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Title: Laser illumination of multiple capillaries that form a waveguide

Abstract

A system and method are disclosed for efficient laser illumination of the interiors of multiple capillaries simultaneously, and collection of light emitted from them. Capillaries in a parallel array can form an optical waveguide wherein refraction at the cylindrical surfaces confines side-on illuminating light to the core of each successive capillary in the array. Methods are provided for determining conditions where capillaries will form a waveguide and for assessing and minimizing losses due to reflection. Light can be delivered to the arrayed capillaries through an integrated fiber optic transmitter or through a pair of such transmitters aligned coaxially at opposite sides of the array. Light emitted from materials within the capillaries can be carried to a detection system through optical fibers, each of which collects light from a single capillary, with little cross talk between the capillaries. The collection ends of the optical fibers can be in a parallel array with the same spacing as the capillary array, so that the collection fibers can all be aligned to the capillaries simultaneously. Applicability includes improving the efficiency of many analytical methods that use capillaries, including particularly high-throughput DNA sequencing and diagnostic methods based on capillary electrophoresis.

Inventors:
 [1];  [2];  [3]
+ Show Inventor Affiliations
  1. Setauket, NY
  2. Middle Island, NY
  3. Stony Brook, NY
Issue Date:
Research Org.:
Associated Universities, Inc., Upton, NY (United States)
OSTI Identifier:
871761
Patent Number(s):
5790727
Application Number:
08/796,097
Assignee:
Brookhaven Science Associates LLC (Upton, NY)
Patent Classifications (CPCs):
G - PHYSICS G02 - OPTICS G02B - OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
laser; illumination; multiple; capillaries; form; waveguide; method; disclosed; efficient; interiors; simultaneously; collection; light; emitted; parallel; array; optical; refraction; cylindrical; surfaces; confines; side-on; illuminating; core; successive; capillary; methods; provided; determining; conditions; assessing; minimizing; losses; due; reflection; delivered; arrayed; integrated; fiber; optic; transmitter; pair; transmitters; aligned; coaxially; opposite; materials; carried; detection; fibers; collects; single; talk; spacing; applicability; improving; efficiency; analytical; including; particularly; high-throughput; dna; sequencing; diagnostic; based; electrophoresis; diagnostic method; multiple capillaries; losses due; cylindrical surface; capillary electrophoresis; optical fibers; fiber optic; optical fiber; dna sequencing; light emitted; optical waveguide; capillary array; laser illumination; optical wave; parallel array; aligned coaxially; cylindrical surfaces; illuminating light; efficient laser; /385/204/

Citation Formats

Dhadwal, Harbans S, Quesada, Mark A, and Studier, F William. Laser illumination of multiple capillaries that form a waveguide. United States: N. p., 1998. Web.
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Dhadwal, Harbans S, Quesada, Mark A, & Studier, F William. Laser illumination of multiple capillaries that form a waveguide. United States.
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Dhadwal, Harbans S, Quesada, Mark A, and Studier, F William. Tue . "Laser illumination of multiple capillaries that form a waveguide". United States. https://www.osti.gov/servlets/purl/871761.
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@article{osti_871761,
title = {Laser illumination of multiple capillaries that form a waveguide},
author = {Dhadwal, Harbans S and Quesada, Mark A and Studier, F William},
abstractNote = {A system and method are disclosed for efficient laser illumination of the interiors of multiple capillaries simultaneously, and collection of light emitted from them. Capillaries in a parallel array can form an optical waveguide wherein refraction at the cylindrical surfaces confines side-on illuminating light to the core of each successive capillary in the array. Methods are provided for determining conditions where capillaries will form a waveguide and for assessing and minimizing losses due to reflection. Light can be delivered to the arrayed capillaries through an integrated fiber optic transmitter or through a pair of such transmitters aligned coaxially at opposite sides of the array. Light emitted from materials within the capillaries can be carried to a detection system through optical fibers, each of which collects light from a single capillary, with little cross talk between the capillaries. The collection ends of the optical fibers can be in a parallel array with the same spacing as the capillary array, so that the collection fibers can all be aligned to the capillaries simultaneously. Applicability includes improving the efficiency of many analytical methods that use capillaries, including particularly high-throughput DNA sequencing and diagnostic methods based on capillary electrophoresis.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 04 00:00:00 EDT 1998},
month = {Tue Aug 04 00:00:00 EDT 1998}
}
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Works referenced in this record:

A Capillary Array Gel Electrophoresis System Using Multiple Laser Focusing for DNA Sequencing
journal, January 1996

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