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Title: Crystallization of M-CSF.alpha.

Abstract

The present invention is directed to methods for crystallizing macrophage colony stimulating factor (M-CSF) and to a crystalline M-CSF produced thereby. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [6];  [6];  [7];  [8]
+ Show Inventor Affiliations
  1. Mystic, CT
  2. Walnut Creek, CA
  3. Moraga, CA
  4. El Cerrito, CA
  5. San Rafael, CA
  6. Oakland, CA
  7. Martinez, CA
  8. Berkeley, CA
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
OSTI Identifier:
872125
Patent Number(s):
5866114
Assignee:
Chiron Corporation (Emeryville, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
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DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
crystallization; m-csf; alpha; directed; methods; crystallizing; macrophage; colony; stimulating; factor; crystalline; produced; designing; producing; agonists; antagonists; information; derived; crystallographic; structure; screening; addition; isolated; purified; soluble; functional; receptor; graphic structure; crystallographic structure; information derived; /424/117/530/999/

Citation Formats

Pandit, Jayvardhan, Jancarik, Jarmila, Kim, Sung-Hou, Koths, Kirston, Halenbeck, Robert, Fear, Anna Lisa, Taylor, Eric, Yamamoto, Ralph, and Bohm, Andrew. Crystallization of M-CSF.alpha.. United States: N. p., 1999. Web.
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Pandit, Jayvardhan, Jancarik, Jarmila, Kim, Sung-Hou, Koths, Kirston, Halenbeck, Robert, Fear, Anna Lisa, Taylor, Eric, Yamamoto, Ralph, & Bohm, Andrew. Crystallization of M-CSF.alpha.. United States.
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Pandit, Jayvardhan, Jancarik, Jarmila, Kim, Sung-Hou, Koths, Kirston, Halenbeck, Robert, Fear, Anna Lisa, Taylor, Eric, Yamamoto, Ralph, and Bohm, Andrew. Fri . "Crystallization of M-CSF.alpha.". United States. https://www.osti.gov/servlets/purl/872125.
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@article{osti_872125,
title = {Crystallization of M-CSF.alpha.},
author = {Pandit, Jayvardhan and Jancarik, Jarmila and Kim, Sung-Hou and Koths, Kirston and Halenbeck, Robert and Fear, Anna Lisa and Taylor, Eric and Yamamoto, Ralph and Bohm, Andrew},
abstractNote = {The present invention is directed to methods for crystallizing macrophage colony stimulating factor (M-CSF) and to a crystalline M-CSF produced thereby. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
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Works referenced in this record:

Human CSF-1: gene structure and alternative splicing of mRNA precursors.
journal, September 1987

Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor
journal, November 1992

[48] Protein crystallization
book, January 1990

Crystallization and preliminary X-ray studies of recombinant human granulocyte-macrophage colony stimulating factor
journal, February 1989

The Molecular and Biological Properties of the Human and Murine Members of the CSF-1 Family
book, January 1987

Purification of the colony-stimulating factor 1 receptor and demonstration of its tyrosine kinase activity.
journal, March 1987

Inducible production of human macrophage growth factor, CSF-1
journal, September 1986

Sparse matrix sampling: a screening method for crystallization of proteins
journal, August 1991

Crystallization of proteins from polyethylene glycol.
journal, October 1976

Deciphering the message in protein sequences: tolerance to amino acid substitutions
journal, March 1990

Physical Principles of Protein Crystallization
book, January 1991

Molecular and Biological Properties of Human Macrophage Growth Factor, CSF-1
journal, January 1986

Human macrophage-colony stimulating factor: Alternative RNA and protein processing from a single gene
journal, August 1988

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