Controlled release of molecular components of dendrimer/bioactive complexes

Segalman, Daniel J; Wallace, J Shield

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Title: Controlled release of molecular components of dendrimer/bioactive complexes

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Abstract

A method for releasing molecules (guest molecules) from the matrix formed by the structure of another molecule (host molecule) in a controllable manner has been invented. This method has many applications in science and industry. In addition, applications based on such molecular systems may revolutionize significant areas of medicine, in particular the treatment of cancer and of viral infection. Similar effects can also be obtained by controlled fragmentation of a source molecule, where the molecular fragments form the active principle.

Inventors:

Segalman, Daniel J ^[1]; Wallace, J Shield ^[1]

Albuquerque, NM

Issue Date:: Thu Jan 01 00:00:00 EST 1998

Research Org.:: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

OSTI Identifier:: 871783

Patent Number(s):: 5795581

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K41/0028 - {Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds}
A61K9/0009 - {involving or responsive to electricity, magnetism or acoustic waves

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S424/16 - Dendrimers and dendritic polymers

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: controlled; release; molecular; components; dendrimer; bioactive; complexes; method; releasing; molecules; guest; matrix; formed; structure; molecule; host; controllable; manner; invented; applications; science; industry; addition; based; systems; revolutionize; significant; medicine; particular; treatment; cancer; viral; infection; similar; effects; obtained; fragmentation; source; fragments; form; active; principle; controlled release; applications based; molecular components; viral infection; molecular component; controllable manner; /424/

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                    Segalman, Daniel J, and Wallace, J Shield. Controlled release of molecular components of dendrimer/bioactive complexes.  United States: N. p., 1998. 
        Web.

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                    Segalman, Daniel J, & Wallace, J Shield. Controlled release of molecular components of dendrimer/bioactive complexes.  United States.

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                    Segalman, Daniel J, and Wallace, J Shield. Thu .  
        "Controlled release of molecular components of dendrimer/bioactive complexes".  United States.  https://www.osti.gov/servlets/purl/871783.

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@article{osti_871783,

  title        = {Controlled release of molecular components of dendrimer/bioactive complexes},

  author       = {Segalman, Daniel J and Wallace, J Shield},

  abstractNote = {A method for releasing molecules (guest molecules) from the matrix formed by the structure of another molecule (host molecule) in a controllable manner has been invented. This method has many applications in science and industry. In addition, applications based on such molecular systems may revolutionize significant areas of medicine, in particular the treatment of cancer and of viral infection. Similar effects can also be obtained by controlled fragmentation of a source molecule, where the molecular fragments form the active principle.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Thu Jan 01 00:00:00 EST 1998},

  month        = {Thu Jan 01 00:00:00 EST 1998}

}

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A method for releasing molecules (guest molecules) from the matrix formed by the structure of another molecule (host molecule) in a controllable manner has been invented. This method has many applications in science and industry. In addition, applications based on such molecular systems may revolutionize significant areas of medicine, in particular the treatment of cancer and of viral infection. Similar effects can also be obtained by controlled fragmentation of a source molecule, where the molecular fragments form the active principle. 13 figs.
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