus structures. Preferred second materials are phosphates, especially calcium phosphates and most particularly calcium apatite. The biologically active molecule is a protein, peptide, DNA segment, RNA segment, nucleotide, polynucleotide, nucleoside, antibiotic, antimicrobal,more » radioisotope, chelated radioisotope, chelated metal, metal salt, anti-inflamatory, steriod, nonsteriod anti-inflammatory, analgesic, antihistamine, receptor binding agent, or chemotherapeutic agent, or other biologically active material. Preferably the biologically active molecule is an osteogenic factor the compositions listed above.

Inventors:
 [1];  [2]
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  1. Kennewick, WA
  2. Richland, WA
Issue Date:
Research Org.:
Battelle Memorial Institute, Columbus, OH (United States)
OSTI Identifier:
872539
Patent Number(s):
5958430
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
film; composition; biological; substance; method; provides; thin-film; comprising; underlying; substrate; material; including; plurality; attachment; sites; functional; chemically; attached; deposited; biologically; active; preferably; assembling; monolayer; preferred; chosen; consisting; carboxylates; sulfonates; phosphates; optionally; substituted; linear; cyclo; alkyl; alkene; alkyne; aryl; alkylaryl; amine; hydroxyl; thiol; silyl; phosphoryl; cyano; metallocenyl; carbonyl; polyphosphate; materials; selected; metal; alloy; plastic; polymer; proteic; membrane; glass; ceramic; inorganic; crystalline; structures; amorphus; organic; especially; calcium; particularly; apatite; molecule; protein; peptide; dna; segment; rna; nucleotide; polynucleotide; nucleoside; antibiotic; antimicrobal; radioisotope; chelated; salt; anti-inflamatory; steriod; nonsteriod; anti-inflammatory; analgesic; antihistamine; receptor; binding; agent; chemotherapeutic; osteogenic; factor; compositions; listed; biologically active; biological substance; material deposited; binding agent; crystalline structures; underlying substrate; composition comprising; active material; metal alloy; metal salt; dna segment; material including; crystalline structure; therapeutic agent; calcium phosphate; preferred materials; optionally substituted; particularly calcium; layer attached; active substance; line structure; /424/

Citation Formats

Campbell, Allison A, and Song, Lin. Thin film composition with biological substance and method of making. United States: N. p., 1999. Web.
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Campbell, Allison A, & Song, Lin. Thin film composition with biological substance and method of making. United States.
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Campbell, Allison A, and Song, Lin. Fri . "Thin film composition with biological substance and method of making". United States. https://www.osti.gov/servlets/purl/872539.
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@article{osti_872539,
title = {Thin film composition with biological substance and method of making},
author = {Campbell, Allison A and Song, Lin},
abstractNote = {The invention provides a thin-film composition comprising an underlying substrate of a first material including a plurality of attachment sites; a plurality of functional groups chemically attached to the attachment sites of the underlying substrate; and a thin film of a second material deposited onto the attachment sites of the underlying substrate, and a biologically active substance deposited with the thin-film. Preferably the functional groups are attached to a self assembling monolayer attached to the underlying substrate. Preferred functional groups attached to the underlying substrate are chosen from the group consisting of carboxylates, sulfonates, phosphates, optionally substituted, linear or cyclo, alkyl, alkene, alkyne, aryl, alkylaryl, amine, hydroxyl, thiol, silyl, phosphoryl, cyano, metallocenyl, carbonyl, and polyphosphate. Preferred materials for the underlying substrate are selected from the group consisting of a metal, a metal alloy, a plastic, a polymer, a proteic film, a membrane, a glass or a ceramic. The second material is selected from the group consisting of inorganic crystalline structures, inorganic amorphus structures, organic crystalline structures, and organic amorphus structures. Preferred second materials are phosphates, especially calcium phosphates and most particularly calcium apatite. The biologically active molecule is a protein, peptide, DNA segment, RNA segment, nucleotide, polynucleotide, nucleoside, antibiotic, antimicrobal, radioisotope, chelated radioisotope, chelated metal, metal salt, anti-inflamatory, steriod, nonsteriod anti-inflammatory, analgesic, antihistamine, receptor binding agent, or chemotherapeutic agent, or other biologically active material. Preferably the biologically active molecule is an osteogenic factor the compositions listed above.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
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Works referenced in this record:

Biomimetic Thin-Film Synthesis
book, July 1992

Measurement of protein using bicinchoninic acid
journal, October 1985

Ceramic Thin-Film Formation on Functionalized Interfaces Through Biomimetic Processing
journal, April 1994

Bioactive Void Metal Composites for Orthopedic Implant Devices
journal, January 1995

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