Ultrasonic characterization of single drops of liquids
Abstract
Ultrasonic characterization of single drops of liquids. The present invention includes the use of two closely spaced transducers, or one transducer and a closely spaced reflector plate, to form an interferometer suitable for ultrasonic characterization of droplet-size and smaller samples without the need for a container. The droplet is held between the interferometer elements, whose distance apart may be adjusted, by surface tension. The surfaces of the interferometer elements may be readily cleansed by a stream of solvent followed by purified air when it is desired to change samples. A single drop of liquid is sufficient for high-quality measurement. Examples of samples which may be investigated using the apparatus and method of the present invention include biological specimens (tear drops; blood and other body fluid samples; samples from tumors, tissues, and organs; secretions from tissues and organs; snake and bee venom, etc.) for diagnostic evaluation, samples in forensic investigations, and detection of drugs in small quantities.
- Inventors:
-
- Los Alamos, NM
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 871473
- Patent Number(s):
- 5739432
- Assignee:
- Regents of University of California (Los Alamos, NM)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- ultrasonic; characterization; single; drops; liquids; closely; spaced; transducers; transducer; reflector; plate; form; interferometer; suitable; droplet-size; samples; container; droplet; held; elements; distance; apart; adjusted; surface; tension; surfaces; readily; cleansed; stream; solvent; followed; purified; air; desired; change; drop; liquid; sufficient; high-quality; measurement; examples; investigated; apparatus; method; biological; specimens; tear; blood; fluid; tumors; tissues; organs; secretions; snake; venom; etc; diagnostic; evaluation; forensic; investigations; detection; drugs; quantities; biological specimens; fluid sample; closely spaced; surface tension; fluid samples; solvent followed; ultrasonic characterization; distance apart; single drops; quality measurement; single drop; /73/
Citation Formats
Sinha, Dipen N. Ultrasonic characterization of single drops of liquids. United States: N. p., 1998.
Web.
Sinha, Dipen N. Ultrasonic characterization of single drops of liquids. United States.
Sinha, Dipen N. Tue .
"Ultrasonic characterization of single drops of liquids". United States. https://www.osti.gov/servlets/purl/871473.
@article{osti_871473,
title = {Ultrasonic characterization of single drops of liquids},
author = {Sinha, Dipen N},
abstractNote = {Ultrasonic characterization of single drops of liquids. The present invention includes the use of two closely spaced transducers, or one transducer and a closely spaced reflector plate, to form an interferometer suitable for ultrasonic characterization of droplet-size and smaller samples without the need for a container. The droplet is held between the interferometer elements, whose distance apart may be adjusted, by surface tension. The surfaces of the interferometer elements may be readily cleansed by a stream of solvent followed by purified air when it is desired to change samples. A single drop of liquid is sufficient for high-quality measurement. Examples of samples which may be investigated using the apparatus and method of the present invention include biological specimens (tear drops; blood and other body fluid samples; samples from tumors, tissues, and organs; secretions from tissues and organs; snake and bee venom, etc.) for diagnostic evaluation, samples in forensic investigations, and detection of drugs in small quantities.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 14 00:00:00 EDT 1998},
month = {Tue Apr 14 00:00:00 EDT 1998}
}
Works referenced in this record:
Ultrasonic Measurements with Milliliter Liquid Samples in the 0.5–100 MHz Range
journal, August 1973
- Eggers, F.; Funck, Th.
- Review of Scientific Instruments, Vol. 44, Issue 8
Frequency scanning ultrasonic pulse echo reflectometer
journal, January 1992
- McClements, D. J.; Fairley, P.
- Ultrasonics, Vol. 30, Issue 6
Development of methods of precise ultrasonic measurements in small volumes of liquids
journal, July 1982
- Sarvazyan, A. P.
- Ultrasonics, Vol. 20, Issue 4