Method to directly radiolabel antibodies for diagnostic imaging and therapy
Abstract
The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein. A kit is also provided wherein the protein and/or reducing agents may be in lyophilized form.
- Inventors:
-
- Cherry Hill, NJ
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 869275
- Patent Number(s):
- 5308603
- Assignee:
- Thomas Jefferson University (Philadelphia, PA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- DOE Contract Number:
- AC04-76
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; directly; radiolabel; antibodies; diagnostic; imaging; therapy; novel; kit; radiolabeling; proteins; antibody; fragments; therapeutic; purposes; comprises; incubating; protein-containing; solution; sodium; ascorbate; adding; required; quantity; reduced; radionuclide; incubated; protein; provided; reducing; agents; lyophilized; form; reducing agents; therapeutic purposes; method comprises; reducing agent; novel method; antibody fragment; method comprise; diagnostic imaging; radiolabel antibodies; radiolabeling proteins; containing solution; reduced radio; antibody fragments; directly radiolabeling; directly radiolabel; /424/530/
Citation Formats
Thakur, Mathew L. Method to directly radiolabel antibodies for diagnostic imaging and therapy. United States: N. p., 1994.
Web.
Thakur, Mathew L. Method to directly radiolabel antibodies for diagnostic imaging and therapy. United States.
Thakur, Mathew L. Sat .
"Method to directly radiolabel antibodies for diagnostic imaging and therapy". United States. https://www.osti.gov/servlets/purl/869275.
@article{osti_869275,
title = {Method to directly radiolabel antibodies for diagnostic imaging and therapy},
author = {Thakur, Mathew L},
abstractNote = {The invention is a novel method and kit for directly radiolabeling proteins such as antibodies or antibody fragments for diagnostic and therapeutic purposes. The method comprises incubating a protein-containing solution with a solution of sodium ascorbate; adding a required quantity of reduced radionuclide to the incubated protein. A kit is also provided wherein the protein and/or reducing agents may be in lyophilized form.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1994},
month = {Sat Jan 01 00:00:00 EST 1994}
}
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