Title: Derivatized gold clusters and antibody-gold cluster conjugates

Abstract

Antibody- or antibody fragment-gold cluster conjugates are shown wherein the conjugate size can be as small as 5.0 nm. Methods and reagents are disclosed in which antibodies, Fab' or F(ab').sub.2 fragments thereof are covalently bound to a stable cluster of gold atoms. The gold clusters may contain 6, 8, 9, 11, 13, 55 or 67 gold atoms in their inner core. The clusters may also contain radioactive gold. The antibody-cluster conjugates are useful in electron microscopy applications as well as in clinical applications that include imaging, diagnosis and therapy.

Inventors:

Hainfeld, James F ^[1]; Furuya, Frederic R ^[2]

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1. Shoreham, NY
2. Williston Park, NY

Issue Date:

Tue Nov 01 00:00:00 EST 1994

Research Org.:

Associated Universities, Inc., Upton, NY (United States)

OSTI Identifier:

869590

Patent Number(s):

5360895

Application Number:

07/988,338

Assignee:

Associated Universities, Inc. (Washington, DC)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K47/6883 - {Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab
A61K47/6923 - {the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

C07F9/5045 - {Complexes or chelates of phosphines with metallic compounds or metals}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/585 - {with a particulate label, e.g. coloured latex}
G01N33/60 - involving radioactive labelled substances

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DOE Contract Number:  

AC02-76CH00016

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

derivatized; gold; clusters; antibody-gold; cluster; conjugates; antibody-; antibody; fragment-gold; shown; conjugate; size; nm; methods; reagents; disclosed; antibodies; fab; fragments; covalently; bound; stable; atoms; contain; 11; 13; 55; 67; inner; core; radioactive; antibody-cluster; useful; electron; microscopy; applications; clinical; imaging; diagnosis; therapy; inner core; covalently bound; antibody fragment; cluster conjugates; electron microscopy; /530/436/