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Title: Nucleic acids encoding a cellulose binding domain

Abstract

A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

Inventors:
 [1];  [2];  [3];  [3]
  1. Karmey Yosef, IL
  2. Rehovot, IL
  3. Davis, CA
Issue Date:
Research Org.:
Univ. of California (United States)
OSTI Identifier:
870329
Patent Number(s):
5496934
Assignee:
Yissum Research Development Company of Hebrew University of Jerusalem (IL); Regents of University of California (CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A01 - AGRICULTURE A01N - PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG03-92ER20069
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
nucleic; acids; encoding; cellulose; binding; domain; cbd; affinity; crystalline; chitin; disclosed; methods; molecular; cloning; recombinant; production; fusion; products; comprising; protein; likewise; described; wide; range; applications; contemplated; including; drug; delivery; separations; diagnostic; techniques; molecular cloning; affinity separations; crystalline cellulose; acids encoding; including drug; likewise described; diagnostic techniques; binding domain; cellulose binding; nucleic acid; wide range; nucleic acids; products comprising; drug delivery; fusion products; recombinant production; /999/435/

Citation Formats

Shoseyov, Oded, Shpiegl, Itai, Goldstein, Marc A, and Doi, Roy H. Nucleic acids encoding a cellulose binding domain. United States: N. p., 1996. Web.
Shoseyov, Oded, Shpiegl, Itai, Goldstein, Marc A, & Doi, Roy H. Nucleic acids encoding a cellulose binding domain. United States.
Shoseyov, Oded, Shpiegl, Itai, Goldstein, Marc A, and Doi, Roy H. Mon . "Nucleic acids encoding a cellulose binding domain". United States. https://www.osti.gov/servlets/purl/870329.
@article{osti_870329,
title = {Nucleic acids encoding a cellulose binding domain},
author = {Shoseyov, Oded and Shpiegl, Itai and Goldstein, Marc A and Doi, Roy H},
abstractNote = {A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1996},
month = {Mon Jan 01 00:00:00 EST 1996}
}

Works referenced in this record:

Immobilization and purification of enzymes with staphylococcal protein A gene fusion vectors.
journal, April 1985


Identification of the cellulose-binding domain of the cellulosome subunit S1 from Clostridium thermocellum YS
journal, December 1992


Nucleotide sequence of rat hsp60 (chaperonin, GroEL homolog) cDNA
journal, January 1990


Essential 170-kDa subunit for degradation of crystalline cellulose by Clostridium cellulovorans cellulase.
journal, March 1990


Fusion to an endoglucanase allows alkaline phosphatase to bind to cellulose
journal, February 1989


Sequence analysis of the Clostridium stercorarium celZ gene encoding a thermoactive cellulase (Avicelase I): Identification of catalytic and cellulose-binding domains
journal, September 1990


Efficient mapping of protein antigenic determinants.
journal, September 1986


Trends in biochemistry and enzymology of cellulose degradation
journal, November 1990


Chitinase from Serratia marcescens
book, January 1988


Deciphering the message in protein sequences: tolerance to amino acid substitutions
journal, March 1990


Immobilized endo-.beta.-glucosidase enriches flavor of wine and passion fruit juice
journal, June 1990


Homologous plant and bacterial proteins chaperone oligomeric protein assembly
journal, May 1988


Primary sequence analysis of Clostridium cellulovorans cellulose binding protein A.
journal, April 1992


Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.
journal, February 1990


Molecular cloning of a Chinese hamster mitochondrial protein related to the “chaperonin” family of bacterial and plant proteins
journal, July 1989


Non–Hydrolytic Disruption of Cellulose Fibres by the Binding Domain of a Bacterial Cellulase
journal, November 1991


A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic.
journal, January 1990


Synovial fluid-derivedYersinia-reactive T cells responding to human 65-kDa heat-shock protein and heat-stressed antigen-presenting cells
journal, September 1991


Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis
journal, January 1988