Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals

Katti, Kattesh V; Singh, Prahlad R; Reddy, V Sreenivasa; Katti, Kavita K; Volkert, Wynn A; Ketring, Alan R

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Title: Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals

Abstract

A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises a functionalized hydroxyalkyl phosphine ligand and a metal combined with the ligand.

Inventors:

Katti, Kattesh V ^[1]; Singh, Prahlad R ^[1]; Reddy, V Sreenivasa ^[1]; Katti, Kavita K ^[1]; Volkert, Wynn A ^[1]; Ketring, Alan R ^[1]

Columbia, MO

Issue Date:: Fri Jan 01 00:00:00 EST 1999

Research Org.:: Univ. of Missouri, Columbia, MO (United States)

OSTI Identifier:: 872168

Patent Number(s):: 5876693

Assignee:: Curators of University of Missouri (Columbia, MO)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2121/00 - Preparations for use in therapy
A61K2123/00 - Preparations for testing in vivo
A61K51/0478 - {complexes from non-cyclic ligands, e.g. EDTA, MAG3}
A61K51/0489 - {Phosphates or phosphonates, e.g. bone-seeking phosphonates

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00 - Drugs for disorders of the nervous system
A61P31/12 - Antivirals
A61P35/00 - Antineoplastic agents
A61P9/00 - Drugs for disorders of the cardiovascular system

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F13/005 - {Compounds without a metal-carbon linkage}
C07F15/008 - {without a metal-carbon linkage}
C07F9/5004 - {Acyclic saturated phosphines}
C07F9/5022 - {Aromatic phosphines
C07F9/5027 - {Polyphosphines}

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DOE Contract Number:: FG02-89ER60875

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: hydroxyalkyl; phosphine; compounds; diagnostic; therapeutic; pharmaceuticals; compound; method; pharmaceutical; comprises; functionalized; ligand; metal; combined; therapeutic pharmaceutical; hydroxyalkyl phosphine; metal combined; phosphine compounds; pharmaceutical comprises; therapeutic pharmaceuticals; functionalized hydroxyalkyl; /424/999/

Citation Formats


                    Katti, Kattesh V, Singh, Prahlad R, Reddy, V Sreenivasa, Katti, Kavita K, Volkert, Wynn A, and Ketring, Alan R. Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals.  United States: N. p., 1999. 
        Web.

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                    Katti, Kattesh V, Singh, Prahlad R, Reddy, V Sreenivasa, Katti, Kavita K, Volkert, Wynn A, & Ketring, Alan R. Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals.  United States.

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                    Katti, Kattesh V, Singh, Prahlad R, Reddy, V Sreenivasa, Katti, Kavita K, Volkert, Wynn A, and Ketring, Alan R. Fri .  
        "Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals".  United States.  https://www.osti.gov/servlets/purl/872168.

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@article{osti_872168,

  title        = {Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals},

  author       = {Katti, Kattesh V and Singh, Prahlad R and Reddy, V Sreenivasa and Katti, Kavita K and Volkert, Wynn A and Ketring, Alan R},

  abstractNote = {A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises a functionalized hydroxyalkyl phosphine ligand and a metal combined with the ligand.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Fri Jan 01 00:00:00 EST 1999},

  month        = {Fri Jan 01 00:00:00 EST 1999}

}

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Works referenced in this record:

Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8
journal, July 1990

Abrams, Michael J.; Larsen, Scott K.; Zubieta, Jon
Inorganica Chimica Acta, Vol. 173, Issue 2
https://doi.org/10.1016/S0020-1693(00)80203-0

Aspects of the Chemistry of Technetium Phosphine Complexes
journal, January 1993

Deutsch, Edward
Radiochimica Acta, Vol. 63, Issue s1
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Coordination compounds in nuclear medicine
journal, May 1993

Jurisson, S.; Berning, D.; Jia, Wei.
Chemical Reviews, Vol. 93, Issue 3
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Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3
journal, July 1992

Ellis, James W.; Harrison, Karl N.; Hoye, Peter A. T.
Inorganic Chemistry, Vol. 31, Issue 14
https://doi.org/10.1021/ic00040a009

Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent.
journal, June 1988

Fritzberg, A. R.; Abrams, P. G.; Beaumier, P. L.
Proceedings of the National Academy of Sciences, Vol. 85, Issue 11
https://doi.org/10.1073/pnas.85.11.4025

Rhodium( I ), rhodium( III ), palladium( II ), and platinum( II ) complexes containing ligands of the type PR _n Q _3–n (n= 0,1, or 2; R = Me, Et, Bu ^t , or Ph; Q = CH ₂ OCOMe or CH ₂ OH)
journal, January 1973

