Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same

Katti, Kattesh V; Berning, Douglas E; Volkert, Wynn A; Ketring, Alan R

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Title: Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same

Abstract

A complex and method for making same for use as a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a gold-ligand complex that is stable in aqueous solutions containing oxygen, serum and other body fluids.

Inventors:

Katti, Kattesh V ^[1]; Berning, Douglas E ^[1]; Volkert, Wynn A ^[1]; Ketring, Alan R ^[1]

Columbia, MO

Issue Date:: Thu Jan 01 00:00:00 EST 1998

Research Org.:: Univ. of Missouri, Columbia, MO (United States)

OSTI Identifier:: 872011

Patent Number(s):: 5843993

Assignee:: Curators of University of Missouri (Columbia, MO)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/66 - Phosphorus compounds
A61K51/0478 - {complexes from non-cyclic ligands, e.g. EDTA, MAG3}
A61K51/0489 - {Phosphates or phosphonates, e.g. bone-seeking phosphonates

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/5045 - {Complexes or chelates of phosphines with metallic compounds or metals}

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DOE Contract Number:: FG02-89ER60875

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: hydroxyalkyl; phosphine; gold; complexes; diagnostic; therapeutic; pharmaceuticals; method; complex; pharmaceutical; ligand; comprising; donor; bound; atom; form; gold-ligand; stable; aqueous; solutions; containing; oxygen; serum; fluids; therapeutic pharmaceutical; hydroxyalkyl phosphine; aqueous solution; aqueous solutions; solutions containing; containing oxygen; phosphine donor; therapeutic pharmaceuticals; ligand comprising; ligand complex; /514/999/

Citation Formats


                    Katti, Kattesh V, Berning, Douglas E, Volkert, Wynn A, and Ketring, Alan R. Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same.  United States: N. p., 1998. 
        Web.

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                    Katti, Kattesh V, Berning, Douglas E, Volkert, Wynn A, & Ketring, Alan R. Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same.  United States.

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                    Katti, Kattesh V, Berning, Douglas E, Volkert, Wynn A, and Ketring, Alan R. Thu .  
        "Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same".  United States.  https://www.osti.gov/servlets/purl/872011.

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@article{osti_872011,

  title        = {Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same},

  author       = {Katti, Kattesh V and Berning, Douglas E and Volkert, Wynn A and Ketring, Alan R},

  abstractNote = {A complex and method for making same for use as a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a gold-ligand complex that is stable in aqueous solutions containing oxygen, serum and other body fluids.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Thu Jan 01 00:00:00 EST 1998},

  month        = {Thu Jan 01 00:00:00 EST 1998}

}

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Works referenced in this record:

In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP)
journal, July 1996

Berning, D. E.; Katti, K. V.; Singh, P. R.
Nuclear Medicine and Biology, Vol. 23, Issue 5
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Chiral Phosphine Ligands Derived from Sugars. 3. Syntheses, Structures, and Spectroscopic Properties of Gold(I) Complexes with Chiral Phosphines from Glucose. X-ray Structures of [Au(2-MBPA)Cl] and [Au(3-MBPA)(2-pyS)]
journal, January 1996

Shi, Ji-Cheng; Huang, Xiao-Ying; Wu, Da-Xu
Inorganic Chemistry, Vol. 35, Issue 10
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Stable gold( I ) complexes with chelate rings: solution studies of bis(phosphino)ethane complexes and X-ray crystal structure of bis[1,2-bis(diphenylphosphino)ethane]gold( I ) hexafluoroantimonate–acetone (1/1)
journal, January 1984

Berners-Price, Susan J.; Mazid, Muhammed A.; Sadler, Peter J.
J. Chem. Soc., Dalton Trans., Issue 5
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Medicinal chemistry and pharmacology of gold compounds
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Relativistic effects on chemical properties
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MISSYM 1.1 – a flexible new release
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Le Page, Y.
Journal of Applied Crystallography, Vol. 21, Issue 6
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Nearly regular tetrahedral geometry in a gold(I)-phosphine complex. X-Ray crystal structure of tetrakis(methyldiphenylphosphine)gold(I) hexafluorophosphate
journal, January 1981

