Automated two-dimensional interface for capillary gas chromatography
Abstract
A multidimensional gas chromatograph (GC) system having wide bore capillary and narrow bore capillary GC columns in series and having a novel system interface. Heart cuts from a high flow rate sample, separated by a wide bore GC column, are collected and directed to a narrow bore GC column with carrier gas injected at a lower flow compatible with a mass spectrometer. A bimodal six-way valve is connected with the wide bore GC column outlet and a bimodal four-way valve is connected with the narrow bore GC column inlet. A trapping and retaining circuit with a cold trap is connected with the six-way valve and a transfer circuit interconnects the two valves. The six-way valve is manipulated between first and second mode positions to collect analyte, and the four-way valve is manipulated between third and fourth mode positions to allow carrier gas to sweep analyte from a deactivated cold trap, through the transfer circuit, and then to the narrow bore GC capillary column for separation and subsequent analysis by a mass spectrometer. Rotary valves have substantially the same bore width as their associated columns to minimize flow irregularities and resulting sample peak deterioration. The rotary valves are heated separately frommore »
- Inventors:
-
- Albuquerque, NM
- Issue Date:
- Research Org.:
- LOVELACE BIOMED & ENV RES INST
- OSTI Identifier:
- 870301
- Patent Number(s):
- 5492555
- Application Number:
- 08/257,388
- Assignee:
- Lovelace Biomedical & Environmental Research Institute, Inc. (Albuquerque, NM)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC04-76EV01013
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- automated; two-dimensional; interface; capillary; gas; chromatography; multidimensional; chromatograph; gc; wide; bore; narrow; columns; series; novel; heart; cuts; flow; rate; sample; separated; column; collected; directed; carrier; injected; compatible; mass; spectrometer; bimodal; six-way; valve; connected; outlet; four-way; inlet; trapping; retaining; circuit; cold; trap; transfer; interconnects; valves; manipulated; mode; positions; collect; analyte; third; fourth; allow; sweep; deactivated; separation; subsequent; analysis; rotary; substantially; width; associated; minimize; irregularities; resulting; peak; deterioration; heated; separately; avoid; temperature; lag; rotary valves; narrow bore; subsequent analysis; capillary column; gas chromatography; cold trap; mass spectrometer; carrier gas; flow rate; gas chromatograph; transfer circuit; gas injected; capillary gas; bore capillary; rotary valve; capillary gc; /95/73/96/
Citation Formats
Strunk, Michael R, and Bechtold, William E. Automated two-dimensional interface for capillary gas chromatography. United States: N. p., 1996.
Web.
Strunk, Michael R, & Bechtold, William E. Automated two-dimensional interface for capillary gas chromatography. United States.
Strunk, Michael R, and Bechtold, William E. Tue .
"Automated two-dimensional interface for capillary gas chromatography". United States. https://www.osti.gov/servlets/purl/870301.
@article{osti_870301,
title = {Automated two-dimensional interface for capillary gas chromatography},
author = {Strunk, Michael R and Bechtold, William E},
abstractNote = {A multidimensional gas chromatograph (GC) system having wide bore capillary and narrow bore capillary GC columns in series and having a novel system interface. Heart cuts from a high flow rate sample, separated by a wide bore GC column, are collected and directed to a narrow bore GC column with carrier gas injected at a lower flow compatible with a mass spectrometer. A bimodal six-way valve is connected with the wide bore GC column outlet and a bimodal four-way valve is connected with the narrow bore GC column inlet. A trapping and retaining circuit with a cold trap is connected with the six-way valve and a transfer circuit interconnects the two valves. The six-way valve is manipulated between first and second mode positions to collect analyte, and the four-way valve is manipulated between third and fourth mode positions to allow carrier gas to sweep analyte from a deactivated cold trap, through the transfer circuit, and then to the narrow bore GC capillary column for separation and subsequent analysis by a mass spectrometer. Rotary valves have substantially the same bore width as their associated columns to minimize flow irregularities and resulting sample peak deterioration. The rotary valves are heated separately from the GC columns to avoid temperature lag and resulting sample deterioration.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 20 00:00:00 EST 1996},
month = {Tue Feb 20 00:00:00 EST 1996}
}
Works referenced in this record:
Multidimensional gas chromatography (MDC) in capillary columns using double oven instruments and a newly designed coupling piece for monitoring detection after pre-separation
journal, December 1982
- Schomburg, G.; Weeke, F.; Müller, F.
- Chromatographia, Vol. 16, Issue 1
Valveless flow switching using constant flow controllers
journal, October 1984
- Abbott, D. J.
- Journal of High Resolution Chromatography, Vol. 7, Issue 10