Chatt, Joseph; Leigh, G. Jeffery; Slade, Roger M.
J. Chem. Soc., Dalton Trans., Issue 19
https://doi.org/10.1039/DT9730002021

Synthesis of a new class of Tc chelating agents: N2S2 monoaminemonoamide (mama) ligands
journal, September 1991

Gustavson, Linda M.; Rao, T. N.; Jones, David S.
Tetrahedron Letters, Vol. 32, Issue 40
https://doi.org/10.1016/0040-4039(91)80064-D

Radiohalogenation of proteins: An overview of radionuclides, labeling methods and reagents for conjugate labeling
journal, November 1992

Wilbur, D. Scott
Bioconjugate Chemistry, Vol. 3, Issue 6
https://doi.org/10.1021/bc00018a001

Tumour targeting with radiolabelled macrocycle–antibody conjugates
journal, January 1990

Parker, David
Chem. Soc. Rev., Vol. 19, Issue 3
https://doi.org/10.1039/CS9901900271

Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver
journal, January 1988

Meares, Claude F.; McCall, Michael J.; Deshpande, Shrikant V.
International Journal of Cancer, Vol. 41, Issue S2
https://doi.org/10.1002/ijc.2910410723

Kinetics and mechanism of reactions of S-protected dithiol monoaminemonoamide (MAMA) ligands with technetium: Characterization of a technetium—thiolate—thioether—MAMA complex, a kinetic intermediate of the reaction
journal, November 1992

Rao, T. N.; Gustavson, Linda M.; Srinivasan, Ananthachari
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 19, Issue 8
https://doi.org/10.1016/0883-2897(92)90175-X

Chemical and physical properties of radionuclides
journal, January 1987

Troutner, David E.
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 14, Issue 3
https://doi.org/10.1016/0883-2897(87)90039-0

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Title: Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals

Abstract

Citation Formats

Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8 journal, July 1990

Aspects of the Chemistry of Technetium Phosphine Complexes journal, January 1993

Coordination compounds in nuclear medicine journal, May 1993

Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3 journal, July 1992

Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent. journal, June 1988

Rhodium( I ), rhodium( III ), palladium( II ), and platinum( II ) complexes containing ligands of the type PR n Q 3–n (n= 0,1, or 2; R = Me, Et, Bu t , or Ph; Q = CH 2 OCOMe or CH 2 OH) journal, January 1973

Synthesis of a new class of Tc chelating agents: N2S2 monoaminemonoamide (mama) ligands journal, September 1991

Radiohalogenation of proteins: An overview of radionuclides, labeling methods and reagents for conjugate labeling journal, November 1992

Tumour targeting with radiolabelled macrocycle–antibody conjugates journal, January 1990

Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver journal, January 1988

Kinetics and mechanism of reactions of S-protected dithiol monoaminemonoamide (MAMA) ligands with technetium: Characterization of a technetium—thiolate—thioether—MAMA complex, a kinetic intermediate of the reaction journal, November 1992

Chemical and physical properties of radionuclides journal, January 1987

Synthesis and crystal and molecular structure of a technetium-hydralazino complex, [TcCl2(C8H5N4)(PPh3)2]·0.75C7H8
journal, July 1990

Aspects of the Chemistry of Technetium Phosphine Complexes
journal, January 1993

Coordination compounds in nuclear medicine
journal, May 1993

Water-soluble tris(hydroxymethyl)phosphine complexes with nickel, palladium, and platinum. Crystal structure of [Pd{P(CH2OH)3}4].cntdot.CH3
journal, July 1992

Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent.
journal, June 1988

Rhodium( I ), rhodium( III ), palladium( II ), and platinum( II ) complexes containing ligands of the type PR _n Q _3–n (n= 0,1, or 2; R = Me, Et, Bu ^t , or Ph; Q = CH ₂ OCOMe or CH ₂ OH)
journal, January 1973

Synthesis of a new class of Tc chelating agents: N2S2 monoaminemonoamide (mama) ligands
journal, September 1991

Radiohalogenation of proteins: An overview of radionuclides, labeling methods and reagents for conjugate labeling
journal, November 1992

Tumour targeting with radiolabelled macrocycle–antibody conjugates
journal, January 1990

Chelate radiochemistry: Cleavable linkers lead to altered levels of radioactivity in the liver
journal, January 1988

Kinetics and mechanism of reactions of S-protected dithiol monoaminemonoamide (MAMA) ligands with technetium: Characterization of a technetium—thiolate—thioether—MAMA complex, a kinetic intermediate of the reaction
journal, November 1992

Chemical and physical properties of radionuclides
journal, January 1987