Elder, R. C.; Zeiher, E. H. Kelle; Onady, Mark
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An empirical correction for absorption anisotropy
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Ludwig Mond Lecture. High-carat gold compounds
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Synthesis of water-soluble (tri(hydroxymethyl)phosphine)gold(I) complexes containing a nucleoside ligand
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Komiya, Sanshiro; Awata, Hiroko; Ishimatsu, Shigeyuki
Inorganica Chimica Acta, Vol. 217, Issue 1-2
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A tetrahedral complex of gold(I). The crystal and molecular structure of Au(Ph2PCH2CH2PPh2)2Cl·2H2O
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NRCVAX – an interactive program system for structure analysis
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Vehicles, Chelators, and Radionuclides: Choosing the “Building Blocks” of an Effective Therapeutic Radioimmunoconjugate
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Schubiger, P. August; Alberto, Roger; Smith, Alan
Bioconjugate Chemistry, Vol. 7, Issue 2
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Hydroxymethyl bis(phosphines) and their palladium(II) and platinum(II) complexes formed via biphasic reactions. Crystal structure of [Pd{(HOH2C)2PC6H4P(CH2OH)2}2]Cl2
journal, January 1996

Reddy, V. Sreenivasa; Katti, Kattesh V.; Barnes, Charles L.
Journal of the Chemical Society, Dalton Transactions, Issue 7
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Chemistry in Environmentally Benign Media. 3. ¹ Synthesis and Characterization of Rhenium(V) Complexes Derived from Novel Water-Soluble (Hydroxymethyl)phosphines. Crystal Structures of [Re(O) ₂ {(HOH ₂ C) ₂ PC ₆ H ₄ P(CH ₂ OH) ₂ } ₂ ]I and [Re(O) ₂ {(HOH ₂ C) ₂ PCH ₂ CH ₂ P(CH ₂ OH) ₂ } ₂ ]Cl
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Inorganic Chemistry, Vol. 35, Issue 7
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Crystal structures and solution electronic absorption and MCD spectra for perchlorate and halide salts of binuclear gold(I) complexes containing bridging Me2PCH2PMe2 (dmpm) or Me2PCH2CH2PMe2 (dmpe) ligands
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Relativistic effects in structural chemistry
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Syntheses and Structural Characterization of Tetrahedral Four-Coordinate Gold(I) Complexes of 1,3,5-Triaza-7-phosphaadamantane. An Example of a Hydrogen-Bond-Directed Supramolecular Assembly
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Similar Records

Title: Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same

Abstract

Citation Formats

In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP) journal, July 1996

Chiral Phosphine Ligands Derived from Sugars. 3. Syntheses, Structures, and Spectroscopic Properties of Gold(I) Complexes with Chiral Phosphines from Glucose. X-ray Structures of [Au(2-MBPA)Cl] and [Au(3-MBPA)(2-pyS)] journal, January 1996

Stable gold( I ) complexes with chelate rings: solution studies of bis(phosphino)ethane complexes and X-ray crystal structure of bis[1,2-bis(diphenylphosphino)ethane]gold( I ) hexafluoroantimonate–acetone (1/1) journal, January 1984

Medicinal chemistry and pharmacology of gold compounds journal, August 1996

Relativistic effects on chemical properties journal, August 1979

MISSYM 1.1 – a flexible new release journal, December 1988

Nearly regular tetrahedral geometry in a gold(I)-phosphine complex. X-Ray crystal structure of tetrakis(methyldiphenylphosphine)gold(I) hexafluorophosphate journal, January 1981

An empirical correction for absorption anisotropy journal, January 1995

Ludwig Mond Lecture. High-carat gold compounds journal, January 1995

Synthesis of water-soluble (tri(hydroxymethyl)phosphine)gold(I) complexes containing a nucleoside ligand journal, March 1994

A tetrahedral complex of gold(I). The crystal and molecular structure of Au(Ph2PCH2CH2PPh2)2Cl·2H2O journal, January 1984

NRCVAX – an interactive program system for structure analysis journal, August 1989

Vehicles, Chelators, and Radionuclides: Choosing the “Building Blocks” of an Effective Therapeutic Radioimmunoconjugate journal, January 1996

Hydroxymethyl bis(phosphines) and their palladium(II) and platinum(II) complexes formed via biphasic reactions. Crystal structure of [Pd{(HOH2C)2PC6H4P(CH2OH)2}2]Cl2 journal, January 1996

Crystal structures and solution electronic absorption and MCD spectra for perchlorate and halide salts of binuclear gold(I) complexes containing bridging Me2PCH2PMe2 (dmpm) or Me2PCH2CH2PMe2 (dmpe) ligands journal, March 1989

Relativistic effects in structural chemistry journal, May 1988

Syntheses and Structural Characterization of Tetrahedral Four-Coordinate Gold(I) Complexes of 1,3,5-Triaza-7-phosphaadamantane. An Example of a Hydrogen-Bond-Directed Supramolecular Assembly journal, January 1996

Application of a segment description of the unique set of reflections to data collection and data reduction journal, October 1979

In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP)
journal, July 1996

Chiral Phosphine Ligands Derived from Sugars. 3. Syntheses, Structures, and Spectroscopic Properties of Gold(I) Complexes with Chiral Phosphines from Glucose. X-ray Structures of [Au(2-MBPA)Cl] and [Au(3-MBPA)(2-pyS)]
journal, January 1996

Stable gold( I ) complexes with chelate rings: solution studies of bis(phosphino)ethane complexes and X-ray crystal structure of bis[1,2-bis(diphenylphosphino)ethane]gold( I ) hexafluoroantimonate–acetone (1/1)
journal, January 1984

Medicinal chemistry and pharmacology of gold compounds
journal, August 1996

Relativistic effects on chemical properties
journal, August 1979

MISSYM 1.1 – a flexible new release
journal, December 1988

Nearly regular tetrahedral geometry in a gold(I)-phosphine complex. X-Ray crystal structure of tetrakis(methyldiphenylphosphine)gold(I) hexafluorophosphate
journal, January 1981

An empirical correction for absorption anisotropy
journal, January 1995

Ludwig Mond Lecture. High-carat gold compounds
journal, January 1995

Synthesis of water-soluble (tri(hydroxymethyl)phosphine)gold(I) complexes containing a nucleoside ligand
journal, March 1994

A tetrahedral complex of gold(I). The crystal and molecular structure of Au(Ph2PCH2CH2PPh2)2Cl·2H2O
journal, January 1984

NRCVAX – an interactive program system for structure analysis
journal, August 1989

Vehicles, Chelators, and Radionuclides: Choosing the “Building Blocks” of an Effective Therapeutic Radioimmunoconjugate
journal, January 1996

Hydroxymethyl bis(phosphines) and their palladium(II) and platinum(II) complexes formed via biphasic reactions. Crystal structure of [Pd{(HOH2C)2PC6H4P(CH2OH)2}2]Cl2
journal, January 1996

Crystal structures and solution electronic absorption and MCD spectra for perchlorate and halide salts of binuclear gold(I) complexes containing bridging Me2PCH2PMe2 (dmpm) or Me2PCH2CH2PMe2 (dmpe) ligands
journal, March 1989

Relativistic effects in structural chemistry
journal, May 1988

Syntheses and Structural Characterization of Tetrahedral Four-Coordinate Gold(I) Complexes of 1,3,5-Triaza-7-phosphaadamantane. An Example of a Hydrogen-Bond-Directed Supramolecular Assembly
journal, January 1996

Application of a segment description of the unique set of reflections to data collection and data reduction
journal, October 1979